Vicent Giménez-Alventosa, José Damián Segrelles, Germán Moltó, Mar Roca-Sogorb
{"title":"APRICOT: Advanced Platform for Reproducible Infrastructures in the Cloud via Open Tools.","authors":"Vicent Giménez-Alventosa, José Damián Segrelles, Germán Moltó, Mar Roca-Sogorb","doi":"10.1055/s-0040-1712460","DOIUrl":"https://doi.org/10.1055/s-0040-1712460","url":null,"abstract":"<p><strong>Background: </strong>Scientific publications are meant to exchange knowledge among researchers but the inability to properly reproduce computational experiments limits the quality of scientific research. Furthermore, bibliography shows that irreproducible preclinical research exceeds 50%, which produces a huge waste of resources on nonprofitable research at Life Sciences field. As a consequence, scientific reproducibility is being fostered to promote Open Science through open databases and software tools that are typically deployed on existing computational resources. However, some computational experiments require complex virtual infrastructures, such as elastic clusters of PCs, that can be dynamically provided from multiple clouds. Obtaining these infrastructures requires not only an infrastructure provider, but also advanced knowledge in the cloud computing field.</p><p><strong>Objectives: </strong>The main aim of this paper is to improve reproducibility in life sciences to produce better and more cost-effective research. For that purpose, our intention is to simplify the infrastructure usage and deployment for researchers.</p><p><strong>Methods: </strong>This paper introduces Advanced Platform for Reproducible Infrastructures in the Cloud via Open Tools (APRICOT), an open source extension for Jupyter to deploy deterministic virtual infrastructures across multiclouds for reproducible scientific computational experiments. To exemplify its utilization and how APRICOT can improve the reproduction of experiments with complex computation requirements, two examples in the field of life sciences are provided. All requirements to reproduce both experiments are disclosed within APRICOT and, therefore, can be reproduced by the users.</p><p><strong>Results: </strong>To show the capabilities of APRICOT, we have processed a real magnetic resonance image to accurately characterize a prostate cancer using a Message Passing Interface cluster deployed automatically with APRICOT. In addition, the second example shows how APRICOT scales the deployed infrastructure, according to the workload, using a batch cluster. This example consists of a multiparametric study of a positron emission tomography image reconstruction.</p><p><strong>Conclusion: </strong>APRICOT's benefits are the integration of specific infrastructure deployment, the management and usage for Open Science, making experiments that involve specific computational infrastructures reproducible. All the experiment steps and details can be documented at the same Jupyter notebook which includes infrastructure specifications, data storage, experimentation execution, results gathering, and infrastructure termination. Thus, distributing the experimentation notebook and needed data should be enough to reproduce the experiment.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 S 02","pages":"e33-e45"},"PeriodicalIF":1.7,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1712460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38250294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Relationship between Mobility and COVID-19 in Germany: Modeling Case Occurrence using Apple's Mobility Trends Data.","authors":"Mark David Walker, Mihály Sulyok","doi":"10.1055/s-0041-1726276","DOIUrl":"https://doi.org/10.1055/s-0041-1726276","url":null,"abstract":"<p><strong>Background: </strong>Restrictions on social interaction and movement were implemented by the German government in March 2020 to reduce the transmission of coronavirus disease 2019 (COVID-19). Apple's \"Mobility Trends\" (AMT) data details levels of community mobility; it is a novel resource of potential use to epidemiologists.</p><p><strong>Objective: </strong>The aim of the study is to use AMT data to examine the relationship between mobility and COVID-19 case occurrence for Germany. Is a change in mobility apparent following COVID-19 and the implementation of social restrictions? Is there a relationship between mobility and COVID-19 occurrence in Germany?</p><p><strong>Methods: </strong>AMT data illustrates mobility levels throughout the epidemic, allowing the relationship between mobility and disease to be examined. Generalized additive models (GAMs) were established for Germany, with mobility categories, and date, as explanatory variables, and case numbers as response.