Scandinavian Journal of Laboratory Animal Science最新文献

HUMANE ENDPOINTS IN SEVERE IRRADIATION EXPERIMENTS USING NON-HUMAN PRIMATES: A RETROSPECTIVE ANALYSIS. 使用非人类灵长类动物的严重辐照实验中的人类终点:回顾性分析。

IF 0.8 4区农林科学

Scandinavian Journal of Laboratory Animal Science Pub Date : 2020-03-25 DOI: 10.23675/SJLAS.V46I1.989

By Jean-Marc Bertho, S. Ancelet, Delphine Denais-Laliève, Nicolas Dudoignon

{"title":"HUMANE ENDPOINTS IN SEVERE IRRADIATION EXPERIMENTS USING NON-HUMAN PRIMATES: A RETROSPECTIVE ANALYSIS.","authors":"By Jean-Marc Bertho, S. Ancelet, Delphine Denais-Laliève, Nicolas Dudoignon","doi":"10.23675/SJLAS.V46I1.989","DOIUrl":"https://doi.org/10.23675/SJLAS.V46I1.989","url":null,"abstract":"A retrospective statistical study has been performed in order to identify the biological, clinical and behavioural variables that could potentially predict the survival status of irradiated non-human primates (NHP) and to refine the future use of humane end points (HEP). The available data come from experiments that were initially designed and implemented to evaluate the efficacy of various treatments of the radiation-induced hematopoietic syndrome. A group of 15 NHP was selected on the basis of similar irradiation and treatment protocols. Among those 15 NHP, 3 animals died during the study despite efforts developed to prevent high suffering and death. Among individual variables collected during the study, the ones retained for the present analysis were Flt3-ligand concentration in plasma, body temperature, alimentary behaviour and general behaviour score. A Bayesian predictive analysis showed that, although some of these variables were of potential interest, none of them alone proved valuable in predicting the death of the three animals. A refined analysis showed that a rapid decrease in body temperature during 3 consecutive days of more than 2.5°C was predictive of the death of two out of three animals. Moreover, a combination of several variables including decrease in body temperature and general behaviour score, improved the prediction of death. These results confirm that a HEP cannot only rely on the use of a single variable, strongly suggesting using a combination of variables, including behaviour, as a composite HEP in NHP experiments using high doses of irradiation.","PeriodicalId":49571,"journal":{"name":"Scandinavian Journal of Laboratory Animal Science","volume":"51 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73213091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Implementation of improved postoperative care decreases the mortalit1y rate of operated mice after an abundant 6-hydroxy dopamine lesion of nigrostriatal dopaminergic neurons 改善术后护理可降低黑质纹状体多巴胺能神经元大量6-羟基多巴胺损伤后手术小鼠的死亡率

IF 0.8 4区农林科学

Scandinavian Journal of Laboratory Animal Science Pub Date : 2019-01-01 DOI: 10.23675/SJLAS.V45I0.581

Sini K. Koski, Sakari Leino, S. Rannanpää, O. Salminen

引用次数: 2

Local infusion of Staphylococcus aureus into the porcine internal carotid artery as a model of sepsis-related brain abscesses - A pilot study 局部输注金黄色葡萄球菌到猪颈内动脉作为败血症相关脑脓肿模型-一项初步研究

IF 0.8 4区农林科学

Scandinavian Journal of Laboratory Animal Science Pub Date : 2017-01-01 DOI: 10.23675/SJLAS.V43I0.492

L. Astrup, T. Iburg, J. Agerholm, B. Aalbæk, O. L. Nielsen, P. S. Leifsson

引用次数: 0

The Association of Early Dietary Supplementation with Vitamin E with the Incidence of Ulcerative Dermatitis in Mice on a C57BL/6 Background: Diet and Ulcerative Dermatitis in Mice. 早期膳食补充维生素E与C57BL/6小鼠溃疡性皮炎发病率的关系

IF 0.8 4区农林科学

Scandinavian Journal of Laboratory Animal Science Pub Date : 2010-01-01

J R Mader, M A Mason, L K Bale, N M Gades, C A Conover

{"title":"The Association of Early Dietary Supplementation with Vitamin E with the Incidence of Ulcerative Dermatitis in Mice on a C57BL/6 Background: Diet and Ulcerative Dermatitis in Mice.","authors":"J R Mader, M A Mason, L K Bale, N M Gades, C A Conover","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to ascertain if prophylactic ingestion of a diet rich in vitamin E would prevent or impede the development of ulcerative dermatitis in mice on a C57BL/6 background. Mice were fed either a standard mouse diet, vitamin E (99 IU/kg), or a mouse diet fortified with vitamin E (3000 IU/kg) after weaning. Cases of ulcerative dermatitis were recorded by individuals unmasked to the diet assignment. The incidence of ulcerative dermatitis in a retrospective cohort of mice on standard diet was compared with the group on the diet fortified with vitamin E. Age was associated with ulcerative dermatitis in standard diet and vitamin E fortified diet groups, r = 0.43, p-value < 0.0001 and r = 0.18, p-value < 0.02, respectively. The average age of incidence for ulcerative dermatitis in the mice fed the standard diet was 89 weeks and for the mice fed the vitamin E diet it was 41 weeks. The unadjusted odds ratio comparing the incidence of ulcerative dermatitis between the two diet groups was 4.6 with a 95% confidence interval of (2.44, 8.58), χ(2) p-value < 0.0001. Therefore, there was an association between the diets and ulcerative dermatitis, with the mice on the vitamin E fortified diet having almost five times the odds of having ulcerative dermatitis compared with mice on the standard diet. Incidence of ulcerative dermatitis was not influenced by sex or genotype. Our study results show that a diet fortified in vitamin E initiated at weaning does not prevent or impede the development of ulcerative dermatitis in mice on a C57BL/6 background and may accelerate development when administered to young mice.</p>","PeriodicalId":49571,"journal":{"name":"Scandinavian Journal of Laboratory Animal Science","volume":"37 4","pages":"253-259"},"PeriodicalIF":0.8,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503310/pdf/nihms298972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31072648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report and Short Communication: Rectal prolapse associated with an unusual combination of pinworms and citrobacter species infection in FVB mice colony 病例报告和简短交流:直肠脱垂与FVB小鼠群体中蛲虫和柠檬酸杆菌的不寻常组合感染有关

IF 0.8 4区农林科学

Scandinavian Journal of Laboratory Animal Science Pub Date : 2004-01-01 DOI: 10.23675/SJLAS.V31I4.72

M. Nireekshan Kumar, P. Nagarajan, R. Venkatesan, R. Juyal

引用次数: 5