The American Journal of Pathology最新文献_第2页

On Baserga's Message. 关于Baserga的信息。

IF 6

The American Journal of Pathology Pub Date : 1990-09-01

V T Marchesi

引用次数: 0

CD Antigens 1989: Summary of Nomenclature System for Human Leacocyte Surface Antigens. cdantigens 1989:人白细胞表面抗原命名系统综述。

IF 6

The American Journal of Pathology Pub Date : 1989-08-01

W Knapp, B Dörken, P Rieber, R E Schmidt, H Stein, A E von dem Borne

引用次数: 0

Editorial statement. 社论声明。

IF 6

The American Journal of Pathology Pub Date : 1982-09-01

V T Marchesi

引用次数: 0

Presentation of the warner-lambert parke-davis award to david a. Clayton and Michael a. Gimbrone, jr: 1982. 颁发华纳-兰伯特帕克-戴维斯奖给大卫·克莱顿和小迈克尔·金布罗尼:1982年。

IF 6

The American Journal of Pathology Pub Date : 1982-09-01

V T Marchesi

引用次数: 0

Presentation of the gold headed cane award to harry m. Zimmerman: 1982. 颁发金头手杖奖给哈里·齐默尔曼:1982年。

IF 6

The American Journal of Pathology Pub Date : 1982-09-01

R D Terry

引用次数: 0

Presentation of the rous-whipple award to emmanuel farber: 1982. 劳斯-惠普尔奖颁发给伊曼纽尔·法伯:1982年。

IF 6

The American Journal of Pathology Pub Date : 1982-09-01

F F Becker

引用次数: 0

Generation of a complement-derived chemotactic factor for tumor cells in experimentally induced peritoneal exudates and its effect on the local metastasis of circulating tumor cells. 实验诱导腹膜渗出液中肿瘤细胞补体来源趋化因子的产生及其对循环肿瘤细胞局部转移的影响。

IF 6

The American Journal of Pathology Pub Date : 1982-07-01

F W Orr, S Mokashi, J Delikatny

{"title":"Generation of a complement-derived chemotactic factor for tumor cells in experimentally induced peritoneal exudates and its effect on the local metastasis of circulating tumor cells.","authors":"F W Orr, S Mokashi, J Delikatny","doi":"","DOIUrl":"","url":null,"abstract":"A chemotactic factor for tumor cells was found in inflammatory exudate fluids induced by giving intraperitoneal injections of glycogen to Sprague-Dawley rats. The quantity of chemotactic activity and the period of time during which it could be detected correlated with the inflammatory reaction, measured by the cellular composition of the exudates and their content of protein and lysosomal enzymes. In gel filtration the chemotactic factor behaved mainly as a molecule having a molecular weight of approximately 6000 daltons. Its biologic activity was blocked by antiserums directed against C5 but not by antiserums against C3 or C4. In these two respects, the factor generated in vivo has the same properties as a previously described chemotactic factor that can be generated in vitro by proteolysis of purified C5 or C5a. Chemotactic activity was not detected in the glycogen-induced peritoneal exudates of rats depleted of serum complement by cobra venom factor. Intravenously injected Walker tumor cells arrested and formed metastases in the mesenteries of rats with peritonitis in greater numbers than in normal controls, animals depleted of complement during the experimental period, or animals given intraperitoneal injections of the vasopermeability agent, histamine. The growth of tumor cells in vitro was not promoted by peritoneal exudate fluids, nor was the number of metastases on vivo greater than in negative controls, in animals in which peritonitis was induced 24 hours after the intravenous injection of tumor cells. It is argued that chemotactic mechanisms can contribute to the formation of metastases at sites of tissue injury.","PeriodicalId":501602,"journal":{"name":"The American Journal of Pathology","volume":" ","pages":"112-8"},"PeriodicalIF":6.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916031/pdf/amjpathol00202-0116.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35263342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interactions between macrophagelike cells and Leishmania braziliensis in vitro. 巨噬样细胞与巴西利什曼原虫体外相互作用的研究。

