Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)最新文献

The Therapeutic Role of Olea europaea in Alcohol Dependence Base in Network Pharmacology Analysis 油橄榄对酒精依赖的治疗作用——基于网络药理学分析

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2486

Faiznanda Awwaluddin, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin

{"title":"The Therapeutic Role of Olea europaea in Alcohol Dependence Base in Network Pharmacology Analysis","authors":"Faiznanda Awwaluddin, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin","doi":"10.18860/planar.v3i0.2486","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2486","url":null,"abstract":"Alcohol dependence is a state of alcohol becoming a vital part of the life of a person who consumes it; when discontinued, it can lead to a wide range of physical and mental health disorders as well as a decrease in life productivity in people with alcohol dependence. Olea Europaea (OE) is a plant capable of treating alcohol dependence. The method used in silico-based pharmacological grid analysis to determine the ability of the OE compound to treat alcohol dependence. EO compound data is obtained from the KnapSack database, absorption, distribution, metabolism, and excretion (ADME) screening using SwissADME, target protein prediction using SwissTargetPrediction, Gene cards, venny, pharmacological grid analysis with String-DB, visualization with Cytoscape 3.10.0. Results are obtained from 63 OE compounds, and 17 have ADME criteria matching the drug compounder (Drug Likeness/DL). The pathways that correlate with therapy are dopamine receptors, dopamine transporter, serotonin receptor, gamma-aminobutyric acid receptor, and toll-like receptors for known therapeutic target proteins: OPRM1, DRD2, ALDH2, ADH1B, ADH1A, ADH1C, ADH4, ADH7, SLC6A3, CNR1, POMC, ARRB2, and NCS1. Compounds associated with alcohol dependency therapy include Hexanal, Nonadienal, Octanal, 3-Hexenal, 3-Methyl-butanal, Methyl nominate, Cinchonidine, cinchonine, (9S)-10,11-Dihydrocinchonan-9-ol, Oleuropeic acid, Butyl acetate, cis-3-hexenyl acetate, and (S)-2,3-Epoxysqualene. Based on the findings, OE is a potential drug candidate for alcohol dependence.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"128 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Potential Analysis of Acorus calamus as a Mental Depression Therapy 菖蒲治疗精神抑郁症的计算机潜力分析

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2473

Fitria Dwi Damayanti, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin

{"title":"In Silico Potential Analysis of Acorus calamus as a Mental Depression Therapy","authors":"Fitria Dwi Damayanti, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin","doi":"10.18860/planar.v3i0.2473","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2473","url":null,"abstract":"Depression is a common but serious mood disorder. This disease causes severe symptoms that affect one's emotions, thoughts, and daily activities, such as sleep, eating, or working. According to the National Youth Mental Health Survey of Indonesia, in 2022, 15.5 million (34.9%) teenagers suffer from mental disorders and 2.45 million (5.5%) have mental illnesses. Acorus calamus is believed to have antispasmodic, carminative, antihelmintic, aromatic, expectorant, nausea, soothing, sedative, and stimulant properties. It is also used to treat epilepsy and mental illness, chronic diarrhea, dysentery, and stomach pain. This study aims to determine the molecular mechanisms of the bioactive compound antidepressant Acorus calamus using pharmacological tissue analysis. Acorus calamus compound data obtained from Dr. Duke's database, screening of the absorption, distribution, metabolism, and excretion (ADME) of Acorus calamus Compounds with SwissADME, prediction of the Acorus calamus target compounds protein with SwissTargetpPrediction, analysis of the pharmacological network with String-DB and its visualization with Cytoscape version 3.10.1. Searching for the contents of Acorus calamus compounds resulted in 69 components and found 12 compounds that have ADME criteria that match the drug compounds (Drug Likeness/DL). The pathways correlated with therapy are the neurotransmitters of serotonin. The known target proteins are MAOA, ESR1, GRM5, CRHR1, HTR2A, DRD2, SLC6A4 and CHR with compounds that correlate with mental depression therapy, among others Aceteugenol, Acoradin, Acoramone, Alpha-Asarone, Beta-Asarone, Calamenone, Camelone, Elemicin, Isoacorone, Sekishone, trans-Isoelemicine, Epoxyisoacoragermacrone.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"130 37","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network Pharmacology Analysis of Cananga odorata as a Treatment for Anxiety Disorders 加南茄治疗焦虑症的网络药理学分析

