European Journal of Paediatric Neurology最新文献

{"title":"Tumefactive demyelinating lesions in children","authors":"Ayberk Selek ,&nbsp;Rahsan Göcmen ,&nbsp;Ceren Günbey ,&nbsp;Bahadır Konuşkan ,&nbsp;Ibrahim Oncel ,&nbsp;Banu Anlar","doi":"10.1016/j.ejpn.2025.03.005","DOIUrl":"10.1016/j.ejpn.2025.03.005","url":null,"abstract":"<div><div>Tumefactive lesions (TDL) are larger than 2 cm in diameter on T2-weighted brain MRI. They are distinguished from other types of demyelinating lesions by their size and degree of perilesional edema and/or rim enhancement, which can make diagnosis challenging.</div></div><div><h3>Aim</h3><div>To study the clinical and radiological features, follow-up and final diagnosis of patients presenting with TDL.</div></div><div><h3>Method</h3><div>Medical records of children seen at the Pediatric neurology and radiology department between 1992 and 2017 were reviewed. 15 patients younger than 18 years of age who had at least one TDL on their first magnetic resonance imaging (MRI) were included. Clinical and radiological features and evolution of imaging findings were studied.</div></div><div><h3>Results</h3><div>First, all patients were admitted acutely with a polysymptomatic presentations (86,6 %) mainly affecting the motor system (92,8 %). The largest diagnostic group was MS (n = 10, 66,6 %) with 9 out of 10 individual's diagnosed during follow up. At least one new clinical or radiological relapse was observed in 12 patients with a mean occurrence of 9 and 14 months respectively. All cases who developed a radiological relapse and most (n: 9, 75 %) of those who experienced a clinical relapse were diagnosed with MS and all had new lesions at the time of diagnosis. All children with MS had positive OCBs. X children were diagnosed with xxxxx Most TDLs (21/24, 87,5 %) were localized in the supratentorial area. TDL + other demyelinating lesions were observed in most 12/15 (80 %) patients and the size of TDL was between 2 and 4 cm (20/24, 83.3 %). All patients with MS, whether they had a single TDL or multiple TDLs, had accompanying small demyelinating lesions. On follow-up all TDLs became smaller (14/15, 93,3 %) or resolved (n = 1).</div></div><div><h3>Conclusion</h3><div>The non-infiltratind pattern, presence of multiple small demyelinating lesions and CSF oligoclonal band positivity may suggest MS, which is one of the most common causes. However, for a definitive diagnosis, patients should continue to be monitored with radiological imaging even in the absence of clinical relapses.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 33-37"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging of masticatory muscles in patients with duchenne muscular dystrophy","authors":"Carmen Meza Fuentealba ,&nbsp;Cristobal Arrieta ,&nbsp;Catalina González ,&nbsp;Nicolás Aranda Ortega ,&nbsp;Luis Salinas ,&nbsp;Rocío Cortés Zepeda ,&nbsp;María de los Ángeles Beytía Reyes ,&nbsp;Raúl G. Escobar ,&nbsp;Sergio Uribe ,&nbsp;Daniela Avila-Smirnow","doi":"10.1016/j.ejpn.2025.03.008","DOIUrl":"10.1016/j.ejpn.2025.03.008","url":null,"abstract":"<div><div>Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy in children. Impairment of masticatory function and swallowing disorders, potentially leading to aspiration and gastrostomy, are linked to fatty infiltration in the masticatory muscles, as previously observed in muscle ultrasound. This study aims to quantify muscle volume and fat fraction in muscle magnetic resonance imaging (MRI) in the masticatory muscles in non-ambulant DMD patients compared to healthy controls and evaluate their correlation with maximum bite force (MBF), which has not been previously described. Fifteen patients with DMD and 16 controls were included. MBF was measured with an oral dynamometer and total muscle volume (TMV) and fat signal fraction (FSF) were quantified using MRI with the Dixon technique. Four DMD patients presented with masticatory or swallowing difficulties. DMD patients had a significantly lower median MBF (141.8 N) compared with healthy controls (481.6 N, p &lt; 0.0001). Additionally, median FSF was significantly higher in DMD patients (47.07 %) compared to controls (5.31 %, p &lt; 0.0001). A strong negative correlation between TMV and MBF was observed in DMD patients (ρ = −0.70, p = 0.0048). A significant negative correlation between MBF and normalized FSF was observed in healthy controls (ρ = −0.5487, <em>p</em> = 0.300) and DMD patients (ρ = −0.5893, <em>p</em> = 0.0224). A non-significant positive correlation between age and FSF in DMD was detected (ρ = 0.38, p = 0.17). MBF, TMV and FSF quantified with the Dixon MRI are sensitive measures to evaluate masticatory function in DMD patients and may serve as biomarkers for clinical follow up. Studies in older patients are needed to evaluate the predictive role of MBF, TMV and FSF in the nutritional status of patients and the need for therapeutic interventions such as gastrostomy.