Journal of Cardiovascular Development and Disease最新文献

Charting the Unseen: How Non-Invasive Imaging Could Redefine Cardiovascular Prevention 描绘看不见的世界：无创成像如何重新定义心血管预防

Journal of Cardiovascular Development and Disease Pub Date : 2024-08-09 DOI: 10.3390/jcdd11080245

Giancarlo Trimarchi, Fausto Pizzino, U. Paradossi, I. Gueli, M. Palazzini, Piero Gentile, Francesco Di Spigno, Enrico Ammirati, A. Garascia, A. Tedeschi, Daniela Aschieri

{"title":"Charting the Unseen: How Non-Invasive Imaging Could Redefine Cardiovascular Prevention","authors":"Giancarlo Trimarchi, Fausto Pizzino, U. Paradossi, I. Gueli, M. Palazzini, Piero Gentile, Francesco Di Spigno, Enrico Ammirati, A. Garascia, A. Tedeschi, Daniela Aschieri","doi":"10.3390/jcdd11080245","DOIUrl":"https://doi.org/10.3390/jcdd11080245","url":null,"abstract":"Cardiovascular diseases (CVDs) remain a major global health challenge, leading to significant morbidity and mortality while straining healthcare systems. Despite progress in medical treatments for CVDs, their increasing prevalence calls for a shift towards more effective prevention strategies. Traditional preventive approaches have centered around lifestyle changes, risk factors management, and medication. However, the integration of imaging methods offers a novel dimension in early disease detection, risk assessment, and ongoing monitoring of at-risk individuals. Imaging techniques such as supra-aortic trunks ultrasound, echocardiography, cardiac magnetic resonance, and coronary computed tomography angiography have broadened our understanding of the anatomical and functional aspects of cardiovascular health. These techniques enable personalized prevention strategies by providing detailed insights into the cardiac and vascular states, significantly enhancing our ability to combat the progression of CVDs. This review focuses on amalgamating current findings, technological innovations, and the impact of integrating advanced imaging modalities into cardiovascular risk prevention, aiming to offer a comprehensive perspective on their potential to transform preventive cardiology.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"15 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Two Generations of Self-Expandable Transcatheter Heart Valves in Nine Surgical Valves: An In Vitro Study 两代可自行扩张的经导管心脏瓣膜与九个手术瓣膜的比较：体外研究

Journal of Cardiovascular Development and Disease Pub Date : 2024-08-08 DOI: 10.3390/jcdd11080244

N. Sadat, M. Scharfschwerdt, Stephan Ensminger, B. Fujita

{"title":"Comparison of Two Generations of Self-Expandable Transcatheter Heart Valves in Nine Surgical Valves: An In Vitro Study","authors":"N. Sadat, M. Scharfschwerdt, Stephan Ensminger, B. Fujita","doi":"10.3390/jcdd11080244","DOIUrl":"https://doi.org/10.3390/jcdd11080244","url":null,"abstract":"(1) Background: This study aimed to analyse the hydrodynamic performance of two generations of self-expanding transcatheter heart valves (THV) as a valve-in-valve (ViV) in different surgical aortic valve (SAV) models under standardised conditions. The nitinol-based Evolut R valve is frequently used in ViV procedures. It is unclear whether its successor, the Evolut PRO, is superior in ViV procedures, particularly considering the previously implanted SAV model. (2) Methods: EvolutTM R 26 mm and EvolutTM PRO 26 mm prostheses were implanted in nine 21 mm labelled size SAV models (Hancock® II, Mosaic® UltraTM, EpicTM Supra, TrifectaTM GT, Perimount®, Perimount® Magna Ease, AvalusTM, IntuityTM, Freestyle®) to analyse their hydrodynamic performance under defined circulatory conditions in a pulse duplicator. (3) Results: Both THVs presented with the lowest effective orifice area (EOA) and highest mean pressure gradient (MPG) inside Hancock® II, whereas THVs in Intuity showed the highest EOA and lowest MPG. Evolut R and Evolut PRO showed significant hydrodynamic differences depending on the SAV. Both THVs performed similarly in porcine valves. Although the Evolut R performed better than Evolut PRO in stented bovine SAVs, the Evolut PRO was superior inside the Intuity. Further, the SAV model design markedly influenced the TAV’s geometric orifice area and pin-wheeling index. (4) Conclusions: These findings show that the Evolut R and Evolut PRO perform differently depending on the previously implanted SAV model. THV selection for treatment of a specific SAV model should consider these results.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"32 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of NT-proBNP Levels in the Diagnosis and Treatment of Heart Failure with Preserved Ejection Fraction—It Is Not Always a Hide-and-Seek Game NT-proBNP 水平在诊断和治疗射血分数保留型心力衰竭中的作用--这并不总是一场捉迷藏游戏

