Journal of the Korean Surgical Society最新文献_第3页

Evaluation of cytolytic activity and phenotypic changes of circulating blood immune cells in patients with colorectal cancer by a simple preparation of peripheral blood mononuclear cells. 简单制备外周血单核细胞评价结直肠癌患者循环血液免疫细胞的细胞溶解活性和表型变化。

Journal of the Korean Surgical Society Pub Date : 2013-11-01 Epub Date: 2013-10-25 DOI: 10.4174/jkss.2013.85.5.230

Jae Cheol Kim, Joungbum Choi, Su Jin Lee, Yun A Lee, Young Min Jeon, Yong Won Kang, Jong Kyun Lee

{"title":"Evaluation of cytolytic activity and phenotypic changes of circulating blood immune cells in patients with colorectal cancer by a simple preparation of peripheral blood mononuclear cells.","authors":"Jae Cheol Kim, Joungbum Choi, Su Jin Lee, Yun A Lee, Young Min Jeon, Yong Won Kang, Jong Kyun Lee","doi":"10.4174/jkss.2013.85.5.230","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.5.230","url":null,"abstract":"Purpose: This study aimed to assess the cytolytic activity and the phenotype of circulating blood immune cells in cancer patients by using a simple preparation of peripheral blood mononuclear cells (PBMCs).Methods: Peripheral blood was obtained from 94 diagnosed colorectal cancer (CRC) patients and 112 healthy donors. PBMCs were cocultured with K562 cells for 2 hours and lactate dehydrogenase released from the dead K562 cells was measured by using a spectrophotometer. Meanwhile, PBMCs were stained with fluorescence conjugated monoclonal antibodies (mAbs) and analyzed by flow cytometry.Results: The cytolytic activity of PBMCs were significantly different between CRC patient and healthy groups (8.82% ± 3.84% vs. 17.51% ± 8.57%; P < 0.001). However, no significant difference in the cytolytic activity was observed after surgery in the CRC patient group (before surgery, 8.82% ± 3.84% vs. after surgery, 9.95% ± 4.94%; P = 0.326). In addition, the percentage of peripheral blood natural killer cells was significantly higher in the preoperative patient group than in the healthy group (19.97% ± 11.51% vs. 15.60% ± 5.77%, P = 0.041). In contrast, the percentage of peripheral blood lymphocytes was lower in the preoperative patient group than in the healthy group (28.41% ± 8.31% vs. 36.4% ± 8.6%, P < 0.001).Conclusion: These results demonstrate that circulating blood immune cells of CRC patients are functionally impaired and undergo an immunophenotypic perturbation, and show that a simple preparation of PBMCs can be useful to evaluate cellular immunity in cancer.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 5","pages":"230-5"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.5.230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31893143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Comparison of Limberg flap and excision and primary closure of pilonidal sinus disease, in terms of quality of life and complications. Limberg皮瓣与毛突窦疾病切除和一期关闭的生活质量和并发症的比较。

Journal of the Korean Surgical Society Pub Date : 2013-11-01 Epub Date: 2013-10-25 DOI: 10.4174/jkss.2013.85.5.236

Ahmet Serdar Karaca, Rıdvan Ali, Muzaffer Capar, Sezar Karaca

{"title":"Comparison of Limberg flap and excision and primary closure of pilonidal sinus disease, in terms of quality of life and complications.","authors":"Ahmet Serdar Karaca, Rıdvan Ali, Muzaffer Capar, Sezar Karaca","doi":"10.4174/jkss.2013.85.5.236","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.5.236","url":null,"abstract":"Purpose: The aim of this study was to compare two different treatment methods for pilonidal sinus with respect to complications, recurrence, and patient quality of life.Methods: Five hundred forty-nine patients who underwent surgery for pilonidal sinus between January 2007 and August 2012 were included in this study. The patients were classified into group I (excision and primary closure) and group II (Limberg flap).Results: There was no significant difference in the mean age and gender of the patients between groups I and II (P = 0.512 and P = 0.472). The duration of surgical operation was lower in group I (P < 0.001). There was no significant difference in hospitalization time after surgery, minor complications, and recurrence between the groups (P = 0.674, P = 1.000, and P = 1.000, respectively). The time required for pain-free walking, urinating, and returning to work was significantly lower in group II (P < 0.001, P < 0.001, and P < 0.001, respectively). The patients in group I stated that they were more satisfied in terms of aesthetics (P < 0.001).Conclusion: According to the results of this study, Limberg flap method has better outcomes compared with excision and primary closure. Therefore, we recommend Limberg flap for treatment of pilonidal sinus disease.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 5","pages":"236-9"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.5.236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31893144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

