The Journal of Urology最新文献

{"title":"Editorial Comment: Pelvic Lymph Node Dissection in Prostate Cancer-is It Really Necessary? A Multicentric Longitudinal Study Assessing Oncological Outcomes in Prostate Cancer Patients Undergoing Pelvic Lymph Node Dissection Vs Radical Prostatectomy Only.","authors":"Adam C Reese","doi":"10.1097/ju.0000000000004606","DOIUrl":"https://doi.org/10.1097/ju.0000000000004606","url":null,"abstract":"","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"31 1","pages":"101097JU0000000000004606"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: A Prospective Randomized Study on Low-Energy Extracorporeal Shockwave Therapy (LI-SWT) for Erectile Dysfunction After Radical Prostatectomy.","authors":"Peter Dietrich,Zachary Werner","doi":"10.1097/ju.0000000000004609","DOIUrl":"https://doi.org/10.1097/ju.0000000000004609","url":null,"abstract":"","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"79 1","pages":"101097JU0000000000004609"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment on \"A Prospective Randomized Study on Low-Energy Extracorporeal Shockwave Therapy (LI-SWT) for Erectile Dysfunction After Radical Prostatectomy\".","authors":"Jaxson Jeffery,Nahid Punjani","doi":"10.1097/ju.0000000000004608","DOIUrl":"https://doi.org/10.1097/ju.0000000000004608","url":null,"abstract":"","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"33 1","pages":"101097JU0000000000004608"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: A Prospective Randomized Study on Low-Energy Extracorporeal Shockwave Therapy (LI-SWT) for Erectile Dysfunction After Radical Prostatectomy.","authors":"Roger Dmochowski","doi":"10.1097/ju.0000000000004607","DOIUrl":"https://doi.org/10.1097/ju.0000000000004607","url":null,"abstract":"","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"137 1","pages":"101097JU0000000000004607"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MIDMID-TERM KIDNEY FUNCTION IN BOYS WITH POSTERIOR URETHRAL VALVES AND A SOLITARY FUNCTIONING KIDNEY.","authors":"Silvia Pecorelli,Mathilde Glenisson,Matthieu Peycelon,Etienne Suply,Marc-David Leclair,Nicolas Kalfa,Pauline Clermidi,Alexis Arnaud,Alice Faure,Quentin Ballouhey,Nadia Boudaoud,Yann Chaussy,Cyril Ferdynus,Thomas Blanc,Luke Harper","doi":"10.1097/ju.0000000000004612","DOIUrl":"https://doi.org/10.1097/ju.0000000000004612","url":null,"abstract":"PURPOSEIt has been suggested that patients with Posterior Urethral Valves (PUV) and a solitary functioning kidney (SFK) have poorer mid-term and long-term renal function than those with 2 functioning kidneys (2FK). We compared mid-term eGFR of PUV patients with and without solitary kidneys.MATERIAL AND METHODSWe used the CIRCUP randomized controlled trial database, which included only patients with prenatally suspected, postnatally confirmed PUV. Standardized follow-up included an early DMSA scan performed between 1 and 6 months of age. We retrospectively compared mid-term eGFR (>5 years of age) between those with or without findings of solitary functioning renal unit (<10% differential function of a renal unit). eGFR was calculated using the updated Schwartz formula. Comparison between groups was done using the Mann-Whitney U-test. The study respects our national ethics regulations.RESULTS68 PUV patients were included, 20 of whom had SFK. There were no differences in baseline characteristics between both groups, nor in timing of DMSA scan or latest follow-up.The median follow-up was 7 years (IQR: 6-8). The median eGFR in each group was: SFK 82.5 (55-109) vs. 2FK 94.5 (71-114).There was no significant difference in mid-term eGFR, nor in the proportion of boys with mid-term eGFR <90 or eGFR<60 between the two groups. However, nadir creatinine was significantly higher in boys with a mid-term eGFR < 90 as opposed to those with a mid-term eGFR >90 (p<0.01).CONCLUSIONSIn boys with PUV, having only one functioning kidney on a DMSA study is insufficient to determine decreased renal reserve.","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"124 1","pages":"101097JU0000000000004612"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Letter: a multi-institutional study of MR/US fusion guided nanoparticle directed focal therapy