</p><p><strong>Results: </strong>Clear reductions in mobility occurred following the implementation of movement restrictions. There was a negative correlation between mobility and confirmed case numbers. GAM using all three categories of mobility data accounted for case occurrence as well and was favorable (AIC or Akaike Information Criterion: 2504) to models using categories separately (AIC with \"driving,\" 2511. \"transit,\" 2513. \"walking,\" 2508).</p><p><strong>Conclusion: </strong>These results suggest an association between mobility and case occurrence. Further examination of the relationship between movement restrictions and COVID-19 transmission may be pertinent. The study shows how new sources of online data can be used to investigate problems in epidemiology.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 6","pages":"179-182"},"PeriodicalIF":1.7,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1726276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25521272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinícius Costa Lima, Filipe Andrade Bernardi, Domingos Alves, Afrânio Lineu Kritski, Rafael Mello Galliez, Rui Pedro Charters Lopes Rijo
{"title":"A Permissioned Blockchain Network for Security and Sharing of De-identified Tuberculosis Research Data in Brazil.","authors":"Vinícius Costa Lima, Filipe Andrade Bernardi, Domingos Alves, Afrânio Lineu Kritski, Rafael Mello Galliez, Rui Pedro Charters Lopes Rijo","doi":"10.1055/s-0041-1727194","DOIUrl":"https://doi.org/10.1055/s-0041-1727194","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) is an infectious disease and is among the top 10 causes of death in the world, and Brazil is part of the top 30 high TB burden countries. Data collection is an essential practice in health studies, and the adoption of electronic data capture (EDC) systems can positively increase the experience of data acquisition and analysis. Also, data-sharing capabilities are crucial to the construction of efficient and effective evidence-based decision-making tools for managerial and operational actions in TB services. Data must be held secure and traceable, as well as available and understandable, for authorized parties.</p><p><strong>Objectives: </strong>In this sense, this work aims to propose a blockchain-based approach to build a reusable, decentralized, and de-identified dataset of TB research data, while increasing transparency, accountability, availability, and integrity of raw data collected in EDC systems.</p><p><strong>Methods: </strong>After identifying challenges and gaps, a solution was proposed to tackle them, considering its relevance for TB studies. Data security issues are being addressed by a blockchain network and a lightweight and practical governance model. Research Electronic Data Capture (REDCap) and KoBoToolbox are used as EDC systems in TB research. Mechanisms to de-identify data and aggregate semantics to data are also available.</p><p><strong>Results: </strong>A permissioned blockchain network was built using Kaleido platform. An integration engine integrates the EDC systems with the blockchain network, performing de-identification and aggregating meaning to data. A governance model addresses operational and legal issues for the proper use of data. Finally, a management system facilitates the handling of necessary metadata, and additional applications are available to explore the blockchain and export data.</p><p><strong>Conclusions: </strong>Research data are an important asset not only for the research where it was generated, but also to underpin studies replication and support further investigations. The proposed solution allows the delivery of de-identified databases built in real time by storing data in transactions of a permissioned network, including semantic annotations, as data are being collected in TB research. The governance model promotes the correct use of the solution.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 6","pages":"205-218"},"PeriodicalIF":1.7,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0041-1727194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38879944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elske Ammenwerth, Georg Duftschmid, Zaid Al-Hamdan, Hala Bawadi, Ngai T Cheung, Kyung-Hee Cho, Guillermo Goldfarb, Kemal H Gülkesen, Nissim Harel, Michio Kimura, Önder Kırca, Hiroshi Kondoh, Sabine Koch, Hadas Lewy, Dara Mize, Sari Palojoki, Hyeoun-Ae Park, Christopher Pearce, Fernan G B de Quirós, Kaija Saranto, Christoph Seidel, Vivian Vimarlund, Martin C Were, Johanna Westbrook, Chung P Wong, Reinhold Haux, Christoph U Lehmann
