Seminars in Radiation Oncology最新文献_第9页

Precision Radiation for Brain Metastases With a Focus on Hypofractionated Stereotactic Radiosurgery 精确放射治疗脑转移瘤，重点是低分割立体定向放射手术

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-04-01 DOI: 10.1016/j.semradonc.2023.01.004

Kevin Shiue , Arjun Sahgal , Simon S. Lo

{"title":"Precision Radiation for Brain Metastases With a Focus on Hypofractionated Stereotactic Radiosurgery","authors":"Kevin Shiue , Arjun Sahgal , Simon S. Lo","doi":"10.1016/j.semradonc.2023.01.004","DOIUrl":"10.1016/j.semradonc.2023.01.004","url":null,"abstract":"<div>There are multiple published randomized controlled trials supporting single-fraction stereotactic radiosurgery (SF-SRS) for patients presenting with 1 to 4 brain metastases, with the benefit of minimizing radiation-induced neurocognitive sequelae as compared to whole brain radiotherapy . More recently, the dogma of SF-SRS as the only means of delivering an SRS treatment has been challenged by hypofractionated SRS (HF-SRS). The ability to deliver 25-35 Gy in 3-5 HF-SRS fractions is a direct consequence of the evolution of radiation technologies to allow image guidance, specialized treatment planning, robotic delivery and/or patient positioning corrections in all 6 degrees-of-freedom, and frameless head immobilization. The intent is to mitigate the potentially devastating complication of radiation necrosis and improve rates of local control for larger metastases. This narrative review provides an overview of outcomes specific to HF-SRS in addition to the more recent developments of staged SRS, preoperative SRS, and hippocampal avoidance-whole brain radiotherapy with simultaneous integrated boost.</div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9282557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palliative Care Delivery Systems and Integration With Palliative Care Teams 姑息治疗提供系统和与姑息治疗团队的整合

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-04-01 DOI: 10.1016/j.semradonc.2022.11.003

Michelle Iocolano , Alyssa Langi , Kavita V. Dharmarajan , Joshua Jones

引用次数: 1

Radiation Therapy in the Management of Adrenal Metastases 放射治疗在肾上腺转移瘤治疗中的应用

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-04-01 DOI: 10.1016/j.semradonc.2022.11.001

Ciro Franzese MD , Sara Stefanini , Marta Scorsetti

引用次数: 0

Pharmacologic Pain Management: What Radiation Oncologists Should Know 药理学疼痛管理:放射肿瘤学家应该知道的

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-04-01 DOI: 10.1016/j.semradonc.2023.01.002

Lara Michal Skarf , Katie Fitzgerald Jones , Jordana L. Meyerson , Janet L. Abrahm

引用次数: 0

Radiotherapy for Lung Metastases: Conventional to Stereotactic Body Radiation Therapy 肺转移瘤的放射治疗：常规到立体定向身体放射治疗

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-04-01 DOI: 10.1016/j.semradonc.2022.11.007

Avipsa Das , Meredith Giuliani , Andrea Bezjak

引用次数: 0

Personalization of Radiation Therapy in the Primary Treatment of Malignant Epidural Spinal Cord Compression (MESCC) 恶性硬膜外脊髓压迫(MESCC)的个体化放射治疗

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-04-01 DOI: 10.1016/j.semradonc.2022.11.005

Dirk Rades , Steven E. Schild

{"title":"Personalization of Radiation Therapy in the Primary Treatment of Malignant Epidural Spinal Cord Compression (MESCC)","authors":"Dirk Rades , Steven E. Schild","doi":"10.1016/j.semradonc.2022.11.005","DOIUrl":"10.1016/j.semradonc.2022.11.005","url":null,"abstract":"<div>“True” malignant epidural spinal cord compression (MESCC) is used here to describe a lesion compressing of infiltrating the spinal cord associated with neurologic deficits. Radiotherapy alone is the most common treatment, for which several dose-fractionation regimens are available including single-fraction, short-course and longer-course regimens. Since these regimens are similarly effective regarding functional outcomes, patients with poor survival are optimally treated with short-course or even single-fraction radiotherapy. Longer-course radiotherapy results in better local control of malignant epidural spinal cord compression. Since most in-field recurrences occur 6 months or later, local control is particularly important for longer-term survivors who, therefore, should receive longer-course radiotherapy. It is important to estimate survival prior to treatment, which is facilitated by scoring tools. Radiotherapy should be supplemented by corticosteroids, if safely possible. Bisphosphonates and RANK-ligand inhibitors may improve local control. Selected patients can benefit from upfront decompressive surgery. Identification of these patients is facilitated by prognostic instruments considering degree of compression, myelopathy, radio-sensitivity, spinal stability, post-treatment ambulatory status, and patients’ performance status and survival prognoses. Many factors including patients’ preferences must be considered when designing personalized treatment regimens.</div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9287573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic Body Radiation Therapy for Spinal Metastases: Benefits and Limitations 立体定向放射治疗脊柱转移:益处和局限性

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-04-01 DOI: 10.1016/j.semradonc.2022.11.006

