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Computational models for predicting liver toxicity in the deep learning era 深度学习时代预测肝脏毒性的计算模型

Frontiers in Toxicology Pub Date : 2024-01-19 DOI: 10.3389/ftox.2023.1340860

Fahad Mostafa, Minjun Chen

{"title":"Computational models for predicting liver toxicity in the deep learning era","authors":"Fahad Mostafa, Minjun Chen","doi":"10.3389/ftox.2023.1340860","DOIUrl":"https://doi.org/10.3389/ftox.2023.1340860","url":null,"abstract":"Drug-induced liver injury (DILI) is a severe adverse reaction caused by drugs and may result in acute liver failure and even death. Many efforts have centered on mitigating risks associated with potential DILI in humans. Among these, quantitative structure-activity relationship (QSAR) was proven to be a valuable tool for early-stage hepatotoxicity screening. Its advantages include no requirement for physical substances and rapid delivery of results. Deep learning (DL) made rapid advancements recently and has been used for developing QSAR models. This review discusses the use of DL in predicting DILI, focusing on the development of QSAR models employing extensive chemical structure datasets alongside their corresponding DILI outcomes. We undertake a comprehensive evaluation of various DL methods, comparing with those of traditional machine learning (ML) approaches, and explore the strengths and limitations of DL techniques regarding their interpretability, scalability, and generalization. Overall, our review underscores the potential of DL methodologies to enhance DILI prediction and provides insights into future avenues for developing predictive models to mitigate DILI risk in humans.","PeriodicalId":502303,"journal":{"name":"Frontiers in Toxicology","volume":"19 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139613757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal exposure to zinc oxide nanoparticles causes cochlear dysfunction in the offspring 母体接触纳米氧化锌会导致后代耳蜗功能障碍

Frontiers in Toxicology Pub Date : 2024-01-11 DOI: 10.3389/ftox.2024.1323681

Luisa Campagnolo, V. Lacconi, Roberta Bernardini, Andrea Viziano, Antonio Pietroiusti, Lorenzo Ippoliti, A. Moleti, R. Sisto

{"title":"Maternal exposure to zinc oxide nanoparticles causes cochlear dysfunction in the offspring","authors":"Luisa Campagnolo, V. Lacconi, Roberta Bernardini, Andrea Viziano, Antonio Pietroiusti, Lorenzo Ippoliti, A. Moleti, R. Sisto","doi":"10.3389/ftox.2024.1323681","DOIUrl":"https://doi.org/10.3389/ftox.2024.1323681","url":null,"abstract":"Introduction: Zinc oxide nanoparticles (ZnO NPs) have been engineered and are largely used in material science and industry. This large and increasing use justifies a careful study about the toxicity of this material for human subjects. The concerns regard also the reproductive toxicity and the fetotoxicity.Materials and methods: The effect of the exposure to ZnO NPs on the cochlear function was studied in a group of pregnant CD1 mice and in their offspring. This study is part of a larger toxicological study about the toxicity of ZnO NPs during pregnancy. Four groups were analyzed and compared, exposed and non-exposed dams and their offspring. The cochlear function was quantitatively assessed by means of Distortion Product Otoacoustic Emissions (DPOAEs).Results and discussion: A large statistically significant difference was found between the non-exposed dams offspring and the exposed dams offspring (p = 1.6 · 10−3), whose DPOAE levels were significantly lower than those of non-exposed dams offspring and comparable to those of the adults. The DPOAE levels of the exposed and non-exposed dams were very low and not significantly different. This occurrence is related to the fact that these mice encounter a rapid aging process.Conclusion: Our findings show that maternal exposure to ZnO NPs does not reflect in overt toxicity on fetal development nor impair offspring birth, however it may damage the nervous tissue of the inner ear in the offspring. Other studies should confirm this result and identify the mechanisms through which ZnO NPs may affect ear development.","PeriodicalId":502303,"journal":{"name":"Frontiers in Toxicology","volume":"43 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139533379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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