Frontiers in Reproductive Health最新文献

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Exploring experiences of HIV care to optimize patient-centred care in Conakry, Guinea: a qualitative study 探索几内亚科纳克里的艾滋病护理经验,优化以患者为中心的护理:定性研究
Frontiers in Reproductive Health Pub Date : 2024-04-09 DOI: 10.3389/frph.2024.1134404
Delphin Kolié, Etienne Guillard, Abdoulaye Sow, Hawa Manet, B. Camara, Théophile Bigirimana, Mamane Harouna, A. Delamou
{"title":"Exploring experiences of HIV care to optimize patient-centred care in Conakry, Guinea: a qualitative study","authors":"Delphin Kolié, Etienne Guillard, Abdoulaye Sow, Hawa Manet, B. Camara, Théophile Bigirimana, Mamane Harouna, A. Delamou","doi":"10.3389/frph.2024.1134404","DOIUrl":"https://doi.org/10.3389/frph.2024.1134404","url":null,"abstract":"Introduction Studies on the organisation of care and the power dynamic between providers and patients with HIV in sub-Saharan Africa are rare. This study aims to describe the patient-provider relationship and explore the challenges to optimal and patient-centred care for HIV patients. Methods This was a qualitative exploratory descriptive study using in-depth individual interviews and focus group discussions. In total, 17 individual interviews and 5 focus group discussions were conducted. This was conducted in four urban health facilities in Conakry, the capital of Guinea. Three group of participants were included in this study namely patients with HIV; health providers including facilities and services managers; and psychosocial counsellors. Psychosocial counsellors provide emotional and psychosocial support to HIV patients. Their role in the organization care in Guinea is new and they contribute to strengthening adherence of patients with HIV to ARV treatment. Results Patients with HIV, health providers, and psychosocial counsellors have a positive perception of the patient-provider relationship. This relationship was characterized essentially by maintaining confidentiality of HIV status disclosure, caring attitudes towards patients (being available, adjusting locations for accessing ART, based on patients’ preferences), and participating in HIV patient’s social life. However, scolding and miscommunication about the interpretation of viral load tests were reported. The shortage of human resources, low salaries of health staff, poor infrastructure, and the financial burden borne by patients with HIV impede the implementation of optimal patient-centred care. Conclusion Integrating psychosocial counsellors in HIV care organization, improving access to ARV, infrastructure, increasing human resources, and removing the financial burden for HIV patients are needed to optimal patient-centred care in Guinea.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140721984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suggestions for political reparations for reproductive abuses against Black women 对黑人妇女遭受的生殖虐待进行政治赔偿的建议
Frontiers in Reproductive Health Pub Date : 2024-04-03 DOI: 10.3389/frph.2023.980828
Micaela Stevenson
{"title":"Suggestions for political reparations for reproductive abuses against Black women","authors":"Micaela Stevenson","doi":"10.3389/frph.2023.980828","DOIUrl":"https://doi.org/10.3389/frph.2023.980828","url":null,"abstract":"","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of risky sexual behavior and associated factors among Injibara University students, Northwest Ethiopia 埃塞俄比亚西北部因吉巴拉大学学生中危险性行为的普遍性及相关因素
Frontiers in Reproductive Health Pub Date : 2024-03-28 DOI: 10.3389/frph.2024.1356790
Mekdes Abera Adal, Saron Abeje Abiy, Mebratu Mitiku Reta, Mezgebu Silamsaw Asres, Yaregal Animut
{"title":"Prevalence of risky sexual behavior and associated factors among Injibara University students, Northwest Ethiopia","authors":"Mekdes Abera Adal, Saron Abeje Abiy, Mebratu Mitiku Reta, Mezgebu Silamsaw Asres, Yaregal Animut","doi":"10.3389/frph.2024.1356790","DOIUrl":"https://doi.org/10.3389/frph.2024.1356790","url":null,"abstract":"Engaging in risky sexual behaviors can lead to HIV infection, sexually transmitted infections, and unintended pregnancy among youths. University students had greater sexual risks for many reasons. Therefore, this study aimed to assess the magnitude and associated factors of risky sexual behaviors among regular undergraduate students at Injibara University, Northwest Ethiopia.A cross-sectional study