{"title":"International Comparison of Six Basic eHealth Indicators Across 14 Countries: An eHealth Benchmarking Study.","authors":"Elske Ammenwerth, Georg Duftschmid, Zaid Al-Hamdan, Hala Bawadi, Ngai T Cheung, Kyung-Hee Cho, Guillermo Goldfarb, Kemal H Gülkesen, Nissim Harel, Michio Kimura, Önder Kırca, Hiroshi Kondoh, Sabine Koch, Hadas Lewy, Dara Mize, Sari Palojoki, Hyeoun-Ae Park, Christopher Pearce, Fernan G B de Quirós, Kaija Saranto, Christoph Seidel, Vivian Vimarlund, Martin C Were, Johanna Westbrook, Chung P Wong, Reinhold Haux, Christoph U Lehmann","doi":"10.1055/s-0040-1715796","DOIUrl":"https://doi.org/10.1055/s-0040-1715796","url":null,"abstract":"<p><strong>Background: </strong>Many countries adopt eHealth applications to support patient-centered care. Through information exchange, these eHealth applications may overcome institutional data silos and support holistic and ubiquitous (regional or national) information logistics. Available eHealth indicators mostly describe usage and acceptance of eHealth in a country. The eHealth indicators focusing on the cross-institutional availability of patient-related information for health care professionals, patients, and care givers are rare.</p><p><strong>Objectives: </strong>This study aims to present eHealth indicators on cross-institutional availability of relevant patient data for health care professionals, as well as for patients and their caregivers across 14 countries (Argentina, Australia, Austria, Finland, Germany, Hong Kong as a special administrative region of China, Israel, Japan, Jordan, Kenya, South Korea, Sweden, Turkey, and the United States) to compare our indicators and the resulting data for the examined countries with other eHealth benchmarks and to extend and explore changes to a comparable survey in 2017. We defined \"availability of patient data\" as the ability to access data in and to add data to the patient record in the respective country.</p><p><strong>Methods: </strong>The invited experts from each of the 14 countries provided the indicator data for their country to reflect the situation on August 1, 2019, as date of reference. Overall, 60 items were aggregated to six eHealth indicators.</p><p><strong>Results: </strong>Availability of patient-related information varies strongly by country. Health care professionals can access patients' most relevant cross-institutional health record data fully in only four countries. Patients and their caregivers can access their health record data fully in only two countries. Patients are able to fully add relevant data only in one country. Finland showed the best outcome of all eHealth indicators, followed by South Korea, Japan, and Sweden.</p><p><strong>Conclusion: </strong>Advancement in eHealth depends on contextual factors such as health care organization, national health politics, privacy laws, and health care financing. Improvements in eHealth indicators are thus often slow. However, our survey shows that some countries were able to improve on at least some indicators between 2017 and 2019. We anticipate further improvements in the future.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 S 02","pages":"e46-e63"},"PeriodicalIF":1.7,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1715796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristian Cuerda, Dulce Romero-Ayuso, Jose A Gallud, Carmen Morales, Ricardo Tesoriero, Jose-Matias Triviño-Juarez, Habib M Fardoun
{"title":"Usability Evaluation of a Distributed User Interface Application for Visuomotor Organization Assessment.","authors":"Cristian Cuerda, Dulce Romero-Ayuso, Jose A Gallud, Carmen Morales, Ricardo Tesoriero, Jose-Matias Triviño-Juarez, Habib M Fardoun","doi":"10.1055/s-0040-1713086","DOIUrl":"https://doi.org/10.1055/s-0040-1713086","url":null,"abstract":"<p><strong>Background: </strong>This article describes the development and evaluation of a distributed user interface (DUI) application to assess visuomotor organization ability. This application enables therapists to evaluate the acquired brain injury (ABI) on patients, and patients, to perform the assessment on a touch screen while therapists can observe the assessment process in real time on a separated monitor without interfering patients during the process as in traditional methodologies employing physical elements.</p><p><strong>Objectives: </strong>The main goal of this research is the evaluation of the quality in use of DUIs in the Pegboard Construction assessment with patients with ABI from the therapist perspective in the area of occupational therapy.</p><p><strong>Methods: </strong>To evaluate our system, we have performed a usability evaluation following the ISO/IEC 25010 and ISO/IEC 25062 standards to evaluate software usability and quality and it was conducted in collaboration with therapists and psychologists that have previously worked with people with ABI in diagnostic and assessment tasks.