Biological and Clinical Sciences Research Journal最新文献

{"title":"IN STENT RESTENOSIS (ISR) IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION (PCI) FOR CORONARY ARTERY DISEASE (CAD)","authors":"S. Ullah, MH Arshad, J. Hussain","doi":"10.54112/bcsrj.v2024i1.826","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.826","url":null,"abstract":"In-stent restenosis (ISR) remains a significant clinical challenge in patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease (CAD). Objectives: The main aim of the study is to find the In-Stent Restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease (CAD). Methods: This cross-sectional study was conducted at Prime Teaching Hospital Peshawar from January 2023 till December 2023. Data were collected from 80 patients from both genders. Patients who underwent PCI for CAD and developed ISR, as confirmed by angiographic or intravascular imaging studies, were included.  Data were collected in a systematically designed performance. Information was collected from electronic medical records, angiographic reports, and procedural databases. Results: Data were collected from 80 patients according to inclusion criteria. The mean age of the patients was 65.09±8.5 years. There were 52 (65%) male and 48 (35%) female patients. Hypertension was present in 60 (75%), dyslipidemia in 48(60%) and DM in 36 (45%) patients. There was a significant association between older age and increased likelihood of ISR development post-PCI (Mean age ISR: 68.01 ± 7.2 years vs. No ISR: 62.39 ± 9.1 years, p=0.02). However, gender did not significantly influence ISR occurrence (71% male ISR vs. 62% male No ISR, p=0.42). Conclusion: It is concluded that ISR represents a significant challenge in patients post-PCI for CAD, with a substantial incidence observed in this study. Older age, diabetes mellitus, and DES implantation were identified as essential contributors to ISR development.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY AND SAFETY OF NICORANDIL FOR PERIPROCEDURAL MYOCARDIAL INJURY IN PATIENTS UNDERGOING PCI","authors":"SB Shah, S. Khan, MU Khan","doi":"10.54112/bcsrj.v2024i1.835","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.835","url":null,"abstract":"Coronary artery disease (CAD) remains a leading cause of morbidity and mortality globally, with percutaneous coronary intervention (PCI) being a typical therapeutic approach. Objectives: In this comparative study, we aimed to investigate the efficacy and safety of nicorandil for periprocedural myocardial injury in patients undergoing PCI. Methods: This comparative study was conducted at Ayub Teaching Hospital from September 2023 to December 2023. Data from 90 patients was recruited for the research using inclusion and exclusion screening standards. Our study was performed on 90 patients treated with percutaneous coronary intervention (PCI). Patients from Group 1 were different from those in Group 2. Group A: the critical study parameters will switch between those patients who received nicorandil and Group B: non-nicorandil patients. Baseline demographic data, past medical history, and relevant laboratory values and clinical characteristics were documented for all patients. In addition, an intraoperative laboratory investigation was conducted, including cardiac biomarkers. Results: Research data were drawn from 90 patients whose gender wasn't a factor based on the research protocol. In Group A, the mean age of the patients was 62 years. Players in group A played for 4 ± 8.5 years. In team B, the players had a slightly longer experience and played for 63. Humans on Earth could do the same, and it could significantly impact future generations: ± 7. 9 years. Of 58 men and 32 women in the control group, there were two persons and persons in the experimental group, respectively. Only one stent differed between the two groups; however, the number was similar. 8 ± 0. 6 mmol/l in the tricorandil group and 1. +9 ± 0 in Case 1. Patients in the Nicorandil group displayed the lowest level of heart problem-causing protein (troponin) at the peak (5. There is a statistically significant 1.8-fold (2 ng/mL versus seven ng/mL) decline in serum lysozyme levels in the group administered rhG-CSF. The treatment group exhibited a substantial increase in haemoglobin levels (t(12) = 3. 74, p-value <0.005) with a mean difference of 0. 5 ± 2 ng/mL. 001, 95% CI: 2. 1 to 3. 