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 47-55"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inherited disorders of vitamin metabolism","authors":"Barbara Plecko","doi":"10.1016/j.ejpn.2025.02.008","DOIUrl":"10.1016/j.ejpn.2025.02.008","url":null,"abstract":"<div><div>Vitamins are essential cofactors of various enzyme reactions in amino acid, neurotransmitter, nucleotide and energy metabolism. Over the past decade a number of inborn errors of metabolism have been identified, that affect different steps in vitamin absorption, transport, activation or recycling and repair of active vitamin cofactors. According to the respective cofactor function this may result in acute or chronic multisystem disease or in disorders that selectively affect the nervous system. Most of these disorders are amenable to specific treatment with excellent results, but diagnostic delay can lead to rapid, irreversible damage or even death. Therefore, especially in case of acute and severe neurologic presentations compatible with one of the here discused disorders, a vitamin trial should be considered while awaiting results of biochemical and genetic testing. Diagnosis of these disorders is especially rewarding, as treatment is often per oral, available worldwide and comparably cheap. This article will review current knowledge of the clinical presentation, biomarkers and specific treatment of inborn errors of vitamin metabolism and illustrates why child neurologists should have vitamins in their pockets.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 18-32"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric paroxysmal movement disorders - A clinical epidemiological study in an Irish cohort","authors":"Susan Harvey ,&nbsp;Nicholas M. Allen ,&nbsp;Susan Byrne ,&nbsp;Bryan Lynch ,&nbsp;Niamh McSweeney ,&nbsp;Siobhan Neville ,&nbsp;Olivia O'Mahony ,&nbsp;Mary O'Regan ,&nbsp;Declan O'Rourke ,&nbsp;Elaine Reade ,&nbsp;David Webb ,&nbsp;Mary D. King ,&nbsp;Kathleen M. Gorman","doi":"10.1016/j.ejpn.2025.03.006","DOIUrl":"10.1016/j.ejpn.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>Paroxysmal movement disorders (PxMD) are characterized by episodic involuntary movements and include paroxysmal dyskinesias (PD) and episodic ataxias (EA). Although reported in the medical literature since 1892, the exact prevalence in children is unknown.</div></div><div><h3>Objectives</h3><div>To determine the prevalence and clinical characteristics of PxMD in the pediatric population in the Republic of Ireland.</div></div><div><h3>Methods</h3><div>Cross-sectional cohort study across pediatric neurology services in the Republic of Ireland incorporating retrospective chart, telephone and clinical reviews.</div></div><div><h3>Results</h3><div>Seventy-nine cases met the inclusion criteria (PD = 37, EA = 38, Alternating Hemiplegia of Childhood = 4). Point prevalence for all PxMD was 6.5 cases per 100,000 persons aged less than 18 years (PD 3/100,000, EA 3.1/100,000, Alternating Hemiplegia of Childhood 0.3/100,000). Sixty-four cases were clinically reviewed by the research team (PD = 33, EA = 31). A cause was identified in 38 % (24/64). The highest investigation yield was from single-gene testing (38 %, 9/24) followed by gene panels (25 %, 11/44). Variable evolution patterns were seen. In PD, 55 % (18/33) resolved and 30 % (10/33) improved. This was due to medication in 61 % (20/33), trigger avoidance in 6 % (2/33) and spontaneous remission in 18 % (6/33). In EA, 45 % (14/31) resolved and 42 % (13/31) improved, with spontaneous remission or improvement in 48 % (17/33).</div></div><div><h3>Discussion</h3><div>This study adds to the PxMD knowledge base by determining PxMD prevalence in a pediatric population for the first time. This prevalence is higher than previous adult population estimates. An aetiology was identified in one-third. A large proportion can expect symptom improvement either with medications, trigger avoidance or spontaneous remission over time.