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Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence 微塑料和纳米塑料的肠道毒性研究最新进展:临床前证据的系统回顾
Microplastics Pub Date : 2024-04-08 DOI: 10.3390/microplastics3020013
M. Djouina, Suzie Loison, M. Body-Malapel
{"title":"Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence","authors":"M. Djouina, Suzie Loison, M. Body-Malapel","doi":"10.3390/microplastics3020013","DOIUrl":"https://doi.org/10.3390/microplastics3020013","url":null,"abstract":"The tremendous plastic production and poor post-use management are current and future sources of environmental and human contamination due to their degradation products: microplastics and nanoplastics (MNPLs). Methodological developments have allowed MNPLs to be detected in an increasing variety of human foods, as well as in stool and colonic mucosa. It was suggested early that the direct contact between MNPLs and intestinal tissues could represent a potential risk for human health. In order to assess this, over the last 3 years, numerous studies have evaluated the impact of MNPL ingestion on intestinal homeostasis in rodents. This comprehensive review reports the preclinical studies published between January 2021 and January 2024, and analyzes their contributions as well as their shortcomings. It shows that evidence is accumulating of the intestinal toxicity of spherical MNPLs, which lead to pro-inflammatory, pro-oxidative, barrier-disruptive and dysbiotic effects. However, the available literature has addressed only a minor part of the potential health issues of MNPLs. Many parameters contributing to MNPL toxicity need to be better taken into account in future studies. Particular attention should be paid to improve the representativeness of MNPLs, as well as to better consider the susceptibility factors of MNPL toxicity, generated especially by an underlying pathology or pathological imprinting.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":"35 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uptake and Cellular Effects of Polymethylmethacrylate on Human Cell Lines 聚甲基丙烯酸甲酯对人类细胞株的吸收和细胞效应
Microplastics Pub Date : 2024-04-05 DOI: 10.3390/microplastics3020012
Arthur Braun, Harald Seitz
{"title":"Uptake and Cellular Effects of Polymethylmethacrylate on Human Cell Lines","authors":"Arthur Braun, Harald Seitz","doi":"10.3390/microplastics3020012","DOIUrl":"https://doi.org/10.3390/microplastics3020012","url":null,"abstract":"The usage of plastic and its decomposition products leads to their ubiquitous distribution, resulting in their uptake by all living beings, including humans. Polymethylmethacrylate (PMMA) is known as a biocompatible polymer and is used widely in medicine and dentistry, although recent findings have shown its induction of oxidative stress within cells. Worryingly, hardly any data exist investigating the uptake of PMMA particles by cells, the potential effects of these particles on cells and cell signaling pathways and their contributing factors. We assessed the uptake of PMMA beads via confocal microscopy after their incubation with HEK293, A549 and MRC5 cells. Through cell staining, we localized multiple PMMA beads within the cytosol of cells. No alterations regarding cell growth, cell morphology or cell division were found, implying no short-term toxicity towards human cells. Using a cAMP response element binding protein (CREB)-mediated reporter assay, we assessed whether internalized PMMA nanobeads alter cell signaling pathways after stimulation of the cells. CREB was chosen as a well-described transcription factor involved in various cellular processes. Our data led to the assumption that PMMA nano- and microbeads are internalized via endocytosis and end up in lysosomes within the cell cytosol. We concluded that differences regarding the surface composition of the PMMA nanobeads affect their potential to alter cell signaling. These findings emphasize the key role the surface composition plays regarding microplastics and their risks for human health, whereas the usage of medical-grade PMMA remains safe.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":"198 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140740171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Methodologies for Microplastic Isolation through Multicriteria Analysis (AHP) 通过多标准分析(AHP)比较微塑料隔离方法
Microplastics Pub Date : 2024-03-10 DOI: 10.3390/microplastics3010011
Valentina Phinikettou, I. Papamichael, I. Voukkali, A. Zorpas
