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LIPID NANOPARTICLES ENABLE EFFICIENT BASE EDITING OF CD45-DIRECTED CAR T CELLS FOR UNIVERSAL BLOOD CANCER IMMUNOTHERAPY 脂质纳米颗粒可对 cd45 定向车载 t 细胞进行高效碱基编辑，从而实现普遍的血癌免疫疗法
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.424
E. K. Ghahe, N. Wellhausen, R. Geczy, A. Balgi, S. Clarke, C. June, S. Gill, F. Herbst-Nowrouzi
{"title":"LIPID NANOPARTICLES ENABLE EFFICIENT BASE EDITING OF CD45-DIRECTED CAR T CELLS FOR UNIVERSAL BLOOD CANCER IMMUNOTHERAPY","authors":"E. K. Ghahe, N. Wellhausen, R. Geczy, A. Balgi, S. Clarke, C. June, S. Gill, F. Herbst-Nowrouzi","doi":"10.1016/j.jcyt.2024.03.424","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.424","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141232381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVALENT PROGRAMMING OF SNAP-CAR T CELLS VIA ANTIBODY ADAPTORS 通过抗体适配器对快车 T 细胞进行共价编程
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.384
E. Ruffo, G. Falcone, V. So, M. Kvorjak, A. Deiters, J. Lohmueller
{"title":"COVALENT PROGRAMMING OF SNAP-CAR T CELLS VIA ANTIBODY ADAPTORS","authors":"E. Ruffo, G. Falcone, V. So, M. Kvorjak, A. Deiters, J. Lohmueller","doi":"10.1016/j.jcyt.2024.03.384","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.384","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXTRACELLULAR VESICLES AS A THERAPY FOR THE TREATMENT OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH) AND HEPATOCELLULAR CARCINOMA (HCC) 细胞外囊泡作为治疗代谢功能障碍相关性脂肪性肝炎（MASH）和肝细胞癌（HCC）的一种疗法
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.137
M. Goonetilleke, J. Correia, Y. Chen, H. McDonald, S.T. Chan, I. Simpson, I.M. Inocencio, W. Sievert, R. Lim
{"title":"EXTRACELLULAR VESICLES AS A THERAPY FOR THE TREATMENT OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS (MASH) AND HEPATOCELLULAR CARCINOMA (HCC)","authors":"M. Goonetilleke, J. Correia, Y. Chen, H. McDonald, S.T. Chan, I. Simpson, I.M. Inocencio, W. Sievert, R. Lim","doi":"10.1016/j.jcyt.2024.03.137","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.137","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PAAVING THE WAY TO HIGH TITRES: EVALUATING PLASMID RATIOS FOR AAV PRODUCTION UTILISING THE AMBR® 15 STIRRED-TANK BIOREACTOR 为高滴度铺平道路：评估利用Ambr® 15搅拌罐生物反应器生产AAV的质粒比率
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.428
S. Mangrati, É. Schulze, U. Jung, S. Boi, S. Mathias, Y. Huang, Q.A. Rafiq
{"title":"PAAVING THE WAY TO HIGH TITRES: EVALUATING PLASMID RATIOS FOR AAV PRODUCTION UTILISING THE AMBR® 15 STIRRED-TANK BIOREACTOR","authors":"S. Mangrati, É. Schulze, U. Jung, S. Boi, S. Mathias, Y. Huang, Q.A. Rafiq","doi":"10.1016/j.jcyt.2024.03.428","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.428","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CARDIAC RISK ASSESSMENT OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES BY TELEMETRY IN CYNOMOLGUS MONKEYS 通过遥测评估间充质干细胞衍生的细胞外囊泡对猴子心脏的风险
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.154
S. Hyun, J. Lee, D. Woo, Y. Cho, K. Moon
{"title":"CARDIAC RISK ASSESSMENT OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES BY TELEMETRY IN CYNOMOLGUS MONKEYS","authors":"S. Hyun, J. Lee, D. Woo, Y. Cho, K. Moon","doi":"10.1016/j.jcyt.2024.03.154","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.154","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141229014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DIFFERENTIAL TFR1 EXPRESSION PATTERNS IMPACT TFR1 TARGETING DELIVERY STRATEGIES IN NEUROMUSCULAR DISEASE MODELS. 不同的 Tfr1 表达模式影响神经肌肉疾病模型中的 Tfr1 靶向递送策略。
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.446
J. Stoodley, D. S. Miraz, N. G. Riera, R. Chalcroft, R. Ellerington, C. Webster, M.J. Wood, M.A. Varela