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 70-78"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development in children with neurofibromatosis type 1 in early childhood","authors":"Franziska Krampe-Heni ,&nbsp;Tamara Fuschlberger ,&nbsp;Ute Wahlländer ,&nbsp;Friedrich Voigt ,&nbsp;Volker Mall ,&nbsp;Verena Kraus","doi":"10.1016/j.ejpn.2025.02.010","DOIUrl":"10.1016/j.ejpn.2025.02.010","url":null,"abstract":"<div><h3>Introduction</h3><div>The development of children with NF1 has so far been primarily studied in school-age children with various subtests showing heterogeneous profiles. The aim of this study is to characterise the development of infants with NF1 across all areas of early childhood development.</div></div><div><h3>Material and methods</h3><div>32 infants with NF1, aged 12–47 months, participated in this cross-sectional cohort study. Development was assessed with the MFED 1–4 comprising 7 test categories. Items measuring visual abilities (colour and visuospatial items) from all subcategories were selected and compared to the normal population.</div></div><div><h3>Results</h3><div>Infants with NF1 showed a global developmental delay, more pronounced in application of memorised knowledge. A particular deficit was found in items requiring spatial vision.</div></div><div><h3>Discussion</h3><div>The present study is the first to examine the global development of children with NF1 under 48 months. Consistent with animal data, we found significant deficits in visuospatial abilities, which may significantly contribute to the perceived global developmental delay. These findings underline the need for early and specific developmental therapy in this patient group in order to train the development early in infancy and to achieve the best neurodevelopmental outcome.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 56-64"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric-onset multiple sclerosis in Greece: A single-center study of the risk factors and a review of the literature","authors":"Evangelia Bechlivani ,&nbsp;Efterpi Pavlidou ,&nbsp;Konstantinos Notas ,&nbsp;Martha Spilioti ,&nbsp;Panagiota Karananou ,&nbsp;Evangelos Pavlou ,&nbsp;Anastasios Orologas ,&nbsp;Dimitrios Zafeiriou ,&nbsp;Athanasios Evangeliou","doi":"10.1016/j.ejpn.2025.04.001","DOIUrl":"10.1016/j.ejpn.2025.04.001","url":null,"abstract":"<div><div>Pediatric-onset multiple sclerosis (POMS) accounts for up to 10 % of the affected population. However, it remains an unexplored field in Greece, as no national registry or disease's atlas are currently available. Because of that, we conducted a single-center study. We searched the registries of our hospital during the period January 2010–September 2023 and catalogued 23 children that were under 16 years old when they were first hospitalized in our department and diagnosed with POMS. We compared our data collected to the available literature regarding demographics and the risk factors, and our findings in general meet the acquired POMS knowledge. Most of our children have vitamin D deficiency, previous EBV infection, whilst some of them have personal or family history of autoimmunity. The mean age of first diagnosis is 12.3 years, similar to the global mean age of POMS. Despite the findings obtained, more studies are essential in this field.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 121-129"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interictal paroxysmal fast activity and functional connectivity in steroid responsive and non-responsive Lennox-Gastaut syndrome","authors":"Zongpu Zhou ,&nbsp;Pan Gong ,&nbsp;Xianru Jiao ,&nbsp;Yue Niu ,&nbsp;Zhao Xu ,&nbsp;Jiong Qin ,&nbsp;Zhixian Yang","doi":"10.1016/j.ejpn.2025.02.005","DOIUrl":"10.1016/j.ejpn.2025.02.005","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the changes in interictal paroxysmal fast activity and functional connectivity before and after steroid pulse therapy in patients with Lennox-Gastaut syndrome (LGS).</div></div><div><h3>Methods</h3><div>The medical records of patients who visited the pediatric neurology clinics with LGS as their primary complaint and completed intravenous methylprednisolone therapy were reviewed. Effects of steroid therapy on clinical seizures and scalp EEG were analyzed. Generalized paroxysmal fast activity (GPFA) burden were detected and compared before and after treatment. As a measure of global functional connectivity, we calculated mutual information (MI) between all channels, which was then used to assess network topology.