5). Conclusion: It is concluded that nicorandil shows positive results for the efficacy (the ability of a drug to bring the desired effect) and safety of the drug in reducing myocardial injury and in maintaining the function of myocardial during percutaneous coronary intervention in patients.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF RENAL PROFILE AND SERUM ELECTROLYTES AMONG DIABETIC AND NON DIABETIC GROUPS IN DISTRICT PESHAWAR KP","authors":".. Abdullah, FE Amin, K. Khan, A. Rehman, Sja Shah, MK Azam, A. Rehman, F KHAN","doi":"10.54112/bcsrj.v2024i1.796","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.796","url":null,"abstract":"Diabetes mellitus is a prevalent non-communicable disease worldwide, contributing significantly to morbidity and mortality. Renal complications are a significant concern in diabetes, with hyperglycemia exacerbating renal dysfunction. Objective: This study aimed to assess renal function and electrolyte balance in diabetic and non-diabetic individuals, focusing on serum urea, creatinine levels, and electrolyte imbalances. Methods: This study was conducted at Al-Khidmat Hospital and processed at the MLT Skill Lab at Abasyn University, Peshawar. A total of 100 participants were enrolled, including diabetic and non-diabetic subjects. Blood samples were collected using a questionnaire design. Renal function tests (RFTs) were analysed using a biochemistry analyser, and serum electrolytes were assessed using an Electrolytes Analyzer. Data collection duration, methodology, and statistical analysis methods were employed. Results: Among the participants, individuals aged 40 to 70 in both genders exhibited a higher prevalence of elevated urea and creatinine levels, particularly in diabetic patients. Diabetic individuals showed a significant association with azotemia. Electrolyte imbalances, notably hypokalemia, were observed, indicating potential complications in diabetic patients. Conclusion: The study highlights the importance of proactive management strategies to mitigate renal complications in diabetic individuals. Comprehensive monitoring of renal function and electrolyte balance is essential in clinical practice.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":" 30","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VISUAL OUTCOME FOLLOWING PARS PLANA VITRECTOMY IN POST-OPERATIVE ENDOPHTHALMITIS PATIENTS","authors":"AK Kundi, T. Shahnam, OU Ahmad, S. Rauf","doi":"10.54112/bcsrj.v2024i1.831","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.831","url":null,"abstract":"Postoperative endophthalmitis is a serious complication following ocular surgery that can lead to significant visual impairment. Pars plana vitrectomy (PPV) is one of the treatment options for managing this condition, but its visual outcomes are not well-established. Objective: This study aimed to assess the visual outcome following pars plana vitrectomy in patients with postoperative endophthalmitis. Methods: This interventional study was conducted at the eye ward of Hayatabad Medical Complex, Peshawar, from September 2023 to February 2024. Forty patients with postoperative endophthalmitis underwent pars plana vitrectomy. Visual acuity was evaluated in the 12th week after the procedure. Results: Among the patients evaluated, 15% demonstrated a visual acuity improvement of 6/18 or higher, while 22.5% showed an improvement of 6/60 or better. Additionally, 35% of patients could count fingers, 17.5% had vision of hand movement, and 10% showed no increase in visual acuity. There was no significant relationship between age distribution and post-follow-up improvement in visual acuity. Conclusion: Pars plana vitrectomy in patients with postoperative endophthalmitis can lead to positive outcomes in terms of improved visual acuity.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FIND THE FREQUENCY OF UTERINE RUPTURE IN VAGINAL BIRTH AFTER CESAREAN SECTION (VBAC) AND COMPARE RATES BETWEEN SHORT AND LONG INTERPREGNANCY INTERVALS","authors":"A. Nazar, T. Aziz, A. Ashfaq, S. Nosheen, AU Khan, QU Ain","doi":"10.54112/bcsrj.v2024i1.832","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.832","url":null,"abstract":"Vaginal births after cesarean (VBAC) is not typical and uterine rupture, the most serious complication of a TOL after Cesarean, is characterized as the complete separation of the myometrium regardless of extrusion of the fetal parts into the maternal peritoneal cavity. Objective: To determine the frequency of uterine rupture in women who attempt vaginal birth after cesarean section and to compare the frequency of uterine rupture in women with short and long inter-pregnancy intervals. Methods: This Descriptive Case Series was conducted from December 23, 2015, to June 22, 2016.  