was conducted at Injibara University from 20 January to 30 2020. Multistage sampling was employed to select 770 students. Data were collected using a semistructured self-administered questionnaire. A binary logistic regression model was used to identify factors associated with risky sexual behavior. Adjusted odds ratios with 95% CIs were determined, and variables with P-values <0.05 were considered significant.A total of 770 students participated in the study, providing a response rate of 100%. In this study, 294 (38%, 95% CI: 35%, 42%) students engaged in risky sexual behaviors. Risky sexual behavior was significantly associated with not tested for HIV (AOR = 1.62, 95% CI: 1.15–2.31), peer pressure (AOR = 1.90, CI: 1.37–2.64), basic HIV knowledge (AOR = 2.16, CI: 1.65–2.89), substance use (AOR = 3.56, CI: 2.11–6.06), watching pornography videos (AOR = 1.58, CI: 1.11–2.23), and HIV risk perception (AOR = 1.37, CI: 1.02–1.91).A substantial proportion of university students in this study engaged in unsafe sexual behavior. Risky sexual behaviors are more likely to occur when students are under peer pressure, use substances, have no perceived HIV risk, watch pornography, and have inadequate basic HIV knowledge. Therefore, tailored strategic interventions such as life skill training should be designed to bring about positive behavioral changes among university students.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring linkages: addressing the relationship between the climate crisis and HIV prevention with recommendations for emerging pre-exposure prophylaxis programs 探索联系:处理气候危机与艾滋病毒预防之间的关系,为新出现的接触前预防计划提出建议
Frontiers in Reproductive Health Pub Date : 2024-03-26 DOI: 10.3389/frph.2024.1369762
Katie M. Williams, Adaobi Lisa Olisa, Rose Wilcher
{"title":"Exploring linkages: addressing the relationship between the climate crisis and HIV prevention with recommendations for emerging pre-exposure prophylaxis programs","authors":"Katie M. Williams, Adaobi Lisa Olisa, Rose Wilcher","doi":"10.3389/frph.2024.1369762","DOIUrl":"https://doi.org/10.3389/frph.2024.1369762","url":null,"abstract":"Short- and long-term impacts of the climate crisis continue to be felt across the public health landscape. Many individuals marginalized by the climate crisis also navigate a higher likelihood of exposure to HIV. By understanding this relationship, we can better position HIV prevention, and pre-exposure prophylaxis (PrEP) programs specifically, to meet user needs in communities experiencing the effects of the climate crisis. In support, we propose four recommendations for mitigating the impact of the climate crisis on those who may benefit from PrEP: (1) leverage existing and emerging research and lived experience to intentionally target and appropriately reach individuals affected by the climate crisis who may need or want PrEP; (2) emphasize the need for more climate-resilient PrEP products within the research and development pipeline; (3) build a continued understanding of the role of the climate crisis-HIV relationship in product introduction through national collaboration; and (4) strengthen the integration of PrEP service delivery and response to intimate partner violence. The PrEP market is set for rapid expansion with the introduction of new prevention methods to enable choice. To be comprehensively responsive to potential PrEP users, we must consider and address how the climate crisis changes not only the environmental landscape, but the prevention ecosystem.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140380305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Ripping Off the Band-Aid”: uncovering future health care Professionals' “Fractured Knowledge” about sexual and reproductive health "撕开创可贴":揭示未来保健专业人员对性健康和生殖健康的 "断裂知识"
Frontiers in Reproductive Health Pub Date : 2024-03-25 DOI: 10.3389/frph.2024.1242885
Angie Mejia, Kara Nyhus, Tessie Burley, Alexis Myhre, Marcela Montes, Kristin Osiecki, Anita Randolph