The effects of flavanoid on the treatment of hepatopulmonary syndrome. 黄酮类化合物治疗肝肺综合征的疗效观察。

Journal of the Korean Surgical Society Pub Date : 2013-11-01 Epub Date: 2013-10-25 DOI: 10.4174/jkss.2013.85.5.219

Talha Atalay, Murat Cakir, Ahmet Tekin, Tevfik Kucukkartallar, Suleyman Kargin, Adil Kartal, Adnan Kaynak

{"title":"The effects of flavanoid on the treatment of hepatopulmonary syndrome.","authors":"Talha Atalay, Murat Cakir, Ahmet Tekin, Tevfik Kucukkartallar, Suleyman Kargin, Adil Kartal, Adnan Kaynak","doi":"10.4174/jkss.2013.85.5.219","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.5.219","url":null,"abstract":"Purpose: Hepatopulmonary syndrome is an arterial oxygenation disorder brought about by advanced liver failure and pulmonary vascular dilatations. The reason why hypoxia develops in hepatopulmonary syndrome depends on the broadening of perialveolar capillary veins. Our study aims to investigate the effects of Flavanoid on hepatopulmonary syndrome through its inhibition of nitric oxide.Methods: Three groups, each having 8 rats, were formed within the scope of our study. Group I (the control group) only received laparatomy, group II received choledoch ligation, and group III was administered Flavanoid (90% flavonoid diosmin, 10% flavonoid hesperidin) following choledoch ligation. The rats were administered Flavanoid at week two following choledoch ligation. The rats' livers and lungs were examined histopathologically following a five-week follow-up and the perialveolar vein diameters were measured. Arterial blood gases and biochemical parameters were evaluated.Results: It was seen that fibrosis and oxidative damage in the liver with obstructive jaundice as well as hypoxia with pulmonary perialveolar vein sizes were significantly lower than the other group with cirrhosis formed through the administration of Flavanoid.Conclusion: We have concluded that Flavanoid administration might be useful in the treatment of hypoxia in hepatopulmonary syndrome and the delay of cirrhosis contraction.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 5","pages":"219-24"},"PeriodicalIF":0.0,"publicationDate":"2013-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.5.219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31892675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A preliminary study: aspirin discontinuation before elective operations; when is the optimal timing? 初步研究:择期手术前停用阿司匹林;什么时候是最佳时机?

Journal of the Korean Surgical Society Pub Date : 2013-10-01 Epub Date: 2013-09-30 DOI: 10.4174/jkss.2013.85.4.185

Kamil Gulpinar, Suleyman Ozdemir, Erpulat Ozis, Zafer Sahli, Selda Demirtas, Atilla Korkmaz

{"title":"A preliminary study: aspirin discontinuation before elective operations; when is the optimal timing?","authors":"Kamil Gulpinar, Suleyman Ozdemir, Erpulat Ozis, Zafer Sahli, Selda Demirtas, Atilla Korkmaz","doi":"10.4174/jkss.2013.85.4.185","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.4.185","url":null,"abstract":"Purpose: To evaluate the optimum timing of aspirin cessation before noncardiac surgeries. We have conducted a pilot study to minimize the aspirin cessation time before various surgeries.Methods: Eighty patients who were taking regular aspirin for secondary prevention undergoing elective surgical operations were enrolled in the study. We separated the patients into two groups. The control group had 35 patients who stopped aspirin intake 10 days before surgery. The study group had 45 patients who stopped their aspirin intake and underwent surgery one day after arachidonic acid aggregation tests were within normal limits. Bleeding, blood loss, and transfusion requirements were assessed perioperatively.Results: The mean time between aspirin cessation and aspirin nonresponsiveness were found to be 4.2 days with a median value of 4 days. In addition, the mean time between aspirin cessation and operation day were found to be 5.5 days with a median value of 5 days. No perioperative bleeding, thromboembolic or cardiovascular complications were encountered.Conclusion: Reducing time of aspirin cessation from 7-10 days to 4-5 days is a possibility for patients using aspirin for secondary prevention without increased perioperative complications.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 4","pages":"185-90"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.4.185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The cutoff value of saphenous vein diameter to predict reflux. 预测反流的隐静脉直径临界值。