Matthias Guckenberger MD , Max Dahele MBChB, PhD , Wee Loon Ong MBBS , Arjun Sahgal MD

引用次数: 4

Pushing the Envelope: The Role of Radiation Therapy in Non-muscle-Invasive Bladder Cancer 突破极限:放射治疗在非肌肉浸润性膀胱癌中的作用

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-01-01 DOI: 10.1016/j.semradonc.2022.10.003

Sri Harsha Kombathula , Peter Hoskin

{"title":"Pushing the Envelope: The Role of Radiation Therapy in Non-muscle-Invasive Bladder Cancer","authors":"Sri Harsha Kombathula , Peter Hoskin","doi":"10.1016/j.semradonc.2022.10.003","DOIUrl":"10.1016/j.semradonc.2022.10.003","url":null,"abstract":"<div>The standard of care for non-muscle-invasive bladder cancer (NMIBC) is transurethral resection followed by risk stratified use of intravesical immune- or chemotherapy and for multifocal, recurrent and high grade disease, radical cystectomy with high rates of cure. Bladder preservation analogous to the trimodality therapy approach in muscle-invasive bladder cancer (MIBC) has not been adequately explored but the available data suggests that NMIBC is a radioresponsive malignancy and that in a proportion of patients bladder preservation would be possible. Combination modality with chemotherapy, hypoxia sensitisation, hyperthermia and immunotherapy are all approaches which have been shown effective. Unfortunately the quality of the available data is poor. Although there are many putative prognostic biomarkers for progression in NMIBC none have emerged in clinical use and there are none predictive for response to non-surgical treatment. This would be an important component of future large scale studies to evaluate the precise role of radiotherapy within a multimodality schedule for bladder reservation in NMIBC.</div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9175431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Role of Neoadjuvant Chemotherapy in Bladder Preservation Approaches in Muscle-Invasive Bladder Cancer 新辅助化疗在肌肉浸润性膀胱癌膀胱保留入路中的作用

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-01-01 DOI: 10.1016/j.semradonc.2022.10.006

Carlos Stecca , Timur Mitin , Srikala S. Sridhar

{"title":"The Role of Neoadjuvant Chemotherapy in Bladder Preservation Approaches in Muscle-Invasive Bladder Cancer","authors":"Carlos Stecca , Timur Mitin , Srikala S. Sridhar","doi":"10.1016/j.semradonc.2022.10.006","DOIUrl":"10.1016/j.semradonc.2022.10.006","url":null,"abstract":"<div>Neoadjuvant chemotherapy (NAC), which aims to eliminate micrometastatic disease, has been established as the standard of care for patients with muscle-invasive bladder cancer (MIBC) undergoing radical cystectomy (RC). This is based on randomized controlled trials showing a survival benefit of NAC prior to RC compared to RC alone. It was anticipated that a similar survival benefit would also be seen when NAC was given prior to bladder preserving approaches, but the e phase III RTOG 8903 study which explored this concept was reported to be a negative study. However, there are a number of important caveats to be considered. First, the profile of patients opting for bladder preservation has changed from the older, frailer non-surgical candidates, to now also include younger, fitter patients opting for bladder preservation and who are also more likely to tolerate NAC. In recent years, there have also been important advances in systemic chemotherapy, immunotherapy, radiation techniques, and supportive care. As such revisitng the role of NAC prior to bladder preserving approaches in MIBC appears warranted.</div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9189543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Small Can We Go? Partial Bladder Radiation Therapy and Brachytherapy 我们能做到多小?部分膀胱放射治疗和近距离治疗

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2023-01-01 DOI: 10.1016/j.semradonc.2022.10.010

Jenna M. Kahn , Geert A.H.J. Smits , Bernard J. Oosterveld , Elzbieta M. van der Steen-Banasik

{"title":"How Small Can We Go? Partial Bladder Radiation Therapy and Brachytherapy","authors":"Jenna M. Kahn , Geert A.H.J. Smits , Bernard J. Oosterveld , Elzbieta M. van der Steen-Banasik","doi":"10.1016/j.semradonc.2022.10.010","DOIUrl":"10.1016/j.semradonc.2022.10.010","url":null,"abstract":"<div>Organ preservation for muscle-invasive bladder cancer (MIBC) may use trimodality therapy. This includes transurethral resection followed by radiation therapy. Radiosensitization has become one of the standard of care approaches for MIBC with high rates of local disease control and overall survival. The goal of organ preservation is to treat MIBC while preserving a well-functioning natural bladder. Debate remains over the best way to optimize radiation therapy in bladder cancer. In MIBC the role of partial cystectomy has been utilized in smaller solitary tumors with adequate local control and good urinary function. As radiation therapy techniques improve and modernize, smaller radiation volumes to a partial bladder may play an increasing role as we utilize imaging techniques coupled with adaptive radiation therapy planning and other techniques such as brachytherapy. In this review, we explore the use of brachytherapy and partial bladder fields of external beam radiation therapy in the treatment of MIBC.</div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9175434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0