Ninety (90) patients were recruited based on inclusion/exclusion criteria. Women were then divided into two groups in short and long interpregnancy intervals per the operational definition. The outcome variable, i.e., uterine rupture, was noted as per the operational definition during the delivery. Results: A total of 90 women were included in this study. The age of the women ranged from 18-40 years. The average age of the women was 28.49 + 4.49, with a mean gestational age of 36.45 + 2.24, mean height of 161.94 + 7.62, mean weight of 67.73 + 11.9, and mean BMI of 25.7 + 4.05. The mean inter-pregnancy interval in women who attempted VBAC was 34.8 + 9.73. 70(78%) had 2-4 parity and 20(22%) had parity >4. 58(64.4%) had long inter pregnancy interval and 32(35.6%) had short pregnancy interval. (Table no: 11) Conclusion: The data indicate that the relative risk of uterine rupture is increased in women undergoing a TOL after Caesarean. Short pregnancy interval increases the risk for uterine rupture two-fold to three-fold in VBAC Women.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"10 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141004516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF DAPAGLIFLOZIN ON CARDIOVASCULAR OUTCOMES IN HFREF PATIENTS: IMPACT OF DIABETES MELLITUS TYPE 2 STATUS","authors":"F. Rabi, A. Ali, SA Bahar, M. Liaqat, D. Nayab, B. Ali, S. Wazir","doi":"10.54112/bcsrj.v2024i1.830","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.830","url":null,"abstract":"Dapagliflozin has shown promise in the treatment of heart failure with reduced ejection fraction (HFrEF), but its effects in patients with and without diabetes remain unclear. Objective: This study aimed to assess the effects of dapagliflozin in HFrEF patients, both with and without diabetes. Methods: From January to July 2023, a six-month case-control study was conducted in the cardiology department of a Tertiary Care Hospital in Peshawar, Pakistan. All patients received an additional dose of dapagliflozin (10 mg) alongside their usual treatment plans. The primary outcome was a composite of heart failure exacerbation or cardiovascular death. Data analysis was performed using SPSS version 22. Results: Patients with diabetes mellitus type 2 (DMT2) exhibited a higher rate of cardiovascular death (22%) and hospitalization for heart failure (14.4%) compared to those without diabetes. The hospitalisation rate for heart failure was also higher in the DMT2 group (12.21%) than in the non-diabetic group (8.6%). Over the trial period, cardiovascular death occurred in 12.44% of patients with DMT2 compared to 7.30% in those without DMT2. Patients with diabetes experienced a significantly higher number of first and recurrent hospitalizations for heart failure and cardiovascular death compared to those without diabetes (32.45% vs. 19.20%, p=0.021). Conclusion: Dapagliflozin therapy in HFrEF patients demonstrated varying effects between those with and without diabetes. The study underscores the importance of personalised management strategies considering comorbid medical conditions. Despite dapagliflozin treatment, patients with both heart failure and diabetes continued to experience cardiovascular complications, highlighting the need for individualised treatment plans that account for a patient's complete medical profile.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"30 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN MODE OF DELIVERY AND BREASTFEEDING PRACTICES: A PROSPECTIVE STUDY IN A TERTIARY CARE HOSPITAL","authors":"SS Fatima, S. Sultan","doi":"10.54112/bcsrj.v2024i1.825","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.825","url":null,"abstract":"Breastfeeding is widely recognised to have numerous health benefits for the infant and child health later, such as lowering the risk of gastrointestinal tract infections, respiratory tract infections, allergies, asthma, obesity, type I and type 2 diabetes mellitus (DM), and sudden infant mortality syndrome. It also protects mothers against conditions like obesity, type 2 DM, and breast