Journal of the Korean Surgical Society Pub Date : 2013-10-01 Epub Date: 2013-09-30 DOI: 10.4174/jkss.2013.85.4.169

Jin Hyun Joh, Ho-Chul Park

{"title":"The cutoff value of saphenous vein diameter to predict reflux.","authors":"Jin Hyun Joh, Ho-Chul Park","doi":"10.4174/jkss.2013.85.4.169","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.4.169","url":null,"abstract":"Purpose: Increased saphenous vein diameter is a common consequence of saphenous vein reflux. Until now, there have been no reports about the correlation between diameter and reflux of saphenous vein in Korea. The aim of this study was to investigate the correlation between saphenous vein reflux and diameter changes.Methods: From April 2009 to August 2012, 777 patients were sent to the vascular laboratory for evaluation of venous reflux. The diameter of the saphenous vein was measured with B-mode imaging, and reflux was quantified based on valve closure time using Doppler spectral tracings. Receiver operating characteristics curve analysis was applied to determine the best saphenous vein diameter cutoff for predicting reflux.Results: The mean diameters of normal great saphenous vein (GSV) and refluxed GSV were 5.0 ± 2.4 mm and 6.4 ± 2.0 mm, respectively. The mean diameters of normal small saphenous vein (SSV) and refluxed SSV were 3.1 ± 1.3 mm and 5.2 ± 2.7 mm, respectively. The diameter differences between the normal and refluxed GSV and SSV were 1.4 mm and 2.1 mm, respectively, and these differences were statistically significant (P < 0.0001). A GSV threshold diameter of 5.05 mm had the best positive predictive value for reflux. The sensitivity and specificity at 5.05 mm were 76% and 60%, respectively. The best SSV diameter for predicting reflux was 3.55 mm. The sensitivity and specificity at 3.55 mm were 87% and 71%, respectively.Conclusion: GSV diameter of ≥5.05 mm had the best positive predictive value for pathologic reflux. For pathologic reflux of SSV, the best cutoff diameter was 3.55 mm.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 4","pages":"169-74"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.4.169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Inguinal hernia developed after radical retropubic surgery for prostate cancer. 腹股沟疝是前列腺癌根治性耻骨后手术后发生的。

Journal of the Korean Surgical Society Pub Date : 2013-10-01 Epub Date: 2013-09-30 DOI: 10.4174/jkss.2013.85.4.175

Choon Sik Chung, Gyu Young Jeong, Seung Han Kim, Dong Keun Lee

{"title":"Inguinal hernia developed after radical retropubic surgery for prostate cancer.","authors":"Choon Sik Chung, Gyu Young Jeong, Seung Han Kim, Dong Keun Lee","doi":"10.4174/jkss.2013.85.4.175","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.4.175","url":null,"abstract":"Purpose: In this retrospective study, we aimed to compare the clinical characteristics of inguinal hernia developed after radical retropubic surgery for prostate cancer to the hernia without previous radical prostatectomy.Methods: Twenty-three patients (group A) who had radical retropubic surgery for prostate cancer underwent laparoscopic or open tension-free inguinal hernia repair from March 2007 to February 2011. Nine hundred and forty patients (group B) without previous radical retropubic surgery received laparoscopic or tension-free open hernia operation.Results: Group A was older than group B (mean ± standard deviation, 69.6 ± 7.2 vs. 54.1 ± 16.1; P < 0.001). Right side (73.9%) and indirect type (91.3%) in group A were more prevalent than in group B (51.5% and 69.4%, respectively) with statistic significance (P = 0.020 and P = 0.023). The rate of laparoscopic surgery in group B (n = 862, 91.7%) was higher than in group A (n = 14, 64.3%, P < 0.001). In comparing perioperative variables between the two groups, operative time (49.4 ± 23.5 minutes) and hospital stay (1.9 ± 0.7 days) in group A were longer than in group B (38.9 ± 16.9, 1.1 ± 0.2; P = 0.046 and P < 0.001, respectively) and pain score at 7 days in group A was higher than in group B (3.1 ± 0.7 vs. 2.3 ± 1.0, P < 0.001). Postoperative recurrence rate was not significantly different between the two groups.Conclusion: Inguinal hernia following radical retropubic surgery for prostate cancer was predominantly right side and indirect type with statistic significance compared to hernias without previous radical prostatectomy.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 4","pages":"175-9"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.4.175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