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2479

Tri Luthfiana Maretha, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin

{"title":"Network Pharmacology Analysis of Cananga odorata as a Treatment for Anxiety Disorders","authors":"Tri Luthfiana Maretha, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin","doi":"10.18860/planar.v3i0.2479","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2479","url":null,"abstract":"Anxiety disorder is a psychological disorder associated with the existence of mental disorders and experiencing constant anxiety. In C. odorata, part of the flower has the potential as a sedative for the nervous system and for dealing with anxiety. The study aims to analyze the potential compound content in Cananga odorata for treating anxiety disorders with In silico-based pharmacological network analysis. CO compound data from the KNApSAck database, Absorption, Distribution, Metabolism, and Excretion (ADME) screening using SwissADME, predicted target proteins using Swiss Target Prediction, GeneCards, Venny, String DB pharmacological network analysis, Visualization with Cytoscape version 3.10.0, and Way2drug. The results of the pharmacological tissue analysis of the compound content in C. odorata obtained 45 compounds, and 18 known active components meet the criteria of Absorption, Distribution, Metabolism, and Excretion (ADME) that correspond to the drug compounder (Drug Likeness/DL). Based on the pathway that correlates with anxiety disorder therapy are the neurotransmitter systems like serotonin receptors and dopamine receptors. The known therapeutic target proteins are HTR1A, HTR2A, SLC6A4, NR3C1, MAOA, DRD4, HSP90AA1, JUN, ten active compounds associated with C. odorata namely Anonaine, (+)-Reticuline, linalool, (-)-Coreximine, Micheline A, (-)-Ushinsunine beta-N-oxide, 4-Terpineol, alpha-Terpeneol, Sampangine, Anaxagoreine. Based on the results of research, C. odorata is potentially a treatment for anxiety disorder.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"128 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Network Pharmacology of Beluntas (Pluchea indica) on Immunity Cases 白莲属(Pluchea indica)免疫病例网络药理研究

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2474

M Amir Fauzi, M Artabah Muchlisin, Ahmad Shobrun Jamil, Irsan Fahmi Almuhtarihan

{"title":"A Network Pharmacology of Beluntas (Pluchea indica) on Immunity Cases","authors":"M Amir Fauzi, M Artabah Muchlisin, Ahmad Shobrun Jamil, Irsan Fahmi Almuhtarihan","doi":"10.18860/planar.v3i0.2474","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2474","url":null,"abstract":"COVID-19 is classified as an outbreak related to the human immune system. The process of spreading was indeed quick, which made this outbreak a particularly dangerous pandemic. As of March 10, 2023, Indonesia had recorded 6,738,225 positive cases and 160,941 deaths from COVID-19 in 2020. The aim is to curb virus spread by boosting the immune system through antibody production. Studies suggest that certain Indonesian plants have immunomodulatory potential. This study aimed to determine the protein network associated with the body's immune system, which was activated by giving beluntas (Pluchea Indica). The research method used is descriptive in silico analysis using a online databases: KNApSAck, Dr. Duke, Pubchem, Swiss ADME, Swiss Target Prediction, Gene Cards, Venny, STRING, and KEGG. Based on the results of pharmacological network analysis, the P. indica contains 234 secondary metabolites, 126 of which have high bioavailability. Proteins associated with P. indica contain 1317 compounds, and those related to immunomodulators contain 1380 proteins. 340 proteins were found to have interacted with P. indica, all linked to immunomodulation, suggesting its potential for developing treatments for immune-related disorders through further research Based on KEGG Pathway analysis, there are five critical pathways in the immunomodulatory system, namely Th17 cell differentiation, IL-17 signaling pathway, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, and TNF signaling pathway. There is 17 compound that can be an immunomodulator because it interacts with five critical pathways in the immunomodulator system.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"128 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Analysis of Steam Distillation and Enfleurage Methods for the Extraction of Cananga odorata Flower Essential Oil 蒸汽蒸馏法和蒸馏法提取加南加花精油的比较分析

