ERJ Open Research最新文献_第4页

Longitudinal validation of King's Sarcoidosis Questionnaire in a prospective cohort with mild sarcoidosis 在轻度肉样瘤病前瞻性队列中对国王肉样瘤病问卷进行纵向验证

ERJ Open Research Pub Date : 2024-06-06 DOI: 10.1183/23120541.00160-2024

J. Møller, T. Prior, O. Hilberg, S. Birring, Elisabeth Bendstrup

引用次数: 0

Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study 美国支气管扩张症和非淋菌性鼻炎研究登记处中病情加重者的特征：一项横断面研究

ERJ Open Research Pub Date : 2024-06-06 DOI: 10.1183/23120541.00185-2024

Nicole C. Lapinel, R. Choate, T. Aksamit, Joseph Feliciano, Kevin Winthrop, Andreas Schmid, S. Fucile, Mark Metersky

{"title":"Characteristics of exacerbators in the US Bronchiectasis and NTM Research Registry: a cross-sectional study","authors":"Nicole C. Lapinel, R. Choate, T. Aksamit, Joseph Feliciano, Kevin Winthrop, Andreas Schmid, S. Fucile, Mark Metersky","doi":"10.1183/23120541.00185-2024","DOIUrl":"https://doi.org/10.1183/23120541.00185-2024","url":null,"abstract":"Exacerbations of non-cystic fibrosis bronchiectasis (bronchiectasis) are associated with reduced health-related quality of life and increased mortality, likelihood of hospitalisation, and lung function decline. This study investigated patient clinical characteristics associated with exacerbation frequency.A cross-sectional cohort study of patients ≥18 years with bronchiectasis enrolled in the US Bronchiectasis and Nontuberculous Mycobacteria (NTM) Research Registry (BRR) September 2008–March 2020. Patients were stratified by exacerbation frequency in their 2 years before enrollment. Patient demographics, respiratory symptoms, healthcare resource utilisation, microbiology, modified bronchiectasis severity index (mBSI), and select comorbidities were collected at enrollment. Patient characteristics associated with exacerbation frequency were assessed using a negative binomial model.The study included 2950 patients (mean age 65.6 years; 79.1% female). Frequency of moderate to severe airway obstruction (forced expiratory volume in 1 s [FEV1] % predicted <50%; most recent measure) was 15.9%, 17.8%, and 24.6% in patients with 1, 2, and ≥3 exacerbationsversus8.9% in patients with 0 exacerbations; severe disease (mBSI) was 27.8%, 24.2%, and 51.1%versus13.2%; respiratory hospitalisation was 24.5%, 33.0%, and 36.5%versus4.1%; andPseudomonas aeruginosainfection was 18.8%, 23.4%, and 35.2%versus11.9%. In multivariable model analysis, respiratory hospitalisation, cough, haemoptysis,P. aeruginosa, younger age, lower FEV1% predicted, asthma, and gastroesophageal reflux disease were associated with more exacerbations.These findings demonstrate a high disease burden, including increased respiratory symptoms, healthcare resource utilisation, andP. aeruginosainfection in patients with bronchiectasis and multiple exacerbations.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breathomics to monitor interstitial lung disease associated with systemic sclerosis 通过呼吸组学监测与系统性硬化症相关的间质性肺病

ERJ Open Research Pub Date : 2024-05-23 DOI: 10.1183/23120541.00175-2024

Thibault Massenet, J. Potjewijd, R. Tobal, Fanny Gester, Delphine Zanella, M. Henket, M. Njock, T. Dejong, Gregory Gridelet, Laurie Giltay, F. Guissard, Béatrice André, Clio Ribbens, R. Louis, Pieter Van Paassen, Julien Guiot, Pierre‐Hugues Stefanuto

引用次数: 0

Impact of outpatient adaptation to home mechanical ventilation on health-related quality of life in patients with chronic obstructive pulmonary disease: the OutVent study 门诊病人适应家用机械通气对慢性阻塞性肺病患者健康相关生活质量的影响：OutVent 研究

