Madeleine Bernet, Eva Soom Ammann, Alexander M Quaas, Michael von Wolff, Marianne Kläusler, Arndt Büssing
{"title":"\"It's like having a second job\": qualitative insights into the emotional burden of infertility and the need for coordinated care.","authors":"Madeleine Bernet, Eva Soom Ammann, Alexander M Quaas, Michael von Wolff, Marianne Kläusler, Arndt Büssing","doi":"10.1080/0167482X.2025.2505589","DOIUrl":"https://doi.org/10.1080/0167482X.2025.2505589","url":null,"abstract":"<p><p>Infertility, affecting one in six individuals worldwide, poses substantial emotional and physical challenges. Its impact on quality of life (QoL), mental health and social relationships is well documented. However, qualitative insights into the lived experiences of those affected remain limited, as do the perspectives of health professionals involved in their care. This study presents qualitative findings from a mixed-method approach. Data were collected through 23 semi-structured interviews with 26 affected individuals and three focus group discussions with 20 healthcare professionals. The results underscore the multifaceted burden of infertility, including emotional distress, relationship strain and a pervasive sense of social exclusion. Participants expressed a clear need for more empathetic and individualized care, while healthcare professionals pointed to structural barriers. The study also identified a lack of societal recognition for infertility and the complex challenges. In some narratives, spirituality emerged as a personal coping resource - though one that is often overlooked or insufficiently addressed in clinical practice. Key recommendations include the expansion of peer support networks, public awareness raising, flexible treatment models and interprofessional collaboration. Future research should evaluate the effectiveness of peer support systems and interdisciplinary care models in addressing the complex and diverse needs of individuals affected by infertility.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2505589"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michele D Levine, Riley J Jouppi, Rachel P Kolko Conlon, Christine C Call, Jennifer L Grace, Gina M Sweeny, Zijing Zhang
{"title":"Prenatal loss of control eating is associated with psychiatric symptoms and distress among individuals with elevated BMI.","authors":"Michele D Levine, Riley J Jouppi, Rachel P Kolko Conlon, Christine C Call, Jennifer L Grace, Gina M Sweeny, Zijing Zhang","doi":"10.1080/0167482X.2025.2483283","DOIUrl":"10.1080/0167482X.2025.2483283","url":null,"abstract":"<p><strong>Purpose: </strong>Loss of control while eating (LOC) or feeling unable to control the amount or type of food consumed during an eating episode, is the core psychopathology in binge eating disorders. Yet, the impact of LOC on other psychiatric symptoms during pregnancy is not known. This study evaluated the contribution of prenatal LOC to psychological distress and disordered eating attitudes.</p><p><strong>Methods: </strong>Pregnant individuals with BMI ≥ 25 (<i>N</i> = 312) recruited for a perinatal health promotion trial self-reported past-month LOC; eating, shape, and weight concerns; prenatal depressive symptoms, anxiety, and stress. Propensity scores were used to reduce bias associated with cross-sectional data.</p><p><strong>Results: </strong>Overall, 34.3% (<i>n</i> = 107) reported LOC. Individuals with prenatal LOC, relative to those without, endorsed more eating disorder symptoms (<i>p</i>s<.001) as well as more symptoms of depression (7.1<math><mrow><mo>±</mo></mrow></math>0.3 vs. 5.4<math><mrow><mo>±</mo></mrow></math>4.9) and anxiety (38.1 ± 11.7 vs. 33.4 ± 11.7) and greater perceived stress (25.0 ± 7.9 vs. 22.0<math><mrow><mo>±</mo></mrow></math>9.9, <i>p</i>s<.001). LOC frequency was associated with significantly more prenatal psychological distress, beyond the effect of other factors that increase the likelihood of LOC. <i>(ps</i><.005).</p><p><strong>Conclusions: </strong>Among individuals with elevated BMI, prenatal LOC is common and relates to eating disorder and other psychiatric symptoms. Prenatal LOC may represent a behavioral mechanism for improved psychological health.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2483283"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Konstantin Hofmann, Susanne Singer, Susanne Theis, Anna Dionysopoulou, Lina Schiestl, Yaman Degirmenci, Annette Hasenburg, Roxana Schwab, Christine Skala
{"title":"Mental state and health-related quality of life in patients with polycystic ovary syndrome under metformin therapy - a prospective study.","authors":"Konstantin Hofmann, Susanne Singer, Susanne Theis, Anna Dionysopoulou, Lina Schiestl, Yaman Degirmenci, Annette Hasenburg, Roxana Schwab, Christine Skala","doi":"10.1080/0167482X.2025.2516669","DOIUrl":"https://doi.org/10.1080/0167482X.2025.2516669","url":null,"abstract":"<p><p>PCOS is one of the most prevalent endocrine disorders among women of reproductive age, often involving obesity, insulin resistance, and mental health challenges that reduce health-related quality of life (HRQOL). Although metformin has been shown to improve HRQOL in PCOS patients, it is unclear whether this effect is due to the drug itself or its metabolic benefits. This study included 66 PCOS patients from the