Le infezioni in medicina最新文献

筛选

英文中文

Histopathologic and transmission electron microscopic findings in monkeypox cutaneous lesions. 猴痘皮肤病变的组织病理学和透射电子显微镜观察结果。

Le infezioni in medicina Pub Date : 2024-03-01 eCollection Date: 2024-01-01 DOI: 10.53854/liim-3201-10

Consuelo Venturi, Antonio Guadagno, Serena Varesano, Valentina Ricucci, Nicola Nigro, Antonio Di Biagio, Matteo Bassetti, Paolo Nozza, Francesco Drago, Aurora Parodi, Giulia Ciccarese

{"title":"Histopathologic and transmission electron microscopic findings in monkeypox cutaneous lesions.","authors":"Consuelo Venturi, Antonio Guadagno, Serena Varesano, Valentina Ricucci, Nicola Nigro, Antonio Di Biagio, Matteo Bassetti, Paolo Nozza, Francesco Drago, Aurora Parodi, Giulia Ciccarese","doi":"10.53854/liim-3201-10","DOIUrl":"10.53854/liim-3201-10","url":null,"abstract":"Background: a few pathologic and ultrastructural findings of monkeypox skin lesions are available in the literature. To integrate such evidence, we aimed to describe the pathologic features of monkeypox skin lesions and to show monkeypox virions by transmission electron microscopy (TEM).Methods: we studied the cutaneous biopsies of three patients affected by monkeypox during the 2022 monkeypox outbreak. Skin biopsies have been collected only from body sites with a recent laboratory-confirmed mpox virus infection, defined by a polymerase chain reaction (PCR) positive result in specimens taken through skin swabs.Results: in all the samples the epidermis showed keratinocytes ballooning degeneration; perivascular/periadnexal infiltrates composed of neutrophils and lymphocytes were observed in the deep dermis. Immunohistochemistry showed that the infiltrate was mostly composed of CD3+ T-cells. TEM revealed monkeypox virus-like particles in various stages of morphogenesis in the dermis and epidermis; virions were interspersed among keratinocytes and within their cytoplasm. At the intracellular level, virions showed a biconcaveshaped central core, surrounded by lateral bodies and an external membrane; they also appeared as rectangular, brick-shaped, or oval particles with eccentric nucleoids. The histologic features of our skin samples confirmed the few other studies on this topic, except for the eosinophilic inclusions of the cytoplasm of keratinocytes (Guarnieri's bodies).Conclusion: the role of molecular biology is crucial for monkeypox diagnosis but when it is not disposable and/or in doubtful cases, skin biopsy and TEM may be helpful to establish the diagnosis.","PeriodicalId":502111,"journal":{"name":"Le infezioni in medicina","volume":"32 1","pages":"76-82"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误。

Le infezioni in medicina Pub Date : 2023-12-01 eCollection Date: 2023-01-01 DOI: 10.53854/liim-3104-20

引用次数: 0

Enterococcal meningitis associated with Strongyloides infection: a case report and literature review. 与斯龙线虫感染相关的肠球菌脑膜炎：病例报告和文献综述。

Le infezioni in medicina Pub Date : 2023-12-01 eCollection Date: 2023-01-01 DOI: 10.53854/liim-3104-18

Lavinia Cosimi, Stefano Di Bella, Roberto Luzzati, Catrin Theresia Simeth, Maurizio Pinamonti, Franco Cominotto, Ugo Giulio Sisto

{"title":"Enterococcal meningitis associated with Strongyloides infection: a case report and literature review.","authors":"Lavinia Cosimi, Stefano Di Bella, Roberto Luzzati, Catrin Theresia Simeth, Maurizio Pinamonti, Franco Cominotto, Ugo Giulio Sisto","doi":"10.53854/liim-3104-18","DOIUrl":"https://doi.org/10.53854/liim-3104-18","url":null,"abstract":"Strongyloides stercoralis is an intestinal nematode endemic throughout tropical and subtropical areas, with a life cycle consisting of free-living and parasitic components. Unlike other soil-transmitted nematodes, it is capable of self-infection, which can cause chronic disease that lasts for decades, or cause overwhelming hyperinfection in people taking corticosteroids or other immunosuppressive drugs or who have impaired Th2 cell-mediated immunity, particularly those infected with human T-lymphotropic virus 1. During hyperinfection, a large numbers of larvae have access to the bloodstream, lungs, central nervous system, and other organs. Bacteremia and polymicrobial meningitis can occur due to disruption of the intestinal mucosa and the presence of bacteria on the surface of foreign larvae. Enterococcal meningitis for instance may occur concurrently with strongyloidiasis as a consequence of haematogenous dissemination. We present a clinical case of a 45-year-old, man from Bangladesh, in which co-infection occurred. The patient was not immunocompromized and had no apparent risk factors, which represents the unusual aspect of this case report. A literature review on enterococcal meningitis and Strongyloides coinfection in adult patients was performed encountering 21 cases. Cases have been reviewed and discussed. Clinicians may suspect S. stercoralis co-infection when identifying an enterococcal meningitis in adult patients coming from endemic areas.","PeriodicalId":502111,"journal":{"name":"Le infezioni in medicina","volume":"31 4","pages":"583-590"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138808152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页