Expert Review of Proteomics最新文献_第9页

Understanding the age-related alterations in the testis-specific proteome. 了解睾丸特异性蛋白质组中与年龄相关的变化。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-12-30 DOI: 10.1080/14789450.2023.2274857

Ana D Martins, João C Ribeiro, Rita Ferreira, Marco G Alves, Pedro F Oliveira

{"title":"Understanding the age-related alterations in the testis-specific proteome.","authors":"Ana D Martins, João C Ribeiro, Rita Ferreira, Marco G Alves, Pedro F Oliveira","doi":"10.1080/14789450.2023.2274857","DOIUrl":"10.1080/14789450.2023.2274857","url":null,"abstract":"Introduction: Fertility rates in developing countries have declined over the past decades, and the trend of delayed fatherhood is rising as societies develop. The reasons behind the decline in male fertility with advancing age remain mysterious, making it a compelling and crucial area for further research. However, the limited number of studies dedicated to unraveling this enigma poses a challenge. Thus, our objective is to illuminate some of the upregulated and downregulated mechanisms in the male testis during the aging process.Areas covered: Herein, we present a critical overview of the studies addressing the alterations of testicular proteome through the aging process, starting from sexually matured young males to end-of-life-expectancy aged males. The comparative studies of the proteomic testicular profile of men with and without spermatogenic impairment are also discussed and key proteins and pathways involved are highlighted.Expert opinion: The difficulty of making age-comparative studies, especially of advanced-age study subjects, makes this topic of study quite challenging. Another topic worth mentioning is the heterogeneous nature and vast cellular composition of testicular tissue, which makes proteome data interpretation tricky. The cell type sorting and comorbidities testing in the testicular tissue of the studied subjects would help mitigate these problems.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"331-343"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50163506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in proteomic-based diagnostics of cystic fibrosis. 囊性纤维化基于蛋白质组学诊断的最新进展。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-07-01 Epub Date: 2023-10-16 DOI: 10.1080/14789450.2023.2258282

Refat M Nimer, Anas M Abdel Rahman

{"title":"Recent advances in proteomic-based diagnostics of cystic fibrosis.","authors":"Refat M Nimer, Anas M Abdel Rahman","doi":"10.1080/14789450.2023.2258282","DOIUrl":"10.1080/14789450.2023.2258282","url":null,"abstract":"Introduction: Cystic fibrosis (CF) is a genetic disease characterized by thick and sticky mucus accumulation, which may harm numerous internal organs. Various variables such as gene modifiers, environmental factors, age of diagnosis, and CF transmembrane conductance regulator (CFTR) gene mutations influence phenotypic disease diversity. Biomarkers that are based on genomic information may not accurately represent the underlying mechanism of the disease as well as its lethal complications. Therefore, recent advancements in mass spectrometry (MS)-based proteomics may provide deep insights into CF mechanisms and cellular functions by examining alterations in the protein expression patterns from various samples of individuals with CF.Areas covered: We present current developments in MS-based proteomics, its application, and findings in CF. In addition, the future roles of proteomics in finding diagnostic and prognostic novel biomarkers.Expert opinion: Despite significant advances in MS-based proteomics, extensive research in a large cohort for identifying and validating diagnostic, prognostic, predictive, and therapeutic biomarkers for CF disease is highly needed.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":" ","pages":"151-169"},"PeriodicalIF":3.4,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41138729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating analysis of proteome profile and drug screening identifies therapeutic potential of MET pathway for the treatment of malignant peripheral nerve sheath tumor. 结合蛋白质组谱分析和药物筛选，确定MET通路治疗恶性周围神经鞘肿瘤的治疗潜力。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-04-01 DOI: 10.1080/14789450.2023.2218035

Ryuto Tsuchiya, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Takuya Ono, Taro Akiyama, Hidetaka Kosako, Akihiko Yoshida, Seiji Ohtori, Akira Kawai, Tadashi Kondo