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2483

Elisa Elisa, Faisal Akhmal Muslikh, Tanaya Jati Dharma Dewi, Burhan Ma’arif

{"title":"A Comparative Analysis of Steam Distillation and Enfleurage Methods for the Extraction of Cananga odorata Flower Essential Oil","authors":"Elisa Elisa, Faisal Akhmal Muslikh, Tanaya Jati Dharma Dewi, Burhan Ma’arif","doi":"10.18860/planar.v3i0.2483","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2483","url":null,"abstract":"Essential oils are made from the natural extracts of many different kinds of plants. Indonesia has a lot of potential for making essential oils that could make it the leader in the essential oil market around the world. One of them is the essential oil from the Cananga odorata flower, which is used a lot in the pharmaceutical industry and others. The aim of this research was to compare methods of extracting essential oils from C. odorata leaves that can produce oils of good quality and that meet standards. In this study, steam distillation and enfleuration methods were used to extract the essential oil from the flower. Essential oil extracted with steam distillation had a yield value of 1.87%. Its characteristics were that it was light yellow in color, had a distinct fragrance, had a refractive index of 1.480, and had a specific gravity of 0.908 g/mL. The yield of essential oil from enfleurage was 2.87%, and it was dark yellow with a distinct fragrance. It had a refractive index of 1.510 and a specific gravity of 0.9012 g/mL. The GC-MS analysis of the essential oil from the steam distillation found 21 different compounds. The highest of these was b-cubebene (19.92%). The GC-MS analysis of the essential oil from enfleuration method found 15 different compounds, with caryophyllene (39.94%) being the highest. Based on the findings, it was concluded that the enfleuration method was more optimal for extracting essential oils from C. odorata.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"130 28","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and Physical Stability Effervescent Powder of Okra Leaves Extract (Abelmoschus esculentus) as an Antidiabetic Supplement 秋葵叶提取物泡腾粉作为抗糖尿病补充剂的评价及物理稳定性

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2466

Agnis Pondineka Ria Aditama, Alfi Nur Ramadhani, Asa Falahi, Dewi Rashati

{"title":"Evaluation and Physical Stability Effervescent Powder of Okra Leaves Extract (Abelmoschus esculentus) as an Antidiabetic Supplement","authors":"Agnis Pondineka Ria Aditama, Alfi Nur Ramadhani, Asa Falahi, Dewi Rashati","doi":"10.18860/planar.v3i0.2466","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2466","url":null,"abstract":"Diabetes Mellitus (DM) is a disease characterized by hyperglycemia, and the most frequently encountered is type 2, which requires oral anti-diabetic therapy. Economic and socio-cultural factors also influence people in choosing alternative medicine. Okra (Abelmoschus esculentus (L.) Moench) is a medicinal plant containing the active substances flavonoids, α-cellulose, and hemicellulose in its leaves which have anti-diabetic properties, especially type 2 DM. This research aims to make a formula and determine the physical stability of the anti-diabetic supplement preparations in the form of effervescent powder from okra leaves extract. The method used is to make okra leaves extract effervescent powder in 3 formulations with a combination percentage of acid (tartaric and citric acid) and base (sodium bicarbonate) F1 = 27.87%: 26.8%, F2 = 26.05%: 28, 62%, F3 = 24.22%: 30.45%. The preparation evaluation includes organoleptic tests, flow rate, water content, effervescence time, pH, and hedonics for 1 and 14 days of storage at cool temperatures (8-15°C), room temperature (15-30°C), and warm temperature (30-40°C). The results showed that variations in acid-base concentration affected organoleptic, physical properties (taste), flow rate, water content, effervescence time, and pH. F3 shows the best formula and is the formula that respondents like most based on texture, color, flavor, and taste parameters. A cool temperature (8-15°C) shows the best stability because of its physical stability.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"130 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery New Drug Cycela barbata in Alcohol Use Disorder Using Pharmacological Methods 用药理学方法发现治疗酒精使用障碍的新药物半夏