ERJ Open Research Pub Date : 2024-05-23 DOI: 10.1183/23120541.00125-2024

C. Ribeiro, C. Jácome, Pedro Oliveira, Manuel Luján, S. Conde

{"title":"Impact of outpatient adaptation to home mechanical ventilation on health-related quality of life in patients with chronic obstructive pulmonary disease: the OutVent study","authors":"C. Ribeiro, C. Jácome, Pedro Oliveira, Manuel Luján, S. Conde","doi":"10.1183/23120541.00125-2024","DOIUrl":"https://doi.org/10.1183/23120541.00125-2024","url":null,"abstract":"Home mechanical ventilation (HMV) is indicated in patients with severe hypercapnic chronic obstructive pulmonary disease (COPD). Initiation of HMV commonly occurs during an inpatient period, but there has been increasing interest for outpatient adaptation.This study aimed to evaluate the outpatient initiation and adaptation of HMV and its impact on health-related quality of life (HRQoL) in patients with severe COPD.A single group pretest-posttest study was conducted in an Outpatient Ventilation Clinic of a tertiary hospital in Portugal. Severe COPD patients with symptoms of chronic respiratory failure with daytime pCO2≥50 mmHg in stable condition or persistent hypercapnia ≥53 mmHg >14 days following an exacerbation with mechanical ventilation were included. After 3-months of HMV, patients completed the Severe Respiratory Insufficiency (SRI), the S3-non-invasive ventilation (S3-NIV) and a patient-experience questionnaire.Fifty-three patients (73.6% male, median 71 [p25-p75 61–77] years.), with a median FEV1of 35 [29–40] % and a median baseline pCO2of 53.5 [51.9–56.5] mmHg completed the study. At 3 months patients had a median HMV usage of 6.5 h and decreased their pCO2by 6.0 mmHg. After 3 months, there was a significant improvement in the SRI Summary Scale (+5.7), above the minimal clinically import difference of 5. Patients who used HMV more than 5 h had higher S3-NIV total score (6.8versus5.7, p=0.04) and S3-NIV Sleep & NIV related side effects subscore (7.1versus5.7, p=0.03).Our findings might indicate that outpatient initiation and adaptation of HMV has a positive impact in short-term HRQoL in patients with COPD and that that this approach is perceived as a positive experience by the patients.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141105315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early serum biomarkers to characterise different phenotypes of primary graft dysfunction after lung transplantation: a systematic scoping review 描述肺移植后原发性移植物功能障碍不同表型的早期血清生物标志物：系统性范围界定综述

ERJ Open Research Pub Date : 2024-05-23 DOI: 10.1183/23120541.00121-2024

V. Scaravilli, Gloria Turconi, S. Colombo, Amedeo Guzzardella, Marco Bosone, A. Zanella, Lieuwe Bos, Giacomo Grasselli

{"title":"Early serum biomarkers to characterise different phenotypes of primary graft dysfunction after lung transplantation: a systematic scoping review","authors":"V. Scaravilli, Gloria Turconi, S. Colombo, Amedeo Guzzardella, Marco Bosone, A. Zanella, Lieuwe Bos, Giacomo Grasselli","doi":"10.1183/23120541.00121-2024","DOIUrl":"https://doi.org/10.1183/23120541.00121-2024","url":null,"abstract":"Lung transplantation (LUTX) often is complicated by primary graft dysfunction (PGD). Plasma biomarkers hold potential for PGD phenotyping and targeted therapy. This scoping review aims to collect the available literature in search of serum biomarkers for PGD phenotyping.Following JBI and PRISMA guidelines, we conducted a systematic review searching MEDLINE, Web of Science, EMBASE, and The Cochrane Library for papers reporting the association between serum biomarkers measured within 72 h of reperfusion and PGD, following ISHLT guidelines. We extracted study details, patient demographics, PGD definition and timing, biomarker concentration, and their performance in identifying PGD cases.Among the 1050 papers screened, 25 prospective observational studies were included, with only 9 conducted in the last decade. These papers included 1793 unique adult patients (1195 double LUTX, median study size 100 (IQR 44–119). Most (n=21) compared PGD grade 3 to less severe PGD, but only 4 adhered to 2016 PGD definitions. Enzyme-linked immunosorbent assays and the multiplex bead array technique were utilised in 23 and 2 papers, respectively. In total, 26 candidate biomarkers were identified, comprising 13 inflammatory, 3 endothelial activation, 3 epithelial injury, 3 cellular damage, 2 coagulation dysregulation markers. Only 5 biomarkers (sRAGE, ICAM-1, PAI-1, SP-D, FSTL-1) underwent AUROCC analysis, yielding a median value of 0.58 (0.51, 0.78) in 406 patients (276 double LUTX).Several biomarkers exhibit promise for future studies aimed at PGD phenotyping after LUTX. To uncover the significant existing knowledge gaps, further international prospective studies incorporating updated diagnostic criteria, modern platforms, and advanced statistical approaches are essential.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141107059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telemedical management of symptomatic Covid-19 outpatients 对有症状的 Covid-19 门诊病人进行远程医疗管理

ERJ Open Research Pub Date : 2024-05-23 DOI: 10.1183/23120541.00277-2024

Aenne S von Falkenhausen, Scott Geipel, Antonia Gail, Clemens Scherer, Sven Stockhausen, Lauren E Sams, Finn Becker, Philipp M Doldi, Eric Lemmermöhle, Paul de Villèle, Michael Schleef, Marc Becker, Moritz Lauterbach, Steffen Massberg, Stefan Kääb, Moritz F Sinner

