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MDSCs Transfer Methylglyoxal to Suppress CD8+ T-cell Activity. MDSCs 转移甲基乙二酸以抑制 CD8+ T 细胞活性
Cancer Discovery Pub Date : 2020-05-08 DOI: 10.1158/2159-8290.CD-RW2020-067
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引用次数: 1
Remaining Prostate Luminal Cells Regenerate after Androgen Deprivation. 雄激素剥夺后残留的前列腺腔隙细胞会再生
Cancer Discovery Pub Date : 2020-05-08 DOI: 10.1158/2159-8290.CD-RW2020-068
{"title":"Remaining Prostate Luminal Cells Regenerate after Androgen Deprivation.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-068","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-068","url":null,"abstract":"Most prostate luminal cells that survive androgen deprivation can contribute to organ regeneration.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"6 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141206005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy Inhibition Synergizes with Immunotherapy in Pancreatic Cancer. 自噬抑制与胰腺癌免疫疗法协同作用
Cancer Discovery Pub Date : 2020-05-01 DOI: 10.1158/2159-8290.CD-RW2020-063
{"title":"Autophagy Inhibition Synergizes with Immunotherapy in Pancreatic Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-063","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-063","url":null,"abstract":"Autophagy-mediated MHC-I degradation facilitated immune evasion in pancreatic ductal adenocarcinoma.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"32 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141208498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Neutrophils Undergo NETosis to Block Cytotoxic Lymphocytes from Tumors. 中性粒细胞通过NETosis阻断来自肿瘤的细胞毒性淋巴细胞
Cancer Discovery Pub Date : 2020-04-24 DOI: 10.1158/2159-8290.CD-RW2020-062
{"title":"Neutrophils Undergo NETosis to Block Cytotoxic Lymphocytes from Tumors.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-062","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-062","url":null,"abstract":"Tumors produce chemokines that attract neutrophils and cause them to undergo NETosis.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"127 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Catastrophic Mutational Events Can Cause Cancer Genome Aberrations. 灾难性突变事件可导致癌症基因组畸变
Cancer Discovery Pub Date : 2020-04-24 DOI: 10.1158/2159-8290.CD-RW2020-061
{"title":"Catastrophic Mutational Events Can Cause Cancer Genome Aberrations.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-061","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-061","url":null,"abstract":"The breakage-fusion-bridge (BFB) cycle is linked to chromothripsis and yields chromosomal aberrations.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"125 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncogenes Hit by Multiple Cooperating Mutations Are Common in Cancers. 癌症中常见的致癌基因有多种合作突变。
Cancer Discovery Pub Date : 2020-04-24 DOI: 10.1158/2159-8290.CD-RW2020-060
{"title":"Oncogenes Hit by Multiple Cooperating Mutations Are Common in Cancers.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-060","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-060","url":null,"abstract":"Many oncogenes contain multiple individually weak mutations that collectively promote oncogenesis.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"130 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ELP1 Loss Disrupts Protein Homeostasis to Promote SHH Medulloblastoma. ELP1缺失会破坏蛋白质稳态，诱发SHH髓母细胞瘤
Cancer Discovery Pub Date : 2020-04-10 DOI: 10.1158/2159-8290.CD-RW2020-055
{"title":"ELP1 Loss Disrupts Protein Homeostasis to Promote SHH Medulloblastoma.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-055","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-055","url":null,"abstract":"Germline loss-of-function ELP1 variants were found in pediatric Sonic Hedgehog medulloblastomas.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"79 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141215404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lurbinectedin Is Safe and Active in Relapsed Small-Cell Lung Cancer. 鲁贝替尼对复发小细胞肺癌具有安全性和活性
Cancer Discovery Pub Date : 2020-04-10 DOI: 10.1158/2159-8290.CD-RW2020-053
{"title":"Lurbinectedin Is Safe and Active in Relapsed Small-Cell Lung Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-053","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-053","url":null,"abstract":"Lurbinectedin produced responses in 35.2% of 105 patients with relapsed small-cell lung cancer.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"82 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141215606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer. 半胱氨酸是防止胰腺癌铁突变的必要条件
Cancer Discovery Pub Date : 2020-04-10 DOI: 10.1158/2159-8290.CD-RW2020-054
{"title":"Cysteine Is Required for Preventing Ferroptosis in Pancreatic Cancer.","authors":"","doi":"10.1158/2159-8290.CD-RW2020-054","DOIUrl":"https://doi.org/10.1158/2159-8290.CD-RW2020-054","url":null,"abstract":"Cysteine depletion caused ferroptosis in human pancreatic cancer cells and improved survival in mice.","PeriodicalId":502270,"journal":{"name":"Cancer Discovery","volume":"79 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141215394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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