{"title":"DIFFERENTIAL TFR1 EXPRESSION PATTERNS IMPACT TFR1 TARGETING DELIVERY STRATEGIES IN NEUROMUSCULAR DISEASE MODELS.","authors":"J. Stoodley, D. S. Miraz, N. G. Riera, R. Chalcroft, R. Ellerington, C. Webster, M.J. Wood, M.A. Varela","doi":"10.1016/j.jcyt.2024.03.446","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.446","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141229965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DEVELOPMENT OF A NEXT-GENERATION EX VIVO DELIVERY PLATFORM USING SILICON NANONEEDLES FOR PHYSICAL CARGO DELIVERY INTO DIFFICULT-TO-TRANSFECT CELLS 利用硅纳米针开发新一代体内外递送平台，向难以转染的细胞递送物理货物
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.422
M. Jain, J. Lesnik, N. Syed
{"title":"DEVELOPMENT OF A NEXT-GENERATION EX VIVO DELIVERY PLATFORM USING SILICON NANONEEDLES FOR PHYSICAL CARGO DELIVERY INTO DIFFICULT-TO-TRANSFECT CELLS","authors":"M. Jain, J. Lesnik, N. Syed","doi":"10.1016/j.jcyt.2024.03.422","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.422","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141229078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UNIVERSAL POST-THAW VIABILITY TESTING OF ALLOGENEIC HEMATOPOIETIC STEM CELL (HPC) COLLECTIONS SHOWS INCREASED RISK OF NON-ENGRAFTMENT AND DELAYED PLATELET ENGRAFTMENT IN PRODUCTS WITH DECREASED POST-THAW VIABLE CD34 (vCD34) YIELD. 对同种异体造血干细胞 (HPC) 采集物进行的通用产后活力测试表明，产后活力下降的 CD34 (vCD34) 产率产品出现不灌封和血小板灌封延迟的风险增加。
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.194
D. Vozniuk, R. Pattarkine, E. Ntrivalas, O. Secka, M. Dontsova, A. Vladimirov, E. Feuer, C. Yang, D. Kehn, A. Johnson, F. Wafa, J. Levin, J. Zhu, J. Veliaj, B. Sa, M. Thomsen, D. Elterman, A. Kolovrat, P.D. Borge, M. Roshal, E. Maryamchik
{"title":"UNIVERSAL POST-THAW VIABILITY TESTING OF ALLOGENEIC HEMATOPOIETIC STEM CELL (HPC) COLLECTIONS SHOWS INCREASED RISK OF NON-ENGRAFTMENT AND DELAYED PLATELET ENGRAFTMENT IN PRODUCTS WITH DECREASED POST-THAW VIABLE CD34 (vCD34) YIELD.","authors":"D. Vozniuk, R. Pattarkine, E. Ntrivalas, O. Secka, M. Dontsova, A. Vladimirov, E. Feuer, C. Yang, D. Kehn, A. Johnson, F. Wafa, J. Levin, J. Zhu, J. Veliaj, B. Sa, M. Thomsen, D. Elterman, A. Kolovrat, P.D. Borge, M. Roshal, E. Maryamchik","doi":"10.1016/j.jcyt.2024.03.194","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.194","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NOVEL NON-VIRAL DELIVERY TECHNOLOGY, SOLUPORE®, ENABLES GENE DELIVERY FOR A HEALTHIER, MORE POTENT, AND SIGNIFICANTLY MORE EFFECTIVE CAR-T THERAPY IN VIVO. 新型非病毒递送技术 Solupore® 可实现基因递送，从而在体内进行更健康、更强效、更有效的 car-t 治疗。
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.418
J. Frankish
{"title":"NOVEL NON-VIRAL DELIVERY TECHNOLOGY, SOLUPORE®, ENABLES GENE DELIVERY FOR A HEALTHIER, MORE POTENT, AND SIGNIFICANTLY MORE EFFECTIVE CAR-T THERAPY IN VIVO.","authors":"J. Frankish","doi":"10.1016/j.jcyt.2024.03.418","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.418","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FAPα-TARGETED IMMUNOTHERAPY WITH SIBROTUZUMAB AND HIGH AFFINITY FC-RECEPTOR EXPRESSING NK92 CELLS: A PROMISING APPROACH TO REVERSE FIBROSIS 使用西布曲马和高活性FC-RECEPTOR表达NK92细胞的FAPα靶向免疫疗法：逆转纤维化的可行方法
Cytotherapy Pub Date : 2024-06-01 DOI: 10.1016/j.jcyt.2024.03.350
S.R. Kuenzel, M. Arriens, W. Rackwitz, J. Pappermann, J. Thiel, R. Kronstein-Wiedemann, J. Eitler, T. Tonn
{"title":"FAPα-TARGETED IMMUNOTHERAPY WITH SIBROTUZUMAB AND HIGH AFFINITY FC-RECEPTOR EXPRESSING NK92 CELLS: A PROMISING APPROACH TO REVERSE FIBROSIS","authors":"S.R. Kuenzel, M. Arriens, W. Rackwitz, J. Pappermann, J. Thiel, R. Kronstein-Wiedemann, J. Eitler, T. Tonn","doi":"10.1016/j.jcyt.2024.03.350","DOIUrl":"https://doi.org/10.1016/j.jcyt.2024.03.350","url":null,"abstract":"","PeriodicalId":505215,"journal":{"name":"Cytotherapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141230093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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