{"title":"Telemedical management of symptomatic Covid-19 outpatients","authors":"Aenne S von Falkenhausen, Scott Geipel, Antonia Gail, Clemens Scherer, Sven Stockhausen, Lauren E Sams, Finn Becker, Philipp M Doldi, Eric Lemmermöhle, Paul de Villèle, Michael Schleef, Marc Becker, Moritz Lauterbach, Steffen Massberg, Stefan Kääb, Moritz F Sinner","doi":"10.1183/23120541.00277-2024","DOIUrl":"https://doi.org/10.1183/23120541.00277-2024","url":null,"abstract":"Covid-19 remains a challenge to individual health and health care resources worldwide. Telemedical surveillance might minimize hospitalization and direct patient-physician-contacts. Yet, randomized clinical trials evaluating telemedical management of Covid-19 patients are lacking.COVID SMART is a randomized, open label, controlled clinical trial investigating whether telemedicine reduces the primary endpoint of hospitalization or any unscheduled utilization of an emergency medical service within 30 days of follow-up. Key secondary endpoints included mortality and primary endpoint components. We enrolled acutely infected SARS-CoV2 patients suitable for outpatient care. All presented with ≥1 risk factor for an adverse Covid-19 course. Patients were randomized 1:1 into a control group receiving standard of care and an intervention group receiving smartphone-based assessment of oxygen saturation, heart rate and electrocardiogram, and telemedical counsellingviaa 24/7 emergency hotline.Of 607 enrolled patients (mean age 46.7±13.5 years), 304 were randomized into the intervention and 303 into the control group. The primary endpoint occurred in 6.9% (n=21) of the intervention and in 9.6% (n=29) of the control group (hazard ratio 0.72, 95% confidence interval 0.41–1.26; p=0.24). No deaths occurred during follow-up. Fewer intervention group participants utilized outpatient-based emergency medical services (hazard ratio 0.43, 95% confidence interval 0.20–0.90; p=0.03).COVID SMART is the first randomized clinical trial assessing the benefit of telemedicine in an acute respiratory infectious disease. Whereas telemedical management did not reduce the primary endpoint of hospitalization, fewer intervention group patients used outpatient-based emergency services, suggesting a potential benefit for less-acutely infected individuals.clinicaltrials.gov (NCT04471636)","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141105914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characterisation of exacerbations of severe eosinophilic asthma occurring on mepolizumab and placebo 严重嗜酸性粒细胞性哮喘患者使用甲泼尼单抗和安慰剂后病情加重的临床特征

ERJ Open Research Pub Date : 2024-05-23 DOI: 10.1183/23120541.00196-2024

I. Howell, Daniel J Bratton, Gareth Hynes, S. Yancey, L. Heaney, I. Pavord, R. Shrimanker

引用次数: 0

Symptom burden and its associations with clinical characteristics in patients with COPD: a clustering approach 慢性阻塞性肺病患者的症状负担及其与临床特征的关系：一种聚类方法

ERJ Open Research Pub Date : 2024-04-25 DOI: 10.1183/23120541.01052-2023

S. Houben-Wilke, Qichen Deng, D. Janssen, F. Franssen, M. Spruit

{"title":"Symptom burden and its associations with clinical characteristics in patients with COPD: a clustering approach","authors":"S. Houben-Wilke, Qichen Deng, D. Janssen, F. Franssen, M. Spruit","doi":"10.1183/23120541.01052-2023","DOIUrl":"https://doi.org/10.1183/23120541.01052-2023","url":null,"abstract":"Symptom burden in people with COPD is often under-recognized. In this cross-sectional analysis, we aimed to study the severity of a variety of (non-)respiratory symptoms in people with COPD and non-COPD subjects and to explore the associations between clusters based on symptom severity and other clinical characteristics.Characteristics were assessed in 538 people with COPD from primary, secondary, tertiary care and 116 non-COPD subjects. Severity of 20 symptoms was measured using a Visual Analogue Scale (VAS), ranging from 0 (no symptom) to 100 mm (maximum severity). K-means cluster analysis was applied on symptoms’ severity in the patient sample only.Patients were comparable with non-COPD subjects in terms of gender (58% vs. 55% male, p=0.132) and age (64 [9]versus63 [6] years, p=0.552) and had a reduced FEV1(57 [23]%versus111 [17]% pred, p<0.001). Patients had higher VAS scores for most symptoms (p<0.05). Most severe symptoms in patients with COPD were dyspnea, fatigue, and muscle weakness while non-COPD subjects mainly experienced insomnia and micturition. Three clusters were identified in the patient sample. Health status and care dependency differed between all clusters, while functional mobility, exacerbation history and lung function differed between clusters 1 and the other two clusters (p<0.05).People with COPD report a high burden of respiratory as well as non-respiratory symptoms. Cluster analysis demonstrated a co-occurrence of different levels of symptom severity highlighting the heterogeneity of symptoms experience. Identifying clusters of patients with shared symptom experiences can help to understand the impact of the disease and define integrated, multidimensional treatment strategies.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical implications of innate immune exhaustion in cystic fibrosis 囊性纤维化先天性免疫衰竭的临床意义

