Ibnosina Journal of Medicine and Biomedical Sciences最新文献

Evaluation of Regional Wall Motion Abnormalities with Echocardiography in the Emergency Department 在急诊科使用超声心动图评估区域室壁运动异常

Ibnosina Journal of Medicine and Biomedical Sciences Pub Date : 2024-07-11 DOI: 10.1055/s-0044-1786685

Yusuf Karancı, Cihan Bedel, F. Selvi, Ökkeş Zortuk

{"title":"Evaluation of Regional Wall Motion Abnormalities with Echocardiography in the Emergency Department","authors":"Yusuf Karancı, Cihan Bedel, F. Selvi, Ökkeş Zortuk","doi":"10.1055/s-0044-1786685","DOIUrl":"https://doi.org/10.1055/s-0044-1786685","url":null,"abstract":"\u0000 Introduction Acute coronary syndrome (ACS) is a major cardiovascular disease, particularly in cases where standard electrocardiogram findings are equivocal. Focused cardiac ultrasound (FOCUS) has become increasingly accepted as a tool in emergency medicine. The primary objective of this study was to evaluate the accuracy, sensitivity, and specificity of FOCUS in detecting regional wall motion abnormalities (RWMA) compared with standard echocardiography (ECHO).\u0000 Materials and Methods This prospective observational study included 91 patients who presented to the emergency department between June 1, 2023, and November 30, 2023. Senior emergency physicians performed FOCUS examinations, which were performed by an emergency assistant or specialist who works in the emergency department, has at least 2 years of experience in ultrasonography (USG), and has basic USG and advanced USG certificates. The examinations assessed the presence of RWMA in each patient's left ventricle.\u0000 Results All 91 patients were included in the study for comparison with formal ECHO. The mean age was 58, and 32% of patients were female. Compared with the criterion standard of formal ECHO, the sensitivity of FOCUS performed by emergency physicians for detecting RWMA was 85% (95% confidence interval [CI], 73–92), the specificity was 53% (95% CI, 36–69), and the overall accuracy was 74% (95% CI, 64–82).\u0000 Conclusion Our study demonstrates the potential utility of FOCUS performed by emergency physicians in detecting RWMA in patients with high suspicion of ACS.","PeriodicalId":504540,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"50 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Delta Troponin on Short-Term Mortality in Patients with Chronic Renal Dysfunction and NSTEMI δ肌钙蛋白对慢性肾功能障碍和 NSTEMI 患者短期死亡率的影响

Ibnosina Journal of Medicine and Biomedical Sciences Pub Date : 2024-07-11 DOI: 10.1055/s-0044-1786687

Burak Acem, S. Eroğlu, Serdar Özdemir

{"title":"Impact of Delta Troponin on Short-Term Mortality in Patients with Chronic Renal Dysfunction and NSTEMI","authors":"Burak Acem, S. Eroğlu, Serdar Özdemir","doi":"10.1055/s-0044-1786687","DOIUrl":"https://doi.org/10.1055/s-0044-1786687","url":null,"abstract":"\u0000 Introduction The relationship between mortality and troponin in non-ST-elevation myocardial infarction (NSTEMI) patients with a history of renal failure is quite limited. This study investigated the relationship between blood delta troponin T levels and 30-day mortality in patients with chronic renal dysfunction and NSTEMI.\u0000 Materials and Methods This study was conducted prospectively by including patients with chronic renal dysfunction and clinical findings of NSTEMI between February 1, 2021, and August 1, 2022. Demographics, medical history, laboratory parameters, and mortality data were noted. Thirty-day morbidity data was used for mortality. Delta troponin T was calculated using initial and first-hour troponin T values. Patients were grouped as healthy and deceased. Data were evaluated using univariant analysis and receiver operating characteristics analysis.\u0000 Results Of the 73 patients included in the study, 29 were female. The mean age of the patients was 67.3 years. The 30-day mortality rate was 9.5%. The sensitivity of the initial troponin T value was 85.7% (42.1–99.6), the specificity was 68.2% (55.6–79.1), and the accuracy was 69.9% (58–80.1), and the sensitivity of the first-hour troponin T value was 85.7% (42.1–99.6), specificity was 75.8% (63.6–85.5), and accuracy was 76.7% (65.4–85.8). The delta troponin T median of the mortality group was 56 (24.2–286.4), and the delta troponin median of the surviving patients was 29.4 (10.7–79.6). The difference was not statistically significant (p = 0.072).\u0000 Conclusion The current study's results show that delta troponin T (initial and first hour) is not associated with short-term mortality in patients with chronic renal dysfunction and NSTEMI.","PeriodicalId":504540,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"77 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Efficiency of an Advanced Hybrid Closed Insulin Pump in Patients with Type 1 Diabetes for Improved Blood Glucose Control 先进的混合封闭式胰岛素泵在 1 型糖尿病患者中改善血糖控制的效率