and ovarian cancers. Objective: To assess the association between mode of delivery and breastfeeding practices. Methodology: This cross-sectional study was carried out in the obstetrics department of Lady Reading Hospital after approval from the hospital’s ethical committee. The study duration was three months, from 1st November 2023 to 31st January 2024. Postnatal mothers were interviewed, and information was collected on a specifically designed proforma 24 hours after the birth of the baby and then on the day of discharge from the hospital. Using openepi software, keeping anticipated frequency 18%, confidence level 95%, power of study 80%, sample size calculated is 227. Data was entered into SPSS version 20. Results: In the current study, 227 patients were enrolled. Based on age-wise distribution, 125 (55.07%) patients were 16-25 years old, 67 (29.52%) were 26-35 years old, and 35 (15.42%) patients were more than 35 years of age. Amongst 227 women, 109 (48.02%) delivered vaginally while caesarean section was done in 118 (51.98%) patients. Based on the initiation of breastfeeding, amongst 109 women who delivered vaginally, breastfeeding within one hour was initiated in 79 (72.48%) patients. In comparison, amongst 118 women with caesarean section within one hour, breastfeeding initiation was observed in 74 (62.71%) patients. The association between breastfeeding initiation and mode of delivery was statistically significant (p=0.001). Conclusion: Our study concludes that the chance of delayed breastfeeding initiation was higher in women who had caesarean delivery. Hence, Counseling regarding the initiation and maintenance of breastfeeding should be a mandatory part of prenatal care provided to women by hospitals. Adequate professional support must be available in the postnatal wards, especially for women who delivered by cesarean section, and should be tailored according to the individual needs.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141016890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FREQUENCY OF EARLY STENT THROMBOSIS (ACUTE AND SUBACUTE) IN PATIENTS PRESENTING WITH ACUTE ST ELEVATION MYOCARDIAL INFARCTION (STEMI) UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION (PCI)","authors":"AU Khan, H. Zeb, S. Ullah, A. Khan, Z. Afzal","doi":"10.54112/bcsrj.v2024i1.824","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.824","url":null,"abstract":"Sudden cardiac stent thrombosis (ST) is a severe clinical risk that can lead to high fatality rates. However, data are scarce on the prevalence of early ST events following ‘primary percutaneous coronary intervention’ (pPCI) and the characteristics that predict it, particularly among Pakistani patients. Objective: The objective is to determine possible indicators and evaluate ‘the frequency of acute and sub-acute stent thrombosis’ (ST) after ‘primary percutaneous coronary intervention’ (PCI). Methods: Five hundred individuals who had undergone primary PCI were enrolled from July 2022 to December 2023. Telephone follow-up assessments were used to gather information on 30-day results, including death rates, recurrence of symptoms, and episodes of ST. ‘ST was classified as acute’ (occurring ‘during the procedure’) or ‘sub-acute’ (‘occurring within 30 days post-procedure) using standardised criteria established by the ‘Academic Research Consortium. Results:  In this study, 500 patients were enrolled, primarily male (80.4%, 362 patients). ‘Stent thrombosis’ (either acute or sub-acute) was observed in 6.8% of patients, with 10.1% (4) classified as definite ST and the remaining 91.9% (34) as probable ST. Male patients were more prevalent among those who developed ST, along with a higher incidence of hypertension, diabetes, reduced left ventricular ejection fraction (LVEF) pre-PCI, and higher Killip Class. Patients with ST experienced a higher in-hospital mortality rate compared to those without ST, with a p-value of 0.02. Notably, ‘Killip Class’ (‘III-IV’) emerged as ‘an independent ST predictor in this patient cohort. These findings underscore the importance of risk assessment and vigilant management, particularly in patients presenting with higher Killip Class and other associated risk factors, to mitigate ST occurrence and adverse outcomes following primary PCI. Conclusion: Early stent thrombosis (ST) appears relatively common in patients undergoing primary PCI. Those with diabetes and hypertension face an elevated risk of ST, while patients presenting in ‘Killip Class III-IV’ demonstrate an ‘independent predictive’ factor for early ST.