University Medical Center Mainz, in two groups: 31 received metformin (M-group) and 35 received alternative or no treatment (C-group). HRQOL and distress were assessed at baseline and after 6 months using the Modified PCOS-Questionnaire (MPCOSQ) and the Hospital Anxiety and Depression Scale (HADS). At baseline, the M-group had significantly worse metabolic markers, including HOMA-IR, waist circumference, Visceral Adiposity Index, and Fatty Liver Index. By follow-up, this group showed greater improvements in these markers. However, both groups improved similarly in HRQOL and distress. Regression analysis revealed that improvements in HOMA-IR and BMI were associated with better HRQOL scores. Group assignment was not a significant predictor. These findings may indicate that improvements in HRQOL and reduced distress are linked to metabolic changes associated with metformin use, underscoring the potential relevance of addressing metabolic health in treatment approaches.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2516669"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effects of music therapy on pain and anxiety in young nulliparous patients undergoing laparoscopic cystectomy for endometriosis: a randomized controlled trial.","authors":"Wenwei Li, Huiyan Feng, Xiaohui Yang, Yue Meng, Yuebo Yang, Qingjian Ye","doi":"10.1080/0167482X.2025.2519385","DOIUrl":"10.1080/0167482X.2025.2519385","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis (EMS) is associated with a markedly increased incidence of depression and anxiety, primarily due to cyclic pain, concerns about infertility from impaired ovarian function, and fear of disease recurrence. Surgery and its associated pain may trigger both emotional and physiological stress responses. Young, nulliparous patients with fertility intentions often experience additional psychological burdens related to surgical safety, postoperative recovery, and the potential impact on future fertility. Music has been shown to promote relaxation, reduce tension and anxiety, and alleviate pain. However, no studies have evaluated the postoperative effects of music therapy in this specific patient population.</p><p><strong>Objective: </strong>To investigate whether music therapy can effectively reduce postoperative pain and alleviate perioperative anxiety in young patients with fertility desires undergoing laparoscopic cystectomy for endometriotic ovarian cysts, and to explore its potential as a simple, non-pharmacological intervention.</p><p><strong>Methods/design: </strong>A single-center, two-arm, single-masked randomized controlled trial (RCT).</p><p><strong>Setting: </strong>The Third Affiliated Hospital of Sun Yat-sen University (a teaching hospital).</p><p><strong>Participants: </strong>A total of 149 patients were included for analysis, with 75 assigned to the music group and 74 to the control group.</p><p><strong>Intervention: </strong>Perioperative music therapy administered to young, nulliparous patients with fertility intentions undergoing laparoscopic cystectomy for EMS.</p><p><strong>Results: </strong>One participant withdrew during follow-up, and 149 patients were included in the final analysis. Baseline characteristics-including age, BMI, marital status, preoperative VAS scores, and GAD-7 scores and anxiety levels-showed no significant differences between groups. Postoperative VAS scores at 6 h (<i>p</i> = 0.20), Day 1 (<i>p</i> = 0.438), Day 3 (<i>p</i> = 0.714), and Day 7 (<i>p</i> = 0.899) revealed no significant differences. Similarly, GAD-7 scores and anxiety severity levels on postoperative Day 1 (<i>p</i> = 0.541; <i>p</i> = 0.984), Day 3 (<i>p</i> = 0.287; <i>p</i> = 0.436), and Day 7 (<i>p</i> = 0.468; <i>p</i> = 0.703) showed no statistical significance between groups.</p><p><strong>Conclusion: </strong>Music therapy may serve as an adjunctive intervention for young, nulliparous patients with fertility intentions undergoing laparoscopic cystectomy for endometriosis; however, no significant effects were observed in reducing perioperative anxiety or postoperative pain in this population.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2519385"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Blok L J, Eysbouts Y K, Bastiaans S, Sweep F C G J, Ottevanger P B
{"title":"Evaluation of the psychosocial impact and received care in patients with gestational trophoblastic disease - a qualitative interview based study.","authors":"Blok L J, Eysbouts Y K, Bastiaans S, Sweep F C G J, Ottevanger P B","doi":"10.1080/0167482X.2025.2451992","DOIUrl":"10.1080/0167482X.2025.2451992","url":null,"abstract":"<p><p>The diagnosis gestational trophoblastic disease (GTD) is known to have a significant psychological impact on women. Our objective was to provide insight in the psychological and physical consequences of women with GTD, while also reflecting on their coping strategies and their experiences of received care. A qualitative study was carried out using semi-structured interviews among women recently diagnosed with GTD. Interviews were audio-recorded, transcribed verbatim and analyzed using a thematic network approach. Eight interviews were analyzed. The abruptness of the diagnosis resulted in women feeling sad, uncertain and powerless. Coping strategies included seeking emotional support, accurate information, peer connections and distraction. Women were generally satisfied with care, emphasizing personalization, empathy, medical expertise and feeling heard as important aspects. They appreciated offered psychological support from specialized nurses. Nevertheless, aspects such as provided information, communication and logistical issues need improvement. The results of this study emphasize the importance of comprehensive patient information, the need for personalized psychological support and more frequent consultations at reference centers, while treatment is conducted locally.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2451992"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao-Lan Zhou, Yu-Rou Wei, Guo-Fen Cao, Su-Mei Zhang, Lei Yang, Xiao-Mei Li