{"title":"Integrating analysis of proteome profile and drug screening identifies therapeutic potential of MET pathway for the treatment of malignant peripheral nerve sheath tumor.","authors":"Ryuto Tsuchiya, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, Takuya Ono, Taro Akiyama, Hidetaka Kosako, Akihiko Yoshida, Seiji Ohtori, Akira Kawai, Tadashi Kondo","doi":"10.1080/14789450.2023.2218035","DOIUrl":"https://doi.org/10.1080/14789450.2023.2218035","url":null,"abstract":"Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with a poor prognosis that requires novel therapeutic agents. Proteome information is useful for identifying new therapeutic candidates because it directly reflects the biological phenotype. Additionally, in vitro drug screening is an effective tool to identify candidate drugs for common cancers. Hence, we attempted to identify novel therapeutic candidates for MPNST by integrating proteomic analysis and drug screening.Methods: We performed comprehensive proteomic analysis on 23 MPNST tumor samples using liquid chromatography - tandem mass spectrometry to identify therapeutic targets. We also conducted drug screening of six MPNST cell lines using 214 drugs.Results: Proteomic analysis revealed that the MET and IGF pathways were significantly enriched in the local recurrence/distant metastasis group of MPNST, whereas drug screening revealed that 24 drugs showed remarkable antitumor effects on the MPNST cell lines. By integrating the results of these two approaches, MET inhibitors, crizotinib and foretinib, were identified as novel therapeutic candidates for the treatment of MPNST.Conclusions: We successfully identified novel therapeutic candidates for the treatment of MPNST, namely crizotinib and foretinib, which target the MET pathway. We hope that these candidate drugs will contribute to the treatment of MPNST.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":"20 4-6","pages":"109-119"},"PeriodicalIF":3.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9740793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a 'plug and play' nanoflow liquid chromatography system for MS-based proteomic characterization of clinical FFPE specimens. 评价“即插即用”纳米流液相色谱系统用于临床FFPE标本的MS-based蛋白质组学表征。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-04-01 DOI: 10.1080/14789450.2023.2219844

Georgia Mitsa, Vincent R Richard, Yasamin Majedi, Josiane Lafleur, Adriana Aguilar-Mahecha, Mark Basik, Christoph H Borchers

{"title":"Evaluation of a 'plug and play' nanoflow liquid chromatography system for MS-based proteomic characterization of clinical FFPE specimens.","authors":"Georgia Mitsa, Vincent R Richard, Yasamin Majedi, Josiane Lafleur, Adriana Aguilar-Mahecha, Mark Basik, Christoph H Borchers","doi":"10.1080/14789450.2023.2219844","DOIUrl":"https://doi.org/10.1080/14789450.2023.2219844","url":null,"abstract":"Introduction: Proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tumor tissue specimens has gained interest in the last 5 years due to technological advances and improved sample collection, as well as biobanking for clinical trials. The real-world implementation of clinical proteomics to these specimens, however, is hampered by tedious sample preparation steps and long instrument acquisition times.Areas covered: To advance the translation of quantitative proteomics into the clinic, we are comparing the performance of the leading commercial nanoflow liquid chromatography (nLC) system (based on literature reviews), the Easy-nLC 1200 (Thermo Fisher Scientific, Waltham, MA, U.S.A.), to the Evosep One HPLC (Evosep Biosystems, Odense, Denmark). We measured FFPE-tissue digests from 21 biological replicates with a similar gradient on both of the LC systems while keeping the on-column amount (1 µg total protein) and the single-shot data-dependent acquisition-based MS/MS method constant.Expert opinion: Overall, the Evosep One facilitates robust and sensitive high-throughput sample acquisition, making it suitable for clinical MS. We found the Evosep One to be a useful platform for positioning mass spectrometry-based proteomics in the clinical setting. The clinical application of nLC/MS will inform clinical decision-making in oncology and other diseases.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":"20 4-6","pages":"87-92"},"PeriodicalIF":3.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9752610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic tools to study phosphorylation of intrinsically disordered proteins. 蛋白质组学工具用于研究内在无序蛋白的磷酸化。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-04-01 DOI: 10.1080/14789450.2023.2217359

Barbara Spolaore, Luca Secco, Giulia Rocca, Guidalberto Manfioletti, Giorgio Arrigoni, Riccardo Sgarra

{"title":"Proteomic tools to study phosphorylation of intrinsically disordered proteins.","authors":"Barbara Spolaore, Luca Secco, Giulia Rocca, Guidalberto Manfioletti, Giorgio Arrigoni, Riccardo Sgarra","doi":"10.1080/14789450.2023.2217359","DOIUrl":"https://doi.org/10.1080/14789450.2023.2217359","url":null,"abstract":"Introduction: Intrinsically disordered proteins (IDPs) represent a family of proteins that lack secondary or tertiary structure. IDPs are hubs in interaction networks, participate in liquid-liquid phase separation processes, and drive the formation of proteinaceous membrane-less organelles. Their unfolded structure makes them particularly prone to post-translational modifications (PTMs) that play key functional modulatory roles.Areas covered: We discuss different analytical approaches to study phosphorylation of IDPs starting from methods for IDP enrichment (strong acid extractions and heat-based pre-fractionation), strategies to enrich and map phosphopeptides/proteins, and mass spectrometry-based tools to study the phosphorylation-dependent conformational alterations of IDPs (limited proteolysis, HDX, chemical cross-linking, covalent labeling, and ion mobility).Expert opinion: There is a growing interest in IDPs and their PTMs since they are involved in several diseases. The intrinsic disorder could be exploited to facilitate purification and synthetic production of IDPs taking full advantage of those structural mass-spectrometry-based methods that can be used to investigate IDPs and their phospho-dependent conformational alterations. The diffusion and implementation of mass spectrometers with ion mobility devices and electron transfer dissociation capabilities could be key-elements for increasing information on IDP biology.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":"20 4-6","pages":"93-107"},"PeriodicalIF":3.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10108674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the clinical use of metaproteomics. 元蛋白质组学的临床应用进展。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-04-01 DOI: 10.1080/14789450.2023.2215440