for prostate ablation.","authors":"Steven E Canfield,Ardeshir R Rastinehad","doi":"10.1097/ju.0000000000004580","DOIUrl":"https://doi.org/10.1097/ju.0000000000004580","url":null,"abstract":"","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"18 1","pages":"101097JU0000000000004580"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging at second surveillance biopsy after diagnosis in patients with Grade Group 1 prostate cancer in the Canary Prostate Active Surveillance Study.","authors":"Meera R Chappidi,Lisa F Newcomb,Yingye Zheng,Menghan Liu,Jeannette M Schenk,Kehao Zhu,Claire M de la Calle,James D Brooks,Peter R Carroll,Atreya Dash,Christopher P Filson,Martin E Gleave,Michael A Liss,Frances Martin,Jesse K McKenney,Todd M Morgan,Andrew A Wagner,Peter S Nelson,Daniel W Lin","doi":"10.1097/ju.0000000000004592","DOIUrl":"https://doi.org/10.1097/ju.0000000000004592","url":null,"abstract":"PURPOSENo clear guidelines exist regarding MRI use after confirmatory biopsy during active surveillance (AS). Our objective was to evaluate MRI performance after confirmatory biopsy in patients with vs. without prior MRI-informed biopsy.METHODSPatients in Canary PASS with Gleason grade group (GG) 1 disease undergoing MRI-informed Biopsy 2, defined as second surveillance biopsy after diagnosis, were separated into prior vs. no prior MRI-informed biopsy groups. Primary outcome was reclassification (≥GG2) at MRI-informed Biopsy 2. Reclassification rates and location (systematic cores, targeted cores, both) were compared between groups. Univariable and multivariable logistic regression identified predictors of reclassification.RESULTSPatients with (n=101) vs. without (n=103) prior MRI-informed biopsy had lower reclassification rates at Biopsy 2 (21% vs. 36%, p=0.017) and lower GG at reclassification (95% vs. 73% of reclassifications to GG2, p=0.039). In multivariable modeling, PI-RADS 4-5 at MRI-informed Biopsy 2 was associated with increased odds of reclassification (OR=2.04 95%CI [1.04-4.05]). The negative predictive value of MRI at Biopsy 2 was 87% (95%CI[78-96]) and 73% (95%CI[61-85]) in with vs. without prior MRI groups, respectively. Reclassification location was identified by targeted cores only in 36% vs. 19% of patients with vs. without prior MRI, respectively (p=0.4). Reclassification location was identified by systematic cores only in 36% vs. 58% of patients with vs. without prior MRI, respectively (p=0.4).CONCLUSIONSThese results support MRI use at Biopsy 2 and suggest negative surveillance MRI should not replace Biopsy 2. Both targeted and systematic cores should be taken at Biopsy 2 in patients with and without prior MRI on AS.","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"36 1","pages":"101097JU0000000000004592"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The AUA/SUFU/AUGS Guideline on Genitourinary Syndrome of Menopause.","authors":"Melissa R Kaufman,A Lenore Ackerman,Katherine A Amin,Marge Coffey,Elisheva Danan,Stephanie S Faubion,Anne Hardart,Irwin Goldstein,Giulia M Ippolito,Gina M Northington,Charles R Powell,Rachel S Rubin,O Lenaine Westney,Tracey S Wilson,Una J Lee","doi":"10.1097/ju.0000000000004589","DOIUrl":"https://doi.org/10.1097/ju.0000000000004589","url":null,"abstract":"PURPOSEGenitourinary syndrome of menopause (GSM) describes the symptoms and physical changes that result from declining estrogen and androgen concentrations in the genitourinary tract during the menopausal transition. There has not been a consensus reached about the number or type of symptoms needed to diagnose GSM, and the associated urinary symptoms are also linked with other common urologic conditions (e.g., overactive bladder) in older patients. This guideline provides information to clinicians regarding identification, diagnosis, counseling, and treatment for patients with GSM to optimize symptom control and quality of life while minimizing adverse events (AEs).METHODSThe systematic review utilized in the creation of this guideline is based on research conducted by the Minnesota Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ) and funded by the Patient Centered Outcomes Research Institute (PCORI). The EPC extracted and synthesized effectiveness and/or