Molecules最新文献_第10页

Carlos Gutiérrez-Merino: Synergy of Theory and Experimentation in Biological Membrane Research 卡洛斯-古铁雷斯-梅里诺：生物膜研究中理论与实验的协同作用

Molecules Pub Date : 2024-02-10 DOI: 10.3390/molecules29040820

S. Antollini, Francisco J. Barrantes

引用次数: 0

Phytochemical Profile and In Vitro Bioactivities of Wild Asparagus stipularis 野生芦笋的植物化学成分和体外生物活性

Molecules Pub Date : 2024-02-10 DOI: 10.3390/molecules29040817

A. Hamdi, S. Jaramillo-Carmona, R. Rodríguez-Arcos, A. Jiménez-Araujo, Najoua Karray Bouraoui, R. Guillén-Bejarano

{"title":"Phytochemical Profile and In Vitro Bioactivities of Wild Asparagus stipularis","authors":"A. Hamdi, S. Jaramillo-Carmona, R. Rodríguez-Arcos, A. Jiménez-Araujo, Najoua Karray Bouraoui, R. Guillén-Bejarano","doi":"10.3390/molecules29040817","DOIUrl":"https://doi.org/10.3390/molecules29040817","url":null,"abstract":"In this study, Asparagus stipularis was characterized concerning its phytochemical composition, antioxidant potential, cytotoxicity, and pancreatic lipase inhibitory activities. Twenty-seven compounds were identified and quantified by HPLC-DAD-MS in the leaf, stem, pericarp, and rhizome of ethanolic extracts. Seven steroidal saponins were detected, and the highest content was quantified in rhizome and pericap. A. stipularis also contained significant amounts of flavonoids in the aerial part. Isorhamnetin tetra-glycoside, quercetin-3-glucosyl-rutinoside, and rutin were the main flavonoid derivatives in leaf, stem, and pericarp extracts, respectively. In addition, eleven phenolic acids were also detected; among them, caffeic acid, protocatechuic acid, p-hydroxybenzoic acid, and ferulic acid were the predominant phenolics, with these having the highest amounts quantified in the rhizome extracts. All the tested extracts possessed antioxidant capacities, with pericarp and rhizome extracts exhibiting the highest activity in DPPH, ABTS, and FRAP assays. The extracts from pericarp and rhizome were revealed to also be the strongest inhibitors of pancreatic lipase. The rhizome extracts exhibited potent cytotoxic activity against HCT-116 and HepG2 with IC50 values of 30 and 54 µg/mL after 48 h of treatment. The present study demonstrated that A. stipularis can be used as a new source of natural antioxidants and potential anticancer and antiobesity compounds.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":"14 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139846310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Novel Homochiral Thioureas Camphor Derived as Asymmetric Organocatalysts in the Stereoselective Formation of Glycosidic Bonds 利用樟脑衍生的新型同手性硫脲作为不对称有机催化剂立体选择性地形成糖苷键

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040811

Mildred López, Gabriela Huelgas, Mario Sánchez, Adalid Armenta, Ángel Mendoza, J. D. Lozada-Ramírez, Cecilia Anaya de Parrodi

{"title":"Use of Novel Homochiral Thioureas Camphor Derived as Asymmetric Organocatalysts in the Stereoselective Formation of Glycosidic Bonds","authors":"Mildred López, Gabriela Huelgas, Mario Sánchez, Adalid Armenta, Ángel Mendoza, J. D. Lozada-Ramírez, Cecilia Anaya de Parrodi","doi":"10.3390/molecules29040811","DOIUrl":"https://doi.org/10.3390/molecules29040811","url":null,"abstract":"We synthesized six new camphor-derived homochiral thioureas 1–6, from commercially available (1R)-(−)-camphorquinone. These new compounds 1–6 were evaluated as asymmetric organocatalysts in the stereoselective formation of glycosidic bonds, with 2,3,4,6-tetra-O-benzyl-D-glucopyranosyl and 2,3,4,6-tetra-O-benzyl-D-galactopyranosyl trichloroacetimidates as donors, and several alcohols as glycosyl acceptors, such as methanol, ethanol, 1-propanol, 1-butanol, 1-octanol, iso-propanol, tert-butanol, cyclohexanol, phenol, 1-naphtol, and 2-naphtol. Optimization of the asymmetric glycosylation reaction was achieved by modifying reaction conditions such as solvent, additive, loading of catalyst, temperature, and time of reaction. The best result was obtained with 2,3,4,6-tetra-O-benzyl-D-galactopyranosyl trichloroacetimidates, using 15 mol% of organocatalyst 1, in the presence of 2 equiv of MeOH in solvent-free conditions at room temperature for 1.5 h, affording the glycosidic compound in a 99% yield and 1:73 α:β stereoselectivity; under the same reaction conditions, without using a catalyst, the obtained stereoselectivity was 1:35 α:β. Computational calculations prior to the formation of the products were modeled, using density functional theory, M06-2X/6-31G(d,p) and M06-2X/6-311++G(2d,2p) methods. We observed that the preference for β glycoside formation, through a stereoselective inverted substitution, relies on steric effects and the formation of hydrogen bonds between thiourea 1 and methanol in the complex formed.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139787766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties 具有抗病毒特性的菊科植物提取物和植物化学物质

