Imaging and radiation research最新文献

Enhancing breast cancer detection in thermographic images using deep hybrid networks 利用深度混合网络加强热成像图像中的乳腺癌检测

Imaging and radiation research Pub Date : 2024-07-19 DOI: 10.24294/irr.v6i2.6195

Rezazadeh Hanieh, Saniei Elham, Salehi Barough Mehdi

引用次数: 0

Molecular dynamics simulation of atomic interaction between mediator protein of human prostate cancer and Fe/C720 buckyballs-statin structures 人类前列腺癌介导蛋白与 Fe/C720 降压球-铂结构之间原子相互作用的分子动力学模拟

Imaging and radiation research Pub Date : 2024-07-18 DOI: 10.24294/irr.v6i2.6398

Mohammad Pour Panah, Roozbeh Sabetvand

{"title":"Molecular dynamics simulation of atomic interaction between mediator protein of human prostate cancer and Fe/C720 buckyballs-statin structures","authors":"Mohammad Pour Panah, Roozbeh Sabetvand","doi":"10.24294/irr.v6i2.6398","DOIUrl":"https://doi.org/10.24294/irr.v6i2.6398","url":null,"abstract":"Atomic interaction between mediator protein of human prostate cancer (PHPC) and Fe/C720 Buckyballs-Statin is important for medical science. For the first time, we use molecular dynamics (MD) approach based on Newton’s formalism to describe the destruction of PHPC via Fe/C720 Buckyballs-Statin with atomic accuracy. In this work, the atomic interaction of PHPC and Fe/C720 Buckyballs-Statin introduced via equilibrium molecular dynamics approach. In this method, each PHPC and Fe/C720 Buckyballs-Statin is defined by C, H, Cl, N, O, P, S, and Fe elements and contrived by universal force field (UFF) and DREIDING force-field to introduce their time evolution. The results of our studies regarding the dynamical behavior of these atom-base compounds have been reported by calculating the Potential energy, center of mass (COM) position, diffusion ratio and volume of defined systems. The estimated values for these quantities show the attraction force between Buckyball-based structure and protein sample, which COM distance of these samples changes from 10.27 Å to 2.96 Å after 10 ns. Physically, these interactions causing the destruction of the PHPC. Numerically, the volume of this biostructure enlarged from 665,276 Å3 to 737,143 Å3 by MD time passing. This finding reported for the first time which can be considered by the pharmaceutical industry. Simulations indicated the volume of the PHPC increases by Fe/C720 Buckyballs-Statin diffusion into this compound. By enlarging this quantity (diffusion coefficient), the atomic stability of PHPC decreases and protein destruction procedure fulfilled.","PeriodicalId":499721,"journal":{"name":"Imaging and radiation research","volume":" 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The anatomy of pain relief: Lumbar oxygen-ozone epidural infiltrations for cervicobrachialgia 疼痛缓解的解剖学腰椎氧-臭氧硬膜外浸润治疗颈椎痛

Imaging and radiation research Pub Date : 2024-04-10 DOI: 10.24294/irr.v6i1.4781

L. Faccioli, Giulio Vara, Luca Spinardi, M. Pastore Trossello, G. Vornetti, Mattia Gentilini, Stefano Ratti

{"title":"The anatomy of pain relief: Lumbar oxygen-ozone epidural infiltrations for cervicobrachialgia","authors":"L. Faccioli, Giulio Vara, Luca Spinardi, M. Pastore Trossello, G. Vornetti, Mattia Gentilini, Stefano Ratti","doi":"10.24294/irr.v6i1.4781","DOIUrl":"https://doi.org/10.24294/irr.v6i1.4781","url":null,"abstract":"Objective: This study investigates the efficacy and safety of epidural infiltration with drugs and an oxygen-ozone mixture for treating cervicobrachialgia due to disc-radicular conflict or on a degenerative basis, utilizing both retrospective analysis and direct visualization techniques. Methods: A retrospective study involving 10 patients treated with epidural infiltrations of an oxygen-ozone mixture and cortisone was conducted. The procedures were performed under CT guidance to ensure precise delivery and to monitor the diffusion of the injected substances. Pain levels were assessed using the Numerical Rating Scale (NRS) and treatment efficacy was evaluated based on symptom relief and reduction in NSAID intake. Results: Significant pain reduction was observed post-treatment, with median NRS scores decreasing from 9 (baseline) to 2 (follow-up), and a significant decrease in on-demand NSAID intake. Only one minor complication of a headache was reported. The study also demonstrated the ability of ozone to diffuse through the epidural adipose tissue, potentially enhancing treatment efficacy. Conclusion: The combined use of an oxygen-ozone mixture and cortisone for epidural infiltration is an effective and safe treatment for cervicobrachialgia, offering significant pain relief and minimizing the risk associated with traditional epidural injections. This technique presents a viable non-surgical option for patients suffering from disc-radicular conflict or degenerative conditions.","PeriodicalId":499721,"journal":{"name":"Imaging and radiation research","volume":"582 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140718952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of neoadjuvant chemoradiotherapy in the treatment of rectal cancer: A comprehensive study 新辅助化放疗治疗直肠癌的效果：综合研究

Imaging and radiation research Pub Date : 2024-01-26 DOI: 10.24294/irr.v6i1.3534

Eda Taş Küçük, R. Habi̇boğlu, İlknur Kayali

引用次数: 0

Exaggeration of consequences of low-dose radiation exposures with special reference to cataracts 夸大低剂量辐照的后果，特别是白内障

Imaging and radiation research Pub Date : 2024-01-23 DOI: 10.24294/irr.v6i1.3387

Sergei V. Jargin

{"title":"Exaggeration of consequences of low-dose radiation exposures with special reference to cataracts","authors":"Sergei V. Jargin","doi":"10.24294/irr.v6i1.3387","DOIUrl":"https://doi.org/10.24294/irr.v6i1.3387","url":null,"abstract":"Publications overestimating the medical and ecological sequels of a slight anthropogenic increase in the radiation background have been reviewed recently with examples of different organs and pathological conditions. The overestimation contributed to the strangulation of atomic energy. The use of nuclear energy for electricity production is on the agenda today due to the increasing energy needs of humankind. Apparently, certain scientific writers acted in the interests of fossil fuel producers. Health risks and environmental damage are maximal for coal and oil, lower for natural gas, and much lower for atomic energy. This letter is an addition to previously published materials, this time focused on studies of cataracts in radiation-exposed populations in Russia. Selection and self-selection bias are of particular significance. Apparently, the self-reporting rate correlates with dose estimates and/or with professional awareness about radiation-related risks among nuclear workers or radiologic technologists, the latter being associated with their work experience/duration and hence with the accumulated dose. Individuals informed of their higher doses would more often seek medical advice and receive more attention from medics. As a result, lens opacities are diagnosed in exposed people earlier than in the general population. This explains dose-effect correlations proven for the incidence of cataracts but not for the frequency of cataract surgeries. Along the same lines, various pathological conditions are more often detected in exposed people. Ideological bias and the trimming of statistics have not been unusual in the Russian medical sciences. It is known that ionizing radiation causes cataracts; however, threshold levels associated with risks are understudied. In particular, thresholds for chronic and fractionated exposures are uncertain and may be underestimated.","PeriodicalId":499721,"journal":{"name":"Imaging and radiation research","volume":"51 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139603610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0