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The COMT Val158Met Polymorphism is Significantly Associated with Early Onset Preeclampsia in Both African American and Caucasian Mothers COMT Val158Met 多态性与非裔美国人和白种人母亲的早发子痫前期显著相关
medRxiv - Obstetrics and Gynecology Pub Date : 2024-05-03 DOI: 10.1101/2024.05.01.24306705
Melissa R. Kaufman, Amy E. Hwang, Anthony M. Pickrel, Cassandra M. Gray, Kriti M. Goel, David N. Dhanraj, Jerome L. Yaklic, Rose A. Maxwell, Thomas L. Brown
{"title":"The COMT Val158Met Polymorphism is Significantly Associated with Early Onset Preeclampsia in Both African American and Caucasian Mothers","authors":"Melissa R. Kaufman, Amy E. Hwang, Anthony M. Pickrel, Cassandra M. Gray, Kriti M. Goel, David N. Dhanraj, Jerome L. Yaklic, Rose A. Maxwell, Thomas L. Brown","doi":"10.1101/2024.05.01.24306705","DOIUrl":"https://doi.org/10.1101/2024.05.01.24306705","url":null,"abstract":"The aim of this study was to evaluate maternal and infant Val<sup>158</sup>Met polymorphisms of Catechol-O-Methyltransferase (COMT), a reported indicator of preeclamptic risk, in a United States population. Healthy control, early-onset preeclamptic, and late-onset preeclamptic patients were enrolled in this study. Genomic DNA was isolated from mothers and infants via buccal swabs and DNA was genotyped via tetra-primer amplification PCR. Our findings indicate that the COMT genotype was not significantly associated with late-onset PE. While there were no significant differences between African American and Caucasian races, the maternal COMT<sup>Met158Met</sup> genotype was significantly associated with early-onset preeclampsia in both African Americans and Caucasians when compared to COMT<sup>Val158Val</sup> or COMT<sup>Val158Met</sup>. These results suggest that the maternal COMT<sup>Met158Met</sup> genotype may be a risk factor for early-onset PE.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140887715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining Effective Patient-Provider Communication in Antenatal Settings across England: An In-Depth Analysis of Woman’s Experiences 研究英格兰产前护理机构中患者与护理人员之间的有效沟通：深入分析妇女的经历
medRxiv - Obstetrics and Gynecology Pub Date : 2024-05-03 DOI: 10.1101/2024.05.02.24306775
Martyna Andrzejczak, Gareth Elfed Jones, Gareth Anthony Nye
{"title":"Examining Effective Patient-Provider Communication in Antenatal Settings across England: An In-Depth Analysis of Woman’s Experiences","authors":"Martyna Andrzejczak, Gareth Elfed Jones, Gareth Anthony Nye","doi":"10.1101/2024.05.02.24306775","DOIUrl":"https://doi.org/10.1101/2024.05.02.24306775","url":null,"abstract":"Pregnancy requires appropriate guidance and support from healthcare professionals. Understanding women’s experiences of effective patient-provider communication through antenatal care is critical, as evidence suggests, inadequate communication could pose various risks to maternal and neonatal well-being. Despite efforts to modernise maternity services, recent assessments reveal persistent challenges, with nearly half of maternity services inspections categorised as ‘inadequate’ or ‘requires improvement’. This qualitative systematic review investigated effective patient-provider communication in antenatal care settings across England, contributing essential insights into women’s experiences and feelings from various backgrounds.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140928827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Usage of AMH as a determining test of fertility in women with polycystic ovary 2 syndrome (PCOS) 使用 AMH 作为多囊卵巢 2 综合征（PCOS）妇女生育能力的决定性检测指标
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-30 DOI: 10.1101/2024.04.29.24306527
Rita Grabowska
{"title":"Usage of AMH as a determining test of fertility in women with polycystic ovary 2 syndrome (PCOS)","authors":"Rita Grabowska","doi":"10.1101/2024.04.29.24306527","DOIUrl":"https://doi.org/10.1101/2024.04.29.24306527","url":null,"abstract":"PCOS is the most common hormonal disorder and cause of infertility in females of reproductive age. The symptoms and their severity vary strongly between particular cases. PCOS is correlated with hormonal, environmental and genetic factors. Complex interactions between genetics and hormonal levels is important to understand the hormonal 31 abnormality and to assess the chance of pregnancy in women with PCOS.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATING THE IMPACT OF COVID-19 ON THE PREGNANCY AND POSTNATAL PERIOD FOR UK WOMEN 评估 COVID-19 对英国妇女怀孕和产后期间的影响
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-30 DOI: 10.1101/2024.04.29.24306539
Gareth A Nye, George Abou Deb, Seóna Dunne
