npj Metabolic Health and Disease最新文献_第7页

The metabolic advantage of being young and male in obesity treatment outcomes in mice. 年轻和雄性在小鼠肥胖治疗结果中的代谢优势。

npj Metabolic Health and Disease Pub Date : 2025-08-01 DOI: 10.1038/s44324-025-00065-2

Amanda S Dirnberger, Elen Yanina Aguirre-Rodriguez, Elias Carlos Aguirre-Rodriguez, John O Degraft Hanson, Yanping Sun, Dave Delima, Benjamin F Bykov, Aneirson Francisco da Silva, Marko Kraljević, Fernando Augusto Silva Marins, Ana Bf Emiliano

{"title":"The metabolic advantage of being young and male in obesity treatment outcomes in mice.","authors":"Amanda S Dirnberger, Elen Yanina Aguirre-Rodriguez, Elias Carlos Aguirre-Rodriguez, John O Degraft Hanson, Yanping Sun, Dave Delima, Benjamin F Bykov, Aneirson Francisco da Silva, Marko Kraljević, Fernando Augusto Silva Marins, Ana Bf Emiliano","doi":"10.1038/s44324-025-00065-2","DOIUrl":"10.1038/s44324-025-00065-2","url":null,"abstract":"Although diversity in clinical trials is important to test the efficacy of a treatment, weight loss trials rarely account for age and sex. To highlight this deficiency, we set out to test whether age and sex affect WAT mobilization after weight loss surgery or intermittent fasting, in an obese mouse model. Here we show that male sex, youth, and WAT transcriptomic plasticity are characteristics associated with improved weight loss outcomes. Conversely, aging impairs WAT mobilization and transcriptomic plasticity. Greater surgical weight loss is associated with changes in the expression of genes relevant to the IL17 inflammatory signaling pathway, angiotensin converting enzyme 2 (ACE2) signaling, lipolysis, carbohydrate metabolism and adipocyte differentiation. In conclusion, female sex and older age appear to hinder molecular processes necessary for the reversal of WAT expansion. Future studies should examine the relevance of these findings to human obesity therapeutics.","PeriodicalId":501710,"journal":{"name":"npj Metabolic Health and Disease","volume":"3 1","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal muscle proteomics: considerations and opportunities. 骨骼肌蛋白质组学：考虑和机会。

npj Metabolic Health and Disease Pub Date : 2025-07-02 DOI: 10.1038/s44324-025-00073-2

Julian P H Wong, Yaan-Kit Ng, Jeppe Kjærgaard, Ronnie Blazev, Atul S Deshmukh, Benjamin L Parker

引用次数: 0

Complex interaction of waist circumference, cardiometabolic markers, and sex on elderly mortality: a cohort study of 0.4 million UK adults. 腰围、心脏代谢指标和性别对老年人死亡率的复杂相互作用：一项针对40万英国成年人的队列研究。

npj Metabolic Health and Disease Pub Date : 2025-07-02 DOI: 10.1038/s44324-025-00075-0

Jingyi Wu, Pengfei Li, Shaomei Shang

{"title":"Complex interaction of waist circumference, cardiometabolic markers, and sex on elderly mortality: a cohort study of 0.4 million UK adults.","authors":"Jingyi Wu, Pengfei Li, Shaomei Shang","doi":"10.1038/s44324-025-00075-0","DOIUrl":"10.1038/s44324-025-00075-0","url":null,"abstract":"This prospective cohort study included 408,760 older adults to investigate complex interaction between waist circumference (WC), blood glucose (BG) or blood pressure (BP), and sex in relation to elderly mortality. We used Cox regression models incorporating a tensor product interaction function to model joint impacts of WC and four cardiometabolic markers on mortality, and developed a two-dimensional exposure-response function (ERF) to quantify the population adaptability to cardiometabolic dysfunction across different WC levels. The linear and nonlinear effects of BG and BP on mortality varied by WC, with significant synergistic interactions. The two-dimensional ERF quantified variations in excess mortality risk across different WC and cardiometabolic marker combinations. Individuals with higher WC exhibited a forward shift in risk thresholds, indicating reduced adaptability to elevated BG and BP levels. Our findings highlight the need for targeted cardiometabolic health management strategies to enhance adaptability and reduce the burden of cardiometabolic diseases in aging populations.","PeriodicalId":501710,"journal":{"name":"npj Metabolic Health and Disease","volume":"3 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: Chain splitting of insulin: an underlying mechanism of insulin resistance? 胰岛素链分裂：胰岛素抵抗的潜在机制？

npj Metabolic Health and Disease Pub Date : 2025-06-20 DOI: 10.1038/s44324-025-00076-z

Christian N Cramer, František Hubálek, Christian Lehn Brand, Hans Helleberg, Peter Kurtzhals, Jeppe Sturis

引用次数: 0

The role of NAD⁺ metabolism and its modulation of mitochondria in aging and disease. NAD+代谢及其对线粒体在衰老和疾病中的调节作用。

npj Metabolic Health and Disease Pub Date : 2025-06-18 DOI: 10.1038/s44324-025-00067-0

Khalishah Yusri, Sandra Jose, Karen S Vermeulen, Trina Chia Min Tan, Vincenzo Sorrentino

