Implementation of improved postoperative care decreases the mortalit1y rate of operated mice after an abundant 6-hydroxy dopamine lesion of nigrostriatal dopaminergic neurons

Abstract

Various ways exist to establish rodent models of Parkinson’s disease, a neurodegenerative motor disorder caused by the death of dopaminergic neurons that have their cell bodies in the substantia nigra pars compacta (SNc) and project into the dorsal striatum. Neurodegeneration and motor symptoms of Parkinson’s disease can be mimicked in animals by degenerating these nigrostriatal neurons with different neurotoxins, administered either systemically or intracranially, or by genetic manipulations (Bové & Perier, 2012). Importantly, different methods can cause difImplementation of improved postoperative care decreases the mortality rate of operated mice after an abundant 6-hydroxydopamine lesion of nigrostriatal dopaminergic neurons