ERJ Open Research Pub Date : 2024-04-25 DOI: 10.1183/23120541.00256-2024

R. Møller, Bibi Uhre Nielsen, E. Rossi, Mads Lausen, M. Skov, T. Pressler, S. Ostrowski, Helle Krogh Johansen

{"title":"Clinical implications of innate immune exhaustion in cystic fibrosis","authors":"R. Møller, Bibi Uhre Nielsen, E. Rossi, Mads Lausen, M. Skov, T. Pressler, S. Ostrowski, Helle Krogh Johansen","doi":"10.1183/23120541.00256-2024","DOIUrl":"https://doi.org/10.1183/23120541.00256-2024","url":null,"abstract":"The lung disease progression in people with cystic fibrosis (pwCF) varies from one individual to another. Different immunological characteristics have been suggested to explain this variation, and we hypothesized that lung capacity may be associated with the innate immune response in pwCF. In an exploratory study, we aimed to investigate potential links between the innate immune response and lung function in pwCF using the standardized immune function assay TruCulture.In a single-centre study with combined cross-sectional and longitudinal data before and after intravenous antibiotics, blood was sampled fromPseudomonas aeruginosainfected pwCF. Whole blood was analysed by TruCulture to reveal the unstimulated and stimulated cytokine release. Tobit regressions and Spearman's correlations were used to estimate the associations between lung function and cytokine release.We included 52 pwCF in the cross-sectional study and 24 in the longitudinal study. In the cross-sectional study, we found that compared to a healthy population the release of toll-like receptor (TLR)3, −4 and −7/8 stimulated IFN-γ, and IL-12p40 were reduced. Although TLR3-stimulated IL-1β and IL-6 release increased with lung function, overall, cytokine release did not correlate well with lung function. In the longitudinal study, the cytokine release was modified by antibiotic treatment, but the cytokine release before antibiotic treatment did not associate with changes in lung function after treatment.The stimulated cytokine release could not predict lung function levels or changes in pwCF, but our data indicate that pwCF experience exhaustion in the innate immune response after years of chronic bacterial infection.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of high-flow nasal therapy on swallowing function: a scoping review 高流量鼻腔疗法对吞咽功能的影响：范围审查

ERJ Open Research Pub Date : 2024-04-25 DOI: 10.1183/23120541.00075-2024

C. Crimi, Rita Chiaramonte, Fabio Vignera, Carlo Vancheri, Michele Vecchio, C. Gregoretti, Annalisa Carlucci, Tiina Andersen, Andrea Cortegiani

{"title":"Effects of high-flow nasal therapy on swallowing function: a scoping review","authors":"C. Crimi, Rita Chiaramonte, Fabio Vignera, Carlo Vancheri, Michele Vecchio, C. Gregoretti, Annalisa Carlucci, Tiina Andersen, Andrea Cortegiani","doi":"10.1183/23120541.00075-2024","DOIUrl":"https://doi.org/10.1183/23120541.00075-2024","url":null,"abstract":"High-flow nasal therapy (HFNT) is widely used in patients with respiratory failure in different clinical settings, but the effect of HFNT on respiratory-swallow coordination is unknown. Understanding this relationship is crucial, considering the necessity for patients to maintain adequate nutrition during daytime HFNT.This scoping review aims to synthesise available data on the effects of HFNT flow rates on swallowing function and the possible risk of aspiration during treatment, focusing on knowledge and evidence gaps.PubMed, Scopus, Web of Science and Google Scholar databases were searched from inception to May 30th, 2023, for studies reporting data on swallowing assessment in healthy adults or patients with acute or chronic respiratory failure receiving HFNT. Data on study design, patients’ characteristics, and quality outcomes were extracted, and risk of bias was assessed.Eight studies were included, four including cohorts of healthy volunteers (n=148) and four including patients with acute or chronic respiratory failure (n=151). Study designs, patient populations, and quality outcome measures were heterogeneous. Two studies indicated improvement, while four articles showed impairment in swallowing function during HFNT; two studies showed that patients’ overall clinical picture and underlying medical conditions influence swallowing-breathing coordination rather than HFNTperse. Risk of bias was judged low for all the included studies.This scoping review found limited and controversial evidence of the impact of HFNT on swallowing function. Remarkably, methods for swallowing function assessment were quite heterogeneous. Additional research is required to test the effect of HFNT on respiratory-swallowing coordination.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0