{"title":"The role of NAD+ metabolism and its modulation of mitochondria in aging and disease.","authors":"Khalishah Yusri, Sandra Jose, Karen S Vermeulen, Trina Chia Min Tan, Vincenzo Sorrentino","doi":"10.1038/s44324-025-00067-0","DOIUrl":"10.1038/s44324-025-00067-0","url":null,"abstract":"Nicotinamide adenine dinucleotide (NAD+) is a coenzyme involved in a plethora of physiological reactions, with a key relevance in supporting mitochondrial function. Due to its critical role in these cellular processes, declining levels of NAD+ are associated with general aging and chronic disorders, including cognitive decline, sarcopenia, and metabolic diseases. These conditions are also typified by loss of mitochondrial health through dysfunction of homeostatic components such as mitophagy, unfolded protein response, and the antioxidant system. Therefore, raising cellular NAD+ through vitamin B3 family precursors or via drug-based interventions has become a broadly used strategy to restore mitochondrial and organismal homeostasis, with NAD+ precursors becoming a popular supplementation approach. As increasing components of the NAD+ biology are unraveled, this comprehensive review summarizes the advances in mechanisms of NAD+ metabolism and its modulation via compound-based strategies. Furthermore, it highlights the role of NAD+ in mitochondrial homeostasis in aging and disease conditions, the latest results of NAD+-boosting therapeutics in clinical trials, and areas of further translational development.","PeriodicalId":501710,"journal":{"name":"npj Metabolic Health and Disease","volume":"3 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspirin reduces the risk of type 2 diabetes associated with COVID-19. 阿司匹林可降低与COVID-19相关的2型糖尿病的风险。

npj Metabolic Health and Disease Pub Date : 2025-06-18 DOI: 10.1038/s44324-025-00072-3

Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Maria Virginia Manzi, Stanislovas S Jankauskas, Paola Gallo, Francesco Rozza, Giuseppe Giugliano, Alessandra Spinelli, Giovanni Esposito, Roberto Piccinocchi, Gaetano Piccinocchi, Carmine Morisco, Maria Lembo, Gaetano Santulli, Bruno Trimarco

{"title":"Aspirin reduces the risk of type 2 diabetes associated with COVID-19.","authors":"Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Maria Virginia Manzi, Stanislovas S Jankauskas, Paola Gallo, Francesco Rozza, Giuseppe Giugliano, Alessandra Spinelli, Giovanni Esposito, Roberto Piccinocchi, Gaetano Piccinocchi, Carmine Morisco, Maria Lembo, Gaetano Santulli, Bruno Trimarco","doi":"10.1038/s44324-025-00072-3","DOIUrl":"10.1038/s44324-025-00072-3","url":null,"abstract":"This study aimed to determine whether daily low-dose aspirin reduces the risk of type 2 diabetes (T2D) associated with COVID-19. A longitudinal cohort of 200,000 adults followed from 2018 to 2022 was analyzed, comparing T2D incidence between aspirin users and non-users. Propensity score matching was used to balance the groups. The incidence of T2D was substantially lower in the aspirin group, with Cox regression showing a 52% risk reduction. Kaplan-Meier analysis confirmed a significant divergence in cumulative T2D risk after two years. This protective effect was observed both before and during the COVID-19 pandemic, with a stronger association during the pandemic period. These findings indicate that daily low-dose aspirin significantly reduces the risk of COVID-19-associated new-onset T2D, highlighting the role of inflammation in the pathogenesis of T2D triggered or unmasked by COVID-19.","PeriodicalId":501710,"journal":{"name":"npj Metabolic Health and Disease","volume":"3 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECM formation and degradation during fibrosis, repair, and regeneration. 在纤维化、修复和再生过程中ECM的形成和降解。

npj Metabolic Health and Disease Pub Date : 2025-06-10 DOI: 10.1038/s44324-025-00063-4

Alejandro E Mayorca-Guiliani, Diana Julie Leeming, Kim Henriksen, Joachim Høg Mortensen, Signe Holm Nielsen, Quentin M Anstee, Arun J Sanyal, Morten A Karsdal, Detlef Schuppan

引用次数: 0

Mechanisms and implications of the gut microbial modulation of intestinal metabolic processes. 肠道微生物调节肠道代谢过程的机制和意义。

npj Metabolic Health and Disease Pub Date : 2025-06-10 DOI: 10.1038/s44324-025-00066-1

Jyoti, Priyankar Dey

引用次数: 0

Author Correction: The potential role of early life feeding patterns in shaping the infant fecal metabolome: implications for neurodevelopmental outcomes. 作者更正：早期生活喂养模式在塑造婴儿粪便代谢组中的潜在作用：对神经发育结果的影响。

npj Metabolic Health and Disease Pub Date : 2025-06-06 DOI: 10.1038/s44324-025-00071-4

Bridget Chalifour, Elizabeth A Holzhausen, Joseph J Lim, Emily N Yeo, Natalie Shen, Dean P Jones, Bradley S Peterson, Michael I Goran, Donghai Liang, Tanya L Alderete

引用次数: 0

FGF21 deletion mildly exacerbates hepatic dysfunction in GAN diet and alcohol fed rats. FGF21缺失轻度加重了GAN饮食和酒精喂养大鼠的肝功能障碍。

npj Metabolic Health and Disease Pub Date : 2025-05-28 DOI: 10.1038/s44324-025-00062-5

Peter Aldiss, Malte Hasle Nielsen, Hayley Burm, Denise Oró, Henrik H Hansen, Michael Feigh, Matthew P Gillum

引用次数: 0