</p><p><strong>Results: </strong>We show the results of the evaluation collected in a table that shows the completeness rate for each user for both, assisted (i.e., the percentage of tasks where participants performed with test director assistance) and unassisted tasks (i.e., the percentage of tasks where participants completed tasks autonomously), the total time participants required to complete proposed tasks, the number of mistakes participants performed during the session, and the number of assists they required to finish proposed tasks. In addition, we also evaluated the user satisfaction regarding our application using the system usability scale.</p><p><strong>Conclusion: </strong>The use of information technologies in this field enables therapists to perform these evaluations in a simpler, efficient, and automated way. This proposal enables patients to perform the assessment as it is performed traditionally using paper providing them with a touch screen in which they can easily insert a set of pins into the holes. The usability evaluation of the proposal meets the appropriate design standards for applications of this type, and this is demonstrated by the high degree of satisfaction of the participants.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 S 02","pages":"e79-e89"},"PeriodicalIF":1.7,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1713086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38448559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antje Wulff, Marcel Mast, Marcus Hassler, Sara Montag, Michael Marschollek, Thomas Jack
{"title":"Designing an openEHR-Based Pipeline for Extracting and Standardizing Unstructured Clinical Data Using Natural Language Processing.","authors":"Antje Wulff, Marcel Mast, Marcus Hassler, Sara Montag, Michael Marschollek, Thomas Jack","doi":"10.1055/s-0040-1716403","DOIUrl":"https://doi.org/10.1055/s-0040-1716403","url":null,"abstract":"<p><strong>Background: </strong>Merging disparate and heterogeneous datasets from clinical routine in a standardized and semantically enriched format to enable a multiple use of data also means incorporating unstructured data such as medical free texts. Although the extraction of structured data from texts, known as natural language processing (NLP), has been researched at least for the English language extensively, it is not enough to get a structured output in any format. NLP techniques need to be used together with clinical information standards such as openEHR to be able to reuse and exchange still unstructured data sensibly.</p><p><strong>Objectives: </strong>The aim of the study is to automatically extract crucial information from medical free texts and to transform this unstructured clinical data into a standardized and structured representation by designing and implementing an exemplary pipeline for the processing of pediatric medical histories.</p><p><strong>Methods: </strong>We constructed a pipeline that allows reusing medical free texts such as pediatric medical histories in a structured and standardized way by (1) selecting and modeling appropriate openEHR archetypes as standard clinical information models, (2) defining a German dictionary with crucial text markers serving as expert knowledge base for a NLP pipeline, and (3) creating mapping rules between the NLP output and the archetypes. The approach was evaluated in a first pilot study by using 50 manually annotated medical histories from the pediatric intensive care unit of the Hannover Medical School.</p><p><strong>Results: </strong>We successfully reused 24 existing international archetypes to represent the most crucial elements of unstructured pediatric medical histories in a standardized form. The self-developed NLP pipeline was constructed by defining 3.055 text marker entries, 132 text events, 66 regular expressions, and a text corpus consisting of 776 entries for automatic correction of spelling mistakes. A total of 123 mapping rules were implemented to transform the extracted snippets to an openEHR-based representation to be able to store them together with other structured data in an existing openEHR-based data repository. In the first evaluation, the NLP pipeline yielded 97% precision and 94% recall.