Chemistry Pub Date : 2024-06-10 DOI: 10.3390/chemistry6030027

A. Mallikarjunaswamy, Gouthami Kuruvalli, K. Syed, Vaddi Damodara Reddy, Vipin A. Nair

引用次数: 0

Visible-Light Photochromic Properties of an Inorganic-Organic Phosphomolybdic Acid/Polythiophene Hybrid Thin Film 无机有机磷钼酸/聚噻吩混合薄膜的可见光光致变色特性

Chemistry Pub Date : 2024-06-07 DOI: 10.3390/chemistry6030026

Wanqing Zhao, Hongmei Zhao, Wei Feng, Honggang Zhao

引用次数: 0

Reaction of β-Nitrostyrene with Diethyl Malonate in the Presence of Bispidines: The Unusual Role of the Organocatalyst 有双吡啶存在时 β-硝基苯乙烯与丙二酸二乙酯的反应：有机催化剂的特殊作用

Chemistry Pub Date : 2024-05-10 DOI: 10.3390/chemistry6030023

Alexander I. Dalinger, Sabina F. Mamedova, J. Burykina, Evgeniy O. Pentsak, Sergey Z Vatsadze

引用次数: 0

Anxiolytic-Like and Antidepressant Effects of a 13H-indolo[2,3-a]thiopyrano[2,3-g]quinolizine Derivative 13H-indolo[2,3-a]thiopyrano[2,3-g]quinolizine 衍生物的抗焦虑和抗抑郁作用

Chemistry Pub Date : 2024-05-09 DOI: 10.3390/chemistry6030022

Carlos E. Castillo-Espinoza, M. Gonzalez-Rivera, Alberto Medina-Ortiz, Juan Carlos Barragan-Galvez, Sergio Hidalgo-Figueroa, David Cruz Cruz, M. Devezé-Álvarez, Gerardo González-García, Clarisa Villegas Gómez, Á. Alonso-Castro

{"title":"Anxiolytic-Like and Antidepressant Effects of a 13H-indolo[2,3-a]thiopyrano[2,3-g]quinolizine Derivative","authors":"Carlos E. Castillo-Espinoza, M. Gonzalez-Rivera, Alberto Medina-Ortiz, Juan Carlos Barragan-Galvez, Sergio Hidalgo-Figueroa, David Cruz Cruz, M. Devezé-Álvarez, Gerardo González-García, Clarisa Villegas Gómez, Á. Alonso-Castro","doi":"10.3390/chemistry6030022","DOIUrl":"https://doi.org/10.3390/chemistry6030022","url":null,"abstract":"Depressive and anxiety disorders constitute some of the most prevalent mental disorders around the world. For years, the development of new lead compounds for drug discovery in this field has been an area of great attention. Recently, a series of tetrahydrocarbazole derivatives have demonstrated important anxiolytic-like activity, associated with their structures and stereochemistry. Here, we present a study of the antidepressant effect and anxiolytic-like activity of a fused thiopyrano-piperidone-tetrahydrocarboline (compound 4). The antidepressant and anxiolytic-like effects of 4 (1–50 mg/kg p.o.) were assessed with the tail suspension test and the hole-board test, respectively. This study determined the possible mechanisms involved in the anxiolytic-like actions of 4 using inhibitors or neurotransmission and evaluated its interaction with 5HT2A receptors using a molecular docking study. As an analog to the tetrahydrocarbazole core, the tetrahydrocarboline derivative showed anxiolytic-like activity (ED50 = 13 mg/kg p.o.) in the hole-board test, with a comparable effect to the reference drug, 1.5 mg/kg clonazepam, with the possible participation of the serotonergic system.","PeriodicalId":502867,"journal":{"name":"Chemistry","volume":" 28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140995604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Fluorescent Chemosensing of Antibiotics Using a Luminescent Zn(II) Coordination Polymer Based on a 4-Amino-1,8-naphthalimide Tröger’s Base Fluorophore 使用基于 4-氨基-1,8-萘二甲酰亚胺特罗格氏碱荧光团的发光 Zn(II) 配位聚合物对抗生素进行差异荧光化学传感

