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NLRP3和PGE2在子宫内膜异位症组织中的表达 NLRP3和PGE2在子宫内膜异位症组织中的表达
临床医学前沿 = Pub Date : 2026-01-01 DOI: 10.37155/2661-4766-0801-3
张培红
{"title":"NLRP3和PGE2在子宫内膜异位症组织中的表达","authors":"张培红","doi":"10.37155/2661-4766-0801-3","DOIUrl":"https://doi.org/10.37155/2661-4766-0801-3","url":null,"abstract":"本研究旨在探讨NOD样受体热蛋白结构域相关蛋白3（NLRP3）和前列腺素E2（PGE2）在子宫内膜异位 症（EMs）异位内膜、在位内膜及正常子宫内膜组织中的表达情况，分析其表达差异性和内在相关性。通过选取2025 年1月至2026年1月我院妇科收治的30例EMs患者异位内膜、30例在位内膜及30例正常子宫内膜组织，采用免疫组织化 学方法检测NLRP3和PGE2的表达，并分析其与病理特征的关系及相关性。结果显示，NLRP3和PGE2在EMs异位内膜 中的表达显著高于在位内膜和正常子宫内膜，且两者在EMs异位内膜中的表达呈正相关。本研究为子宫内膜异位症发 病机制的研究提供了新的方向，并为寻找有效的治疗靶点提供了理论依据。","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"8 1","pages":"7-9"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
木犀草素以P16依赖的方式阻止缺氧诱导的宫颈癌细胞恶性表型 木犀草素以P16依赖的方式阻止缺氧诱导的宫颈癌细胞恶性表型
临床医学前沿 = Pub Date : 2026-01-01 DOI: 10.37155/2661-4766-0801-2
满晓丽, 周传亚
{"title":"木犀草素以P16依赖的方式阻止缺氧诱导的宫颈癌细胞恶性表型","authors":"满晓丽, 周传亚","doi":"10.37155/2661-4766-0801-2","DOIUrl":"https://doi.org/10.37155/2661-4766-0801-2","url":null,"abstract":"","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"8 1","pages":"4-6"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ojs.omniscient.sg/index.php/lcyxqy/article/download/72874/71315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
膜联蛋白 A2/A5/A9 在乳腺癌患者血清中的表达特征及诊断效能评估 膜联蛋白 A2/A5/A9 在乳腺癌患者血清中的表达特征及诊断效能评估
临床医学前沿 = Pub Date : 2026-01-01 DOI: 10.37155/2661-4766-0802-22
宫方岩
{"title":"膜联蛋白 A2/A5/A9 在乳腺癌患者血清中的表达特征及诊断效能评估","authors":"宫方岩","doi":"10.37155/2661-4766-0802-22","DOIUrl":"https://doi.org/10.37155/2661-4766-0802-22","url":null,"abstract":"","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"8 2","pages":"64-66"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147894611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
宫颈-阴道液衍生蛋白质（HPT、LG3BP、FGA、LY6D和IGHM）对绝经后出血患者子宫内膜癌的预测价值 宫颈-阴道液衍生蛋白质（HPT、LG3BP、FGA、LY6D和IGHM）对绝经后出血患者子宫内膜癌的预测价值
临床医学前沿 = Pub Date : 2026-01-01 DOI: 10.37155/2661-4766-0801-19
陈东英, 周传亚
{"title":"宫颈-阴道液衍生蛋白质（HPT、LG3BP、FGA、LY6D和IGHM）对绝经后出血患者子宫内膜癌的预测价值","authors":"陈东英, 周传亚","doi":"10.37155/2661-4766-0801-19","DOIUrl":"https://doi.org/10.37155/2661-4766-0801-19","url":null,"abstract":"目的：探讨宫颈-阴道液中衍生蛋白质组氨酸磷酸酶（HPT）、半乳糖凝集素3结合蛋白（LG3BP）、 纤维蛋白原α链（FGA）、淋巴细胞抗原6复合物基因座D（LY6D）和免疫球蛋白重链恒定区μ（IGHM）对绝经后出 血患者子宫内膜癌的预测价值。方法：选取因绝经后出血就诊的患者作为研究对象，根据病理检查结果分为子宫内 膜癌组和非子宫内膜癌组，收集两组患者的宫颈-阴道液样本，采用酶联免疫吸附试验（ELISA）检测样本中HPT、 LG3BP、FGA、LY6D和IGHM的浓度，比较两组间各蛋白质浓度差异。结果：子宫内膜癌组患者宫颈-阴道液中 HPT、LG3BP、FGA和LY6D浓度显著高于非子宫内膜癌组，而IGHM浓度显著低于非子宫内膜癌组，差异均具有统 计学意义（P < 0.05）。