{"title":"Comparison of Methodologies for Microplastic Isolation through Multicriteria Analysis (AHP)","authors":"Valentina Phinikettou, I. Papamichael, I. Voukkali, A. Zorpas","doi":"10.3390/microplastics3010011","DOIUrl":"https://doi.org/10.3390/microplastics3010011","url":null,"abstract":"Environmental pollution caused by microplastics has evolved into a global concern; however, limited knowledge exists about microplastics in soils due to the absence of standardized extraction methods. This research aimed to develop an inexpensive, rapid method with user-friendly and environmentally sustainable outcomes for microplastics retrieval. Three salt solutions (Sodium Chloride, Magnesium Sulfate, Sodium Hexametaphosphate) and an oil solution (canola oil) underwent evaluation for microplastics extraction through the flotation process due to the density and oleophilic properties of plastics. Four widely used plastic types, obtained through fragmentation using a grinding mill from clean new plastic containers or membranes, were subjected to analysis. The experimental procedures for microplastics retrieval varied among the evaluated solutions. Through a comprehensive multicriteria analysis, the saturated Sodium Chloride solution emerged as the optimal scenario for microplastics extraction, followed closely by the canola oil scenario. The recovery method utilizing Sodium Chloride demonstrated economic feasibility, safety, and reliability. This study provides valuable insights into an effective and sustainable approach for mitigating microplastic pollution in soil, offering a promising avenue for future environmental conservation efforts.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":"62 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140255794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crafting a Scientific Framework to Mitigate Microplastic Impact on Ecosystems 制定科学框架,减轻微塑料对生态系统的影响
Microplastics Pub Date : 2024-03-04 DOI: 10.3390/microplastics3010010
M. Nikpay, Sayna Toorchi Roodsari
{"title":"Crafting a Scientific Framework to Mitigate Microplastic Impact on Ecosystems","authors":"M. Nikpay, Sayna Toorchi Roodsari","doi":"10.3390/microplastics3010010","DOIUrl":"https://doi.org/10.3390/microplastics3010010","url":null,"abstract":"Microplastics (MPs), microscopic particles originating from plastic products, have emerged as a persistent environmental challenge, posing threats to both ecosystems and human health. Their omnipresence, extending from the highest mountains to the deepest oceans and infiltrating the bodies of humans and animals, requires urgent attention. In the face of escalating annual plastic production and inefficient waste management, where 79% of plastic production ends up in landfill sites or enters the environment, MPs multiply as its consequence. This emphasizes the urgent need for a comprehensive global framework that transcends borders to systematically address and control the growth of MPs. In response, our research conducts an in-depth investigation and proposes a seven-step strategy, providing a global perspective for mitigating microplastic pollution. The proposed approach begins with initial research steps and closes in predicting the remediation of areas impacted by microplastic pollution.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":"12 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140266043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microplastics in Atlantic Ribbed Mussels (Geukensia demissa) from the Delaware Inland Bays, USA 美国特拉华州内陆海湾大西洋棱贝(Geukensia demissa)体内的微塑料
Microplastics Pub Date : 2024-03-01 DOI: 10.3390/microplastics3010009
Jeffrey Ashley, Amanda Pilat, Ariana Ohlweiler, Connor Ogden, Owen Bradley, Priya Modi, Spencer Talbot, Caya Smith, Justin O’Pella, G. Ozbay
{"title":"Microplastics in Atlantic Ribbed Mussels (Geukensia demissa) from the Delaware Inland Bays, USA","authors":"Jeffrey Ashley, Amanda Pilat, Ariana Ohlweiler, Connor Ogden, Owen Bradley, Priya Modi, Spencer Talbot, Caya Smith, Justin O’Pella, G. Ozbay","doi":"10.3390/microplastics3010009","DOIUrl":"https://doi.org/10.3390/microplastics3010009","url":null,"abstract":"Due to the prevalence of plastic pollution in coastal ecosystems, aquatic organisms are at high risk for accumulating microplastics (MPs). Filter-feeding bivalves, such as mussels and oysters, may be exposed to, and subsequently accumulate, MPs due to the high volume of water they pass through their bodies. This study assessed the levels of MPs within Atlantic ribbed mussels (Geukensia demissa), a common filter feeder found along the United States Atlantic Coast, from 12 sites within Rehoboth Bay, Indian River Bay, and Little Assawoman Bay, collectively known as the Delaware Inland Bays. Composited mussels from each site were digested using potassium hydroxide and filtered. Microplastics were physically identified, sorted based on color, and counted using a digital microscope. Microplastics, almost entirely dominated by synthetic microfibers, were found in all mussels well above laboratory blanks. Across all sites, 40% of microfibers were black, and 27% of fibers were clear. The composite concentrations of MPs ranged from 0.25 to 2.06 particles/g wet tissue, with a mean of 0.08 ± 0.06. In general, higher concentrations were found in mussels collected at sites that were adjacent to more urbanized land use versus those from rural sites. At two sites, individual mussels, in addition to composites, were analyzed and had MP concentrations ranging from 11 to 69 particles/mussel. This study represents the first evaluation of MPs in this ecologically important coastal species and suggests its viability as a biomonitoring species for microplastic pollution.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140084114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Image-Processing Tool for Size and Shape Analysis of Manufactured Irregular Polyethylene Microparticles 用于分析人造不规则聚乙烯微粒尺寸和形状的图像处理工具
