{"title":"Reply to: Vascularized reconstruction following extremity sarcoma resection – more than just a means to close a wound’","authors":"","doi":"10.1016/j.ejso.2024.108536","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108536","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"40 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141709779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Di Fiore, Rosa Drago‐Ferrante, S. Suleiman, Neville Calleja, J. Calleja-Agius
{"title":"The role of microRNA-9 in Ovarian and Cervical Cancers: an Updated Overview","authors":"R. Di Fiore, Rosa Drago‐Ferrante, S. Suleiman, Neville Calleja, J. Calleja-Agius","doi":"10.1016/j.ejso.2024.108546","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108546","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"58 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Raos, Nikolina Vučemilo Paripović, P. Ozretić, M. Sabol
{"title":"Current status of in vitro models for rare gynaecological cancer research","authors":"D. Raos, Nikolina Vučemilo Paripović, P. Ozretić, M. Sabol","doi":"10.1016/j.ejso.2024.108549","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108549","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"53 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141713436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T.M. Gilbert, L. Randle, M. Quinn, O. McGreevy, L. O’leary, R. Young, R. Diaz-Neito, R.P. Jones, B. Greenhalf, C. Goldring, S. Fenwick, H. Malik, D.H. Palmer
{"title":"Molecular biology of cholangiocarcinoma and its implications for targeted therapy in patient management","authors":"T.M. Gilbert, L. Randle, M. Quinn, O. McGreevy, L. O’leary, R. Young, R. Diaz-Neito, R.P. Jones, B. Greenhalf, C. Goldring, S. Fenwick, H. Malik, D.H. Palmer","doi":"10.1016/j.ejso.2024.108352","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108352","url":null,"abstract":"Cholangiocarcinoma (CCA) remains a devastating malignancy and a significant challenge to treat. The majority of CCA patients are diagnosed at an advanced stage, making the disease incurable in most cases. The advent of high-throughput genetic sequencing has significantly improved our understanding of the molecular biology underpinning cancer. The identification of ‘druggable’ genetic aberrations and the development of novel targeted therapies against them is opening up new treatment strategies. Currently, 3 targeted therapies are approved for use in CCA; Ivosidenib in patients with IDH1 mutations and Infigratinib/Pemigatinib in those with FGFR2 fusions. As our understanding of the biology underpinning CCA continues to improve it is highly likely that additional targeted therapies will become available in the near future. This is important, as it is thought up to 40 % of CCA patients harbour a potentially actionable mutation. In this review we provide an overview of the molecular pathogenesis of CCA and highlight currently available and potential future targeted treatments.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140803494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shady A. Saleem, Fatma El-Zahraa A. Mustafa, Hanan H. Abd-Elhafeez, Gilan A. Ahmed
{"title":"Congenital and gynecological tumors: A review","authors":"Shady A. Saleem, Fatma El-Zahraa A. Mustafa, Hanan H. Abd-Elhafeez, Gilan A. Ahmed","doi":"10.1016/j.ejso.2024.108316","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108316","url":null,"abstract":"Congenital tumors are rare, and malignant congenital tumors are uncommon. Benign tu,mors might be life-threatening, depending on the location and size of the tumor. Different factors affect congenital tumors, such as maternal and placental hormones and environmental factors such as drugs, radiation, and infection. Developing fetal imaging methods and continuous follow-up during pregnancy are important factors in congenital tumor prognosis. Ultrasound is the most common method used for fetal evaluation. The complementary evaluation method is MRI. Both methods are helpful and widely spread for the detection of congenital tumors. These imaging methods help the medical team make a suitable decision about therapy. Some of these tumors regressed spontaneously, and some need surgical treatments. Treatment of tumors has developed rapidly, and recently molecular-targeted drugs have been used.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140806464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulio Anichini, Maria Leiloglou, Zepeng Hu, Kevin O'Neill, Daniel Elson