Ibnosina Journal of Medicine and Biomedical Sciences Pub Date : 2024-07-11 DOI: 10.1055/s-0044-1787111

Amal Owaydah, Kamal Abouglila, Triantafillos Liloglou

{"title":"The Efficiency of an Advanced Hybrid Closed Insulin Pump in Patients with Type 1 Diabetes for Improved Blood Glucose Control","authors":"Amal Owaydah, Kamal Abouglila, Triantafillos Liloglou","doi":"10.1055/s-0044-1787111","DOIUrl":"https://doi.org/10.1055/s-0044-1787111","url":null,"abstract":"\u0000 Background Diabetes technology, especially advanced hybrid closed-loop (AHCL) systems, is rapidly advancing, offering improved glycemic control, reduced hypoglycemia, and reduced treatment burden for patients with type 1 diabetes (T1D). This study aimed to evaluate the clinical efficiency of an AHCL system—the Medtronic MiniMed 780G insulin pump combined with continuous glucose monitoring—among individuals with T1D in real-world clinical settings.\u0000 Methods In an observational retrospective study, we identified a cohort of 41 patients (mean age, 47.1 ± 13.7 years; T1D duration, 23.6 ± 13 years; 73.2% female) previously using an insulin pump or those on multiple daily insulin injections, currently using the AHCL system for at least 6 months. Primary outcomes were the changes of the following parameters, before AHCL initiation and at 6 months after treatment; (1) time in range (TIR): time with glucose levels in the range of 70 to 180 mg/dL, (2) time below range (TBR): time with glucose levels below 70 mg/dL, and (3) time above range (TAR): time with glucose levels above 180 mg/dL.\u0000 Results Data analysis from 41 patients showed a significant 16.5% ± 13.8% increase in TIR (from 56.6 ± 17.9 to 73.1 ± 10.6%, p < 0.001). Both TBR and TAR decreased by 2.9 ± 4.8% (p = 0.004) and 13.6 ± 16.4% (p < 0.001), respectively. Mean glucose concentration, coefficient of variation, and glucose management indicator significantly improved.\u0000 Conclusion The AHCL system effectively improved glucose control regarding TIR, TBR, and TAR. Enhanced glycemic control metrics highlight the potential for wider adoption of AHCL technology.","PeriodicalId":504540,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"104 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital Myopathy-1B due to RYR 1 Gene Mutation in Three Libyan Families 三个利比亚家庭的 RYR 1 基因突变导致先天性肌病-1B

Ibnosina Journal of Medicine and Biomedical Sciences Pub Date : 2024-06-01 DOI: 10.1055/s-0043-1778047

Samira Etarhuni, Majdi Kara, Nadia Alghazir

{"title":"Congenital Myopathy-1B due to RYR 1 Gene Mutation in Three Libyan Families","authors":"Samira Etarhuni, Majdi Kara, Nadia Alghazir","doi":"10.1055/s-0043-1778047","DOIUrl":"https://doi.org/10.1055/s-0043-1778047","url":null,"abstract":"Abstract Introduction We report a series of patients in three different Libyan families diagnosed with congenital myopathy to study the wide clinical variability between these families, and the genetic heterogeneity. Description of Cases We describe six patients, one patient presented with severe neonatal-onset RYR1-associated myopathy while the other five patients came mainly due to delay in motor development; genetic testing confirmed the diagnosis of CMY-1B disease due to RYR1 mutation in all patients. Clinical features of congenital widely varied between the families ranging from profound hypotonia during the neonatal period in one family to a motor delay and abnormal gait during childhood in other two families. Whereas the clinical picture is quite similar in the patients of same family, the patient who presented with severe neonatal presentation of RYR1-associated myopathy also had gastrostomy feeding, respiratory involvement, clubfeet, cleft palate, and undescended testes. The five patients who presented due to delay in motor development all were ambulatory without the need of support, except the youngest one aged 4 years still walking with support. The genetic study in the form of whole-exon sequencing as well as next-generation sequencing showed homozygosity of a gene mutation in five patients and a compound heterozygosity in one patient which presented with neonatal severe hypotonia. Conclusion CMY-1B disease is a rare autosomal dominant and recessive genetic disorder that has variable clinical presentations. The early diagnosis is very important for genetic counseling as well as avoiding malignant hyperthermia. We also report rare and unusual presentations that may further delay the diagnosis.","PeriodicalId":504540,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"55 10","pages":"077 - 084"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reviews, Research Articles, and Cases 评论、研究文章和案例

Ibnosina Journal of Medicine and Biomedical Sciences Pub Date : 2024-06-01 DOI: 10.1055/s-0044-1786973

E. Elkhammas

引用次数: 0