ROC曲线分析结果显示，HPT、LG3BP、FGA、LY6D和IGHM单独检测对子宫内膜癌均有一 定的预测价值，曲线下面积（AUC）分别为0.782、0.756、0.723、0.701和0.689；联合检测上述五种蛋白质时，AUC 提高至0.895，敏感度为85.7%，特异度为82.3%，显著优于各蛋白质单独检测。结论：宫颈-阴道液中HPT、LG3BP、 FGA、LY6D和IGHM浓度在绝经后出血患者子宫内膜癌和非子宫内膜癌患者间存在差异，联合检测这五种蛋白质对子 宫内膜癌具有较高的预测价值，有望为绝经后出血患者子宫内膜癌的早期诊断提供新的生物标志物。","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"8 1","pages":"55-57"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ojs.omniscient.sg/index.php/lcyxqy/article/download/72891/71332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
外伤后凹陷性瘢痕的手术修复技术选择与效果评估 外伤后凹陷性瘢痕的手术修复技术选择与效果评估
临床医学前沿 = Pub Date : 2025-01-01 DOI: 10.37155/2661-4766-0705-25
曹树英
{"title":"外伤后凹陷性瘢痕的手术修复技术选择与效果评估","authors":"曹树英","doi":"10.37155/2661-4766-0705-25","DOIUrl":"https://doi.org/10.37155/2661-4766-0705-25","url":null,"abstract":"","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"7 5","pages":"73-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ojs.omniscient.sg/index.php/lcyxqy/article/download/65468/64073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
全方位护理对改善多发肋骨骨折合并肺挫裂伤患者术后疼痛及睡眠质量的作用 全方位护理对改善多发肋骨骨折合并肺挫裂伤患者术后疼痛及睡眠质量的作用
临床医学前沿 = Pub Date : 2025-01-01 DOI: 10.37155/2661-4766-0704-6
郭宝钰
{"title":"全方位护理对改善多发肋骨骨折合并肺挫裂伤患者术后疼痛及睡眠质量的作用","authors":"郭宝钰","doi":"10.37155/2661-4766-0704-6","DOIUrl":"https://doi.org/10.37155/2661-4766-0704-6","url":null,"abstract":"目的：分析全方位护理在多发肋骨骨折合并肺挫裂伤患者中的应用效果。方法：选取2023年11月-2024 年11月本院68例多发肋骨骨折合并肺挫裂伤患者开展研究，用随机数字表法平均分为对照组34例，行常规护理，观察 组34例，行全方位护理，比较两组护理效果。结果：观察组的疼痛（VAS）、睡眠质量（PSQ）评分和并发症发生率 均明显低于对照组，差异有统计学意义（P < 0.05）。结论：治疗多发肋骨骨折合并肺挫裂伤患者时，实施全方位护 理，能减轻疼痛，提高睡眠质量，减少并发症，值得推广。","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"7 4","pages":"16-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ojs.omniscient.sg/index.php/lcyxqy/article/download/60776/59503","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
调节肠道菌群及短链脂肪酸：治疗溃疡性结肠炎的新进展 调节肠道菌群及短链脂肪酸：治疗溃疡性结肠炎的新进展
临床医学前沿 = Pub Date : 2025-01-01 DOI: 10.37155/2661-4766-0705-30
培 张, 周玉平
{"title":"调节肠道菌群及短链脂肪酸：治疗溃疡性结肠炎的新进展","authors":"培 张, 周玉平","doi":"10.37155/2661-4766-0705-30","DOIUrl":"https://doi.org/10.37155/2661-4766-0705-30","url":null,"abstract":"","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"7 5","pages":"88-92"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
超声引导下细针穿刺活检在甲状腺癌淋巴结转移术前评估中的应用价值 超声引导下细针穿刺活检在甲状腺癌淋巴结转移术前评估中的应用价值
临床医学前沿 = Pub Date : 2025-01-01 DOI: 10.37155/2661-4766-0706-38
王海峰