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-16 DOI: 10.3390/jcdd11070225

Christina Chrysohoou, Konstantinos Konstantinou, Kostas P Tsioufis

引用次数: 0

Intricate MIB1-NOTCH-GATA6 Interactions in Cardiac Valvular and Septal Development 心脏瓣膜和室间隔发育过程中错综复杂的 MIB1-NOTCH-GATA6 相互作用

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-15 DOI: 10.3390/jcdd11070223

Rebeca Piñeiro-Sabarís, D. MacGrogan, J. L. de la Pompa

{"title":"Intricate MIB1-NOTCH-GATA6 Interactions in Cardiac Valvular and Septal Development","authors":"Rebeca Piñeiro-Sabarís, D. MacGrogan, J. L. de la Pompa","doi":"10.3390/jcdd11070223","DOIUrl":"https://doi.org/10.3390/jcdd11070223","url":null,"abstract":"Genome-wide association studies and experimental mouse models implicate the MIB1 and GATA6 genes in congenital heart disease (CHD). Their close physical proximity and conserved synteny suggest that these two genes might be involved in analogous cardiac developmental processes. Heterozygous Gata6 loss-of-function mutations alone or humanized Mib1 mutations in a NOTCH1-sensitized genetic background cause bicuspid aortic valve (BAV) and a membranous ventricular septal defect (VSD), consistent with MIB1 and NOTCH1 functioning in the same pathway. To determine if MIB1-NOTCH and GATA6 interact in valvular and septal development, we generated compound heterozygote mice carrying different Mib1 missense (Mib1K735R and Mib1V943F) or nonsense (Mib1R530X) mutations with the Gata6STOP/+ heterozygous null mutation. Combining Mib1R530X/+ or Mib1K735R/+ with Gata6STOP/+ does not affect Gata6STOP/+ single mutant phenotypes. In contrast, combining Mib1V943F/+ with Gata6STOP/+ decreases the incidence of BAV and VSD by 50%, suggesting a suppressive effect of Mib1V943F/+ on Gata6STOP/+. Transcriptomic and functional analyses revealed that while the EMT pathway term is depleted in the Gata6STOP/+ mutant, introducing the Mib1V943F variant robustly enriches this term, consistent with the Mib1V943F/+ phenotypic suppression of Gata6STOP/+. Interestingly, combined Notch1 and Gata6 insufficiency led to a nearly fully penetrant VSD but did not affect the BAV phenotype, underscoring the complex functional relationship between MIB1, NOTCH, and GATA6 in valvular and septal development.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"55 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141644616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary Artery Calcium and Aging: Physiological Basis, Assessment, and Treatment Options in Percutaneous Coronary Intervention 冠状动脉钙化与衰老：经皮冠状动脉介入治疗的生理基础、评估和治疗方案

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-15 DOI: 10.3390/jcdd11070224

M. Abdirashid, Umberto Barbero, C. Cavallino, Ludovica Maltese, Elodi Bacci, Danilo Reale, Giorgio Marengo, M. de Benedictis, Francesco Rametta, Fabrizio Ugo