Chemistry Pub Date : 2024-02-07 DOI: 10.3390/chemistry6010011

Purti Patel, Mannanthara Kunhumon Noushija, S. Shanmugaraju

{"title":"Differential Fluorescent Chemosensing of Antibiotics Using a Luminescent Zn(II) Coordination Polymer Based on a 4-Amino-1,8-naphthalimide Tröger’s Base Fluorophore","authors":"Purti Patel, Mannanthara Kunhumon Noushija, S. Shanmugaraju","doi":"10.3390/chemistry6010011","DOIUrl":"https://doi.org/10.3390/chemistry6010011","url":null,"abstract":"The design and development of useful chemosensors for the ultra-trace detection of environmental pollutants and contaminants is a topical area of research. Herein, we report a new nanoscale emissive Zn(II) coordination polymer (TB-Zn-CP) for differential fluorescence sensing of various antibiotics in water. TB-Zn-CP was synthesized using a unique V-shaped green emitting 4-amino-1,8-naphthalimide Tröger’s base (TBNap) fluorophore. The structural and morphological features of TB-Zn-CP were characterized by various standard spectroscopic and microscopy techniques. The fluorescence titration studies in water demonstrated a remarkable sensitivity and differential fluorescence sensing properties of TB-Zn-CP for the fast detection of different antibiotics. Among different antibiotics, chloramphenicol (CRP), 1,2-dimethyl-5-nitroimidazole (DMZ), and sulfamethazine (SMZ) displayed the highest fluorescence-quenching efficiency and superior sensitivity in their detection. The differential sensing capability of TB-Zn-CP was also indicated by visualizable color changes. The Stern–Volmer quenching constant KSV was determined to be in the order of 103–104 M−1, and the sensitivity was shown to be at a nanomolar (10−9 M) level. All these results confirm that TB-Zn-CP can be a potential and practically useful polymeric sensor for differential fluorescence and visual detection of different antibiotics in water.","PeriodicalId":502867,"journal":{"name":"Chemistry","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Fluorescent Chemosensing of Antibiotics Using a Luminescent Zn(II) Coordination Polymer Based on a 4-Amino-1,8-naphthalimide Tröger’s Base Fluorophore 使用基于 4-氨基-1,8-萘二甲酰亚胺特罗格氏碱荧光团的发光 Zn(II) 配位聚合物对抗生素进行差异荧光化学传感

Chemistry Pub Date : 2024-02-07 DOI: 10.3390/chemistry6010011

Purti Patel, Mannanthara Kunhumon Noushija, S. Shanmugaraju

{"title":"Differential Fluorescent Chemosensing of Antibiotics Using a Luminescent Zn(II) Coordination Polymer Based on a 4-Amino-1,8-naphthalimide Tröger’s Base Fluorophore","authors":"Purti Patel, Mannanthara Kunhumon Noushija, S. Shanmugaraju","doi":"10.3390/chemistry6010011","DOIUrl":"https://doi.org/10.3390/chemistry6010011","url":null,"abstract":"The design and development of useful chemosensors for the ultra-trace detection of environmental pollutants and contaminants is a topical area of research. Herein, we report a new nanoscale emissive Zn(II) coordination polymer (TB-Zn-CP) for differential fluorescence sensing of various antibiotics in water. TB-Zn-CP was synthesized using a unique V-shaped green emitting 4-amino-1,8-naphthalimide Tröger’s base (TBNap) fluorophore. The structural and morphological features of TB-Zn-CP were characterized by various standard spectroscopic and microscopy techniques. The fluorescence titration studies in water demonstrated a remarkable sensitivity and differential fluorescence sensing properties of TB-Zn-CP for the fast detection of different antibiotics. Among different antibiotics, chloramphenicol (CRP), 1,2-dimethyl-5-nitroimidazole (DMZ), and sulfamethazine (SMZ) displayed the highest fluorescence-quenching efficiency and superior sensitivity in their detection. The differential sensing capability of TB-Zn-CP was also indicated by visualizable color changes. The Stern–Volmer quenching constant KSV was determined to be in the order of 103–104 M−1, and the sensitivity was shown to be at a nanomolar (10−9 M) level. All these results confirm that TB-Zn-CP can be a potential and practically useful polymeric sensor for differential fluorescence and visual detection of different antibiotics in water.","PeriodicalId":502867,"journal":{"name":"Chemistry","volume":"9 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4,4-Bis(isopropylthio)-1,1-diphenyl-2-azabuta-1,3-diene Adducts with Cadmium(II), Mercury(II) and Copper(I) Iodides: Crystal, Molecular and Electronic Structures of d10 Transition Metal Chelate Complexes 4,4-双（异丙基硫基）-1,1-二苯基-2-氮杂吲哚-1,3-二烯与镉（II）、汞（II）和铜（I）碘化物的加合物：d10 过渡金属螯合物的晶体、分子和电子结构