{"title":"EVALUATING THE IMPACT OF COVID-19 ON THE PREGNANCY AND POSTNATAL PERIOD FOR UK WOMEN","authors":"Gareth A Nye, George Abou Deb, Seóna Dunne","doi":"10.1101/2024.04.29.24306539","DOIUrl":"https://doi.org/10.1101/2024.04.29.24306539","url":null,"abstract":"<strong>INTRODUCTION</strong> Pregnancy is a crucial period which ultimately directly impacts two individuals health and wellbeing. Within the UK, a standardised pattern of care is established with collaborations across disciplines to the benefit of women and babies. During the COVID19 pandemic, this pattern of care was disrupted to align with protective protocols which until now, has not been formally reported.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating Musculoskeletal Pain Among Pregnant Women in Dhaka Division: A Cross-Sectional Study 调查达卡地区孕妇的肌肉骨骼疼痛：横断面研究
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-29 DOI: 10.1101/2024.04.27.24306482
Jalal Uddin, Shahida Sultana Shumi
{"title":"Investigating Musculoskeletal Pain Among Pregnant Women in Dhaka Division: A Cross-Sectional Study","authors":"Jalal Uddin, Shahida Sultana Shumi","doi":"10.1101/2024.04.27.24306482","DOIUrl":"https://doi.org/10.1101/2024.04.27.24306482","url":null,"abstract":"<strong>Objectives</strong> This study aimed to investigate musculoskeletal pain among pregnant women in Dhaka Division, Bangladesh, considering demographic factors, pain and pregnancy-related experiences.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Dural Puncture headache after caesarean section at a Tertiary Hospital in the Gambia 冈比亚一家三级医院剖腹产术后硬膜穿刺头痛的发病率
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-28 DOI: 10.1101/2024.04.25.24306406
Matthew Anyanwu, Admire Coker, Donkor Simon
{"title":"Prevalence of Dural Puncture headache after caesarean section at a Tertiary Hospital in the Gambia","authors":"Matthew Anyanwu, Admire Coker, Donkor Simon","doi":"10.1101/2024.04.25.24306406","DOIUrl":"https://doi.org/10.1101/2024.04.25.24306406","url":null,"abstract":"<strong>Background</strong> Following a caesarean section performed under spinal anaesthesia, a common complication is post-dural puncture headache (PDPH). Spinal anaesthesia has become the most common anaesthetic procedure during caesarean section in our practice. Therefore, knowing the prevalence and risk factors of PDPH will inform practice and add value in our obstetrics practice.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does anyone fit the average? Describing the heterogeneity of pregnancy symptoms using wearables and mobile apps 有人符合平均值吗？利用可穿戴设备和移动应用程序描述怀孕症状的异质性
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-27 DOI: 10.1101/2024.04.26.24306455
Sarah Goodday, Robin Yang, Emma Karlin, Jonell Tempero, Christiana Harry, Alexa Brooks, Tina Behrouzi, Jennifer Yu, Anna Goldenberg, Marra Francis, Daniel Karlin, Corey Centen, Sarah Smith, Stephen Friend
{"title":"Does anyone fit the average? Describing the heterogeneity of pregnancy symptoms using wearables and mobile apps","authors":"Sarah Goodday, Robin Yang, Emma Karlin, Jonell Tempero, Christiana Harry, Alexa Brooks, Tina Behrouzi, Jennifer Yu, Anna Goldenberg, Marra Francis, Daniel Karlin, Corey Centen, Sarah Smith, Stephen Friend","doi":"10.1101/2024.04.26.24306455","DOIUrl":"https://doi.org/10.1101/2024.04.26.24306455","url":null,"abstract":"Wearables, apps and other remote smart devices can capture rich, objective physiologic, metabolic, and behavioral information that is particularly relevant to pregnancy. The objectives of this paper were to 1) characterize individual level pregnancy self-reported symptoms and objective features from wearables compared to the aggregate; 2) determine whether pregnancy self-reported symptoms and objective features can differentiate pregnancy-related conditions; and 3) describe associations between self-reported symptoms and objective features. Data are from the Better Understanding the Metamorphosis of Pregnancy study, which followed individuals from preconception to three-months postpartum. Participants (18-40 years) were provided with an Oura smart ring, a Garmin smartwatch, and a Bodyport Cardiac Scale. They also used a study smartphone app with surveys and tasks to measure symptoms. Analyses included descriptive spaghetti plots for both individual-level data and cohort averages for select weekly reported symptoms and objective measures from wearables. This data was further stratified by pregnancy-related clinical conditions such as preeclampsia and preterm birth. Mean Spearman correlations between pairs of self-reported symptoms and objective features were estimated. Self-reported symptoms and objective features during pregnancy were highly heterogeneous between individuals. While some aggregate trends were notable, including an inflection in heart rate variability approximately eight weeks prior to delivery, these average trends were highly variable at the n-of-1 level, even among healthy individuals. Pregnancy conditions were not well differentiated by objective features. With the exception of self-reported swelling and body fluid volume, self-reported symptoms and objective features were weakly correlated (mean Spearman correlations &lt;0.1).","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140842167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modified one-step conservative surgery for placenta accreta spectrum versus caesarean hysterectomy: The CMNT PAS prospective comparative Non-Randomized pilot study 改良的一步法胎盘早剥保守手术与剖腹产子宫切除术：CMNT PAS 前瞻性比较非随机试验研究