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040814

Jimena Borgo, Mariel S. Wagner, L. Laurella, O. Elso, Mariana G. Selener, M. Clavin, Hernán Bach, César A. N. Catalán, Augusto E. Bivona, Claudia S. Sepúlveda, V. Sülsen

{"title":"Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties","authors":"Jimena Borgo, Mariel S. Wagner, L. Laurella, O. Elso, Mariana G. Selener, M. Clavin, Hernán Bach, César A. N. Catalán, Augusto E. Bivona, Claudia S. Sepúlveda, V. Sülsen","doi":"10.3390/molecules29040814","DOIUrl":"https://doi.org/10.3390/molecules29040814","url":null,"abstract":"Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared from six Asteraceae species, including Acmella bellidioides, Campuloclinium macrocephalum, Grindelia pulchella, Grindelia chiloensis, Helenium radiatum, and Viguiera tuberosa, along with pure phytochemicals isolated from Asteraceae: mikanolide (1), eupatoriopicrin (2), eupahakonenin B (3), minimolide (4), estafietin (5), 2-oxo-8-deoxyligustrin (6), santhemoidin C (7), euparin (8), jaceidin (9), nepetin (10), jaceosidin (11), eryodictiol (12), eupatorin (13), and 5-demethylsinensetin (14). Results showed that the dichloromethane extracts of C. macrocephalum and H. radiatum and the methanolic extracts prepared from C. macrocephalum and G. pulchella were highly active and selective against DENV-2, affording EC50 values of 0.11, 0.15, 1.80, and 3.85 µg/mL, respectively, and SIs of 171.0, 18.8, >17.36, and 64.9, respectively. From the pool of phytochemicals tested, compounds 6, 7, and 8 stand out as the most active (EC50 = 3.7, 3.1, and 6.8 µM, respectively; SI = 5.9, 6.7, and >73.4, respectively). These results demonstrate that Asteraceae species and their chemical constituents represent valuable sources of new antiviral molecules.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139788720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Identification of Structural Changes in the Lithium Hexamethyldisilazide–Toluene System via Ultrasonic Relaxation Spectroscopy and Theoretical Calculations 通过超声波松弛光谱和理论计算识别六甲基二硅氮化锂-甲苯体系中的结构变化

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040813

C. Kouderis, A. Tryfon, T. Kabanos, A. Kalampounias

{"title":"The Identification of Structural Changes in the Lithium Hexamethyldisilazide–Toluene System via Ultrasonic Relaxation Spectroscopy and Theoretical Calculations","authors":"C. Kouderis, A. Tryfon, T. Kabanos, A. Kalampounias","doi":"10.3390/molecules29040813","DOIUrl":"https://doi.org/10.3390/molecules29040813","url":null,"abstract":"Ultrasonic absorption measurements were carried out over a wide concentration and temperature range by means of a pulse technique to examine the structural mechanisms and the dynamical properties in lithium hexamethyldisilazide (LiHMDS)–toluene solutions. Acoustic spectra revealed two distinct Debye-type relaxational absorptions attributed to the formation of trimers from dimeric and monomer units and to the formation of aggregates between a LiHMDS dimer and one toluene molecule in low and high frequencies, respectively. The formation of aggregates was clarified by means of molecular docking and DFT methodologies. The aggregation number, the rate constants and the thermodynamic properties of these structural changes were determined by analyzing in detail the concentration-dependent relaxation parameters. The low-frequency relaxation mechanism dominates the acoustic spectra in the high LiHMDS mole fractions, while the high-frequency relaxation influences the spectra in the low LiHMDS mole fractions. In the intermediate mole fraction region (0.25 to 0.46), both relaxations prevail in the spectra. The adiabatic compressibility, the excess adiabatic compressibility and the theoretically estimated mean free length revealed a crossover in the 0.25 to 0.46 LiHMDS mole fractions that signified the transition from one structural mechanism related with the hetero-association of LiHMDS dimers with toluene molecules to the other structural mechanism assigned to the formation of LiHMDS trimers. The combined use of acoustic spectroscopy with theoretical calculations permitted us to disentangle the underlying structural mechanisms and evaluate the volume changes associated with each reaction. The results were compared with the corresponding theoretically predicted volume changes and discussed in the context of the concentration effect on intermolecular bonding.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a New Compound, Erinacerin W, from the Mycelia of Hericium erinaceus, with Immunomodulatory and Neuroprotective Effects 从具有免疫调节和神经保护作用的麦角菌丝体中发现新化合物 Erinacerin W