Microplastics Pub Date : 2024-02-09 DOI: 10.3390/microplastics3010008
M. Fritz, Lukas F. Deutsch, Karunia Putra Wijaya, Thomas Götz, Christian B. Fischer
{"title":"An Image-Processing Tool for Size and Shape Analysis of Manufactured Irregular Polyethylene Microparticles","authors":"M. Fritz, Lukas F. Deutsch, Karunia Putra Wijaya, Thomas Götz, Christian B. Fischer","doi":"10.3390/microplastics3010008","DOIUrl":"https://doi.org/10.3390/microplastics3010008","url":null,"abstract":"Microplastics (MPs) pose a significant risk to humans and animals due to their ability to absorb, adsorb, and desorb organic pollutants. MPs catchment from either sediments or water bodies is crucial for risk assessment, but fast and effective particle quantification of irregularly shaped particles is only marginally addressed. Many studies used microscopy methods to count MP particles, which are tedious for large sample sizes. Alternatively, this work presents an algorithm developed in the free software GNU Octave to analyze microscope images of MP particles with variable sizes and shapes. The algorithm can detect and distinguish different particles, compensate for uneven illumination and low image contrast, find high-contrast areas, unify edge regions, and fill the remaining pixels of stacked particles. The fully automatic algorithm calculates shape parameters such as convexity, solidity, reciprocal aspect ratio, rectangularity, and the Feret major axis ratio and generates the particle size distribution. The study tested low-density polyethylene particles with sizes of 50–100 µm and 200–300 µm. A scanning electron microscope image series analyzed with Octave was compared to a manual evaluation using ImageJ. Although the fully automatic algorithm did not identify all particles, the comprehensive tests demonstrate a qualitatively accurate particle size and shape monitoring applicable to any MPs, which processes larger data sets in a short time and is compatible with MATLAB-based codes.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Image-Processing Tool for Size and Shape Analysis of Manufactured Irregular Polyethylene Microparticles 用于分析人造不规则聚乙烯微粒尺寸和形状的图像处理工具
Microplastics Pub Date : 2024-02-09 DOI: 10.3390/microplastics3010008
M. Fritz, Lukas F. Deutsch, Karunia Putra Wijaya, Thomas Götz, Christian B. Fischer
{"title":"An Image-Processing Tool for Size and Shape Analysis of Manufactured Irregular Polyethylene Microparticles","authors":"M. Fritz, Lukas F. Deutsch, Karunia Putra Wijaya, Thomas Götz, Christian B. Fischer","doi":"10.3390/microplastics3010008","DOIUrl":"https://doi.org/10.3390/microplastics3010008","url":null,"abstract":"Microplastics (MPs) pose a significant risk to humans and animals due to their ability to absorb, adsorb, and desorb organic pollutants. MPs catchment from either sediments or water bodies is crucial for risk assessment, but fast and effective particle quantification of irregularly shaped particles is only marginally addressed. Many studies used microscopy methods to count MP particles, which are tedious for large sample sizes. Alternatively, this work presents an algorithm developed in the free software GNU Octave to analyze microscope images of MP particles with variable sizes and shapes. The algorithm can detect and distinguish different particles, compensate for uneven illumination and low image contrast, find high-contrast areas, unify edge regions, and fill the remaining pixels of stacked particles. The fully automatic algorithm calculates shape parameters such as convexity, solidity, reciprocal aspect ratio, rectangularity, and the Feret major axis ratio and generates the particle size distribution. The study tested low-density polyethylene particles with sizes of 50–100 µm and 200–300 µm. A scanning electron microscope image series analyzed with Octave was compared to a manual evaluation using ImageJ. Although the fully automatic algorithm did not identify all particles, the comprehensive tests demonstrate a qualitatively accurate particle size and shape monitoring applicable to any MPs, which processes larger data sets in a short time and is compatible with MATLAB-based codes.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":"22 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micro- and Nanoplastics in the Atmosphere: Methodology for Microplastics Size-Fractionation Sampling 大气中的微塑料和纳米塑料:微塑料粒度分馏采样方法
Microplastics Pub Date : 2024-02-08 DOI: 10.3390/microplastics3010006
Yuliya Logvina, Isabel M. Matas, Helena Ribeiro, Luís Pinto da Silva, Pedro Rodrigues, João Leitão, J. E. da Silva