{"title":"“Ripping Off the Band-Aid”: uncovering future health care Professionals' “Fractured Knowledge” about sexual and reproductive health","authors":"Angie Mejia, Kara Nyhus, Tessie Burley, Alexis Myhre, Marcela Montes, Kristin Osiecki, Anita Randolph","doi":"10.3389/frph.2024.1242885","DOIUrl":"https://doi.org/10.3389/frph.2024.1242885","url":null,"abstract":"Research has shown the role of identity on future health professionals' confidence and competence in addressing the sexual and reproductive health (SRH) needs of their patients. While there has been some work in increasing the sexual health literacy of future providers via various curricular approaches and comprehensive clinical-based training, there are research gaps on how social differences around identity impact future healthcare professionals’ knowledge and practices around SRH.This article presents research findings on the experiences of US undergraduate students attending a campus that provides training in the health sciences and health professions. Our study aims to understand the perspectives of these students as they pertain to their future career choices in healthcare, with a focus on how their past experiences learning about sex, sexuality, and reproduction impact their current and future professional trajectories.We present a qualitative analysis from 40 in-depth interviews with U.S. undergraduates. The interview questions were designed in collaboration with undergraduate researchers interested in sexual health education. These student researchers collected all the interview data and worked with senior researchers to analyze some of these data.The themes that emerged from the interviews were around experiences with what students perceived as “fractured” sexual and reproductive health (SRH) knowledge they received as children and adolescents. This knowledge shaped essential aspects of their identity as young adults and future healers. Data indicated unique processes implicated in how past as well as present socialization experiences learning about sex, sexuality, and reproduction positions undergraduates in health professions to see young adulthood as a journey of “catching up” on sexual knowledge but also as an ongoing experience of anticipation and planning influencing their career-building journey.The importance of sexual health literacy among healthcare professionals cannot be overstated, as it is vital in providing patient-centered and non-judgmental sexual and reproductive health (SRH) care and services. To date, there is a shortage of studies looking at the impact of sexual health knowledge on healthcare professionals. More research is needed on educational strategies that could be implemented at the intra-personal level to assist college-aged young adults in healthcare career tracks to “catch up” or “fill in the gaps” in their sexual education journey.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Young female migrants and job placement brokers in Addis Ababa, Ethiopia 埃塞俄比亚亚的斯亚贝巴的年轻女性移民和职业介绍经纪人
Frontiers in Reproductive Health Pub Date : 2024-01-24 DOI: 10.3389/frph.2024.1241571
A. Erulkar, Eyasu Hailu
{"title":"Young female migrants and job placement brokers in Addis Ababa, Ethiopia","authors":"A. Erulkar, Eyasu Hailu","doi":"10.3389/frph.2024.1241571","DOIUrl":"https://doi.org/10.3389/frph.2024.1241571","url":null,"abstract":"Rates of urbanization in Ethiopia are high and adolescent girls and young women are predominant among those who move from rural to urban areas. Young women frequently undertake rural-urban migration on their own or with a friend, and with little planning for their initial settlement in the city. They frequently rely on job placement brokers to place them into jobs upon arrival, with positions such as domestic work normally including accommodation.This is a qualitative study undertaken at the two largest bus stages in Addis Ababa, which are points of arrival for a large number of migrants from rural areas. Three categories of respondents were interviewed in-depth: migrant young women who had arrived within the last few days, job placement brokers who are located in and around the bus station, and market women/vendors at the bus stations who interact with both migrants and brokers.Migrant girls' point of arrival was an inflection point of risk, especially among girls who were on their own, not accompanied or met at the bus terminal and lacking in plans or preparation of accommodation. Such girls were targeted by thieves at the bus station and by unscrupulous brokers, some of whom forced girls into sexual relations before placing them into paid work. In contrast, market women and some well-meaning brokers took steps to protect girls such as providing temporary accommodation.This research underscores the need for intensified support to rural-urban migrants to ensure safety and security at the time of arrival at their destination. This includes promotion of pre-migration education and planning; safety assets including sufficient money, cell phones and alternative contacts in the city; and arrangement for immediate, safe and secure accommodation. As a result of the study, a pilot program has been developed, using local resources to extend support for newly arriving migrant girls and young women.