Journal of Biomedicine and Biochemistry最新文献

Assessment of Role s100A7 and Eotaxin (CCL24) in Patients with Atopic Dermatitis in Babylon City s100A7和Eotaxin (CCL24)在巴比伦市特应性皮炎患者中的作用评价

Journal of Biomedicine and Biochemistry Pub Date : 2023-09-01 DOI: 10.57238/jbb.2023.6944.1034

Mahmoud Muhammad, Thanaa Juda, Zina Al-Fadili

{"title":"Assessment of Role s100A7 and Eotaxin (CCL24) in Patients with Atopic Dermatitis in Babylon City","authors":"Mahmoud Muhammad, Thanaa Juda, Zina Al-Fadili","doi":"10.57238/jbb.2023.6944.1034","DOIUrl":"https://doi.org/10.57238/jbb.2023.6944.1034","url":null,"abstract":"Background Atopic dermatitis (AD) is a chronic, diverse, inflamma- tory skin disease that generally starts in infancy and lasts into adulthood. Tcell-driven inflammation, mostly through T helper (Th) 2- and Th17- derived cytokines, which are controlled by the Janus kinase (JAK) signal- ing pathway, is critical to AD. S100a7 and eotaxin(ccl24) were measured in serum samples.Objective Finding diagnostic, prognostic, and predictive biomarkers that can be used to diagnose atopic dermatitis patients early in the course of the disease is the goal of the current study. It also aims to determine changes in s1007a and eotaxin as a biomarker in atopic dermatitis patients and the study of these markers to give advice on how to treat AD.Material and methods The samples were obtained from the derma- tology clinic’s registered patients at Al-Musayyib General Hospital, Al- Imam Al-Sadiq Hospital, and Murjan Teaching Hospital between October 1 and November 1, 2022. Blood samples were utilized to analyze the bio- chemical properties of the serum, such as s100a7 and eotaxin(ccl24). were assessed for patients using the ELISA technique. The statistical analysis was carried out using SPSS software.Results Results of the examination of the eotaxin biomarker in the pa- tient group with atopic dermatitis were substantially better than those in the control group (p ≤ 0.05), and the s100a7 biomarker increased in the patient groups compared to the control group (p ≤0.05).Conclusion Patients with atopic dermatitis had considerably higher levels of every parameter compared to healthy persons.","PeriodicalId":497721,"journal":{"name":"Journal of Biomedicine and Biochemistry","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135735865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Prolactin and Infertil 催乳素与不孕的关系

Journal of Biomedicine and Biochemistry Pub Date : 2023-09-01 DOI: 10.57238/jbb.2023.6951.1035

Abdulrazaq Mohammed, Hamza Jasim, Mustafa Shanshool, Faez Hadi

引用次数: 0

Circulating Microrna-22 As a Biomarker Related to Oxidative Stress in Hyperthyroid Women Patient 循环Microrna-22作为与甲状腺功能亢进女性患者氧化应激相关的生物标志物

Journal of Biomedicine and Biochemistry Pub Date : 2023-09-01 DOI: 10.57238/jbb.2023.7019.1039

Zahraa Ali Abd, Nawal Jabbar

{"title":"Circulating Microrna-22 As a Biomarker Related to Oxidative Stress in Hyperthyroid Women Patient","authors":"Zahraa Ali Abd, Nawal Jabbar","doi":"10.57238/jbb.2023.7019.1039","DOIUrl":"https://doi.org/10.57238/jbb.2023.7019.1039","url":null,"abstract":"Background Recent studies have connected microribonucleic acid (miRNA) to several illnesses as a stimulant or inhibitor. Oxidative stress and thyroid diseases are connected to miRNA-22. The underlying pro- cesses remain unknown. In this study, hyperthyroid women’s miRNA-22 expression is linked to oxidative stress.Materials and Methods 40 women suffering from hyperthyroidism and 40 in this study, healthy volunteers who served as controls were in- cluded. The levels of serum thyroid-stimulating hormone (TSH) were mea- sured by sandwich assay, While the competitive binding immunoenzymatic assay was used to determine the levels of free triiodothyronine (FT3) and thyroxine (T4). To assess lipid profiles, an automated analyzer was em- ployed. By enzyme-linked immunosorbent assay (ELISA), Interleukin 6 (IL-6) levels were measured. Activity of superoxide dismutase (SOD), catalase activity (CAT), (MDA) malondialdehyde, and levels of advanced oxidation protein products (AOPPs) assessed using a colorimetric tech- nique. The quantitative polymerase chain reaction was used to evaluate the expression of serum miRNA-22.Results Non-significantly increase SOD and significantly increase CAT activity were identified in patient groups than in the control group (P<0.05), also the patient group’s AOPP and MDA concentrations were discovered to significantly rise from those of the control group. (P< 0.05). IL-6 levels were significantly higher in the patient group than in (P<0.05) the control group. The level of miRNA-22 was higher in the sick group as compared to the control groups (P<0.05).Conclusion The pathophysiology of oxidative stress brought on by hy- perthyroidism involves miRNA-22 expression, Oxidative stress increases and miRNA-22 gene expression increase in a reciprocal manner, which results in the disease’s development.","PeriodicalId":497721,"journal":{"name":"Journal of Biomedicine and Biochemistry","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135894968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