Chemistry Pub Date : 2023-12-25 DOI: 10.3390/chemistry6010004

Rodolphe Kinghat, A. Khatyr, M. Knorr, Carsten Strohmann, M. Kubicki

{"title":"4,4-Bis(isopropylthio)-1,1-diphenyl-2-azabuta-1,3-diene Adducts with Cadmium(II), Mercury(II) and Copper(I) Iodides: Crystal, Molecular and Electronic Structures of d10 Transition Metal Chelate Complexes","authors":"Rodolphe Kinghat, A. Khatyr, M. Knorr, Carsten Strohmann, M. Kubicki","doi":"10.3390/chemistry6010004","DOIUrl":"https://doi.org/10.3390/chemistry6010004","url":null,"abstract":"The thioether-functionalized 2-azabutadiene (iPrS)2C=C(H)-N=CPh2 L ligates to CdI2 and HgI2 to form the chelate compounds [CdI2{(iPrS)2C=C(H)-N=CPh2] (1) and [HgI2(iPrS)2C=C(H)-N=CPh2] (2). Their crystal structures were solved via X-ray diffraction. Both crystallize in the non-centrosymmetric space groups: monoclinic P21 (1) and orthorhombic P212121 (2), respectively. The closed-shell d10 metal centers are four-coordinated (two iodides and S and N coordinating atoms from the ligand L) in both complexes. The geometrical indexes τ indicate that a highly distorted trigonal pyramidal is adopted for 1 and a seesaw geometry for 2. The comparative nature of metal–ligand bonds is discussed on the basis of metric parameters and of QT-AIM (quantum theory of atoms in molecules) calculations. L was also treated with CuI to obtain the dinuclear species [LCu(μ2-I2)CuL] (3), in which the two Cu(I) centers are linked by a short metal–metal bond. The geometric and electronic properties of 3 are compared with those of 1 and 2.","PeriodicalId":502867,"journal":{"name":"Chemistry","volume":"18 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139157841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Polymorph of β-Cyclodextrin with a Higher Bioavailability 生物利用度更高的β-环糊精新多聚物

