{"title":"Chemotropic axon guidance molecules in tumorigenesis.","authors":"Alain Chédotal","doi":"10.1159/000100048","DOIUrl":"https://doi.org/10.1159/000100048","url":null,"abstract":"<p><p>Recent studies suggest that secreted proteins in several families of axon guidance molecules, the slits, the semaphorins and the netrins may play important roles in cancers. The expression of many of these proteins is either down-regulated or up-regulated in cancer cell lines and tumors. Several of the corresponding genes are localized on chromosomal regions associated with frequent loss-of-heterozygosity and their promoters are hypermethylated, suggesting that they may act as tumor suppressors. Moreover, many axon guidance proteins were also shown to control the development of the vasculature and may thus control angiogenesis in the tumors. These axon guidance molecules may also control the migration and invasion potential of cancer cells. Lastly, they could stimulate their proliferation and regulate cell death. Thus, axon guidance molecules appear as good targets for the development of novel therapeutic agents for the treatment of malignancy.</p>","PeriodicalId":49661,"journal":{"name":"Progress in Tumor Research","volume":"39 ","pages":"78-90"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000100048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26620799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Organization of peripheral nerves in skin, musculoskeletal system and viscera.","authors":"Monika von Düring, Britta Fricke","doi":"10.1159/000100043","DOIUrl":"https://doi.org/10.1159/000100043","url":null,"abstract":"<p><p>Skin, musculoskeletal system and all organs of the body are supplied by nerve fibers of the somatic and autonomic nervous system, each of the systems with its specific nerve fiber types, fiber composition, fiber density and targets. Experimental data support the hypothesis that tumor tissue might interact with nerve fibers. The peripheral nervous system possesses an extraordinary cellular equipment to protect the axons against pathological stimuli. Only restricted areas lacking a cellular barrier are weak points within the nervous network. Therefore, this article focuses on the functional morphology of the peripheral nervous system and its regional differences.</p>","PeriodicalId":49661,"journal":{"name":"Progress in Tumor Research","volume":"39 ","pages":"30-44"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000100043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26565372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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