Endocrinologist最新文献_第4页

Familial Clustering of Metabolic Syndrome Components in Parents of Obese Children 肥胖儿童父母代谢综合征成分的家族聚类分析

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F64E6D

Ş. Erdeve, E. Şimşek, Y. Dallar, Z. Bıyıklı

引用次数: 1

Nodular Thyroid Disease: Natural History of Nodules Without an Initial Indication for Cytology 甲状腺结节性疾病:没有细胞学初步适应症的结节的自然史

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F6503F

P. Rosário, D. Salles, Breno Bessa, S. Purisch

{"title":"Nodular Thyroid Disease: Natural History of Nodules Without an Initial Indication for Cytology","authors":"P. Rosário, D. Salles, Breno Bessa, S. Purisch","doi":"10.1097/TEN.0B013E3181F6503F","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181F6503F","url":null,"abstract":"We investigated the evolution of thyroid nodules ≤1 cm without suspicious ultrasonographic characteristics and hot nodules detected by 131I scintigraphy (that do not require cytologic evaluation) in patients who are at low risk for malignancy. \u0000A total of 148 patients with 290 nodules ≤1 cm without suspicious characteristics and 32 subjects with low thyroid stimulating hormone and 55 hot nodules were studied. Thirty-six of the 290 nodules ≤1 cm without suspicious characteristics exhibited growth during follow-up and were punctured. Cytology was interpreted as benign in 28 cases, insufficient in 6, indeterminate in 1, and suspicious of malignancy in another (papillary carcinoma). Ten patients with hot nodules were treated with radioiodine because of progression to hyperthyroidism. Twenty patients with 35 hot nodules were followed and none had significant nodule growth. Therefore, malignancy was observed in only 1 of 345 nodules (0.3%) without an initial indication for cytology. \u0000Cytology is not necessary in the case of nodules ≤1 cm that have no suspicious radiologic features or hot nodules in patients without a history of neck radiation during childhood or a family history of thyroid carcinoma.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"39 1","pages":"243-244"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74814660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The effect of rosiglitazone on retinol binding protein 4 in subjects of impaired glucose tolerance 罗格列酮对糖耐量受损患者视黄醇结合蛋白4的影响

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F661EC

C. Hsieh, Y. Hung, D. Pei, Chung-Ze Wu, Fone-Ching Hsiao

{"title":"The effect of rosiglitazone on retinol binding protein 4 in subjects of impaired glucose tolerance","authors":"C. Hsieh, Y. Hung, D. Pei, Chung-Ze Wu, Fone-Ching Hsiao","doi":"10.1097/TEN.0B013E3181F661EC","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181F661EC","url":null,"abstract":"Abstract: Retinol-binding protein-4 (RBP4) is a novel adipokine, which is reported to be associated with obesity and insulin resistance (IR). We studied the effect of rosiglitazone (ROS), an insulin sensitizer, on the RBP4 plasma concentrations in subjects with impaired glucose tolerance (IGT). A single-blind, placebo-controlled comparison trial was conducted. A total of 26 IGT patients (mean age of 54 years) were enrolled; 14 received ROS (4 mg daily) and 12 received placebo. An enzyme immunoassay (EIA) was used to measure plasma RBP4 concentrations before and after therapy in both treatment groups. Plasma RBP4 concentrations were not associated with IR and cardiovascular risk factors with the exception of serum creatine levels. ROS therapy decreased RBP4 levels independent of IR, but associated with the changes in aspartate aminotransferase and triglyceride levels as well as basal serum RBB4 concentrations. In brief, plasma RBP4 concentrations in IGT subjects did not correlate with most cardiovascular risk factors and IR. However, treating IGT subjects with ROS resulted in decreased RBP4 levels independent of IR.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"2 1","pages":"250-253"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88776941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged Treatment With Antithyroid Drugs: How Long to Treat Safely … Months, Years, or a Lifetime? 抗甲状腺药物的长期治疗:治疗多长时间是安全的?几个月，几年，还是一生?

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F47FB2

Peggy Nelson, V. Gossain

{"title":"Prolonged Treatment With Antithyroid Drugs: How Long to Treat Safely … Months, Years, or a Lifetime?","authors":"Peggy Nelson, V. Gossain","doi":"10.1097/TEN.0B013E3181F47FB2","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181F47FB2","url":null,"abstract":"Objective: To describe a case where continuous use of antithyroid medications was safely and effectively employed for the treatment of hyperthyroidism over a period of 14 years in a patient who refused radioactive ablative therapy and surgery. Case Report: The patient is a 71-year-old woman who presented with complaints of tachycardia and tremors along with a diffusely enlarged goiter without appreciable nodules. At the time of evaluation, she was clinically and biochemically hyperthyroid. An I123 thyroid uptake and scan revealed a toxic multinodular goiter. She was started on propylthiouracil therapy, which was discontinued due to generalized pruritus. After approximately 4 months of refusing alternative antithyroid therapy, she was started on methimazole. In the subsequent 14 years of management, she relapsed 3 times off antithyroid drugs. However, she never developed any major side effects with the maintenance of methimazole dose of 5 mg daily. Conclusions: The goal of treatment for hyperthyroidism is to render the patient euthyroid safely. However, when treated with radioactive ablative therapy or surgery, the patient is at high risk of being on lifelong thyroxine therapy. Therefore, it appears reasonable that well-informed patients who would prefer lifelong antithyroid therapy, as opposed to lifelong thyroxine therapy, should be given that option.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"1 1","pages":"217-219"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88326811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hyper- and Hypocalcemia: Pitfalls in Interpretation and Treatment 高钙和低钙:解释和治疗的陷阱