{"title":"超声引导下细针穿刺活检在甲状腺癌淋巴结转移术前评估中的应用价值","authors":"王海峰","doi":"10.37155/2661-4766-0706-38","DOIUrl":"https://doi.org/10.37155/2661-4766-0706-38","url":null,"abstract":"目的：探讨超声引导下细针穿刺活检（Ultrasound-Guided Fine-Needle Aspiration Biopsy，US-FNAB）在 甲状腺癌淋巴结转移术前评估中的临床价值。方法：选取2022年1月—2024年12月我院收治的120例甲状腺癌患者作为 研究对象，按随机数字表法分为观察组（60例）与对照组（60例）。观察组采用超声引导下细针穿刺活检，对照组 采用传统触诊引导细针穿刺活检。以术后病理结果为金标准，比较两组对甲状腺癌淋巴结转移的诊断准确率、灵敏 度、特异度及并发症发生率。结果：观察组诊断准确率为93.3%（56/60），灵敏度为95.2%（39/41），特异度为90.9% （19/21），并发症发生率为3.3%（2/60）；对照组诊断准确率为75.0%（45/60），灵敏度为80.5%（33/41），特异度 为63.6%（14/21），并发症发生率为11.7%（7/60）。两组数据差异均有统计学意义（P < 0.05）。结论：超声引导下 细针穿刺活检在甲状腺癌淋巴结转移术前评估中具有更高的诊断准确性及安全性，可为临床治疗方案制定提供更可靠 的依据。","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"7 6","pages":"112-114"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ojs.omniscient.sg/index.php/lcyxqy/article/download/68387/66955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
产后皮肤接触对母乳喂养率的作用机制与影响分析 产后皮肤接触对母乳喂养率的作用机制与影响分析
临床医学前沿 = Pub Date : 2025-01-01 DOI: 10.37155/2661-4766-0703-49
张思之
{"title":"产后皮肤接触对母乳喂养率的作用机制与影响分析","authors":"张思之","doi":"10.37155/2661-4766-0703-49","DOIUrl":"https://doi.org/10.37155/2661-4766-0703-49","url":null,"abstract":"产后皮肤接触对母乳喂养有着极为重要的影响。它通过刺激催乳素、催产素等激素的分泌，在增强母婴 情感连接、提升母乳分泌量的帮助婴儿建立正确的吸吮反射。母婴间的情感互动，能改善母亲情绪稳定性，降低产后 抑郁风险，进一步增强其坚持母乳喂养的动力。鉴于文化、社会、经济等因素会左右皮肤接触效果，医疗机构和社会 支持体系推动母乳喂养的作用不容小觑。优化医院政策、强化家庭参与并提供全方位支持，可有效提高母乳喂养的持 续性，保障婴儿充足的营养与情感关怀。","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"7 3","pages":"147-149"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ojs.omniscient.sg/index.php/lcyxqy/article/download/56967/55801","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147905428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
协同护理模式在超声引导下肾穿刺活检术中的应用 协同护理模式在超声引导下肾穿刺活检术中的应用
临床医学前沿 = Pub Date : 2025-01-01 DOI: 10.37155/2661-4766-0706-30
李秋香, 张建欣, 尹小菊, 赵惠霞*
{"title":"协同护理模式在超声引导下肾穿刺活检术中的应用","authors":"李秋香, 张建欣, 尹小菊, 赵惠霞*","doi":"10.37155/2661-4766-0706-30","DOIUrl":"https://doi.org/10.37155/2661-4766-0706-30","url":null,"abstract":"目的：探究协同护理模式在超声引导下肾穿刺活检术患者中的应用效果。方法：选取2023年6月-2025年 5月我院120例行该术的患者，随机分为对照组和观察组各60例。对照组常规护理，观察组协同护理。比较两组护理 前后焦虑、抑郁评分，穿刺成功率、并发症发生率及护理满意度。结果：护理后，观察组SAS和SDS评分低于对照组 （P < 0.05）；穿刺成功率96.67%，高于对照组的83.33%（P < 0.05）；并发症发生率5.00%，低于对照组的18.33%（P < 0.05）；护理满意度98.33%，高于对照组的85.00%（P < 0.05）。结论：协同护理模式应用于该术患者，可缓解不良 情绪，提高穿刺成功率，降低并发症，提升满意度，值得推广。","PeriodicalId":495700,"journal":{"name":"临床医学前沿 =","volume":"7 6","pages":"88-90"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ojs.omniscient.sg/index.php/lcyxqy/article/download/68379/66947","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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