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139601197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Add-on effects of oral tocopherol supplementation to surgical varicocelectomy on the outcome of assisted reproductive technology: a single-center pilot study report 在精索静脉曲张切除术后口服生育酚补充剂对辅助生殖技术结果的附加影响:单中心试点研究报告
Frontiers in Reproductive Health Pub Date : 2024-01-22 DOI: 10.3389/frph.2023.1325566
T. Takeshima, Takahiro Mihara, Makoto Tomita, Shinnosuke Kuroda, Y. Yumura, H. Ueno, M. Yamamoto, M. Murase
{"title":"Add-on effects of oral tocopherol supplementation to surgical varicocelectomy on the outcome of assisted reproductive technology: a single-center pilot study report","authors":"T. Takeshima, Takahiro Mihara, Makoto Tomita, Shinnosuke Kuroda, Y. Yumura, H. Ueno, M. Yamamoto, M. Murase","doi":"10.3389/frph.2023.1325566","DOIUrl":"https://doi.org/10.3389/frph.2023.1325566","url":null,"abstract":"Varicocelectomy is well known to improve the pregnancy outcome of patients with clinical varicoceles in assisted reproductive technologies as well as spontaneous conception. Therefore, this study aimed to evaluate the additional effects of oral antioxidant therapy after varicocelectomy on the pregnancy outcome in the assisted reproductive technology setting.This study was a retrospective cohort study. The subjects were couples among whom the male partner had undergone varicocelectomy and was scheduled for subsequent assisted reproductive technology. Pregnancy outcomes were followed retrospectively in 62 couples with male partners who received tocopherol (antioxidant group) and 37 couples who did not (control group). The tocopherol and control groups were assigned dependent on the decision of the physician in charge and the patient's request. The clinical pregnancy rates per couple and embryo transfer, time to pregnancy, and the number of cycles during transfer to pregnancy were evaluated.No significant differences were observed in the pregnancy rate per couple (antioxidant group 70.9% vs. control group 64.9%, P = 0.55) and per embryo transfer (50.4% vs. 39.6%, P = 0.22). Regarding the time to event analyzed by adjusted restricted mean survival time, the mean time to pregnancy was significantly shorter in the antioxidant (tocopherol) group (14.2 vs. 17.4 months, P = 0.025). No significant difference was observed in the embryo transfer cycle to pregnancy (mean embryo transfer cycles: 2.6 vs. 3.0, P = 0.238).Additional oral tocopherol nicotinate as antioxidant therapy after varicocelectomy was shown to shorten the time to pregnancy. It is recommended that add-on effects be tested in more well-designed randomized controlled trials to examine whether it improves assisted reproductive outcomes.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Awareness and utilization of pre-exposure prophylaxis and HIV prevention services among transgender and non-binary adolescent and young adults 变性和非二元青少年和年轻成年人对接触前预防和艾滋病毒预防服务的认识和利用情况
Frontiers in Reproductive Health Pub Date : 2024-01-22 DOI: 10.3389/frph.2023.1150370
Arianna Rodriguez, Keith J. Horvath, Nadia Dowshen, Raina V. Voss, Jonathan Warus, Megan Jacobs, K. Kidd, David J. Inwards-Breland, Jill Blumenthal
{"title":"Awareness and utilization of pre-exposure prophylaxis and HIV prevention services among transgender and non-binary adolescent and young adults","authors":"Arianna Rodriguez, Keith J. Horvath, Nadia Dowshen, Raina V. Voss, Jonathan Warus, Megan Jacobs, K. Kidd, David J. Inwards-Breland, Jill Blumenthal","doi":"10.3389/frph.2023.1150370","DOIUrl":"https://doi.org/10.3389/frph.2023.1150370","url":null,"abstract":"Transgender and gender non-binary (TGNB) individuals are disproportionally affected by HIV and face high rates of discrimination and stigmatization, resulting in limited access to HIV prevention services. Pre-exposure prophylaxis (PrEP) is highly efficacious for reducing the risk of HIV transmission. However, little