Cancer Research and Treatment最新文献

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The Role of Early and Delayed Surgery for Infants with Congenital Brain Tumors 早期和延迟手术对先天性脑肿瘤婴儿的作用
Cancer Research and Treatment Pub Date : 2023-12-28 DOI: 10.4143/crt.2023.1174
Jong Seok Lee, Ji Yeoun Lee, K. Kim, Sung-Hye Park, Eun Jung Koh, Seung-Ki Kim, J. Phi
{"title":"The Role of Early and Delayed Surgery for Infants with Congenital Brain Tumors","authors":"Jong Seok Lee, Ji Yeoun Lee, K. Kim, Sung-Hye Park, Eun Jung Koh, Seung-Ki Kim, J. Phi","doi":"10.4143/crt.2023.1174","DOIUrl":"https://doi.org/10.4143/crt.2023.1174","url":null,"abstract":"Purpose The present study aimed to evaluate the role of early and delayed surgery in congenital brain tumors and analyze the clinical outcomes of infantile brain tumors. Materials and Methods We performed a retrospective cohort study on 69 infantile brain tumors at a single institution from January 2008 to June 2023. Outcomes were assessed as early mortality (within 30 days following surgery) to evaluate the risk of early surgery in congenital brain tumors. Outcomes of recurrence and overall survival were analyzed in infantile brain tumors. Results Surgery-related early mortality appeared to occur in young and low-body-weight patients. Cut-off values of age and body weight were found to be 1.3 months and 5.2 kg to avoid early mortality. Three patients (3/10, 30%) showed early mortality in the early surgery group, and early mortality occurred in one patient (1/14, 7.14%) in the delayed surgery group, whose tumor was excessively enlarged. Younger age at diagnosis (< 3 months of age, HR: 7.1, 95% CI: 1.4 - 35.6, p=0.018) and leptomeningeal seeding (LMS, HR: 30.6, 95% CI: 3.7 - 253.1, p=0.002) were significant independent risk factors for high mortality in infantile brain tumors. Conclusion We suggest delaying surgery until the patient reaches 1.3 months of age and weighs over 5.2 kg with short-term imaging follow-up unless tumors grow rapidly in congenital brain tumors. Younger ages and the presence of LMS are independent risk factors for high mortality in infantile brain tumors.","PeriodicalId":504022,"journal":{"name":"Cancer Research and Treatment","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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