harms outcomes from 68 publications. An additional 66 publications evaluating 46 non-hormonal interventions, were described in an evidence map.RESULTSClinicians diagnose GSM based on symptoms, with or without related physical findings, and after ruling out other etiologies or co-occurring pathologies. There is a large body of evidence examining the use of hormonal and non-hormonal treatment options to manage the symptoms of GSM; however, the local low-dose vaginal estrogen has the most robust evidence base.CONCLUSIONThe strategies defined in this document were derived from evidence-based and consensus-based processes. Given that there is insufficient information to recommend one hormonal therapy over another, this guideline is not meant to support a stepwise progression through different hormonal approaches. The clinician should make treatment decisions in the context of shared decision-making considering patient goals and preferences, using the evidence of efficacy and AEs of each possible intervention as a guide.","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"86 1","pages":"101097JU0000000000004589"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic lymph node dissection in prostate cancer - is it really necessary? A multicentric longitudinal study assessing oncological outcomes in prostate cancer patients undergoing pelvic lymph node dissection vs radical prostatectomy only.","authors":"Marc A Furrer,Niranjan J Sathianathen,Clancy J Mulholland,Nathan Papa,Andreas Katsios,Christopher Soliman,Nathan Lawrentschuk,Justin S Peters,Homi Zargar,Anthony J Costello,Christopher M Hovens,Peter Liodakis,Conrad Bishop,Ranjit Rao,Raymond Tong,Daniel Steiner,Declan G Murphy,Daniel Moon,Benjamin C Thomas,Philip Dundee,Jeremy Goad,Jose Antonio Rodriguez Calero,George N Thalmann,Niall Corcoran","doi":"10.1097/ju.0000000000004587","DOIUrl":"https://doi.org/10.1097/ju.0000000000004587","url":null,"abstract":"PURPOSEWith the availability of PSMA-PET scans, it is controversial whether pelvic lymph-node dissection (PLND) at time of radical prostatectomy (RP) is still the most reliable and accurate staging modality for lymph-node assessment. Furthermore, the oncological benefit of PLND remains unclear. Aim of this study was to assess whether omitting PLND in patients undergoing RP for prostate cancer is associated with the risk of tumor recurrence and progression to metastasis.MATERIAL AND METHODSIn this longitudinal multicentre cohort-study, we reviewed data of 2346 consecutive patients with prostate cancer who underwent RP with (n=1650) and without (n=696) extended-PLND between 01/1996 and 12/2021. Recurrence-free survival (RFS) and metastases-free survival (MFS) were analysed as a time-to-event outcome using Kaplan-Meier analyses with log-rank tests. To assess effect of PLND, we created multivariable Cox proportional hazards models adjusting for relevant clinical and demographic characteristics.RESULTS AND LIMITATIONSMedian follow-up was 44 months. There was no difference in RFS between men who had a PLND and those who did not [HR 1.07, 95%CI 0.87-1.32, p=0.52]. Patients with D'Amico high-risk-disease (PSA>20ug/l and/or ISUP-GG≥4) demonstrated a significantly prolonged MFS if they underwent PLND [HR 0.57, 0.36-0.91, p=0.02]. PLND also improved MFS in patients with intermediate-risk disease [HR 0.48, 95%CI 0.25-0.90, p=0.023]. Further significant prognostic variables for MFS on multivariable Cox proportional hazard regression were PSA, ISUP-GG, and pathological T-stage.CONCLUSIONSPLND improves MFS in D'Amico intermediate and high-risk prostate cancer patients and may therefore be considered in men undergoing RP.","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"18 1","pages":"101097JU0000000000004587"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Re: Utility of Preoperative Antimicrobial Prophylaxis in Hypospadias Repair: Results from NSQIP-Pediatric.","authors":"Douglas E Coplen","doi":"10.1097/ju.0000000000004575","DOIUrl":"https://doi.org/10.1097/ju.0000000000004575","url":null,"abstract":"","PeriodicalId":501636,"journal":{"name":"The Journal of Urology","volume":"9 1","pages":"101097JU0000000000004575"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}