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040812

Jingchao Lin, Yen-Po Chen, Ting-Wei Lin, Tsung-Ju Li, Yu-Wen Chen, I-Chen Li, Chin-Chu Chen

引用次数: 0

From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design 从植物到化学：用于药物化学和药物设计的非阿片类抗痛活性原理的来源

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040815

R. Turnaturi, Silvia Piana, Salvatore Spoto, Giuliana Costanzo, L. Reina, L. Pasquinucci, C. Parenti

{"title":"From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design","authors":"R. Turnaturi, Silvia Piana, Salvatore Spoto, Giuliana Costanzo, L. Reina, L. Pasquinucci, C. Parenti","doi":"10.3390/molecules29040815","DOIUrl":"https://doi.org/10.3390/molecules29040815","url":null,"abstract":"Pain is associated with many health problems and a reduced quality of life and has been a common reason for seeking medical attention. Several therapeutics are available on the market, although side effects, physical dependence, and abuse limit their use. As the process of pain transmission and modulation is regulated by different peripheral and central mechanisms and neurotransmitters, medicinal chemistry continues to study novel ligands and innovative approaches. Among them, natural products are known to be a rich source of lead compounds for drug discovery due to their chemical structural variety and different analgesic mechanisms. Numerous studies suggested that some chemicals from medicinal plants could be alternative options for pain relief and management. Previously, we conducted a literature search aimed at identifying natural products interacting either directly or indirectly with opioid receptors. In this review, instead, we have made an excursus including active ingredients derived from plants whose mechanism of action appears from the literature to be other than the modulation of the opioid system. These substances could, either by themselves or through synthetic and/or semi-synthetic derivatives, be investigated in order to improve their pharmacokinetic characteristics and could represent a valid alternative to the opioid approach to pain therapy. They could also be the basis for the study of new mechanisms of action in the approach to this complex and disabling pathology.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":" 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Novel Homochiral Thioureas Camphor Derived as Asymmetric Organocatalysts in the Stereoselective Formation of Glycosidic Bonds 利用樟脑衍生的新型同手性硫脲作为不对称有机催化剂立体选择性地形成糖苷键

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040811

Mildred López, Gabriela Huelgas, Mario Sánchez, Adalid Armenta, Ángel Mendoza, J. D. Lozada-Ramírez, Cecilia Anaya de Parrodi

{"title":"Use of Novel Homochiral Thioureas Camphor Derived as Asymmetric Organocatalysts in the Stereoselective Formation of Glycosidic Bonds","authors":"Mildred López, Gabriela Huelgas, Mario Sánchez, Adalid Armenta, Ángel Mendoza, J. D. Lozada-Ramírez, Cecilia Anaya de Parrodi","doi":"10.3390/molecules29040811","DOIUrl":"https://doi.org/10.3390/molecules29040811","url":null,"abstract":"We synthesized six new camphor-derived homochiral thioureas 1–6, from commercially available (1R)-(−)-camphorquinone. These new compounds 1–6 were evaluated as asymmetric organocatalysts in the stereoselective formation of glycosidic bonds, with 2,3,4,6-tetra-O-benzyl-D-glucopyranosyl and 2,3,4,6-tetra-O-benzyl-D-galactopyranosyl trichloroacetimidates as donors, and several alcohols as glycosyl acceptors, such as methanol, ethanol, 1-propanol, 1-butanol, 1-octanol, iso-propanol, tert-butanol, cyclohexanol, phenol, 1-naphtol, and 2-naphtol. Optimization of the asymmetric glycosylation reaction was achieved by modifying reaction conditions such as solvent, additive, loading of catalyst, temperature, and time of reaction. The best result was obtained with 2,3,4,6-tetra-O-benzyl-D-galactopyranosyl trichloroacetimidates, using 15 mol% of organocatalyst 1, in the presence of 2 equiv of MeOH in solvent-free conditions at room temperature for 1.5 h, affording the glycosidic compound in a 99% yield and 1:73 α:β stereoselectivity; under the same reaction conditions, without using a catalyst, the obtained stereoselectivity was 1:35 α:β. Computational calculations prior to the formation of the products were modeled, using density functional theory, M06-2X/6-31G(d,p) and M06-2X/6-311++G(2d,2p) methods. We observed that the preference for β glycoside formation, through a stereoselective inverted substitution, relies on steric effects and the formation of hydrogen bonds between thiourea 1 and methanol in the complex formed.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":"27 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilizing Integrated UHPLC-Q-Exactive Orbitrap-MS, Multivariate Analysis, and Bioactive Evaluation to Distinguish between Wild and Cultivated Niudali (Millettia speciosa Champ.) 综合利用 UHPLC-Q-Exactive Orbitrap-MS、多元分析和生物活性评价来区分野生和栽培牛大力（Millettia speciosa Champ.）