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141018656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEARL-21: SIX ROWED, HIGH YIELDING, HEAT STRESS RESISTANT, AND EARLY MATURING BARLEY CULTIVAR","authors":"J. Ahmad, A. Ahsan, M. Makhdoom, S. Shamim, S. Gulnaz, M. Owais, S. Asghar, A. Mahmood, M. Riaz, M. Saleem","doi":"10.54112/bcsrj.v2024i1.803","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.803","url":null,"abstract":"Pearl-21, an early maturing barley cultivar that was developed keeping in view the fluctuating climatic scenarios as drought stress is severely impairing the yield of crops in Pakistan. The exquisite genotypes were received from the International Center for Agricultural Research in the Dry Areas (ICARDA), Lebanon. The superior line was screened out from the international barley segregating population received from ICARDA. It was evaluated under code B-14035 in station yield trails for two years (2014-15 & 2015-16). It excelled by 15.26% and 7.38% in provincial barley yield trials during 2017-18 and 18.77% and 10.18% in national barley yield trials during 2018-19 in contrast to commercial checks Haider-93 and Sultan-17, respectively over four locations. It also presented encouraging results in rainfed yield trials. Pathological studies depicted that the proposed cultivar had exceptional resistance against rust diseases. Pearl-21 has plant height ranging from 95-99 cm with semi-erect growth habit both at the seedling and booting stage. It has a high tillering trend (140 productive tillers per meter).  It took only 99-101 days to head while, 123-130 days for maturity.  It bears 60-70 seeds per ear and has 34-38g thousand-grain weight. The prominent features it encompasses are drought and lodging tolerance and short duration. Due to encouraging steady performance for better grain yield, resistance against rusts, and quality Punjab Seed Council approved it in 2021 with the name “Pearl-21” for general cultivation in Punjab, Pakistan.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140660798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADAPTOGENIC EFFECTS OF PANAX GINSENG PLANT EXTRACT ON IMMUNE MODULATION IN LAYERS AGAINST SALMONELLA ENTERITIDIS","authors":"M. Taimoor, H. Noor, S. Yasmin, M. Usman, D. Ashraf, D. Hussain, S. Iqbal, W. Hasan, N. Zafar, R. Ajaz","doi":"10.54112/bcsrj.v2024i1.806","DOIUrl":"https://doi.org/10.54112/bcsrj.v2024i1.806","url":null,"abstract":"Panax ginseng, a traditional medicinal herb known for its adaptogenic properties, has garnered significant attention for its potential role in immune modulation and disease prevention. In this study, we investigate the adaptogenic effects of Panax ginseng on immune modulation in layers against Salmonella Enteritidis.  This randomized control trial was conducted at Zarrar Shaheed Road, Lahore Cantt from January 2023 to October 2023. A total of 450 laying hens were included in this study. The laying hens were randomly assigned to different experimental groups to ensure unbiased representation and minimize confounding variables. The laying hens were separated into several experimental groups, including a benchmark group and one or more treatment groups receiving Panax ginseng supplementation. A total of 450 laying hens were included in the study, divided into five experimental groups: a control group (n = 90) and four treatment groups receiving varying doses of Panax ginseng supplementation (n = 90 each). Compared to the control group, hens receiving low, medium, and high portions of ginseng displayed elevated degrees of IgG and IgM antibodies. Specifically, the high-portion ginseng group demonstrated the most noteworthy mean values for both IgG (75 ± 18) and IgM (50 ± 12), indicating a vigorous invulnerable reaction. It is concluded that supplementation with Panax ginseng holds promise as a natural intervention for enhancing immune modulation and reducing pathogen load in laying hens challenged with Salmonella Enteritidis. Ginseng may serve as a valuable adjunct therapy in poultry production to mitigate infectious diseases and improve overall health outcomes.","PeriodicalId":504575,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":"104 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}