Maximilian Wolf, Kay Schallert, Luca Knipper, Albert Sickmann, Alexander Sczyrba, Dirk Benndorf, Robert Heyer

引用次数: 1

Data-independent acquisition mass spectrometry reveals comprehensive plasma protein profiles in the natural history of patients with hereditary transthyretin amyloidosis (ATTRv). 数据独立采集质谱揭示了遗传性甲状腺转蛋白淀粉样变性(ATTRv)患者自然史中的全面血浆蛋白谱。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-01-01 DOI: 10.1080/14789450.2023.2195096

Shan He, XinYue He, RuoKai Pan, LuRong Pan, Xiaoying Lv, YuTong Jin, Yue Fan, YuTong Wang, Zhuang Tian, ShuYang Zhang

{"title":"Data-independent acquisition mass spectrometry reveals comprehensive plasma protein profiles in the natural history of patients with hereditary transthyretin amyloidosis (ATTRv).","authors":"Shan He, XinYue He, RuoKai Pan, LuRong Pan, Xiaoying Lv, YuTong Jin, Yue Fan, YuTong Wang, Zhuang Tian, ShuYang Zhang","doi":"10.1080/14789450.2023.2195096","DOIUrl":"https://doi.org/10.1080/14789450.2023.2195096","url":null,"abstract":"Objectives: Hereditary transthyretin amyloidosis (ATTRv) is a rare, fatal, autosomal dominant disease with more than 140 mutations discovered. Three phenotypes of amyloid infiltration are neuropathy (ATTRv-PN), cardiopathy (ATTRv-CM), and neuropathy + cardiopathy (ATTRv-MIX). The lack of ATTR-specific biomarkers, difficulties in biopsy evidence, and limited known pathogenic mechanisms have made diagnosis difficult. Newly emerging noninvasive measures for monitoring progression and disease-modifying therapies have improved early diagnosis and patient management.Methods: Our research applies the latest technology, Data-Independent Acquisition-Based Quantitative Proteomics (DIA), to reveal comprehensive plasma protein profiles in the natural history of Chinese patients with hereditary transthyretin amyloidosis (ATTRv). We analyzed differentially expressed proteins (DEPs) in three phenotypes (ATTRv-PN, ATTRv-CM, and ATTRv-MIX).Results: Serum samples were collected from a total of 18 patients (6 ATTRv-PN, 5 ATTRv-CM, and 7 ATTRv-MIX patients) and 20 healthy participants as a control group. Combined with the results of the proteomic and bioinformatic analyses, we found 30 DEPs and protein interaction networks clustered in KRT family proteins and DSC3 between ATTRv-PN and the control, which were rich in the estrogen signaling pathway and the cell adhesion molecule (CAM) pathway.Conclusion: This study demonstrates a global and significant proteomic profile in different stages of ATTRv.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":"20 1-3","pages":"57-69"},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9536233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC-MS/MS: A sensitive and selective analytical technique to detect COVID-19 protein biomarkers in the early disease stage. LC-MS/MS:一种在疾病早期检测COVID-19蛋白生物标志物的灵敏和选择性分析技术。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-01-01 DOI: 10.1080/14789450.2023.2191845

Siva Nageswara Rao Gajula, Ankita Sahebrao Khairnar, Pallavi Jock, Nikita Kumari, Kendre Pratima, Vijay Munjal, Pavan Kalan, Rajesh Sonti

