Frontiers in Dental Medicine最新文献

{"title":"Editorial: Molecular pathways and novel therapeutic targets in regenerative dentistry","authors":"Bruno Cavalcanti, Waruna Lakmal Dissanayaka, Yusuke Takahashi","doi":"10.3389/fdmed.2024.1426500","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1426500","url":null,"abstract":"","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"37 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141118884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: A rare case of bilateral molar natal teeth in a term newborn","authors":"B. M. Varriano, L. Ades, S. R. Vaughan","doi":"10.3389/fdmed.2024.1336865","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1336865","url":null,"abstract":"Reports of natal and neonatal teeth have been well documented in the literature, though the presence of natal primary molars remains rare, and a clear management strategy does not exist. This is a case study of a female newborn delivered at a gestational age of 41 weeks 1 day to a 31-year-old G1P1001 mother. Apgar scores were 8 and 9 at 1 and 5 min, respectively. The infant was delivered by cesarean section and was admitted to the Mass General Hospital Newborn Nursery, where she received routine care. The patient had two posterior molars, which warranted consultation for oral maxillofacial surgery. Due to the gross mobility of the natal teeth and the risk of aspiration in a small breastfeeding newborn, the decision was made to extract the natal teeth immediately. Understanding the management of natal teeth is important for the pediatrician.","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"70 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140655250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying early permanent teeth caries factors in children using random forest algorithm","authors":"Fatemeh Masaebi, Zahra Ghorbani, Mehdi Azizmohammad Looha, Marzie Deghatipour, Morteza Mohammadzadeh, M. G. Ahsaie, Fariba Asadi, Farid Zayeri","doi":"10.3389/fdmed.2024.1359379","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1359379","url":null,"abstract":"Early permanent dental caries can pose a serious threat to oral health in the coming years. This study aimed to investigate the key factors influencing early dental caries in permanent teeth among first-grade Iranian children.A cross-sectional study involving 778 randomly selected first-grade children from public schools in Tehran, Iran, was conducted between November 2017 and January 2018. The oral health of the children, evaluated by two trained dentists, was recorded based on the DMFT index. Information on maternal education, gender, dmft index, brushing frequency, dental visits, flossing, and sweet consumption was also collected. The Random Forest method was employed to identify factors associated with early permanent dental caries, and its performance was compared with logistic regression using the Area Under the Curve (AUC) index.Logistic regression, represented by odds ratios (OR), revealed a significant association between early permanent dental caries and dmft index [OR1.13, 95% CI (1.07, 1.20), p-value <0.001], maternal education [OR = 2.04, 95% CI (1.15, 3.62), p-value <0.05], and sweet consumption [OR = 0.59, 95% CI (0.36, 0.98), p-value <0.05]. Random Forest analysis indicated that male gender, higher maternal education, and lower sweet consumption were associated with increased likelihood of being caries-free. Notably, Random Forest demonstrated superior performance (AUC = 0.81) compared to logistic regression (AUC = 0.72).Early permanent dental caries can be effectively managed by caring primary teeth and reducing consumption of sweet. Maternal education emerged as a pivotal factor in mitigating the risk of early permanent dental caries. Therefore, prioritizing these factors and preventing permanent teeth caries in childhood can be remarkably influential in reducing future caries. The usage of the Random Forest algorithm is highly recommended for identifying relevant risk factors associated with early permanent teeth.","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"18 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140711721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The interaction between the oral microbiota and systemic diseases","authors":"Camila Lopes Crescente, M. Nobre‐Dos‐Santos, Fabíola Galbiatti Carvalho, Ramiro Mendonça Murata, Lívia Araujo Alves, T. Parisotto","doi":"10.3389/fdmed.2024.1390188","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1390188","url":null,"abstract":"","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"54 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140726446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning enabled design features of antimicrobial peptides selectively targeting peri-implant disease progression","authors":"Kyle Boone, Natalia Tjokro, Kalea N. Chu, Casey Chen, Malcolm L. Snead, C. Tamerler","doi":"10.3389/fdmed.2024.1372534","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1372534","url":null,"abstract":"Peri-implantitis is a complex infectious disease that manifests as progressive loss of alveolar bone around the dental implants and hyper-inflammation