Frontiers in Stroke最新文献_第2页

Pulmonary hypertension leads to poor inpatient outcome in non-white patients admitted with stroke: an analysis of national inpatient sample 肺动脉高压导致非白人脑卒中患者住院效果不佳：全国住院病人样本分析

Frontiers in Stroke Pub Date : 2024-02-08 DOI: 10.3389/fstro.2024.1350825

D. Jayaraman, Stephanie Kjelstrom, Georgia Montone, Divya Rajasekaran

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Transient ischemic attack in the twenty first century: is it still a useful construct? 二十一世纪的短暂性脑缺血发作：它还是一个有用的概念吗？

Frontiers in Stroke Pub Date : 2024-01-19 DOI: 10.3389/fstro.2023.1241649

Louis R. Caplan

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Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke patients, a systematic review and meta-analysis 缺血性中风患者静脉注射间充质干细胞的疗效和安全性，系统回顾和荟萃分析

Frontiers in Stroke Pub Date : 2024-01-17 DOI: 10.3389/fstro.2023.1339331

Maged Elsayed Hassanein, Jaber Fayad, Jilan Ali Shabana, Esraa M. AlEdani, M. Hefnawy, Hazem. S Ghaith, A. Negida

{"title":"Efficacy and safety of intravenous mesenchymal stem cells for ischemic stroke patients, a systematic review and meta-analysis","authors":"Maged Elsayed Hassanein, Jaber Fayad, Jilan Ali Shabana, Esraa M. AlEdani, M. Hefnawy, Hazem. S Ghaith, A. Negida","doi":"10.3389/fstro.2023.1339331","DOIUrl":"https://doi.org/10.3389/fstro.2023.1339331","url":null,"abstract":"Clinical trials have evaluated the efficacy of intravenous mesenchymal stem cells (MSCs) for acute and subacute ischemic stroke. Therefore, we conducted this meta-analysis to investigate the efficacy and safety of intravenous MSC treatments compared to placebo for acute and subacute ischemic stroke patients.We searched PubMed, SCOPUS, Web of Science, and Cochrane CENTRAL for randomized controlled trials evaluating any clinical trials of intravenous MSCs for acute and subacute ischemic stroke patients. The efficacy outcomes of this study were the rates of improvement in National Institutes of Health Stroke Scale (NIHSS) scores, good scores on the modified Rankin Scale (mRS), and Barthel Index (BI) scores, while the safety outcomes were the rates of mortality and stroke recurrence. We compared intravenous MSC and placebo treatments on a fixed-effect meta-analysis model in R software.Four randomized controlled studies involving 97 patients were included in the analysis. In the meta-analysis, MSC treatments were superior to placebo treatments in good mRS (MD −0.95, 95% CI [−1.39, −0.52]) or BI (MD 21.36, 95% CI [9.96, 32.75]) scores, and MSC treatments were not superior to placebo treatments in the rate of improvement of the NIHSS scores (MD −1.81, 95% CI [−4.123, 0.494]). MSCs were associated with neither decreased mortality nor stroke recurrence (risk ratio 0.58 and 0.59, respectively; p-value = 0.51 and p-value = 0.533, respectively).For patients with acute and subacute ischemic stroke who are eligible for further damage to neural tissue, MSCs achieve high efficacy and acceptable safety.Prospero, unique ID: CRD42023457655.","PeriodicalId":504975,"journal":{"name":"Frontiers in Stroke","volume":" 546","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139617914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Editorial: Pushing the frontiers of stroke care and research - where are we heading? 社论：推动中风护理和研究的前沿发展--我们的方向在哪里？

Frontiers in Stroke Pub Date : 2024-01-15 DOI: 10.3389/fstro.2023.1353566

Ana Catarina Fonseca

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The facilitators and barriers to home-based robotic rehabilitation in India: a pilot feasibility study 印度家庭机器人康复的促进因素和障碍：试点可行性研究

Frontiers in Stroke Pub Date : 2024-01-12 DOI: 10.3389/fstro.2023.1265702

Aravind Nehrujee, A. T. Prabhakar, Sathish Balaraman, Rasika Bombatkar, H. Prakash, Selvaraj Samuelkamaleshkumar, Sanjith Aaron, Suranjan Bhattacharji, S. Sujatha, Sivakumar Balasubramanian

{"title":"The facilitators and barriers to home-based robotic rehabilitation in India: a pilot feasibility study","authors":"Aravind Nehrujee, A. T. Prabhakar, Sathish Balaraman, Rasika Bombatkar, H. Prakash, Selvaraj Samuelkamaleshkumar, Sanjith Aaron, Suranjan Bhattacharji, S. Sujatha, Sivakumar Balasubramanian","doi":"10.3389/fstro.2023.1265702","DOIUrl":"https://doi.org/10.3389/fstro.2023.1265702","url":null,"abstract":"Robot-assisted rehabilitation has emerged as a promising approach for enhancing motor function in stroke survivors. However, the feasibility and effectiveness of home-based robotic training in this population are underexplored, especially in low/middle-income countries.This feasibility study aimed to address this gap by examining the feasibility and effectiveness of independent home-based training using PLUTO, a robotic device for hand training. A total of 7 chronic stroke survivors were recruited, with 5 completing the study.The results revealed high engagement and adherence to the home-based training program, with participants averaging 1659.8 min of training over 24.8 days. The PLUTO system demonstrated excellent usability and elicited positive user perceptions. Significant improvements were observed in functional outcomes, as evidenced by a noteworthy increase in Fugl-Meyer Assessment scores (mean increase of 6.2 points, exceeding the minimal clinically important difference (MCID) of 5.35 points). Furthermore, participants showed improvements in the ABILHAND measure (mean improvement of 1.24 logits, surpassing the MCID of 0.2 logits) and the Barthel Index (mean increase of 8.8 points).These findings demonstrate the feasibility and effectiveness of home-based robotic rehabilitation for chronic stroke survivors. This has implications for expanding access to rehabilitation services in low- and middle-income countries, enhancing patient engagement and adherence, and improving functional outcomes. Larger controlled studies are warranted to evaluate the effectiveness of home-based robotic rehabilitation programs.","PeriodicalId":504975,"journal":{"name":"Frontiers in Stroke","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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