</div></div><div><h3>Results</h3><div>Steroid pulse therapy improved seizure control in 20 (27 %) patients. Fourteen (18.9 %) children became complete seizure-free, but 8 patients experienced relapses subsequently. The later age of disease onset, shorter duration of epilepsy, and definite cerebral structural etiology were found to advantageous for hormone response. A significant correlation was observed between GPFA burden and diary seizure number. Patients with higher GPFA burdens and higher MI values exhibited a poor response to steroid treatment. Patients who respond positively to steroids therapy demonstrated longer characteristic path length, higher modularity and lower global efficiency in high beta and gamma bands.</div></div><div><h3>Conclusion</h3><div>Add-on steroid therapy can be considered as an optional adjunct for LGS. GPFA could be utilized as a parameter to predict treatment effects and prognosis for LGS. The group that responded to steroids showed a high level of local clustering and low long-range network connectivity. This study provides real-world evidence regarding the effectiveness of steroid in refractory LGS.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 38-46"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of greater occipital nerve anesthetic blockade in the treatment of status migrainosus in the pediatric emergency department","authors":"Adrián García Ron ,&nbsp;Eva Arias Vivas ,&nbsp;Guillermo Fernando Ruiz Ocaña de las Cuevas ,&nbsp;Elsa Santana Carera ,&nbsp;Rafael Sánchez-del Hoyo ,&nbsp;Marta Bote Gascón","doi":"10.1016/j.ejpn.2025.02.011","DOIUrl":"10.1016/j.ejpn.2025.02.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Headaches are becoming increasingly common in children and adolescents, leading to a rise in emergency department visits and hospitalizations. This study explores alternative therapeutic options, focusing on the anesthetic blockade of the greater occipital nerve (GON) for paediatric migraines.</div></div><div><h3>Materials and methods</h3><div>A prospective study assessing the utility of the anesthetic blockade in the GON zone with 0.5 % Bupivacaine in adolescents with refractory migraines. Inclusion criteria involve adolescents aged 12 to 17 with a diagnosis of migraine status. The study outlines the infiltration technique, efficacy assessment, and sustained utility evaluation, aiming to determine the safety, effectiveness, and patient satisfaction associated with the procedure.</div></div><div><h3>Results</h3><div>Out of 24 patients with migraine status, 92 % were females, with an average age of 14 years. Two-thirds reported incapacitating pain, and associated symptoms included nausea, vomiting, dizziness, syncope, phonophobia, and photophobia. The anesthetic blockade resulted in statistically significant total or partial improvement in the majority of patients, with sustained effectiveness observed at the 7-day follow-up. High satisfaction with the treatment was reported, and no adverse effects were documented.</div></div><div><h3>Conclusion</h3><div>The anesthetic blockade in the GON zone emerges as a safe and effective strategy for the treatment of paediatric migraines in the emergency department. High patient satisfaction and sustained effectiveness support its consideration, emphasizing the need for consensus and clinical trials to standardize procedures and indications across diverse populations.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 65-69"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor phenotyping in a Greek cohort of patients with neonatal and infantile onset developmental and epileptic encephalopathy","authors":"Elissavet Kollia ,&nbsp;Eleftheria Kokkinou ,&nbsp;Chrysa Outsika ,&nbsp;Georgia Koltsida ,&nbsp;Vasiliki Zouvelou ,&nbsp;Adamantios Vontzalidis ,&nbsp;Zoi Dalivigka ,&nbsp;Danai Veltra ,&nbsp;Christalena Sofocleous ,&nbsp;Nikolaos M. Marinakis ,&nbsp;Faidon-Nikolaos Tilemis ,&nbsp;Christos Yapijakis ,&nbsp;Katherine K. Anagnostopoulou ,&nbsp;Yannis L. Loukas ,&nbsp;Maria Spanou ,&nbsp;Argirios Dinopoulos ,&nbsp;Eirini Nikaina ,&nbsp;Anna-Venetia Skiathitou ,&nbsp;Tania Siahanidou ,&nbsp;Elissavet Georgiadou ,&nbsp;Roser Pons","doi":"10.1016/j.ejpn.2025.03.001","DOIUrl":"10.1016/j.ejpn.