{"title":"Comparison of the W-DEQ and CAQ in assessing FOC among pregnant women in China.","authors":"Xiao-Lan Zhou, Yu-Rou Wei, Guo-Fen Cao, Su-Mei Zhang, Lei Yang, Xiao-Mei Li","doi":"10.1080/0167482X.2025.2469178","DOIUrl":"10.1080/0167482X.2025.2469178","url":null,"abstract":"<p><p>This study compared the efficacy of the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) and the Childbirth Attitudes Questionnaire (CAQ) in assessing fear of childbirth (FOC) among hospitalized pregnant women, aiming to identify a practical screening tool. A total of 184 pregnant women were recruited from the Northwest Women's and Children's Hospital using convenience sampling. Data were collected through the General Demographic Questionnaire, Fear of Birth Scale (FOBS), W-DEQ, and CAQ. Using the FOBS as a reference, the diagnostic performance of the W-DEQ and CAQ was evaluated <i>via</i> receiver operating characteristic curves and Bayesian discriminant analysis. The area under the curve (AUC) for the W-DEQ (0.888) was significantly higher than that of the CAQ (0.789; Z = -2.189, <i>p</i> < 0.05). Optimal cutoff values were 80.5 for the W-DEQ and 31.5 for the CAQ. Cross-validation revealed accuracy rates of 75.6% and 70.7%, respectively. The incidence of FOC, as assessed by the W-DEQ, CAQ, and FOBS, was 29.9%, 43.9%, and 37.2%. Both tools demonstrated good reliability and validity, but the W-DEQ showed superior performance. It is recommended as the preferred tool for assessing FOC among pregnant women in China due to its comprehensive evaluation capacity.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2469178"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long working hours related to elevated psychological distress among United States pregnant workers: findings from the National Health Interview Survey.","authors":"Megan Guardiano, Tong Xia, Liwei Chen, Jian Li","doi":"10.1080/0167482X.2025.2521780","DOIUrl":"10.1080/0167482X.2025.2521780","url":null,"abstract":"<p><p>Long working hours and psychological distress have each been related to adverse maternal health and birth outcomes. Understanding the potential psychological health impacts of long working hours among pregnant workers may support the implementation of maternity work protections in the United States (U.S.). This cross-sectional study among a weighted sample of 3637 pregnant workers from the U.S. population-based National Health Interview Survey (NHIS) 1997-2018 aimed to examine the association of working hours with psychological distress. Multivariable linear regression models analyzed associations between categories of weekly working hours and continuous scores of psychological distress measured by the Kessler 6 (K6) scale, while accounting for demographic, socioeconomic, behavior and health characteristics. In the fully adjusted model, compared to the standard workweek of 35-40 h/week, working ≥49 h/week was associated with higher psychological distress [<i>β</i> (SE): 0.59 (0.21); <i>p</i> = .0058]. This initial evidence connecting excessive working hours with increased psychological distress among a U.S. sample of pregnant women supports clinical practices in prenatal assessments of occupational risk factors, and the provision of work-related resources and work accommodations. Future research is warranted to investigate potential occupational effects on maternal mental health throughout the course of pregnancy and postpartum using cohort studies.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2521780"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meike K Blecker, Daria Daehn, Sinha Engel, Susann Steudte-Schmiedgen, Susan Garthus-Niegel, Christine Knaevelsrud, Sarah Schumacher
{"title":"Childbirth-related posttraumatic stress symptoms: exploring the predictive potential of intrapartum hotspots.","authors":"Meike K Blecker, Daria Daehn, Sinha Engel, Susann Steudte-Schmiedgen, Susan Garthus-Niegel, Christine Knaevelsrud, Sarah Schumacher","doi":"10.1080/0167482X.2025.2469290","DOIUrl":"10.1080/0167482X.2025.2469290","url":null,"abstract":"<p><p>Childbirth-related posttraumatic stress symptoms (CB-PTSS) affect around 12% of postpartum individuals. While the subjective experience of childbirth is a key predictor of CB-PTSS, the specific defining characteristics of negative birth experiences remain poorly understood. This study aims to refine our understanding of negative birth experiences by investigating intrapartum hotspots, i.e. moments of extreme distress, and their association with CB-PTSS. In a cross-sectional study