PRX Life最新文献_第2页

Ion Channels in Critical Membranes: Clustering, Cooperativity, and Memory Effects 临界膜中的离子通道：集群、合作和记忆效应

PRX Life Pub Date : 2024-01-15 DOI: 10.1103/prxlife.2.013007

A. Suma, Daniel Sigg, Séamus Gallagher, G. Gonnella, Vincenzo Carnevale

引用次数: 0

Phenotypic Variability Shapes Bacterial Responses to Opposing Gradients 表型变异性决定了细菌对相反梯度的反应

PRX Life Pub Date : 2024-01-09 DOI: 10.1103/prxlife.2.013001

Lusi Li, Xuanqi Zhang, Yanhong Sun, Ouyang Qi, Yuhai Tu, Chunxiong Luo

引用次数: 0

Interplay Between Mechanosensitive Adhesions and Membrane Tension Regulates Cell Motility 机械敏感粘附和膜张力之间的相互作用调控着细胞的运动性

PRX Life Pub Date : 2023-12-06 DOI: 10.1103/prxlife.1.023007

Yuzhu Chen, D. Saintillan, P. Rangamani

{"title":"Interplay Between Mechanosensitive Adhesions and Membrane Tension Regulates Cell Motility","authors":"Yuzhu Chen, D. Saintillan, P. Rangamani","doi":"10.1103/prxlife.1.023007","DOIUrl":"https://doi.org/10.1103/prxlife.1.023007","url":null,"abstract":"The initiation of directional cell motion requires symmetry breaking that can happen with or without external stimuli. During cell crawling, forces generated by the cytoskeleton and their transmission through mechanosen-sitive adhesions to the extracellular substrate play a crucial role. In a recently proposed one-dimensional model [P. Sens, Proc. Natl. Acad. Sci. USA 117 , 24670 (2020)], a mechanical feedback loop between force-sensitive adhesions and cell tension was shown to be sufﬁcient to explain spontaneous symmetry breaking and multiple motility patterns through stick-slip dynamics, without the need to account for signaling networks or active polar gels. We extend this model to two dimensions to study the interplay between cell shape and mechanics during crawling. Through a local force balance along a deformable boundary, we show that the membrane tension coupled with shape change can regulate the spatiotemporal evolution of the stochastic binding of mechanosensitive adhesions. Linear stability analysis identiﬁes the unstable parameter regimes where spontaneous symmetry breaking can take place. Using simulations to solve the fully coupled nonlinear system of equations, we show that, starting from a randomly perturbed circular shape, this instability can lead to keratocyte-like shapes. Simulations predict that different adhesion kinetics and membrane tension can result in different cell motility modes including gliding, zigzag, rotating, and sometimes chaotic movements. Thus, using a minimal model of cell motility, we identify that the interplay between adhesions and tension can select emergent motility modes. DOI: 10.1103/PRXLife.1.023007","PeriodicalId":500583,"journal":{"name":"PRX Life","volume":"68 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of Single- versus Multi-State Allostery 单态变构与多态变构的出现

PRX Life Pub Date : 2023-11-09 DOI: 10.1103/prxlife.1.023004

Eric Rouviere, Rama Ranganathan, Olivier Rivoire

{"title":"Emergence of Single- versus Multi-State Allostery","authors":"Eric Rouviere, Rama Ranganathan, Olivier Rivoire","doi":"10.1103/prxlife.1.023004","DOIUrl":"https://doi.org/10.1103/prxlife.1.023004","url":null,"abstract":"Several physical mechanisms have been proposed to explain allostery in proteins. They differ by the number of internal states that they assume a protein to occupy, leaving open the question of what controls the emergence of these distinct physical forms of allostery. Here, we analyze a simplified model of protein allostery under a range of physical and evolutionary constraints. We find that a continuum of mechanisms between two archetypes emerges through evolution. In one limit, a single-state mechanism exists where ligand binding induces a displacement along a single normal mode, and in the other limit, a multi-state mechanism exists where ligand binding induces a switch across an energy barrier to a different stable state. Importantly, whenever the two mechanisms are possible, the multi-state mechanism confers a stronger allosteric effect and thus a selective advantage. This work defines the essential constraints that distinguish single- and multi-state allostery and sets the stage for a physical theory of its evolutionary origins.Received 18 September 2022Revised 22 May 2023Accepted 21 September 2023DOI:https://doi.org/10.1103/PRXLife.1.023004Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.Published by the American Physical SocietyPhysics Subject Headings (PhySH)Research AreasBiomolecular structureMolecular evolutionProtein dynamics, structure & functionPhysical SystemsProteinsPhysics of Living Systems","PeriodicalId":500583,"journal":{"name":"PRX Life","volume":" 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semantic Information in a Model of Resource Gathering Agents 资源收集代理模型中的语义信息

PRX Life Pub Date : 2023-10-17 DOI: 10.1103/prxlife.1.023003

Damian R. Sowinski, Jonathan Carroll-Nellenback, Robert N. Markwick, Jordi Piñero, Marcelo Gleiser, Artemy Kolchinsky, Gourab Ghoshal, Adam Frank

引用次数: 0

Odd Elastohydrodynamics: Non-Reciprocal Living Material in a Viscous Fluid 奇弹性流体力学:粘性流体中的非互易活性物质

PRX Life Pub Date : 2023-10-11 DOI: 10.1103/prxlife.1.023002

Kenta Ishimoto, Clément Moreau, Kento Yasuda

引用次数: 0

Connecting cooperative transport by ants with the physics of self-propelled particles 将蚂蚁的合作运输与自推进粒子的物理学联系起来

PRX Life Pub Date : 2023-10-05 DOI: 10.1103/prxlife.1.023001

Tabea Heckenthaler, Tobias Holder, Ariel Amir, Ofer Feinerman, Ehud Fonio