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-15 DOI: 10.1101/2024.04.14.24305051
Hassine S Abouda, Haithem Aloui, Sofiene B Marzouk, Hatem Frikha, Rami Hammami, Rachid Hentati, Badis Chennoufi, Hayen Maghrebi
{"title":"Modified one-step conservative surgery for placenta accreta spectrum versus caesarean hysterectomy: The CMNT PAS prospective comparative Non-Randomized pilot study","authors":"Hassine S Abouda, Haithem Aloui, Sofiene B Marzouk, Hatem Frikha, Rami Hammami, Rachid Hentati, Badis Chennoufi, Hayen Maghrebi","doi":"10.1101/2024.04.14.24305051","DOIUrl":"https://doi.org/10.1101/2024.04.14.24305051","url":null,"abstract":"<strong>Introduction</strong> The surgical procedure known as one-step conservative surgery for placenta accreta spectrum involves the excision of the placenta and its attachment site on the myometrium. We aimed to conduct a non-randomized comparative study between conservative surgical treatment of placenta accreta spectrum and classical caesarean hysterectomy, under the name of the “CMNT PAS” study. To determine the sample size and the expected difference between the two groups, we conduct this pilot study.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140609073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Digital Landscape: A Comprehensive Analysis of Infertility Narratives on Instagram 探索数字景观：全面分析 Instagram 上的不孕不育叙事
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-09 DOI: 10.1101/2024.04.07.24305110
Abhijay Gillellamudi, Venkata Sujatha Vellanki, Binay Kumar Panjiyar
{"title":"Exploring the Digital Landscape: A Comprehensive Analysis of Infertility Narratives on Instagram","authors":"Abhijay Gillellamudi, Venkata Sujatha Vellanki, Binay Kumar Panjiyar","doi":"10.1101/2024.04.07.24305110","DOIUrl":"https://doi.org/10.1101/2024.04.07.24305110","url":null,"abstract":"In the digital age, the prevalence of infertility and the trend of delaying childbearing have significantly influenced fertility choices. Social media, particularly Instagram, has emerged as a vital part of daily life for many, with a notable percentage of American adults engaging daily. Recognizing the impact of online platforms, this cross-sectional observational study, conducted in May 2023, delved into the nature and quality of 673 Instagram posts related to infertility. It aimed to analyze the information and support available to individuals’ navigating infertility, particularly focusing on the posts DISCERN and Global Quality Scores (GQS) to assess their reliability and quality.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy 作为早产生物标志物的产妇阴道分泌物外泌体 miRNA：无创液体活检技术
medRxiv - Obstetrics and Gynecology Pub Date : 2024-04-03 DOI: 10.1101/2024.04.03.24304152
Taewoon Kim, Jee Yoon Park, Hyo Jin Lee, Bo young Choi, Hyeon Ji Kim, Luke P. Lee, Jong Wook Hong
{"title":"Exosomal miRNAs from maternal vaginal discharge as biomarkers for preterm labor: non-invasive liquid biopsy","authors":"Taewoon Kim, Jee Yoon Park, Hyo Jin Lee, Bo young Choi, Hyeon Ji Kim, Luke P. Lee, Jong Wook Hong","doi":"10.1101/2024.04.03.24304152","DOIUrl":"https://doi.org/10.1101/2024.04.03.24304152","url":null,"abstract":"Preterm labor is a serious issue that can lead to preterm birth, posing significant risks to both the mother and the neonate. Despite the high incidence of approximately 15 million preterm births worldwide per year, there is a lack of sufficient strategies for predicting and preventing preterm labor. Here, we found that exosomal miRNAs in maternal vaginal discharge can serve as biomarkers for early diagnosis of life-threatening conditions in both the mother and neonate. Our non-invasive biopsy of vaginal discharge using a swab allows us to isolate enriched exosomes via an advanced microfluidic platform called BEST (Biologically intact Exosome Separation Technology). We have identified specific miRNAs differentially expressed in mothers with preterm labor compared to those with full-term mothers. These miRNAs included hsa-miR-206, which was up-regulated in preterm labor, and hsa-miR-3674, hsa-miR-365a-5p, and hsa-miR-193b-3p, which were down-regulated. We believe our discovery of unique miRNAs as biomarkers can aid in early detection and effective treatment of preterm labor, potentially revolutionizing global healthcare.","PeriodicalId":501409,"journal":{"name":"medRxiv - Obstetrics and Gynecology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140596443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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