Journal of Cellular and Comparative Physiology最新文献

Safety and feasibility of thoracoscopic pericardial window in recurrent pericardial effusion - A single-centre experience. 胸腔镜心包开窗治疗复发性心包积液的安全性和可行性 - 单中心经验。

IF 0.8

Journal of Cellular and Comparative Physiology Pub Date : 2024-01-01 Epub Date: 2022-10-31 DOI: 10.4103/jmas.jmas_144_22

Mohan Venkatesh Pulle, Manish Bansal, Belal Bin Asaf, Harsh Vardhan Puri, Sukhram Bishnoi, Arvind Kumar

{"title":"Safety and feasibility of thoracoscopic pericardial window in recurrent pericardial effusion - A single-centre experience.","authors":"Mohan Venkatesh Pulle, Manish Bansal, Belal Bin Asaf, Harsh Vardhan Puri, Sukhram Bishnoi, Arvind Kumar","doi":"10.4103/jmas.jmas_144_22","DOIUrl":"10.4103/jmas.jmas_144_22","url":null,"abstract":"Background: This study aimed to report the surgical outcomes and also evaluating the safety and feasibility of thoracoscopic pericardial window (PW) for recurrent pericardial effusion.Materials and methods: This was a retrospective analysis of eight cases of recurrent pericardial effusion, managed by thoracoscopic method in a tertiary-level thoracic surgery centre over 5 years. A detailed analysis of all perioperative variables, including complications, was carried out.Results: A total of eight patients underwent thoracoscopic PW during the study period. Males (87.5%) were predominant in the cohort. The median age was 54 years (range: 28-78 years). The median duration of symptoms was 2 months (range: 1-3 months). Tuberculosis (50%), malignancy (37.5%) and chronic kidney disease (12.5%) were the causes of recurrent effusion. All patients underwent thoracoscopic procedure with no conversions. The median operative time was 45 min (range: 40-70 min). The median effusion volume drained was 500 ± 100 ml. The median hospital stay was 3 days (range: 2-4 days) with no post-procedural complications. All the patients had complete resolution of symptoms. No recurrence was noted in the median follow-up period of 28 months (range: 6-60 months).Conclusions: Thoracoscopic PW is a safe and feasible minimally invasive option in the management of recurrent pericardial effusion in selected patients. Surgical fitness, haemodynamic status and estimated survival (in malignant effusion) should be considered before the procedure.","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":"5 1","pages":"19-23"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72513472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of NF2-associated vestibular schwannomas in children and young adults: influence of surgery and clinical factors on tumor volume and growth rate. 儿童和青少年NF2相关前庭裂神经瘤的治疗：手术和临床因素对肿瘤体积和生长速度的影响。

IF 2.1

Journal of Cellular and Comparative Physiology Pub Date : 2019-08-23 Print Date: 2019-11-01 DOI: 10.3171/2019.6.PEDS1947

Isabel Gugel, Florian Grimm, Christian Teuber, Lan Kluwe, Victor-Felix Mautner, Marcos Tatagiba, Martin Ulrich Schuhmann

{"title":"Management of NF2-associated vestibular schwannomas in children and young adults: influence of surgery and clinical factors on tumor volume and growth rate.","authors":"Isabel Gugel, Florian Grimm, Christian Teuber, Lan Kluwe, Victor-Felix Mautner, Marcos Tatagiba, Martin Ulrich Schuhmann","doi":"10.3171/2019.6.PEDS1947","DOIUrl":"10.3171/2019.6.PEDS1947","url":null,"abstract":"Objective: The authors' aim was to evaluate the tumor volume and growth rate of neurofibromatosis type 2 (NF2)-associated vestibular schwannomas (VSs) and the clinical factors or type of mutations before and after surgery in children and adults younger than 25 years at the time of diagnosis.Methods: A total of 579 volumetric measurements were performed in 46 operated tumors in 28 NF2 patients, using thin-slice (< 3 mm) T1-weighted contrast-enhanced MRI. The follow-up period ranged from 21 to 167 months (mean 75 months). Growth rate was calculated using a multilinear regression model. Mutation analysis of the NF2 gene was performed in 25 patients.Results: Surgery significantly (p = 0.013) slowed the VS growth rate from 0.69 ± 1.30 cm3/yr to 0.23 ± 0.42 cm3/yr. Factors significantly associated with a higher growth rate of VSs were increasing patient age (p < 0.0005), tumor volume (p = 0.006), tumor size (p = 0.001), and constitutional truncating mutations in the NF2 gene (p = 0.018). VS growth rates tended to be higher in patients with spinal ependymomas and in right-sided tumors and lower in the presence of peripheral schwannomas; however, no statistical significance was achieved.Conclusions: Decompression of the internal auditory canal with various degrees of tumor resection decreases the postoperative tumor growth rate in children and young adults with NF2-associated VS. Patients with potential risk factors for accelerated growth (e.g., large volume, truncating mutations) and with increasing age should be monitored more closely before and after surgery.","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":"7 1","pages":"584-592"},"PeriodicalIF":2.1,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72513662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of rat and frog liver enzymes on the hydrolysis of ortho and pyrophosphoric esters of thiamine 大鼠和青蛙肝酶对硫胺素邻苯二甲酸酯和焦磷酸酯水解的影响