{"title":"Coronary Artery Calcium and Aging: Physiological Basis, Assessment, and Treatment Options in Percutaneous Coronary Intervention","authors":"M. Abdirashid, Umberto Barbero, C. Cavallino, Ludovica Maltese, Elodi Bacci, Danilo Reale, Giorgio Marengo, M. de Benedictis, Francesco Rametta, Fabrizio Ugo","doi":"10.3390/jcdd11070224","DOIUrl":"https://doi.org/10.3390/jcdd11070224","url":null,"abstract":"Coronary artery calcification is a complex anatomical and histological pathology with different pathways that contribute to calcium deposit and calcification progression. As part of the atherosclerotic process, extensive calcifications are becoming more common and are associated with poorer PCI outcomes if not properly addressed. Since no drug has shown to be effective in changing this process once it is started, proper knowledge of the underlying pathogenesis and how to diagnose and manage it is essential in contemporary coronary intervention. Atherosclerosis is a pandemic disease, quickly spreading across the world and not limited anymore to the industrialized Western world. In this paper, we review the role of intracoronary imaging and the main technologies available and propose a simple and rational algorithm for the choice of a preferential first strategy in the treatment of severely calcified coronary atherosclerosis, followed by three emblematic cases on how we successively applied it.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"17 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141646507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arrhythmic Risk Stratification in Cardiac Amyloidosis: A Review of the Current Literature 心脏淀粉样变性的心律失常风险分层：当前文献综述

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-14 DOI: 10.3390/jcdd11070222

Eleonora Bonvicini, A. Preda, C. Tognola, Raffaele Falco, Roberto Gidiucci, Giulio Leo, S. Vargiu, Marisa Varrenti, Lorenzo Gigli, Matteo Baroni, Marco Carbonaro, Giulia Colombo, A. Maloberti, Cristina Giannattasio, Patrizio Mazzone, Fabrizio Guarracini

{"title":"Arrhythmic Risk Stratification in Cardiac Amyloidosis: A Review of the Current Literature","authors":"Eleonora Bonvicini, A. Preda, C. Tognola, Raffaele Falco, Roberto Gidiucci, Giulio Leo, S. Vargiu, Marisa Varrenti, Lorenzo Gigli, Matteo Baroni, Marco Carbonaro, Giulia Colombo, A. Maloberti, Cristina Giannattasio, Patrizio Mazzone, Fabrizio Guarracini","doi":"10.3390/jcdd11070222","DOIUrl":"https://doi.org/10.3390/jcdd11070222","url":null,"abstract":"Cardiac amyloidosis is the most frequent infiltrative disease caused by the deposition of misfolded proteins in the cardiac tissue, leading to heart failure, brady- and tachyarrhythmia and death. Conduction disorders, atrial fibrillation (AF) and ventricular arrhythmia (VA) significantly impact patient outcomes and demand recognition. However, several issues remain unresolved regarding early diagnosis and optimal management. Extreme bradycardia is the most common cause of arrhythmic death, while fast and sustained VAs can be found even in the early phases of the disease. Risk stratification and the prevention of sudden cardiac death are therefore to be considered in these patients, although the time for defibrillator implantation is still a subject of debate. Moreover, atrial impairment due to amyloid fibrils is associated with an increased risk of AF resistant to antiarrhythmic therapy, as well as recurrent thromboembolic events despite adequate anticoagulation. In the last few years, the aging of the population and progressive improvements in imaging methods have led to increases in the diagnosis of cardiac amyloidosis. Novel therapies have been developed to improve patients’ functional status, quality of life and mortality, without data regarding their effect on arrhythmia prevention. In this review, we consider the latest evidence regarding the arrhythmic risk stratification of cardiac amyloidosis, as well as the available therapeutic strategies.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"58 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141649679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time Changes of Survival and Cardiovascular Determinants in a Cohort of Middle-Aged Men Followed Up for 61 Years until Extinction 随访 61 年直至消亡的中年男子队列中存活率和心血管决定因素的时间变化