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040806

Yuwei Zeng, Qing Yang, Binbin Huang, Ming Chen, Zichang Liang, Zhifeng Zhang, Jianguang Zhang

{"title":"Utilizing Integrated UHPLC-Q-Exactive Orbitrap-MS, Multivariate Analysis, and Bioactive Evaluation to Distinguish between Wild and Cultivated Niudali (Millettia speciosa Champ.)","authors":"Yuwei Zeng, Qing Yang, Binbin Huang, Ming Chen, Zichang Liang, Zhifeng Zhang, Jianguang Zhang","doi":"10.3390/molecules29040806","DOIUrl":"https://doi.org/10.3390/molecules29040806","url":null,"abstract":"Millettia speciosa Champ. (MSCP) enjoys widespread recognition for its culinary and medicinal attributes. Despite the extensive history of MSCP cultivation, the disparities in quality and bioactivity between wild and cultivated varieties have remained unexplored. In this study, 20 wild and cultivated MSCP samples were collected from different regions in China. We embarked on a comprehensive investigation of the chemical constituents found in both wild and cultivated MSCP utilizing UHPLC-Q-Exactive Orbitrap-MS technology and multivariate analysis such as principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). In total, 62 chemical components were unequivocally identified or tentatively characterized. Via the multivariate statistical analysis, we successfully pinpointed nine compounds with the potential to serve as chemical markers, enabling the differentiation between wild and cultivated MSCP varieties. Moreover, both genotypes exhibited substantial antioxidant and anti-fatigue properties. The bioactivities of wild MSCP were marginally higher when compared to their cultivated counterparts. This study illuminates the impressive antioxidant and anti-fatigue potential present in both wild and cultivated MSCP genotypes, further augmenting the allure of this species and opening new avenues for the economic valorization of MSCP. Hence, this study provides a valuable method for the identification and quality control of MSCP and a method in chemistry and pharmacology to assess an alternative possibility for cultivated MSCP.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imidazole-Based Lithium Salt LiHDI as a Solid Electrolyte Interphase-Stabilising Additive for Lithium-Conducting Electrolytes 咪唑基锂盐 LiHDI 作为固体电解质相间稳定添加剂用于锂传导电解质

Molecules Pub Date : 2024-02-09 DOI: 10.3390/molecules29040804

Marek Broszkiewicz, Bartosz Brzozowski, T. Trzeciak, A. Zalewska, J. Ryl, L. Niedzicki

{"title":"Imidazole-Based Lithium Salt LiHDI as a Solid Electrolyte Interphase-Stabilising Additive for Lithium-Conducting Electrolytes","authors":"Marek Broszkiewicz, Bartosz Brzozowski, T. Trzeciak, A. Zalewska, J. Ryl, L. Niedzicki","doi":"10.3390/molecules29040804","DOIUrl":"https://doi.org/10.3390/molecules29040804","url":null,"abstract":"Lithium salt LiHDI (lithium 4,5-dicyano-2-(n-heptafluoropropyl)imidazolide) is proposed as a solid electrolyte interphase-stabilising additive for lithium-ion batteries, which can be added in a smaller amount than fluoroethylene carbonate (FEC) and vinylene carbonate (VC) additives. Electrolytes containing either lithium 4,5-dicyano-2-(trifluoromethyl)imidazolide (LiTDI) or battery-standard LiPF6 were tested with various amounts of LiHDI additive. Chemical stability in the presence of water and the thermal stability of LiHDI are on par with LiTDI. LiHDI additive does not negatively affect the properties of electrolytes. Conductivity measurements of solutions, galvanostatic cycling of graphite-LiFePO4 cells at room temperature, cells’ cycling at 60 °C, internal cell resistance monitoring during cycling, and XPS analysis of electrodes’ surfaces after cycling have been performed. LiHDI, unlike the FEC-VC mixture, does not negatively affect the properties of the electrolyte. Cycling showed improved capacity retention with LiHDI additive with both graphite and LiFePO4 as capacity-limiting electrodes over samples without additives. At elevated temperatures, samples with LiHDI exhibited better capacity retention during cycling than those with FEC-VC. Internal cell resistance can be correlated with capacity retention. XPS results show changes in the composition of SEI depending on the composition of the electrolyte and the duration of cycling.","PeriodicalId":503105,"journal":{"name":"Molecules","volume":"202 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139848753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0