Journal of Cellular and Comparative Physiology Pub Date : 1965-08-01 DOI: 10.1002/JCP.1030660111

Rina Singer-Altbeker, A. Ber

引用次数: 1

The attachment of glycolytic enzymes to muscle ultrastructure 糖酵解酶在肌肉超微结构上的附着

Journal of Cellular and Comparative Physiology Pub Date : 1965-08-01 DOI: 10.1002/JCP.1030660108

W. R. Amberson, F. Roisen, A. C. Bauer

{"title":"The attachment of glycolytic enzymes to muscle ultrastructure","authors":"W. R. Amberson, F. Roisen, A. C. Bauer","doi":"10.1002/JCP.1030660108","DOIUrl":"https://doi.org/10.1002/JCP.1030660108","url":null,"abstract":"The glycolytic enzymes, lactic dehydrogenase and aldolase, usually thought to be freely dissolved in the sarcoplasmic matrix, are in good part attached to the muscle ultrastructure. This attachment becomes manifest when the enzyme activities and specific activities of the press juices of whole skeletal muscles (rabbit) are compared with those of minced muscles, all obtained by ultracentrifugation of the tissues at 40,000 xpm for 16 to 20 hours. Mincing causes a great increase in the activities, associated with a rise in the volume and protein concentration of the press juices. We interpret these increases to be due to the solution in the matrix of enzymes previously attached to the ultrastructure. \u0000 \u0000 \u0000 \u0000The same conclusion is reached by a different method, which we call “washing the ultrastructure.” It consists in multiple centrifugations of whole skeletal muscles, and removal of press juices, alternating with periods of imbibition of a buffer (0.1 M phosphate at pH 7.5) too dilute to dissolve out the fibrous proteins. During the imbibitions enzymes diffuse out into the buffer not imbibed, which becomes an extract. After four centrifugation-imbibition sequences in as many days nearly all of the fluid matrix has been replaced by buffer. Enzyme activities fall steeply in press juices and extracts until nearly all freely dissolved enzymes have been washed away. Homogenates of the pressed muscles then show activities which are about half of those found in the homogenates of unpressed control muscles. We conclude that the enzymes found in the homogenates of the pressed muscles have previously been attached to the ultrastructure. \u0000 \u0000 \u0000 \u0000Similar experiments with heart muscle indicate that nearly all of these enzymes are normally attached to the ultrastructure. Press juices contain only traces of activity, even after the heart has been minced. A fraction of the enzymes is slowly detached during the centrifugation-imbibition sequences, appearing mainly in the extracts.","PeriodicalId":50243,"journal":{"name":"Journal of Cellular and Comparative Physiology","volume":"66 1","pages":"71-90"},"PeriodicalIF":0.0,"publicationDate":"1965-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/JCP.1030660108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50891671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 49

PHYSICAL CHANGES AND MUTAGENESIS. 物理变化和诱变。

Journal of Cellular and Comparative Physiology Pub Date : 1964-10-01

R B Setlow

引用次数: 0

CHANGES IN PATTERNS OF NUCLEIC ACID AND PROTEIN SYNTHESIS CAUSED BY A PURINE ANALOGUE. 嘌呤类似物引起的核酸和蛋白质合成模式的变化

Journal of Cellular and Comparative Physiology Pub Date : 1964-10-01

H Chantrenne

引用次数: 0

REACTION OF SOME MUTAGENIC AND CARCINOGENIC COMPOUNDS WITH NUCLEIC ACIDS. 一些致突变和致癌化合物与核酸的反应。

Journal of Cellular and Comparative Physiology Pub Date : 1964-10-01

P Brookes, P D Lawley