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-13 DOI: 10.3390/jcdd11070221

Alessandro Menotti, P. Puddu

{"title":"Time Changes of Survival and Cardiovascular Determinants in a Cohort of Middle-Aged Men Followed Up for 61 Years until Extinction","authors":"Alessandro Menotti, P. Puddu","doi":"10.3390/jcdd11070221","DOIUrl":"https://doi.org/10.3390/jcdd11070221","url":null,"abstract":"Objective: To study possible determinants of longevity in a cohort of middle-aged men followed for 61 years until extinction using measurements taken at baseline and at years 31 or 61 of follow-up. Material and Methods: In 1960, two rural cohorts including a total of 1712 men aged 40–59 years were enrolled within the Italian section of the Seven Countries Study of Cardiovascular Diseases, and measurements related to mainly cardiovascular risk factors, lifestyle behaviors, and chronic diseases were taken at year 0 and year 31 of follow-up (when only 390 could be examined). Multiple linear regression models were computed to relate personal characteristics with the length of survival in both dead men and survivors. Results: Baseline cardiovascular risk factors, smoking and dietary habits, and chronic diseases (taken at year 0 with men aged 40–59 years) were significant predictors of the length of survival both from year 0 to year 31 and from year 0 to year 61, but only chronic diseases were independent predictors for the period of 31 to 61 years. Significant predictors of survival using measurements taken at year 31 (age range 71 to 90 years) were only smoking and dietary habits and chronic diseases. Conclusions: During a lifetime of follow-up, the personal characteristics with continuous predictive power of survival were only lifestyle behaviors and major chronic diseases.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"55 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141651910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and Long-Term Prognosis of Patients with Different Phenotypes of Dilated Cardiomyopathy 不同表型扩张型心肌病患者的特征和长期预后

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-12 DOI: 10.3390/jcdd11070220

Shuyuan Zhang, Shiqi Gao, Zhuang Tian, Shuyang Zhang

{"title":"Characterization and Long-Term Prognosis of Patients with Different Phenotypes of Dilated Cardiomyopathy","authors":"Shuyuan Zhang, Shiqi Gao, Zhuang Tian, Shuyang Zhang","doi":"10.3390/jcdd11070220","DOIUrl":"https://doi.org/10.3390/jcdd11070220","url":null,"abstract":"Background: Long-term prognosis of dilated cardiomyopathy (DCM) in the Chinese population is lacking, and the left ventricular (LV) hypertrabeculation phenotype usually overlaps with DCM. Objectives: The study aims to investigate whether the presence of the LV hypertrabeculation phenotype confers additional adverse prognostic information for DCM patients. Methods: We retrospectively reviewed all DCM patients (≥18 years of age at diagnosis) hospitalized in the Peking Union Medical College Hospital between September 2002 and September 2022. The eligible patients were divided into two groups based on echocardiography at diagnosis: the isolated DCM (n = 353), and DCM with the LV hypertrabeculation phenotype (n = 97). The primary endpoint was major adverse cardiac events (MACEs), and multivariate Cox hazards regression models were used to compare the endpoints between the two groups. Results: During a mean follow-up time of 4.6 years, there was no significant difference in the primary endpoint between the isolated DCM and DCM with the LV hypertrabeculation phenotype (p = 0.19). The risk of MACEs in the first 5 years was significantly higher in DCM with the LV hypertrabeculation phenotype than isolated DCM (adjusted HR [95%CI]: 1.83 [1.21–2.77]) and after 5 years the effect of the LV hypertrabeculation phenotype as a prognostic attenuated. Subgroup analysis found a significant interaction for the incidence of MACEs between sex and DCM subtypes (p for interaction = 0.01). Conclusions: DCM with LV hypertrabeculation phenotypes had a higher early (first 5 years) risk of MACEs. For males, the presence of LV hypertrabeculation phenotypes might be an important clue for identifying high-risk DCM patients.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"83 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141653333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Echocardiography Assessment in the Management of Alcapa Syndrome: Case Report 阿尔卡帕综合征治疗中的高级超声心动图评估：病例报告