{"title":"Hyperspectral and multispectral imaging in neurosurgery: a systematic literature review and meta-analysis","authors":"Giulio Anichini, Maria Leiloglou, Zepeng Hu, Kevin O'Neill, Daniel Elson","doi":"10.1016/j.ejso.2024.108293","DOIUrl":"https://doi.org/10.1016/j.ejso.2024.108293","url":null,"abstract":"The neuro-surgical community is witnessing a rising interest for surgical application of multispectral/hyperspectral imaging. Several potential technical applications of this optical imaging are reported, but the set-up is variable and so are the processing methods. We present a systematic review of the relevant literature on the topic. A literature search based on the PRISMA principles was performed on PubMed, SCOPUS, and Web of Science, using MESH terms and Boolean operators. Papers regarding intra-operative in-vivo application of multispectral and/or hyperspectral imaging in humans during neurosurgical procedures were included. Papers reporting technologies related to radiological applications were excluded. A meta-analysis on the performance metrics was also conducted. Our search string retrieved 20 papers. The main applications of optical imaging during neurosurgery concern tumour detection and improvement of the extent of resection (15 papers) or visualization of perfusion changes during neuro-oncology or neuro-vascular surgery (5 papers). All the retrieved articles were pilot studies, proof of concepts, or case reports, with limited number of patients recruited. Sensitivity, specificity, and accuracy were promising in most of the reports, but the metanalysis showed heterogeneous approaches and results among studies. The present review shows that several approaches are currently being tested to integrate hyperspectral imaging in neurosurgery, but most of the studies reported a limited pool of patients, with different approaches to data collection and analysis. Further studies on larger cohorts of patients are therefore desirable to fully explore the potential of this imaging technique.","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140799339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of microbiome involved in the development of second primary cancer in patients with breast cancer","authors":"Jeongshin An, Hyungju Kwon, Young Ju Kim","doi":"10.1016/j.ejso.2023.107327","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107327","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni Cisternino, Rosa Di Micco, Margherita Monticelli, Veronica Zuber, Sara Baleri, Elena Venturini, Carla Canevari, Patrizia Magnani, Nicole Rotmensz, Angelica Critelli, Annarita Savi, Michela Olivieri, Paola Silvia Corona, Francesca Calabretto, Mario Rampa, Pietro Panizza, Arturo Chiti, Isabella Sassi, Oreste Davide Gentilini
{"title":"High-resolution PET-CT imaging for intraoperative margin assessment in early-stage breast cancer: initial results from a prospective international clinical study.","authors":"Giovanni Cisternino, Rosa Di Micco, Margherita Monticelli, Veronica Zuber, Sara Baleri, Elena Venturini, Carla Canevari, Patrizia Magnani, Nicole Rotmensz, Angelica Critelli, Annarita Savi, Michela Olivieri, Paola Silvia Corona, Francesca Calabretto, Mario Rampa, Pietro Panizza, Arturo Chiti, Isabella Sassi, Oreste Davide Gentilini","doi":"10.1016/j.ejso.2023.107469","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107469","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"1993 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Boligo, Vasco Silva Cardoso, Miguel Trigo Silvestre, Joana Pedro Marques, Margarida Santos Bessa, Ana Rita Martins, Patrícia Amaral, Zacharoula Sidiropoulou
{"title":"Prevalence of Imaging Detected Silent Female Breast Cancer in Autopsy Specimens: Study of the Disease Held by Image-Guided Biopsies","authors":"Sofia Boligo, Vasco Silva Cardoso, Miguel Trigo Silvestre, Joana Pedro Marques, Margarida Santos Bessa, Ana Rita Martins, Patrícia Amaral, Zacharoula Sidiropoulou","doi":"10.1016/j.ejso.2023.107459","DOIUrl":"https://doi.org/10.1016/j.ejso.2023.107459","url":null,"abstract":"","PeriodicalId":501116,"journal":{"name":"European Journal of Surgical Oncology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}