{"title":"Micro- and Nanoplastics in the Atmosphere: Methodology for Microplastics Size-Fractionation Sampling","authors":"Yuliya Logvina, Isabel M. Matas, Helena Ribeiro, Luís Pinto da Silva, Pedro Rodrigues, João Leitão, J. E. da Silva","doi":"10.3390/microplastics3010006","DOIUrl":"https://doi.org/10.3390/microplastics3010006","url":null,"abstract":"Micro- and nanoplastics (MNPs) are an important atmospheric aerosol constituent. However, there still needs to be a standard procedure for their sampling and size fractionation, which is an obstacle to the aggregation and critical analysis of results obtained by different research groups. This review focuses on the sampling and fractionation methodologies used for MNPs. Moreover, a streamlined, simplified methodology for sampling and fractionation is proposed.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":"30 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139852378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements and Regulatory Situation in Microplastics Removal from Wastewater and Drinking Water: A Comprehensive Review 从废水和饮用水中去除微塑料的进展和监管情况:全面回顾
Microplastics Pub Date : 2024-02-08 DOI: 10.3390/microplastics3010007
Vyoma Jani, Shenghua Wu, Kaushik Venkiteshwaran
{"title":"Advancements and Regulatory Situation in Microplastics Removal from Wastewater and Drinking Water: A Comprehensive Review","authors":"Vyoma Jani, Shenghua Wu, Kaushik Venkiteshwaran","doi":"10.3390/microplastics3010007","DOIUrl":"https://doi.org/10.3390/microplastics3010007","url":null,"abstract":"In recent years, the ubiquitous occurrence of plastic debris has become a significant environmental concern, posing considerable harm to our ecosystems. Microplastics (MPs) (1 μm–5 mm) and nanoplastics (NPs) (<1 μm) are noticeable in diverse forms, spreading throughout the environment. Notably, wastewater treatment plants (WWTPs) emerge as major contributors to the generation of MP and NP. Within these treatment plants, water influx from domestic and commercial sources carries a considerable load of MPs derived from items like fiber clothing, personal care products, and toothpaste. Lacking dedicated removal mechanisms, these MPs persist through the wastewater treatment process, ultimately entering natural water bodies and the soil environment. The novelty of this review lies in its detailed examination of contemporary methodologies for sampling, detecting, and eliminating MPs specifically from WWTPs. By critically assessing the efficacy of current removal techniques at various treatment stages, the review offers targeted insights into practical aspects of MP management in these facilities. As the study of micro/nano plastics is still in its early stages, this article aims to contribute by offering a comprehensive review of the methods utilized for plastic debris removal in both WWTPs and drinking water treatment plants (DWTPs). Furthermore, the article provides a comprehensive overview of the existing rules, regulations, and policies concerning MPs in the United States. This inclusion not only broadens the scope of the review but also establishes it as a valuable reference for understanding the regulatory framework related to MPs. This review uniquely combines a focused evaluation of WWTPs/DWTPs, an exploration of removal methods, and an examination of regulatory framework, making a different contribution to the review article. Through this review, we aim to enhance understanding and awareness of the multi-layered challenges posed by MPs, offering insights that can inform future research directions and policy initiatives.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139791105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micro- and Nanoplastics in the Atmosphere: Methodology for Microplastics Size-Fractionation Sampling 大气中的微塑料和纳米塑料:微塑料粒度分馏采样方法
Microplastics Pub Date : 2024-02-08 DOI: 10.3390/microplastics3010006
Yuliya Logvina, Isabel M. Matas, Helena Ribeiro, Luís Pinto da Silva, Pedro Rodrigues, João Leitão, J. E. da Silva
{"title":"Micro- and Nanoplastics in the Atmosphere: Methodology for Microplastics Size-Fractionation Sampling","authors":"Yuliya Logvina, Isabel M. Matas, Helena Ribeiro, Luís Pinto da Silva, Pedro Rodrigues, João Leitão, J. E. da Silva","doi":"10.3390/microplastics3010006","DOIUrl":"https://doi.org/10.3390/microplastics3010006","url":null,"abstract":"Micro- and nanoplastics (MNPs) are an important atmospheric aerosol constituent. However, there still needs to be a standard procedure for their sampling and size fractionation, which is an obstacle to the aggregation and critical analysis of results obtained by different research groups. This review focuses on the sampling and fractionation methodologies used for MNPs. Moreover, a streamlined, simplified methodology for sampling and fractionation is proposed.","PeriodicalId":503046,"journal":{"name":"Microplastics","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139792469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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