of <i>N</i> = 1,140 individuals who had given birth eight to ten weeks before, we examined the following: the types of hotspots, differences in hotspot-related distress, interpersonal difficulties during the hotspot, and CB-PTSS between the various types of hotspots and whether hotspot-related distress and interpersonal difficulties independently predicted CB-PTSS. Participants completed several items based on previous qualitative work [1] to assess the worst hotspot, hotspot-related distress, and interpersonal difficulties during the hotspot and the City Birth Trauma Scale to measure CB-PTSS, alongside relevant pregnancy- and birth-related questions. <i>Medical interventions</i> were the most frequently experienced worst hotspot and <i>separation from the child</i> was associated with the highest levels of hotspot-related distress, interpersonal difficulties, and CB-PTSS. Hotspot-related distress and interpersonal difficulties independently predicted CB-PTSS. Examining intrapartum hotspots poses a promising approach to define highly negative birth experiences.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2469290"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mindfulness-based body scan training in multimodal physiotherapy for vulvodynia - a randomized controlled feasibility study.","authors":"Heidi Halbedl, Daniela Melitta Pfabigan, Irene Ebhardt, Gerda Trutnovsky","doi":"10.1080/0167482X.2025.2531057","DOIUrl":"10.1080/0167482X.2025.2531057","url":null,"abstract":"<p><p>This randomized controlled trial explored the feasibility and preliminary effectiveness of integrating mindfulness-based body scan (MBBS) interventions into multimodal pelvic floor physiotherapy for vulvodynia treatment. Participants received ten sessions of standardized physiotherapy. The mindfulness intervention group was instructed to additionally perform home-based audio-file guided MBBS five times a week. The primary study endpoint was feasibility. The effect on pain intensity, pain characteristics and sexuality were assessed with Numeric Rating scales (NRS), the McGill-Melzack Pain Questionnaire (MPQ), the Female Sexual Distress Scale (FSDS) and Female Sexual Function Index (FSFI) and digital assessment of pelvic floor. Thirty-three women were randomized and completed the end-of-treatment assessments and 26 (79%) attended the follow-up. 15 of 17 participants of the intervention group (88%) performed the body scans more than ten times and the feasibility criteria were achieved. The intervention group showed significantly better improvements in NRS of average pain, MPQ subscales and FSDS total score. Pelvic floor assessment showed a significant improvement of myofascial pressure points over time with no difference between study groups. Integration of MBBS trainings into multimodal pelvic floor physiotherapy for vulvodynia is feasible and well accepted and may improve pain reduction and sexual function.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2531057"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xu Yu, Jingya Nie, Lifang Zhou, Yubin Mao, Yanping Jiang
{"title":"Association between mental health and HPV in American women: an analysis based on the 2005-2016 NHANES database.","authors":"Xu Yu, Jingya Nie, Lifang Zhou, Yubin Mao, Yanping Jiang","doi":"10.1080/0167482X.2025.2541955","DOIUrl":"10.1080/0167482X.2025.2541955","url":null,"abstract":"<p><strong>Background: </strong>Human papillomavirus (HPV) is one of the most prevalent sexually transmitted infections (STIs). Individuals with depression face higher risks of other STIs; however, the relationship between depression and HPV remains unclear.</p><p><strong>Objective: </strong>To investigate the association between depression and HPV among American women.</p><p><strong>Methods: </strong>Data were sourced from the National Health and Nutrition Examination Survey (NHANES) conducted from 2005 to 2016. We employed weighted logistic regression models to explore the relationship between depression scores, depressive states, depression severity and HPV infection risk. The stability of intergroup relationships was assessed by subgroup analyses.</p><p><strong>Results: </strong>Seven thousand and twenty-four American women were included, including 3138 HPV-positive individuals. Logistic regression analyses revealed a significant positive correlation between increased depression scores (OR = 1.02, 95% CI: 1.00-1.03, <i>p</i> = .009) and the presence of depression (OR = 1.33, 95% CI: 1.07-1.65, <i>p</i> = .010) with HPV infection risk. The HPV infection risk was elevated in the moderate depression group (OR = 1.32, 95% CI = 1.02-1.70, <i>p</i> = .036). Subgroup analyses indicated that marital status, body mass index and sexual activity frequency interacted with the relationship between depression and HPV (<i>p-</i>interaction < .05).</p><p><strong>Conclusions: </strong>Our findings highlight an association between depression and increased HPV infection risk among American women, underscoring the importance of enhancing HPV protection awareness among women with depression.</p>","PeriodicalId":50072,"journal":{"name":"Journal of Psychosomatic Obstetrics & Gynecology","volume":"46 1","pages":"2541955"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144849521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}