</p><p><strong>Conclusion: </strong>The use of NLP and openEHR archetypes was demonstrated as a viable approach for extracting and representing important information from pediatric medical histories in a structured and semantically enriched format. We designed a promising approach with potential to be generalized, and implemented a prototype that is extensible and reusable for other use cases concerning German medical free texts. In a long term, this will harness unstructured clinical data for further research purposes such as the design of clinical decision support systems. Together with structured data already integrated in openEHR-based representations, we aim at developi","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 S 02","pages":"e64-e78"},"PeriodicalIF":1.7,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1716403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38592529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Dental, Oral, Medical Epidemiological (DOME) Study: Protocol and Study Methods.","authors":"Galit Almoznino, Ron Kedem, Ronit Turgeman, Tarif Bader, Nirit Yavnai, Dorit Zur, Boaz Shay","doi":"10.1055/s-0040-1718582","DOIUrl":"https://doi.org/10.1055/s-0040-1718582","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and present the methods utilized for the Dental, Oral, Medical Epidemiological (DOME) study.</p><p><strong>Methods: </strong>The DOME is an electronic record-based cross-sectional study, that was conducted to measure the dental, periodontal, and oral morbidities and their associations with systemic morbidities, among a nationally representative sample of young to middle-aged adults military personnel from the IDF (Israel Defense Forces). To that end, we developed a strict protocol including standardized terminology, data collection, and handling.</p><p><strong>Results: </strong>Data for the DOME study was derived simultaneously from three electronic records of the IDF: (1) a central demographic database, (2) the dental patient record (DPR), and (3) the medical computerized patient record (CPR). The established DOME repository includes socio-demographic, dental and medical records of 132,354 young to middle-age military personnel from the IDF, who attended the dental clinics during the year 2015. Records of general military personnel (<i>N</i> > 50,000), with no recorded dental visits during the study period, served as a control group regarding all other parameters except dental. The DOME study continues and is currently collecting longitudinal data from the year 2010 until 2020. The IDF employs a standardized uniform administrative and clinical work-up and treatment protocols as well as uniform computerized codes. We describe the standardized definitions for all the parameters that were included: socio-demographics, health-related habits, medical and dental attendance patterns, and general and dental health status. Multicollinearity analysis results of the sociodemographic and medical study parameters are presented.</p><p><strong>Conclusion: </strong>Standardized work-up and definitions are essential to establish the centralized DOME data repository to study the extent of dental and systemic morbidities and their associations.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 4-05","pages":"119-130"},"PeriodicalIF":1.7,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1718582","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38512202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qian Zhu, Dac-Trung Nguyen, Eric Sid, Anne Pariser
{"title":"Leveraging the UMLS As a Data Standard for Rare Disease Data Normalization and Harmonization.","authors":"Qian Zhu, Dac-Trung Nguyen, Eric Sid, Anne Pariser","doi":"10.1055/s-0040-1718940","DOIUrl":"https://doi.org/10.1055/s-0040-1718940","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to evaluate the capability of the Unified Medical Language System (UMLS) as one data standard to support data normalization and harmonization of datasets that have been developed for rare diseases. Through analysis of data mappings between multiple rare disease resources and the UMLS, we propose suggested extensions of the UMLS that will enable its adoption as a global standard in rare disease.</p><p><strong>Methods: </strong>We analyzed data mappings between the UMLS and existing datasets on over 7,000 rare diseases that were retrieved from four publicly accessible resources: Genetic And Rare Diseases Information Center (GARD), Orphanet, Online Mendelian Inheritance in Men (OMIM), and the Monarch Disease Ontology (MONDO). Two types of disease mappings were assessed, (1) curated mappings extracted from those four resources; and (2) established mappings generated by querying the rare disease-based integrative knowledge graph developed in the previous study.