MicroRNA profiling of tacrolimus-stimulated Jurkat human T lympocytes. 他克莫司刺激Jurkat人T淋巴细胞的MicroRNA分析。

Journal of the Korean Surgical Society Pub Date : 2013-10-01 Epub Date: 2013-09-30 DOI: 10.4174/jkss.2013.85.4.161

Ho Kyun Lee, Sang Young Chung, Soo Jin Na Choi

{"title":"MicroRNA profiling of tacrolimus-stimulated Jurkat human T lympocytes.","authors":"Ho Kyun Lee, Sang Young Chung, Soo Jin Na Choi","doi":"10.4174/jkss.2013.85.4.161","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.4.161","url":null,"abstract":"Purpose: This study investigated the Jurkat T cell line expresses cytotoxicity when treated with different concentrations of FK506, and analyzed the expression pattern of microRNA when stimulated by FK506 using the microRNAs microarray, as well as the expression pattern of a gene that is related to the differentiation, activation and proliferation of T cells after being affected by the change of microRNAs.Methods: To investigate the effects of FK506 on microRNA expression, we purified total RNA of Jurkat cells treated with 20 µM FK506 for 72 hours and used to analyze microRNA profiling by using Agilent's chip.Results: These results demonstrated that treatment with FK506 markedly induced the down-regulation of 20 microRNAs as well as the up-regulation of 20 microRNAs in a time-dependent manner. The genes that down-regulated by FK506 include let-7a(*), miR-20a(*), and miR-487a. Otherwise miR-202, miR-485-5p, and miR-518c(*) are gradually up-regulated in expression. Sanger Institute and DAVIDs bioinformatics indicated that microRNAs regulated the several transcriptomes including nuclear factor of activated T cell-related, T cell receptor/interleukin-2 signaling, and Ca(2+)-calmodulin-dependent phosphatase calcineurin pathways.Conclusion: As a result of treating FK506 to a Jurkat cell line and running the microRNA microarray, it was found that FK506 not only took part in the suppression of T cell proliferation/activation by inhibiting calcineurin in Jurkat apoptosis, but also affected the microRNAs that are involved in the regulation of various signal transduction pathways.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 4","pages":"161-8"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.4.161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31792631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Application of negative pressure wound therapy in patients with wound dehiscence after abdominal open surgery: a single center experience. 负压伤口治疗在腹部开放手术后伤口裂开患者中的应用:单中心经验。

Journal of the Korean Surgical Society Pub Date : 2013-10-01 Epub Date: 2013-09-30 DOI: 10.4174/jkss.2013.85.4.180