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>Developmental and epileptic encephalopathy (DEE) includes diseases where there is developmental impairment related to both the underlying etiology independent of epileptiform activity and the epileptic encephalopathy. Patients often present with movement disorders (MD). This study aims to delineate the motor phenotype in a cohort of patients with DEE.</div></div><div><h3>Methods</h3><div>Retrospective review of 82 patients with DEE. MD type and distribution were documented and when available, video recordings were reviewed.</div></div><div><h3>Results</h3><div>Patients were classified into five etiological groups: 30.5 % had a likely genetic diagnosis, 29.3 % a confirmed genetic diagnosis, 18.3 % an inborn error of metabolism (IEM), 14.6 % an acquired brain lesion, and 7.3 % a brain dysplasia. Hyperkinetic MDs were present in 85.4 % of patients, including dystonia (48.8 %), stereotypies (22.0 %), chorea (20.7 %), hyperekplexia (15.9 %), tremor (14.6 %), and myoclonus (6.1 %). Parkinsonism was observed in 11 % of patients, ataxia in 8.5 % and multiple MDs in 50 %. Paroxysmal episodes of MD exacerbation occurred in 6 patients, and transient MD in 8. Dystonia was most frequent in patients with acquired brain lesions (p = 0.003). Parkinsonism was more frequent in patients with brain dysplasias and IEM (p = 0.043).</div></div><div><h3>Conclusions</h3><div>This study confirms the high frequency of hyperkinetic and combined MD in DEE, and identifies characteristic MDs in conditions such <em>SCN8A, FOXG1</em> and <em>ARX</em> related DEE, as well as ataxia and tremor in <em>STXBP1, SCN1A, MTRFR, KCTD7</em> and 15q111-13 deletion. Novel observations, include the occurrence of paroxysmal dyskinetic exacerbations in <em>FOXG1</em>, axial stereotypies in <em>KCNQ2</em>, hyperekplexia in cortical dysplasia and Parkinsonism in <em>ECHS1</em> with <em>DEE.</em></div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 1-8"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurring impairments in several domains of memory following neonatal hypoxic-ischaemic encephalopathy have real-life implications","authors":"Abby Holder ,&nbsp;Rina Cianfaglione ,&nbsp;Jade Burns ,&nbsp;Brigitte Vollmer ,&nbsp;Caroline J. Edmonds","doi":"10.1016/j.ejpn.2025.03.002","DOIUrl":"10.1016/j.ejpn.2025.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Neonatal Hypoxic-Ischaemic Encephalopathy (HIE) increases the risk for neurodevelopmental impairment. Information on school-age memory function is limited in children who received hypothermia treatment (TH) for neonatal HIE.</div></div><div><h3>Objectives</h3><div>To evaluate memory function in school-aged children who had neonatal HIE and TH and survived without major neuromotor impairment.</div></div><div><h3>Method</h3><div>Fifty-one children with neonatal HIE and 41 typically developing (TD) peers participated. At age 6–8 years general cognitive abilities (FSIQ) were assessed with Wechsler Intelligence Scale for Children (WISC-V), immediate and delayed visual and verbal memory with Children's Memory Scale (CMS), everyday memory with Rivermead Behavioural Memory Test for Children (RBMT-C), and working memory with WISC-V. Real-life implications were assessed with Behavior Rating Inventory for Executive Function (BRIEF; Parent and Teacher). Group differences were examined and correlations calculated to assess associations between memory measures. Relationship maps illustrate co-occurring impairments.</div></div><div><h3>Results</h3><div>FSIQ was in the normal range for both groups but significantly lower in the HIE group. Children with HIE had significantly more deficits in working memory (20.4 % vs 0 %), verbal immediate (20.0 % vs 2.5 %), verbal delayed (17.8 % vs 2.5 %), visual immediate (28.9 % vs 7.5 %), and everyday memory (38.8 % vs 5.6 %). Relationship maps identified more co-occurring clinical/borderline impairments in children with HIE (45.1 % vs 4.9 %) and more frequent clinical impairments in real-world memory measures.</div></div><div><h3>Conclusion</h3><div>Despite hypothermia treatment, and with general cognitive abilities in the normal range, children with neonatal HIE are at risk of memory impairments in multiple domains, affecting everyday functioning at home and school. Timely identification is important for individually targeted support.</div></div>","PeriodicalId":50481,"journal":{"name":"European Journal of Paediatric Neurology","volume":"55 ","pages":"Pages 9-17"},"PeriodicalIF":2.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}