</p><p><strong>Results: </strong>We found that 100% of OMIM concepts, and over 50% of concepts from GARD, MONDO, and Orphanet were normalized by the UMLS and accurately categorized into the appropriate UMLS semantic groups. We analyzed 58,636 UMLS mappings, which resulted in 3,876 UMLS concepts across these resources. Manual evaluation of a random set of 500 UMLS mappings demonstrated a high level of accuracy (99%) of developing those mappings, which consisted of 414 mappings of synonyms (82.8%), 76 are subtypes (15.2%), and five are siblings (1%).</p><p><strong>Conclusion: </strong>The mapping results illustrated in this study that the UMLS was able to accurately represent rare disease concepts, and their associated information, such as genes and phenotypes, and can effectively be used to support data harmonization across existing resources developed on collecting rare disease data. We recommend the adoption of the UMLS as a data standard for rare disease to enable the existing rare disease datasets to support future applications in a clinical and community settings.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 4-05","pages":"131-139"},"PeriodicalIF":1.7,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1718940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38569033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Luis Parra-Calderón, Ferran Sanz, Leslie D McIntosh
{"title":"The Challenge of the Effective Implementation of FAIR Principles in Biomedical Research.","authors":"Carlos Luis Parra-Calderón, Ferran Sanz, Leslie D McIntosh","doi":"10.1055/s-0040-1721726","DOIUrl":"https://doi.org/10.1055/s-0040-1721726","url":null,"abstract":"1TI Research, Hospitales Universitarios Virgen del Rocío—Avda. Manuel Siurot, s/n Centro de Documentación Clínica Hospitales Universitarios Virgen del Rocío, Seville, Spain 2Group of Research and Innovation in Biomedical Informatics, Biomedical Engineering and Health Economy, Institute of Biomedicine of Seville/Virgen del Rocío University Hospital/CSIC/ University of Seville, Seville, Spain 3Washington University in St. Louis, Missouri, United States","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 4-05","pages":"117-118"},"PeriodicalIF":1.7,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1721726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25399996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuchen Fei, Fengyu Zhang, Chen Zu, Mei Hong, Xingchen Peng, Jianghong Xiao, Xi Wu, Jiliu Zhou, Yan Wang
{"title":"MRF-RFS: A Modified Random Forest Recursive Feature Selection Algorithm for Nasopharyngeal Carcinoma Segmentation.","authors":"Yuchen Fei, Fengyu Zhang, Chen Zu, Mei Hong, Xingchen Peng, Jianghong Xiao, Xi Wu, Jiliu Zhou, Yan Wang","doi":"10.1055/s-0040-1721791","DOIUrl":"https://doi.org/10.1055/s-0040-1721791","url":null,"abstract":"<p><strong>Background: </strong>An accurate and reproducible method to delineate tumor margins is of great importance in clinical diagnosis and treatment. In nasopharyngeal carcinoma (NPC), due to limitations such as high variability, low contrast, and discontinuous boundaries in presenting soft tissues, tumor margin can be extremely difficult to identify in magnetic resonance imaging (MRI), increasing the challenge of NPC segmentation task.</p><p><strong>Objectives: </strong>The purpose of this work is to develop a semiautomatic algorithm for NPC image segmentation with minimal human intervention, while it is also capable of delineating tumor margins with high accuracy and reproducibility.</p><p><strong>Methods: </strong>In this paper, we propose a novel feature selection algorithm for the identification of the margin of NPC image, named as modified random forest recursive feature selection (MRF-RFS). Specifically, to obtain a more discriminative feature subset for segmentation, a modified recursive feature selection method is applied to the original handcrafted feature set. Moreover, we combine the proposed feature selection method with the classical random forest (RF) in the training stage to take full advantage of its intrinsic property (i.e., feature importance measure).</p><p><strong>Results: </strong>To evaluate the segmentation performance, we verify our method on the T1-weighted MRI images of 18 NPC patients. The experimental results demonstrate that the proposed MRF-RFS method outperforms the baseline methods and deep learning methods on the task of segmenting NPC images.</p><p><strong>Conclusion: </strong>The proposed method could be effective in NPC diagnosis and useful for guiding radiation therapy.</p>","PeriodicalId":49822,"journal":{"name":"Methods of Information in Medicine","volume":"59 4-05","pages":"151-161"},"PeriodicalIF":1.7,"publicationDate":"2020-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0040-1721791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25399997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}