Oncology in Clinical Practice最新文献_第2页

Rectal ulceration and rectourethral fistula as rare complications of radiotherapy for prostate cancer—a case report and literature review 直肠溃疡和直肠尿道瘘是前列腺癌放疗的罕见并发症--病例报告和文献综述

Oncology in Clinical Practice Pub Date : 2024-01-16 DOI: 10.5603/ocp.96805

Krzysztof Kowalik, Anna Gruszczyńska, K. Hetman, Katarzyna Kołaczyk, Michał Falco, Krystian Kasperowicz, Andrzej Modrzejewski

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Sex cord-stromal tumors of the testis — a rare group of benign and malignant gonadal neoplasms. Literature review 睾丸性索间质瘤--一组罕见的良性和恶性性腺肿瘤。文献综述

Oncology in Clinical Practice Pub Date : 2024-01-16 DOI: 10.5603/ocp.97184

Krzysztof Kowalik, K. Hetman, Krystian Kasperowicz, Andrzej Modrzejewski

引用次数: 0

Clear cell sarcoma from diagnosis and multidisciplinary treatment to clinical trials 透明细胞肉瘤从诊断、多学科治疗到临床试验

Oncology in Clinical Practice Pub Date : 2024-01-12 DOI: 10.5603/ocp.98279

A. Czarnecka, Paulina Chmiel, Paweł Sobczuk, M. Spałek, A. Szumera-Ciećkiewicz, Ewa Bartnik, M. Zdzienicki, Tomasz Świtaj, M. Dudzisz-Śledź, Piotr Rutkowski

{"title":"Clear cell sarcoma from diagnosis and multidisciplinary treatment to clinical trials","authors":"A. Czarnecka, Paulina Chmiel, Paweł Sobczuk, M. Spałek, A. Szumera-Ciećkiewicz, Ewa Bartnik, M. Zdzienicki, Tomasz Świtaj, M. Dudzisz-Śledź, Piotr Rutkowski","doi":"10.5603/ocp.98279","DOIUrl":"https://doi.org/10.5603/ocp.98279","url":null,"abstract":"Clear cell sarcoma (CCS), formerly called soft tissue melanoma, is a rare malignant soft tissue sarcoma (STS) characterized by a propensity for lymphatic spread and poor prognosis. Clear cell sarcoma can be distinguished by a t(12; 22) (q13; q12) translocation, which in addition to diagnostic implications may be important for targeted treatment in the future. Clear cell sarcoma occurs mainly on the extremities, most often the shin (in the feet and ankle area), in the tendons, and aponeurosis, often at a young age. Considering the signiﬁcant ability to develop metastases to regional lymph nodes (about 30% of cases), a sentinel node biopsy (SLNB) should be considered in diagnosis, with possible subsequent radical lymphadenectomy (LND) in the case of metastases. Treatment of localized disease is limited to radical local excision with optional complementary radiotherapy. Due to the resistance to classical chemotherapy and the presence of characteristic molecular abnormalities, research focusing on the use of molecular targeted therapies in this group of cancers is ongoing. In clinical trials, MET inhibitors, and tyrosine kinase inhibitors (TKI) were evaluated. Clear cell sarcoma was also one of the subtypes of tumors assessed in the CREATE clinical trial with crizotinib and IMMUNOSARC with checkpoint inhibitors. However, a poor understanding of the biology and natural course of this sarcoma requires further research to develop an eﬀective treatment and unify clinical guidelines.","PeriodicalId":503057,"journal":{"name":"Oncology in Clinical Practice","volume":" 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139624181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation recall dermatitis induced by a second course of radiation therapy in the absence of clinically significant field overlap 在没有明显临床视野重叠的情况下，第二个放射治疗疗程诱发的放射回忆皮炎

Oncology in Clinical Practice Pub Date : 2024-01-10 DOI: 10.5603/ocp.97685

Isaac Kong, Ka-Kit David Yeung, Anand Swaminath, Justin Lee, Mira Goldberg

引用次数: 0