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2485

Nuvandaru Fajar Dzikra Febriyandi, Ahmad Shobrun Jamil, M Artabah Muchlisin

{"title":"Discovery New Drug Cycela barbata in Alcohol Use Disorder Using Pharmacological Methods","authors":"Nuvandaru Fajar Dzikra Febriyandi, Ahmad Shobrun Jamil, M Artabah Muchlisin","doi":"10.18860/planar.v3i0.2485","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2485","url":null,"abstract":"Alcohol use disorder (AUD) is a medical condition characterized by an impaired ability to stop or control alcohol use including conditions that some refer to as alcohol abuse, alcohol dependence, alcohol addiction, and the colloquial term, alcoholism. The aim of this research is to find the potential of grass jelly (Cyclea barbata) for treating alcohol. The method used is in silico pharmacological network analysis. Secondary metabolite compound data was obtained from the Knapsack database, prediction of the ability to penetrate the blood brain barrier using the Boiled-Egg method in SwissADME. Prediction of proteins related to C. barbata used SwisstTargetPrediction. Pharmacological network analysis using StringDB and Disease Gene methods. The screening results from KnapSack showed 18 compounds, and only three compounds, namely beta-Cyclanoline, (-)-N-Methylcoclaurine, and (+)-Coclaurine, were predicted to be able to penetrate the blood-brain barrier using Boiled-EGG. From SwissTargetPrediction, 125 proteins related to C. barbata were obtained. From pharmacological network analysis, it was found that 6 proteins were related to alcohol use disorder, namely DRD3, HTR2A, SLC6A3, DRD2, OPRM1, and SLC6A4. So it can be concluded that C. barbata has potential as a plant that can be used to treat AUD.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"130 35","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Network Pharmacology of Camellia sinensis (Green Tea) 茶树(绿茶)的网络药理研究

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2487

Sri Wahyuni, Ahmad Shobrun Jamil, M Artabah Muchlisin

{"title":"A Network Pharmacology of Camellia sinensis (Green Tea)","authors":"Sri Wahyuni, Ahmad Shobrun Jamil, M Artabah Muchlisin","doi":"10.18860/planar.v3i0.2487","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2487","url":null,"abstract":"Network pharmacology focuses on the therapeutic concept of one-target-one-drug to network-target-components to combat complex diseases. This research uses bioinformatics and high-throughput screening methods to facilitate the prediction of various drug target networks based on the establishment of biological models and becomes more important in uncovering the underlying mechanisms of drug action. Tea (Camelia sinensis) is one of the most ancient and popular therapeutic drinks consumed throughout the world and prepared as a drink that can have many health effects. This research aims to determine the pharmacological network analysis of C. sinensis. The list of C. sinensis secondary metabolite compounds was obtained from the Dr. database Duke. Protein predictions associated with C. sinensis were obtained from SwissTargetPrediction. Pharmacological network analysis was performed with StringDB and KEGG enrichment. From the search results, 57 compounds were obtained. From network pharmacology analysis, 15 biomolecular pathways were obtained that were closely related to secondary metabolite compounds in C. sinensis. From the results of further analysis, it was found that C. sinensis has a role in the treatment of hypertension, cancer, and anti-inflammation.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"128 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Network Pharmacology of Lemongrass (Cymbopogon citratus) on COVID-19 Cases 柠檬草对新型冠状病毒感染的网络药理作用

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2471

Dominyda Vebrianto Saputro, Ahmad Shobrun Jamil, M Artabah Muchlisin, Irsan Fahmi Almuhtarihan