associated with microbial dysbiosis. Using antibiotics in treating peri-implantitis is controversial because of antibiotic resistance threats, the non-selective suppression of pathogens and commensals within the microbial community, and potentially serious systemic sequelae. Therefore, conventional treatment for peri-implantitis comprises mechanical debridement by nonsurgical or surgical approaches with adjunct local microbicidal agents. Consequently, current treatment options may not prevent relapses, as the pathogens either remain unaffected or quickly re-emerge after treatment. Successful mitigation of disease progression in peri-implantitis requires a specific mode of treatment capable of targeting keystone pathogens and restoring bacterial community balance toward commensal species. Antimicrobial peptides (AMPs) hold promise as alternative therapeutics through their bacterial specificity and targeted inhibitory activity. However, peptide sequence space exhibits complex relationships such as sparse vector encoding of sequences, including combinatorial and discrete functions describing peptide antimicrobial activity. In this paper, we generated a transparent Machine Learning (ML) model that identifies sequence-function relationships based on rough set theory using simple summaries of the hydropathic features of AMPs. Comparing the hydropathic features of peptides according to their differential activity for different classes of bacteria empowered predictability of antimicrobial targeting. Enriching the sequence diversity by a genetic algorithm, we generated numerous candidate AMPs designed for selectively targeting pathogens and predicted their activity using classifying rough sets. Empirical growth inhibition data is iteratively fed back into our ML training to generate new peptides, resulting in increasingly more rigorous rules for which peptides match targeted inhibition levels for specific bacterial strains. The subsequent top scoring candidates were empirically tested for their inhibition against keystone and accessory peri-implantitis pathogens as well as an oral commensal bacterium. A novel peptide, VL-13, was confirmed to be selectively active against a keystone pathogen. Considering the continually increasing number of oral implants placed each year and the complexity of the disease progression, prevalence of peri-implant diseases continues to rise. Our approach offers transparent ML-enabled paths towards developing antimicrobial peptide-based therapies targeting the changes in the microbial communities that can beneficially impact disease progression.","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"12 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140739898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum MMP-8 and TIMP-1 concentrations in a population-based cohort: effects of age, gender, and health status","authors":"Julia Ranta, A. Havulinna, T. Tervahartiala, Katriina Niemi, Ghazal Aarabi, T. Vihervaara, V. Salomaa, Timo Sorsa, P. Pussinen, A. Salminen","doi":"10.3389/fdmed.2024.1315596","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1315596","url":null,"abstract":"Matrix-degrading proteinases and their regulators, such as matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of matrix metalloproteinase 1 (TIMP-1), may contribute to various pathological events. Elevated MMP-8 concentrations have been associated with e.g., cardiovascular diseases and periodontitis. However, there is little knowledge on physiological concentrations of these molecules in serum, or the effect of demographic or lifestyle factors on their levels.We investigated the effect of various demographic characteristics and behavioral habits, such as aging, sex, smoking, and BMI, on serum concentrations of MMP-8 and TIMP-1. We used the FINRISK97 cohort (n = 8,446), which has comprehensive information on demographic and lifestyle factors, clinical data, laboratory measurements, and register data available. Further, we investigated the concentrations of MMP-8, TIMP-1, and the MMP-8/TIMP-1 ratio in different age groups of healthy and diseased participants. T-test was used to compare log-transformed mean levels in different groups and linear regression was used to evaluate the association between MMP-8 and TIMP-1 and selected diseases and background variables.MMP-8 levels decreased with increasing age in the whole population and for women, while TIMP-1 concentration increased slightly with age for the whole population and both genders separately (p for linear trend <0.001). The concentrations of MMP-8 were lower and TIMP-1 higher in men compared to women (p < 0.001). Additionally, significant positive association was found for MMP-8 and smoking, CRP, and inverse association with obesity and fasting time. For TIMP-1, significant positive associations were found with smoking, CRP and obesity, and an inverse association with prevalent diabetes.The association of serum MMP-8 and TIMP-1 concentrations with cardiometabolic risk is frequently investigated. MMP-8 levels decrease significantly with age and fasting time. In addition, sex, smoking, and obesity are associated with both MMP-8 and TIMP-1 concentrations. These factors should be