SOX9 Up-Regulation Can Change Survival and Anticancer Resistance in Different Cancer Type SOX9上调可改变不同类型肿瘤的生存和耐药

Journal of Biomedicine and Biochemistry Pub Date : 2023-09-01 DOI: 10.57238/jbb.2023.7047.1043

Namariq Al-Saadi, Husam Al-hraishawi

{"title":"SOX9 Up-Regulation Can Change Survival and Anticancer Resistance in Different Cancer Type","authors":"Namariq Al-Saadi, Husam Al-hraishawi","doi":"10.57238/jbb.2023.7047.1043","DOIUrl":"https://doi.org/10.57238/jbb.2023.7047.1043","url":null,"abstract":"Background Y-box member SOX9 determines sex. This family’s eight subgroups (A–H) have one to three members each. Sox gene transcription factors are critical for development and conserved across species. Several studies have shown that a tiny percentage of malignant cells, called cancer stem-like cells (CSCs) or tumor-initiating cells, have stem cell traits such self-renewal and differentiation. Self-renewal is thought to cause tumor growth and progression. Mechanistic studies show that SOX9 controls cancer-specific gene networks that are involved in self-renewal, differentia- tion, and extracellular matrix/cytoskeleton remodeling.Objective This review examines SOX9 as a predictive biomarker and its function in cancer beginnings, progression, and therapeutic resistance across many cancer types. This review discusses genetic/epigenetic SOX9 deregulation in several cancers.Results Multiple cancer types revealed high SOX9 expression and prog- nosis in the CBIOportal database. SOX9-targeting small molecules may diminish chemotherapy resistance. Finally, SOX9 over-expression, malig- nant prognosis, and resistance need additional study.","PeriodicalId":497721,"journal":{"name":"Journal of Biomedicine and Biochemistry","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135894966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Direct Oral Anticoagulants in The Treatment Of Acute Venous Thromboembolism in Patients With Obesity: A Systematic Review With Meta-Analysis 直接口服抗凝剂治疗肥胖患者急性静脉血栓栓塞:一项荟萃分析的系统综述

Journal of Biomedicine and Biochemistry Pub Date : 2023-09-01 DOI: 10.57238/jbb.2023.6960.1038

Abiya Ahad

{"title":"Direct Oral Anticoagulants in The Treatment Of Acute Venous Thromboembolism in Patients With Obesity: A Systematic Review With Meta-Analysis","authors":"Abiya Ahad","doi":"10.57238/jbb.2023.6960.1038","DOIUrl":"https://doi.org/10.57238/jbb.2023.6960.1038","url":null,"abstract":"DOACs are the anticoagulation drugs of choice. Using nitroglycerin- containing preparations or sublingual glyceryl trinitrate is not permitted in morbidly obese patients. The lack of supporting evidence made it difficult to support the use of these methods. As a result, the International Soci- ety on Thrombosis and Haemostasis did not recommend using antiplatelet drugs for patients who experienced cerebrovascular accidents. Due to the absence of therapeutic monitoring and the need for anticoagulant bridg- ing, the use of direct oral anticoagulants (DOACs) has gained substantial popularity. Few studies have examined their efficacy in people with obe- sity and VTE. It is presently not advised that these medicines be used as first-line treatments due to preliminary subgroup and pharmacokinetic investigations suggesting lower effectiveness in patients with a bodyweight >120 kg or body mass index (BMI) 40 kg per m2. Our study’s primary objective was to evaluate the recurrence of VTE after DOAC treatment in morbidly obese individuals with a VTE diagnosis. A recent study suggests that DOAC use will benefit Parkinson’s disease patients. This paper aimed to systematically review the literature exploring the efficacy and safety of these agents compared to warfarin in treating heart disease in severely obese patients. Accordingly, the international society on thrombosis and haemostasis has forbidden their use in this cohort of patients. There is am- ple evidence for the benefit of DOACs for these purposes. We wanted to learn about the effectiveness and safety issues of novel oral anticoagulants compared to warfarin. A systematic review of PubMed and EMBASE to 01/04/2020. Our analysis of real-world observational data supports the use of DOAC analogues for treating obese patients with a greater body weight ofFIXME>FIXME120 kg and a BMI ofFIXME>FIXME40 kg/m2. This finding helps to address in this cohort the uncertainty associated with the application of DOACs.","PeriodicalId":497721,"journal":{"name":"Journal of Biomedicine and Biochemistry","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135690578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence Rate of Thyroid Cancer in Wasit Province From (2017–2021) Related with Age and Gender Wasit省(2017-2021)甲状腺癌发病率与年龄、性别的关系