IF 6

The American Journal of Pathology Pub Date : 1982-07-01

M Aikawa, L D Hendricks, Y Ito, M Jagusiak

{"title":"Interactions between macrophagelike cells and Leishmania braziliensis in vitro.","authors":"M Aikawa, L D Hendricks, Y Ito, M Jagusiak","doi":"","DOIUrl":"","url":null,"abstract":"The interaction between macrophagelike cells (P388D murine tumor cells) and Leishmania braziliensis panamensis promastigotes was studied in vitro under various conditions by light and electron microscopy. When the macrophagelike cells and L braziliensis promastigate were incubated together for 2 minutes, 90% of the promastigotes were attached to the macrophagelike cells by the tip of the flagella. The macrophagelike cells did not form pseudopods or aggregated microfilaments around the inserted flagellum. After a 5-minute incubation period, the parasites attached to the macrophagelike cells did not show preferred orientation. At this time, numerous pseudopods and aggregated microfilaments of the macrophagelike cells were seen around the invading parasites. When the relationship between the cytochalasin B-treated promastigotes and the macrophagelike cells were examined, no interaction of the promastigote flagella with macrophagelike cells was observed at 2 minutes. After a 5-minute incubation period, 50% of the attached parasites adhered to a macrophagelike cell without any particular orientation. When the interaction between the promastigotes and cytochalasin B-treated macrophagelike cells were examined, the cytochalasin B-treated cells showed fewer pseudopods than the untreated cells, and the number of parasites attached to them was reduced considerably after a 5-minute incubation period. This data demonstrated, for the first time, that the mode of entry by Leishmania promastigotes into macrophagelike cells is dependent on the activation of the macrophagelike cells following the attachment of Leishmania promastigotes.","PeriodicalId":501602,"journal":{"name":"The American Journal of Pathology","volume":" ","pages":"50-9"},"PeriodicalIF":6.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916017/pdf/amjpathol00202-0054.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35263778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testicular atrophy in the spontaneously diabetic BB Wistar rat. 自发性糖尿病BB Wistar大鼠睾丸萎缩。

IF 6

The American Journal of Pathology Pub Date : 1982-07-01

J R Wright, A J Yates, H M Sharma, C Shim, R L Tigner, P Thibert

引用次数: 0

Pulmonary intravascular sequestration of activated neutrophils: failure to induce light-microscopic evidence of lung injury in rabbits. 活化中性粒细胞在肺血管内的隔离:未能诱导兔肺损伤的光显微镜证据。

IF 6

The American Journal of Pathology Pub Date : 1982-07-01

J O Shaw, P M Henson

{"title":"Pulmonary intravascular sequestration of activated neutrophils: failure to induce light-microscopic evidence of lung injury in rabbits.","authors":"J O Shaw, P M Henson","doi":"","DOIUrl":"","url":null,"abstract":"Rabbits were injected intravenously with glycogen-elicited allogenic peritoneal polymorphonuclear neutrophil leukocytes (PMNs) for the study of the light-microscopic effects of acute and chronic sequestration of PMNs in the pulmonary vascular bed. Infusion of 51Cr-labeled PMNs demonstrated that approximately half of the cells were sequestered in the lung, with no difference observed between PMNs incubated with 10% normal rabbit serum and PMNs incubated with 10% zymosan-activated serum (ZAS) prior to infusion. Quantitative histologic studies demonstrated that the number of ZAS-activated PMNs present in the alveolar walls at 4 hours rapidly declined over the ensuing 20 hours and was back to buffer control values by 48 hours. No PMNs, red cells, or signs of edema were visible in the alveolar spaces. In rabbits injected chronically (twice weekly for 8 weeks) with 2 x 10(8) PMNs (ZAS-stimulated and unstimulated), no qualitative or quantitative (mean linear intercept) evidence for damage to alveolar walls was observed. These studies indicate that acute and chronic pulmonary sequestration of PMNs activated in vitro, infused in the absence of activated serum products, does not cause light-microscopic evidence of lung injury.","PeriodicalId":501602,"journal":{"name":"The American Journal of Pathology","volume":" ","pages":"17-23"},"PeriodicalIF":6.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916034/pdf/amjpathol00202-0021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35263777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0