{"title":"A Network Pharmacology of Lemongrass (Cymbopogon citratus) on COVID-19 Cases","authors":"Dominyda Vebrianto Saputro, Ahmad Shobrun Jamil, M Artabah Muchlisin, Irsan Fahmi Almuhtarihan","doi":"10.18860/planar.v3i0.2471","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2471","url":null,"abstract":"Various ways and treatment efforts are carried out to avoid the severe impact of COVID-19 cases, one of which is using plants as natural immunomodulatory agents. One of the plants that is proven to act as a natural immunomodulator is lemongrass (Cymbopogon citratus). This study aimed to determine the protein tissue associated with the body's immune system activated by C. citratus. The secondary metabolites of C. citratus were identified using the KNApSAck and Dr. Duke databases. Target proteins associated with plant-secondary metabolite compounds from the SwissTargetPrediction database and immunomodulatory-associated target proteins were obtained from the GeneCards database. The intersected proteins were put into StringDB and analyzed using KEGG to obtain network pharmacology. 98 secondary metabolite compounds of C. citratus were obtained from the database. Proteins associated with C. citratus contain 1096 compounds, and those related to immunomodulators contain 1380 proteins. The intersection results obtained 244 proteins predicted to interact with C. citratus and are related to immunomodulators. From the results of KEGG analysis, five pathways related to C. citratus were obtained, namely PD-L1 expression and PD-1 checkpoint pathway in cancer, Fc epsilon RI signaling pathway, Th17 cell differentiation, T cell receptor signaling pathway, and IL-17 signaling pathway. MAPK 1, MAPK 3, and MAPK 14 proteins are predicted to be in all five related pathways, and Mol 13 compounds are predicted to be able to interact with these three proteins. Thus, it can be concluded that the compound Mol 13 is the compound that plays the most role in acting as an immunomodulator in C. citratus.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"123 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melaleuca leucadendra Pharmacological Network for Identifying Potential Target of Alcohol Dependence 鉴别酒精依赖潜在靶点的白千层药理网络

Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR) Pub Date : 2023-11-13 DOI: 10.18860/planar.v3i0.2477

Risma Ayu Setiawan, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin

{"title":"Melaleuca leucadendra Pharmacological Network for Identifying Potential Target of Alcohol Dependence","authors":"Risma Ayu Setiawan, Ahmad Shobrun Jamil, Siti Rofida, M Artabah Muchlisin","doi":"10.18860/planar.v3i0.2477","DOIUrl":"https://doi.org/10.18860/planar.v3i0.2477","url":null,"abstract":"Melaleuca leucadendra (ML) contains a compound that is potentially a candidate for alcohol dependence. Alcohol dependence is defined by desire, tolerance, anxiety with alcohol, and continuing to drink even though the consequences are dangerous. The study aims to analyze the potential of the ML compound content for alcohol dependence therapy within silico-based pharmacological chain analysis. ML compound data is obtained from the Knapsack database, screening of absorption, distribution, metabolism, and excretion (ADME) of the compounds ML with SwissADME, prediction of the protein of the target compounder ML with the Swiss TargetpPrediction, Gene cards, venny, analysis of the pharmacological network with String-DB and its visualization with Cytoscape version 3.10.0. The pathways correlated with therapy are dopamine receptors, dopamine carriers, serotonin, gamma-aminobutyric acid receptors, and toll-like receptors for known therapeutic target proteins: OPRM1, DRD2, ALDH2, ADH1B, ADH1A, ADH1C, ADH4, SLC6A3, CNR1, POMC, ARRB2, and NCS1. Alcohol-dependent therapies include alpha-Campholenal, Benzaldehyde, trans-Pinocarveol, Borneol, linalool, alfa-Terpineol, (-)-alpha-Bisabolol oxide B, alphaterpine acetate, and Caryophylla-4(148),15-dien-5alphaol.","PeriodicalId":497601,"journal":{"name":"Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR)","volume":"124 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136351320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0