Journal of Biomedicine and Biochemistry Pub Date : 2023-09-01 DOI: 10.57238/jbb.2023.6939.1032

Zainab Abdalameer Alqurashi

{"title":"Incidence Rate of Thyroid Cancer in Wasit Province From (2017–2021) Related with Age and Gender","authors":"Zainab Abdalameer Alqurashi","doi":"10.57238/jbb.2023.6939.1032","DOIUrl":"https://doi.org/10.57238/jbb.2023.6939.1032","url":null,"abstract":"Background Thyroid cancer developing when the cells of thyroid gland grow abnormally. The characteristic of thyroid cancer involve swelling or a tumor in the neck.Objective Knowledge the incidence rate of Thyroid cancer in Wasit Province from (2017–2021) related with Age and Gender.Results In our research, cancer data were taken in Wasit Governorate for patients attending the Al-Karama Teaching Hospital for the period From 2017 to 2021, the results showed that thyroid cancer had recorded in- cidence reach (13.004%), where 42 out of 323 cases of cancer were recorded in last five years.The data were distributed according to the years as they were distributed over the years (2017 to 2021), where the highest rate of in- fection was in the year 2020,While the lowest rate of infection was recorded in 2019 with a frequency of 5 cases.As for the relationship of thyroid cancer with gender, the results showed that thyroid cancer had 21.42% of cases in males, while in females had 78.57%.The relationship of the disease with the age was found the majority of the 9 patients in this study were between the ages of 50 and 59, making about 21.4% of the total. Eight instances (19.1%) were found in people aged 40–49, while seven cases (16.7%) were found in people aged 30–39. Two occurrences of thyroid cancer were re- ported in people aged 70 to 79, the age group with the lowest incidence rate.Conclusion Thyroid cancer in the past 5 years showed the highest rate of cases was recorded in 2020. Relationship of the disease with gender has shown that females are more affected than male . Relationship with age factor found that the most vulnerable age groups are 50-59 years old.","PeriodicalId":497721,"journal":{"name":"Journal of Biomedicine and Biochemistry","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135894967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation Of Lipid Profile, and Preptin Between Obese Non-Diabetic Patients and Women with Polycystic Ovary Syndrome in Al Diwaniyah, Iraq 伊拉克Al Diwaniyah地区肥胖非糖尿病患者和多囊卵巢综合征女性患者的血脂和激素水平评估

Journal of Biomedicine and Biochemistry Pub Date : 2023-09-01 DOI: 10.57238/jbb.2023.7061.1045

Zainab Alobaidy, Haider Alammar, Maather AL-harmooshee

{"title":"Evaluation Of Lipid Profile, and Preptin Between Obese Non-Diabetic Patients and Women with Polycystic Ovary Syndrome in Al Diwaniyah, Iraq","authors":"Zainab Alobaidy, Haider Alammar, Maather AL-harmooshee","doi":"10.57238/jbb.2023.7061.1045","DOIUrl":"https://doi.org/10.57238/jbb.2023.7061.1045","url":null,"abstract":"Background Obesity has been associated with polycystic ovarian syn- drome (PCOS) since Stein and Leventhal first described it in 1935. When using equivalent diagnostic criteria. This implies that lifestyle variables like obesity cause PCOS. Obesity worsens PCOS-related reproductive and metabolic problems.Materials and Method The present study included 40 women with polycystic ovarian syndrome at ages (17 -36) years, in addition, the study included 40 non-diabetic obese women with a mean age range of (18 -56) years, Between November 2022 and May 2023, the participants in this research were enrolled at Al-Diwanyah Teaching Hospital. All laboratory test analysis was completed at the Clinical Chemistry Research Lab and AL Diwaniyah Teaching Hospital, both located in the College of Medicine at the University of Al-Qadisiyah.Results In the present results lipid profile, the mean cholesterol was significantly higher in the PCOS Group in comparison with the obese OND . There was no significant difference in the mean serum triglycerides, HDL, LDL, and VLDL between the PCOS Group and the OND group. There was no significant difference in the mean preptin level between the PCOS group and the obese OND (p = 0.473). Then there was a comparison of preptin levels before and after the treatment in OND patients there was a significant reduction in the level (p < 0.001), and in comparison of preptin levels before and after the treatment in PCOS patients there was a significant reduction in the level (p < 0.001).Conclusion According to the current findings, treating overweight or obese PCOS patients with insulin resistance, the Homeostatic Model As- sessment for Insulin Resistance, and metformin had comparable outcomes.","PeriodicalId":497721,"journal":{"name":"Journal of Biomedicine and Biochemistry","volume":"384 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135735867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0