Frontiers in Aging Neuroscience最新文献

{"title":"Editorial: Hospitalization and Parkinson's disease: safety, quality and outcomes","authors":"Hooman Azmi, Benjamin L. Walter, Anne Brooks, Irene Richard, Katherine Amodeo, Michael S. Okun","doi":"10.3389/fnagi.2024.1398947","DOIUrl":"https://doi.org/10.3389/fnagi.2024.1398947","url":null,"abstract":"","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"9 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial-temporal parameters during unobstructed walking in people with Parkinson's disease and healthy older people: a public data set","authors":"T. Penedo, C. Kalva-Filho, Jônatas Augusto Cursiol, M. H. Faria, Daniel Boari Coelho, F. A. Barbieri","doi":"10.3389/fnagi.2024.1354738","DOIUrl":"https://doi.org/10.3389/fnagi.2024.1354738","url":null,"abstract":"","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"31 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Therapeutic neuromodulation for aging-related disorders associated with the autonomic nervous system","authors":"S. Tjen-A-Looi, Liang Fu, Shaista Malik, Richard E. Harris, Sae Uchida","doi":"10.3389/fnagi.2024.1399972","DOIUrl":"https://doi.org/10.3389/fnagi.2024.1399972","url":null,"abstract":"","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"102 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Insights in neurocognitive aging and behavior: 2022","authors":"Kristy A. Nielson, Annalena Venneri, Shin Murakami","doi":"10.3389/fnagi.2024.1361839","DOIUrl":"https://doi.org/10.3389/fnagi.2024.1361839","url":null,"abstract":"","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"35 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139528697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Cardiovascular disease risk models and dementia or cognitive decline: a systematic review","authors":"","doi":"10.3389/fnagi.2023.1355151","DOIUrl":"https://doi.org/10.3389/fnagi.2023.1355151","url":null,"abstract":"","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"8 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139381333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The intersection of cognitive, motor, and sensory processing in aging: links to functional outcomes, volume II","authors":"U. Marušič, Jeannette R. Mahoney","doi":"10.3389/fnagi.2023.1340547","DOIUrl":"https://doi.org/10.3389/fnagi.2023.1340547","url":null,"abstract":"","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"53 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: World digestive health day: investigating the link between neurodegenerative disease and gut microbiota","authors":"Shampa Ghosh, Sunil Dhungel, Mohd. Farooq Shaikh, J. K. Sinha","doi":"10.3389/fnagi.2023.1351855","DOIUrl":"https://doi.org/10.3389/fnagi.2023.1351855","url":null,"abstract":"","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"23 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139388865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between gut microbiota and Parkinson's disease: The role of microbiota-derived amino acid metabolism.","authors":"Wang Wang,&nbsp;Shujun Jiang,&nbsp;Chengcheng Xu,&nbsp;Lili Tang,&nbsp;Yan Liang,&nbsp;Yang Zhao,&nbsp;Guoxue Zhu","doi":"10.3389/fnagi.2022.976316","DOIUrl":"https://doi.org/10.3389/fnagi.2022.976316","url":null,"abstract":"<p><p>Non-motor symptoms (NMS) of Parkinson's disease (PD), such as constipation, sleep disorders, and olfactory deficits, may emerge up to 20 years earlier than motor symptoms. A series of evidence indicates that the pathology of PD may occur from the gastrointestinal tract to the brain. Numerous studies support that the gut microbiota communicates with the brain through the immune system, special amino acid metabolism, and the nervous system in PD. Recently, there is growing recognition that the gut microbiota plays a vital role in the modulation of multiple neurochemical pathways <i>via</i> the \"gut microbiota-brain axis\" (GMBA). Many gut microbiota metabolites, such as fatty acids, amino acids, and bile acids, convey signaling functions as they mediate the crosstalk between gut microbiota and host physiology. Amino acids' abundance and species alteration, including glutamate and tryptophan, may disturb the signaling transmission between nerve cells and disrupt the normal basal ganglia function in PD. Specific amino acids and their receptors are considered new potential targets for ameliorating PD. The present study aimed to systematically summarize all available evidence on the gut microbiota-derived amino acid metabolism alterations associated with PD.</p>","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":" ","pages":"976316"},"PeriodicalIF":4.8,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40477394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation.","authors":"Juan Jiang,&nbsp;Chen Yang,&nbsp;Jia-Qi Ai,&nbsp;Qi-Lei Zhang,&nbsp;Xiao-Lu Cai,&nbsp;Tian Tu,&nbsp;Lily Wan,&nbsp;Xiao-Sheng Wang,&nbsp;Hui Wang,&nbsp;Aihua Pan,&nbsp;Jim Manavis,&nbsp;Wei-Ping Gai,&nbsp;Chong Che,&nbsp;Ewen Tu,&nbsp;Xiao-Ping Wang,&nbsp;Zhen-Yan Li,&nbsp;Xiao-Xin Yan","doi":"10.3389/fnagi.2022.926904","DOIUrl":"https://doi.org/10.3389/fnagi.2022.926904","url":null,"abstract":"<p><p>Extracellular β-amyloid (Aβ) deposition and intraneuronal phosphorylated-tau (pTau) accumulation are the hallmark lesions of Alzheimer's disease (AD). Recently, \"sorfra\" plaques, named for the extracellular deposition of <i>sor</i>tilin c-terminal <i>fra</i>gments, are reported as a new AD-related proteopathy, which develop in the human cerebrum resembling the spatiotemporal trajectory of tauopathy. Here, we identified intraneuronal sortilin aggregation as a change related to the development of granulovacuolar degeneration (GVD), tauopathy, and sorfra plaques in the human hippocampal formation. Intraneuronal sortilin aggregation occurred as cytoplasmic inclusions among the pyramidal neurons, co-labeled by antibodies to the extracellular domain and intracellular C-terminal of sortilin. They existed infrequently in the brains of adults, while their density as quantified in the subiculum/CA1 areas increased in the brains from elderly lacking Aβ/pTau, with pTau (i.e., primary age-related tauopathy, PART cases), and with Aβ/pTau (probably/definitive AD, pAD/AD cases) pathologies. In PART and pAD/AD cases, the intraneuronal sortilin aggregates colocalized partially with various GVD markers including casein kinase 1 delta (Ck1δ) and charged multivesicular body protein 2B (CHMP2B). Single-cell densitometry established an inverse correlation between sortilin immunoreactivity and that of Ck1δ, CHMP2B, p62, and pTau among pyramidal neurons. In pAD/AD cases, the sortilin aggregates were reduced in density as moving from the subiculum to CA subregions, wherein sorfra plaques became fewer and absent. Taken together, we consider intraneuronal sortilin aggregation an aging/stress-related change implicating protein sorting deficit, which can activate protein clearance responses including <i>via</i> enhanced phosphorylation and hydrolysis, thereby promoting GVD, sorfra, and Tau pathogenesis, and ultimately, neuronal destruction and death.</p>","PeriodicalId":503985,"journal":{"name":"Frontiers in Aging Neuroscience","volume":" ","pages":"926904"},"PeriodicalIF":4.8,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9376392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40706100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}