{"title":"LC-MS/MS: A sensitive and selective analytical technique to detect COVID-19 protein biomarkers in the early disease stage.","authors":"Siva Nageswara Rao Gajula, Ankita Sahebrao Khairnar, Pallavi Jock, Nikita Kumari, Kendre Pratima, Vijay Munjal, Pavan Kalan, Rajesh Sonti","doi":"10.1080/14789450.2023.2191845","DOIUrl":"https://doi.org/10.1080/14789450.2023.2191845","url":null,"abstract":"Introduction: The COVID-19 outbreak has put enormous pressure on the scientific community to detect infection rapidly, identify the status of disease severity, and provide an immediate vaccine/drug for the treatment. Relying on immunoassay and a real-time reverse transcription polymerase chain reaction (rRT-PCR) led to many false-negative and false-positive reports. Therefore, detecting biomarkers is an alternative and reliable approach for determining the infection, its severity, and disease progression. Recent advances in liquid chromatography and mass spectrometry (LC-MS/MS) enable the protein biomarkers even at low concentrations, thus facilitating clinicians to monitor the treatment in hospitals.Areas covered: This review highlights the role of LC-MS/MS in identifying protein biomarkers and discusses the clinically significant protein biomarkers such as Serum amyloid A, Interleukin-6, C-Reactive Protein, Lactate dehydrogenase, D-dimer, cardiac troponin, ferritin, Alanine transaminase, Aspartate transaminase, gelsolin and galectin-3-binding protein in COVID-19, and their analysis by LC-MS/MS in the early stage.Expert opinion: Clinical doctors monitor significant biomarkers to understand, stratify, and treat patients according to disease severity. Knowledge of clinically significant COVID-19 protein biomarkers is critical not only for COVID-19 caused by the coronavirus but also to prepare us for future pandemics of other diseases in detecting by LC-MS/MS at the early stages.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":"20 1-3","pages":"5-18"},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9831802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mapping the human sperm proteome - novel insights into reproductive research. 绘制人类精子蛋白质组图——生殖研究的新见解。

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-01-01 DOI: 10.1080/14789450.2023.2210764

Mika Alexia Miyazaki, Raquel Lozano Guilharducci, Paula Intasqui, Ricardo Pimenta Bertolla

{"title":"Mapping the human sperm proteome - novel insights into reproductive research.","authors":"Mika Alexia Miyazaki, Raquel Lozano Guilharducci, Paula Intasqui, Ricardo Pimenta Bertolla","doi":"10.1080/14789450.2023.2210764","DOIUrl":"https://doi.org/10.1080/14789450.2023.2210764","url":null,"abstract":"Introduction: Spermatozoa are highly specialized cells with unique morphology. In addition, spermatozoa lose a considerable amount of cytoplasm during spermiogenesis, when they also compact their DNA, resulting in a transcriptionally quiescent cell. Throughout the male reproductive tract, sperm will acquire proteins that enable them to interact with the female reproductive tract. After ejaculation, proteins undergo post-translational modifications for sperm to capacitate, hyperactivate, and fertilize the oocyte. Many proteins have been identified as predictors of male infertility and also investigated in diseases that compromise reproductive potential.Areas covered: In this review, we proposed to summarize the recent findings about the sperm proteome and how they affect sperm structure, function, and fertility. A literature search was performed using PubMed and Google Scholar databases within the past 5 years until August 2022.Expert opinion: Sperm function depends on protein abundance, conformation, and PTMs; understanding the sperm proteome may help to identify pathways essential to fertility, even making it possible to unravel the mechanisms involved in idiopathic infertility. In addition, proteomics evaluation offers knowledge regarding alterations that compromise the male reproductive potential.","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":"20 1-3","pages":"19-45"},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9479004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

How valuable can proteogenomics be in clinical breast cancer research? 蛋白质基因组学在临床乳腺癌研究中的价值有多大?

IF 3.4 3区生物学

Expert Review of Proteomics Pub Date : 2023-01-01 DOI: 10.1080/14789450.2023.2203390

Anh M Tran-Huynh, Matthew V Holt, Meenakshi Anurag

{"title":"How valuable can proteogenomics be in clinical breast cancer research?","authors":"Anh M Tran-Huynh, Matthew V Holt, Meenakshi Anurag","doi":"10.1080/14789450.2023.2203390","DOIUrl":"https://doi.org/10.1080/14789450.2023.2203390","url":null,"abstract":"Nearly, 45,000 women are estimated to die from breast cancer in 2022 in the US alone [1,2]. Breast cancer displays high heterogeneity with a wide spectrum of clinical, pathological, and molecular features, which makes it challenging for successful therapy. As we are inching toward the era of personalized medicine, advances in subtyping breast tumors have impacted prognosis and therapeutics [3]. Proteogenomics, which is an integrative profiling approach utilizing DNA, RNA, and protein data, has clearly played a critical role in illuminating the complexity of breast tumor biology, and predicting treatment response. Since DNA and RNA sequencing has gained momentum in breast cancer clinical assays including targeted mutation panel or RNA-based PAM50-based intrinsic subtyping, it is important to highlight the capabilities of integrative approaches rather than focusing on proteomics in silo. The complementation of proteomics platform provides an opportunity not just for biomarker assessment but also better quantification of targetable proteins and pathways. This methodological advancement provides an elaborate molecular landscape of breast tumors in light of treatment response and toxicity [4,5].","PeriodicalId":50463,"journal":{"name":"Expert Review of Proteomics","volume":"20 1-3","pages":"1-4"},"PeriodicalIF":3.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9849746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0