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-11 DOI: 10.3390/jcdd11070219

Asmaa Carla Hagău, Horațiu Suciu, Anca Voichița Popoiu, I. Muntean

{"title":"Advanced Echocardiography Assessment in the Management of Alcapa Syndrome: Case Report","authors":"Asmaa Carla Hagău, Horațiu Suciu, Anca Voichița Popoiu, I. Muntean","doi":"10.3390/jcdd11070219","DOIUrl":"https://doi.org/10.3390/jcdd11070219","url":null,"abstract":"Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare and potentially life-threatening condition affecting infants that requires immediate corrective surgery to restore blood flow to the myocardium. We present a case of an infant with ALCAPA and severe heart failure. What sets this case apart is the utilization of speckle-tracking echocardiography as a non-invasive method for assessing global and regional myocardial function before and after surgical intervention. Our preoperative analysis revealed compromised contraction in specific areas of the left ventricle (LV), in the regions that were supplied by both the left coronary artery (LCA) and the right coronary artery (RCA). Interestingly, despite an increase in ejection fraction (EF) measured by conventional echocardiography, the postoperative speckle-tracking analysis revealed persistent impairment in the anterior territories supplied by LCA, highlighting the potential of this technique in identifying myocardial abnormalities during postoperative follow-up. In conclusion, speckle-tracking echocardiography may be a valuable tool for identifying subtle myocardial changes in ALCAPA patients with a higher sensitivity in detecting regional left ventricular (LV) dysfunction compared to conventional echocardiography.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"100 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arrhythmic Mitral Valve Prolapse Syndrome and Ventricular Arrhythmias: A Comprehensive Review and the Role of Catheter Ablation 心律失常性二尖瓣脱垂综合征和室性心律失常：全面回顾与导管消融的作用

Journal of Cardiovascular Development and Disease Pub Date : 2024-07-10 DOI: 10.3390/jcdd11070218

Ehsan Mahmoodi, Haris M. Haqqani

{"title":"Arrhythmic Mitral Valve Prolapse Syndrome and Ventricular Arrhythmias: A Comprehensive Review and the Role of Catheter Ablation","authors":"Ehsan Mahmoodi, Haris M. Haqqani","doi":"10.3390/jcdd11070218","DOIUrl":"https://doi.org/10.3390/jcdd11070218","url":null,"abstract":"Mitral valve prolapse (MVP) affects 2–3% of the general population, and despite its benign prognosis overall, it is associated with sudden death in a small subset of patients. The term “arrhythmic MVP syndrome” (AMVPS) refers to the presence of frequent or complex ventricular arrhythmias, commonly reported in female patients with a stereotypical phenotype including bileaflet myxomatous disease, ECG repolarisation abnormalities in inferior leads, mitral annular disjunction, and significant fibrosis in the inferolateral LV and papillary muscles. Modern imaging technologies have led to the identification of new risk factors that have been implemented in recent risk stratification guidelines; however, screening for patients with MVP who are at risk of sudden cardiac death (SCD) remains challenging. In addition, there is a limited amount of data on the outcomes of different treatment approaches in AMVP and no specific indication for targeted or disease-modifying therapies within current guidelines. Potential arrhythmic substrates in patients with AMVP syndrome have been the subject of interest in previous studies, with areas consisting of fibrosis at the papillary muscle level and the Purkinje system. Premature ventricular contractions (PVCs) originating from these areas have been shown to play an important role as triggers for ventricular fibrillation and SCD in patients with AMVP. Catheter ablation has emerged as a potential treatment modality in patients with MVP and ventricular arrhythmias (VAs), targeting arrhythmic substrates and triggering PVC foci. The aim of this review is to explore the role of catheter ablation in treating patients with AMVP.","PeriodicalId":502527,"journal":{"name":"Journal of Cardiovascular Development and Disease","volume":"23 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0