carefully considered in epidemiological studies on serum MMP-8 and TIMP-1.","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Cross-kingdom interactions in oral dysbiosis and host response","authors":"Z. Loewy","doi":"10.3389/fdmed.2024.1398868","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1398868","url":null,"abstract":"","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":" 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital orthodontic setup and clear aligners system for treating adult patients with periodontitis: a descriptive case report","authors":"V. Ronsivalle, Claudia Malara, M. Cicciù, Piero Venezia, A. Lo Giudice","doi":"10.3389/fdmed.2024.1353114","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1353114","url":null,"abstract":"This case report describes the treatment of an adult female patient with a history of periodontitis (Stage 3 -Grade B) and presenting significant crowding in both maxillary and mandibular arches. After periodontal stabilization, the patient underwent orthodontic treatment with clear aligners (CAT) for less than one year. CAT provided an effective quantitative and qualitative control of the forces applied to resolve the malocclusion. This case report provides a detailed description of the clinical strategy and features associated with the clear aligners system which were considered ideal tools for treating periodontal patients during the decisional workflow. The orthodontic treatment goals have been successfully achieved considering functional, periodontal, and aesthetics expectations. Several characteristics of clear aligners could support the recurrence of this orthodontic system for treating patients with a history of periodontitis or at risk of periodontal damage.","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"42 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital orthodontic setup and clear aligners system for treating adult patients with periodontitis: a descriptive case report","authors":"V. Ronsivalle, Claudia Malara, M. Cicciù, Piero Venezia, A. Lo Giudice","doi":"10.3389/fdmed.2024.1353114","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1353114","url":null,"abstract":"This case report describes the treatment of an adult female patient with a history of periodontitis (Stage 3 -Grade B) and presenting significant crowding in both maxillary and mandibular arches. After periodontal stabilization, the patient underwent orthodontic treatment with clear aligners (CAT) for less than one year. CAT provided an effective quantitative and qualitative control of the forces applied to resolve the malocclusion. This case report provides a detailed description of the clinical strategy and features associated with the clear aligners system which were considered ideal tools for treating periodontal patients during the decisional workflow. The orthodontic treatment goals have been successfully achieved considering functional, periodontal, and aesthetics expectations. Several characteristics of clear aligners could support the recurrence of this orthodontic system for treating patients with a history of periodontitis or at risk of periodontal damage.","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"2 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139804130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does diabetes mellitus affect guided bone regeneration outcomes in individuals undergoing dental implants? A systematic review and meta-analysis","authors":"L. M. Oliveira, F. Zanatta, R. Antoniazzi, Patrícia Almeida Miguez","doi":"10.3389/fdmed.2024.1352763","DOIUrl":"https://doi.org/10.3389/fdmed.2024.1352763","url":null,"abstract":"This systematic review aimed to verify if diabetes affects vertical and horizontal ridge augmentation in individuals undergoing dental implant treatment with guided bone regeneration (GBR).Five databases were systematically screened up to September 2023, according to predefined eligibility criteria. The methodological risk of bias of included studies was assessed using the ROBINS-I tool, and GRADE was used to evaluate the certainty of evidence. Random-effects pairwise meta-analyses were used to compare changes in vertical (height) and horizontal (width) alveolar bone dimensions between individuals exposed and unexposed to diabetes, through standardized mean differences (SMDs).Three non-randomized controlled trials met the inclusion criteria, all of which showed a serious risk of bias. The results showed, with overall very low certainty on evidence, that individuals with diabetes did not exhibit a significant difference in horizontal (SMD = −0.41, 95% CI: −0.92–0.10) and vertical (SMD = 0.06, 95% CI: −0.43–0.56) ridge augmentation compared to the those without diabetes.The available evidence, albeit of very low certainty, suggests that diabetic individuals with moderate or good glycemic control undergoing dental implants and GBR show comparable horizontal and vertical bone gains to their unexposed counterparts.\u0000https://osf.io/bpx3t.","PeriodicalId":502488,"journal":{"name":"Frontiers in Dental Medicine","volume":"67 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139601984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}