Chemistry Pub Date : 2023-12-23 DOI: 10.3390/chemistry6010003

A. K. Gatiatulin, Ilya S. Balakhontsev, Sofia M. Talashmanova, M. Ziganshin, V. Gorbatchuk

{"title":"New Polymorph of β-Cyclodextrin with a Higher Bioavailability","authors":"A. K. Gatiatulin, Ilya S. Balakhontsev, Sofia M. Talashmanova, M. Ziganshin, V. Gorbatchuk","doi":"10.3390/chemistry6010003","DOIUrl":"https://doi.org/10.3390/chemistry6010003","url":null,"abstract":"A new polymorph of anhydrous β-cyclodextrin (polymorph III) was obtained and characterized for the first time using powder X-ray diffraction, infrared spectroscopy, and thermal analysis. The solution enthalpy and time of dissolution in water were determined using solution calorimetry for this polymorph and compared with those of the dried commercial form of β-cyclodextrin (polymorph I), its amorphous form, and 2-hydroxypropyl-β-cyclodextrin. The specific heat capacities of polymorphs I and III were determined using differential scanning calorimetry across a wide range of temperatures, providing enthalpy and Gibbs energy values for the polymorphic transition at 298 K. The affinities of polymorph III and 2-hydroxypropyl-β-cyclodextrin for water were characterized by determining their hydration isotherms, which provided values of hydration Gibbs energy. Being energy-rich, the new-found polymorph of β-cyclodextrin has a significantly higher dissolution rate and an increased affinity for water compared with the dried commercial form of β-cyclodextrin. These properties render the new polymorph promising in industrial applications for guest inclusion in aqueous solutions and pastes, and may be a desirable alternative for water-soluble β-cyclodextrin derivatives.","PeriodicalId":502867,"journal":{"name":"Chemistry","volume":"172 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dn Number in Transition Metal Chemistry: Its Utility and Limitations 过渡金属化学中的 dn 数：其实用性和局限性

Chemistry Pub Date : 2023-11-21 DOI: 10.3390/chemistry5040170

Nicholas C. Norman, Paul G. Pringle

引用次数: 0

New Zwitterionic Imidazolones with Enhanced Water Solubility and Bioavailability: Synthesis, Anticancer Activity, and Molecular Docking 具有更高水溶性和生物利用度的新型齐聚物咪唑啉酮：合成、抗癌活性和分子对接

Chemistry Pub Date : 2023-11-21 DOI: 10.3390/chemistry5040169

Saber Abu-Jabal, Ahmad Ghareeb, Derar Smadi, Othman Hamed, M. Assali, Avni Berisha, N. Abutaha, Waseem Mansour, Ameed Omairah, Alaa Janem, Ataa Jaser

{"title":"New Zwitterionic Imidazolones with Enhanced Water Solubility and Bioavailability: Synthesis, Anticancer Activity, and Molecular Docking","authors":"Saber Abu-Jabal, Ahmad Ghareeb, Derar Smadi, Othman Hamed, M. Assali, Avni Berisha, N. Abutaha, Waseem Mansour, Ameed Omairah, Alaa Janem, Ataa Jaser","doi":"10.3390/chemistry5040169","DOIUrl":"https://doi.org/10.3390/chemistry5040169","url":null,"abstract":"Finding an effective anticancer drug to combat cancer cell resistance remains a challenge. Herein, we synthesized a new series of imidazolone derivatives 4a–4i and assessed their anticancer activities against liver cancer cells (Hep3B), Hela cells, and normal LX2 cells. The imidazolne derivatives were synthesized by the condensation cyclization reaction using the natural product vanillin as a starting material. Among the synthesized imidazolones are those with an alkyl sulfate moiety that are water-soluble and showed enhanced anticancer activity against the tested cancer cells. The anticancer testing results showed that compound 4d with the NO2 group at position 4 of the benzene ring was superior to the other compounds; it showed an IC50 value of 134.2 ± 4.4 µM against Hep3B cells, while compound 4h with the pyridyl moiety showed the highest cytotoxicity against Hela cells with an IC50 of 85.1 ± 2.1 µM. The anticancer activity of some imidazolones was greatly enhanced by adding to them the zwitterionic properties that made them more polar and water-soluble. DNA binding studies with compounds 4a1, 4d, and 4g indicated a docking score ranging from approximately −6.8 to −8.7 kcal/mol. This could be attributed to the outstanding interaction between the molecule and the DNA binding sites, which primarily relies on its inherent capability to establish hydrogen bonds, facilitated by the electron pair present at the oxygen atoms and the drug’s amino group. In conclusion, water-soluble imidazolone with zwitterionic functionality could be a promising tool for the development of anticancer medication. To outline the general idea and the relationships for the effect of the developed compounds under study, as well as their mechanism of action, further extensive research is also necessary.","PeriodicalId":502867,"journal":{"name":"Chemistry","volume":"145 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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