Ji Young Jang, Hongjin Shim, Yun Jin Lee, Seung Hwan Lee, Jae Gil Lee

{"title":"Application of negative pressure wound therapy in patients with wound dehiscence after abdominal open surgery: a single center experience.","authors":"Ji Young Jang, Hongjin Shim, Yun Jin Lee, Seung Hwan Lee, Jae Gil Lee","doi":"10.4174/jkss.2013.85.4.180","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.4.180","url":null,"abstract":"Purpose: Since the 1990's, negative pressure wound therapy (NPWT) has been used to treat soft tissue defects, burn wounds, and to achieve skin graft fixation. In the field of abdominal surgery, the application of NPWT is increasing in cases with an open abdominal wound requiring temporary wound closure and a second look operation. In the present study, the authors analyzed patients that underwent NPWT for postoperative wound dehiscence.Methods: The computerized records of patients that had undergone an abdominal operation from November 2009 to May 2012 were retrospectively analyzed.Results: The number of total enrolled patients was 50, and 30 patients (60%) underwent an emergency operation. Diagnoses were as follows: panperitonitis or intra-abdominal abscess (24 cases, 48%), intestinal obstruction (10 cases, 20%), cancer (7 cases, 14%), mesentery ischemia (3 cases, 6%), and hemoperitoneum (1 case, 2%). NPWT was applied at a mean of 12.9 ± 8.2 days after surgery and mean NPWT duration was 17.9 days (2 to 96 days). The 11 patients (22%) with unsuccessful wound closure had a deeper and more complex wound than the other 39 patients (78%) (90.9% vs. 38.5%, P = 0.005). There were two complication cases (4%) due to delayed wound healing.Conclusion: Most patients recovered well due to granulation formation and suturing. NPWT was found to be convenient and safe, but a prospective comparative study is needed to confirm the usefulness of NPWT in patients whose wounds are dehisced.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 4","pages":"180-4"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.4.180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Xanthogranulomatous cholecystits in 2-month-old infant. 2月龄婴儿黄色肉芽肿性胆囊炎。

Journal of the Korean Surgical Society Pub Date : 2013-10-01 Epub Date: 2013-09-30 DOI: 10.4174/jkss.2013.85.4.191

Soo-Hong Kim, Hyun-Young Kim, Sung-Eun Jung, Kwi-Won Park, Young Hun Choi, Woo-Sun Kim, Sung-Hye Park

引用次数: 3

Prospective multicenter phase II clinical trial of FOLFIRI chemotherapy as a neoadjuvant treatment for colorectal cancer with multiple liver metastases. FOLFIRI化疗作为结直肠癌多发肝转移新辅助治疗的前瞻性多中心II期临床试验

Journal of the Korean Surgical Society Pub Date : 2013-10-01 Epub Date: 2013-09-30 DOI: 10.4174/jkss.2013.85.4.154

Ji Yeon Kim, Jin Soo Kim, Moo Jun Baek, Chang Nam Kim, Won Jun Choi, Dong Kook Park, Hwan Namgung, Sang Chul Lee, Sang-Jeon Lee

{"title":"Prospective multicenter phase II clinical trial of FOLFIRI chemotherapy as a neoadjuvant treatment for colorectal cancer with multiple liver metastases.","authors":"Ji Yeon Kim, Jin Soo Kim, Moo Jun Baek, Chang Nam Kim, Won Jun Choi, Dong Kook Park, Hwan Namgung, Sang Chul Lee, Sang-Jeon Lee","doi":"10.4174/jkss.2013.85.4.154","DOIUrl":"https://doi.org/10.4174/jkss.2013.85.4.154","url":null,"abstract":"Purpose: This study evaluated the efficacy of neoadjuvant chemotherapy combining 5-flurouracil/folinic acid with irinotecan (FOLFIRI) in colorectal multiple liver metastases regardless of resectability.Methods: Forty-four patients with multiple (at least two) colorectal liver metastases were enrolled at seven tertiary referral hospitals between May 2007 and September 2010. All patients received the FOLFIRI chemotherapeutic regimen. Response to chemotherapy was assessed after three cycles (6 weeks) and once more after six cycles (12 weeks) of treatment.Results: Objective response was noted in 27 patients (61.4%) and 4 patients (9.1%) had progressive disease. Of 44 patients, 10 patients (22.7%) underwent curative surgery (R0 resection) and 34 patients did not receive R0 resection. Grades 3 to 4 hematological toxicity was noted in 12 patients (27.3%) and grades 3 to 4 nonhematologic toxicity was identified in 5 patients (11.4%).Conclusion: FOLFIRI chemotherapy as a neoadjuvant chemotherapy for multiple colorectal liver metastases regardless of resectability demonstrated the possibility of R0 resection, high rate of objective response, and tolerable toxicities in this study.","PeriodicalId":49991,"journal":{"name":"Journal of the Korean Surgical Society","volume":"85 4","pages":"154-60"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4174/jkss.2013.85.4.154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31792629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9