research is available regarding PrEP awareness and utilization among TGNB adolescents and young adults (AYA).TGNB AYA ages 15–24 years old were recruited between December 2021 and November 2022 for participation in a one-time, anonymous online survey study to assess PrEP awareness and perceptions, as well as barriers to its use. Participants were recruited from seven academic centers offering gender-affirming care to TGNB AYA across the United States.Of the 156 TGNB AYA individuals who completed the survey, most (67%) were aware of PrEP; however, few (7%) had been prescribed PrEP. Many (60%) had not spoken to a medical provider and, even if the medication was free and obtained confidentially, most participants did not plan to take PrEP due to low perceived HIV risk, lack of PrEP knowledge, and concern about interactions between their hormone therapy and PrEP.These findings underscore the need for broad PrEP educational efforts for both TGNB AYA and their providers to improve knowledge, identify potential PrEP candidates among TGNB AYA and improve access by addressing identified barriers.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Female urogenital devices used during their lifetime—managing menstruation including pelvic health 社论:终生使用的女性尿道器械--管理月经,包括盆腔健康
Frontiers in Reproductive Health Pub Date : 2024-01-04 DOI: 10.3389/frph.2023.1339278
Catherine C. Davis, Kenneth W. Miller, Julie A. Peterson
{"title":"Editorial: Female urogenital devices used during their lifetime—managing menstruation including pelvic health","authors":"Catherine C. Davis, Kenneth W. Miller, Julie A. Peterson","doi":"10.3389/frph.2023.1339278","DOIUrl":"https://doi.org/10.3389/frph.2023.1339278","url":null,"abstract":"","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restoration of serum estradiol and reduced incidence of miscarriage in patients with low serum estradiol during pregnancy: a retrospective cohort study using a multifactorial protocol including DHEA 妊娠期血清雌二醇偏低患者血清雌二醇的恢复和流产发生率的降低:一项采用包括 DHEA 在内的多因素方案的回顾性队列研究
Frontiers in Reproductive Health Pub Date : 2024-01-04 DOI: 10.3389/frph.2023.1321284
Phil Boyle, Karolina Andralojc, Susanne van der Velden, Shahpar Najmabadi, Theun de Groot, Craig Turczynski, Joseph B. Stanford
{"title":"Restoration of serum estradiol and reduced incidence of miscarriage in patients with low serum estradiol during pregnancy: a retrospective cohort study using a multifactorial protocol including DHEA","authors":"Phil Boyle, Karolina Andralojc, Susanne van der Velden, Shahpar Najmabadi, Theun de Groot, Craig Turczynski, Joseph B. Stanford","doi":"10.3389/frph.2023.1321284","DOIUrl":"https://doi.org/10.3389/frph.2023.1321284","url":null,"abstract":"Low serum estradiol in early pregnancy is associated with an elevated risk of miscarriage. We sought to determine whether efforts to restore low blood estradiol via estradiol or dehydroepiandrosterone (DHEA) supplementation would reduce the risk of miscarriage as part of a multifactorial symptom-based treatment protocol.This retrospective cohort study included women with low serum estradiol levels in early pregnancy, defined as ≤50% of reference levels by gestational age. Estradiol or DHEA were administered orally, and the primary outcome measure was serum estradiol level, in reference to gestational age. The secondary outcome measures included miscarriage, birth weight, and gestational age at birth.We found no significant effect of estradiol supplementation on serum estradiol levels referenced to gestational age, while DHEA supplementation strongly increased estradiol levels. For pregnancies with low estradiol, the miscarriage rate in the non-supplemented group was 45.5%, while miscarriage rate in the estradiol and DHEA supplemented groups were 21.2% (p = 0.067) and 17.5% (p = 0.038), respectively. Birth weight, size, gestational age, and preterm deliveries were not significantly different. No sexual abnormalities were reported in children (n = 29) of DHEA-supplemented patients after 5–7 years follow-up.In conclusion, DHEA supplementation restored serum estradiol levels, and when included in the treatment protocol, there was a statistically significant reduction in miscarriage.","PeriodicalId":503122,"journal":{"name":"Frontiers in Reproductive Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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