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F47CE8

H. Rehman, Claire E. Michaels

引用次数: 0

Polymorphisms in Genes Involved in Testosterone Metabolism in Slovak Autistic Boys 斯洛伐克自闭症男孩睾酮代谢相关基因多态性研究

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F661D2

E. Schmidtová, S. Kelemenova, P. Celec, A. Ficek, D. Ostatníková

{"title":"Polymorphisms in Genes Involved in Testosterone Metabolism in Slovak Autistic Boys","authors":"E. Schmidtová, S. Kelemenova, P. Celec, A. Ficek, D. Ostatníková","doi":"10.1097/TEN.0B013E3181F661D2","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181F661D2","url":null,"abstract":"Autism spectrum disorders (ASDs) are neurodevelopment disorders which are characterized by impairments in the following core domains: social interaction, language development, verbal/nonverbal communication, and repetitive and restricted behaviors. The androgen theory of autism proposes that autism spectrum disorders develop in part due to elevated fetal testosterone levels, which correlate with a number of autistic traits. The present study evaluates androgen and estrogen levels in saliva as well as polymorphisms in genes for androgen receptor (AR), 5-alpha reductase (SRD5A2), and estrogen receptor alpha (ESR1) in the Slovak population of prepubertal (under 10 years) and pubertal (over 10 years) children with autism spectrum disorders. The examined prepubertal patients with autism, pubertal patients with autism, and prepubertal patients with Asperger syndrome had significantly increased levels of salivary testosterone (P 0.05, P 0.01, and P 0.05, respectively) in comparison with control subjects. We found a lower number of (CAG)n repeats in the AR gene in boys with Asperger syndrome (P 0.001). Autistic boys had an increased frequency of the T allele in the SRD5A2 gene in comparison with the control group. The frequencies of T and C alleles in ESR1 gene were comparable in all assessed groups. The modulating influence of studying genotypes on the effect of testosterone could provide insight into the pathogenesis of autism spectrum disorders.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"4 1","pages":"245-249"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87424857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Radioiodine Therapy After Pretreatment With Recombinant Thyroid-stimulating Hormone (tsh) in Toxic Multinodular Goiter With Low Radioactive Iodine Uptake 重组促甲状腺激素(tsh)治疗毒性多结节性甲状腺肿伴低放射性碘摄取后的放射性碘治疗

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181E94ABF

H. Padmanabhan

引用次数: 0

Hashimoto Thyroiditis as a Manifestation of Struma Ovarii 桥本甲状腺炎是卵巢甲状腺肿的表现

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F64E80

A. Dʼantonio, A. Caleo, O. Caleo, F. Sessa, B. Angrisani

{"title":"Hashimoto Thyroiditis as a Manifestation of Struma Ovarii","authors":"A. Dʼantonio, A. Caleo, O. Caleo, F. Sessa, B. Angrisani","doi":"10.1097/TEN.0B013E3181F64E80","DOIUrl":"https://doi.org/10.1097/TEN.0B013E3181F64E80","url":null,"abstract":"Abstract: We describe clinicopathologic features, laboratory data, and imaging and therapeutic management of a rare case of Hashimoto thyroiditis arising in struma ovarii. The patient was a 38-year-old woman with clinical symptoms of hyperthyroidism. Laboratory data showed elevated levels of total and free thyroxine, low thyrotropin level, and positive specific antithyroid antibodies without ultrasound evidence of morphologic abnormalities of the thyroid gland. Pelvic ultrasonography and magnetic resonance imaging of the abdomen showed bilateral solid ovarian masses containing cystic and fat areas diagnostic of teratoma. The performance of a 131I whole-body scan demonstrated a focus of intense uptake in the pelvis with minimal residual thyroid gland. The patient had a bilateral oophorectomy, and histologic examination revealed thyroid tissue in both masses with all the features of Hashimoto thyroiditis in the right ovary. Symptoms of hyperthyroidism diminished after the surgery, and the thyroid hormone levels and antithyroid antibodies were in the normal range in 1 month. The present case further confirms the rare occurrence of Hashimoto thyroiditis in struma ovarii. This diagnosis should be suggested in the differential diagnosis of patients with symptoms of thyroid disease and a normal thyroid gland.","PeriodicalId":50531,"journal":{"name":"Endocrinologist","volume":"118 1","pages":"220-221"},"PeriodicalIF":0.0,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73748416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Vitamin D Deficiency and Primary Hyperparathyroidism 维生素D缺乏和原发性甲状旁腺功能亢进

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F64C7A

H. Rehman

引用次数: 0

Celiac Disease Presenting With Low Back Pain: Do Not Forget Osteomalacia 以腰痛为表现的乳糜泻:不要忘记骨软化

Endocrinologist Pub Date : 2010-09-01 DOI: 10.1097/TEN.0B013E3181F660E9

A. Ulasli, M. Saraçoğlu, H. Genç, H. Erdem

引用次数: 0