Seminars in Radiation Oncology最新文献_第5页

The Future of Education in Radiation Oncology 放射肿瘤学教育的未来

IF 2.6 3区医学

Seminars in Radiation Oncology Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.009

Luca Boldrini , Laura La Porta , Chiara Gasparotto , Jesper Grau Eriksen

引用次数: 0

Global Workforce and Access: Demand, Education, Quality 全球劳动力与获取：需求、教育、质量

IF 2.6 3区医学

Seminars in Radiation Oncology Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.003

Surbhi Grover , Laurence Court , Sheldon Amoo-Mitchual , John Longo , Danielle Rodin , Aba Anoa Scott , Yolande Lievens , Mei Ling Yap , May Abdel-Wahab , Peter Lee , Ekaterina Harsdorf , Jamal Khader , Xun Jia , Manjit Dosanjh , Ahmed Elzawawy , Taofeeq Ige , Miles Pomper , David Pistenmaa , Patricia Hardenbergh , Daniel G Petereit , C. Norman Coleman

{"title":"Global Workforce and Access: Demand, Education, Quality","authors":"Surbhi Grover , Laurence Court , Sheldon Amoo-Mitchual , John Longo , Danielle Rodin , Aba Anoa Scott , Yolande Lievens , Mei Ling Yap , May Abdel-Wahab , Peter Lee , Ekaterina Harsdorf , Jamal Khader , Xun Jia , Manjit Dosanjh , Ahmed Elzawawy , Taofeeq Ige , Miles Pomper , David Pistenmaa , Patricia Hardenbergh , Daniel G Petereit , C. Norman Coleman","doi":"10.1016/j.semradonc.2024.07.003","DOIUrl":"10.1016/j.semradonc.2024.07.003","url":null,"abstract":"<div><p>There has long existed a substantial disparity in access to radiotherapy globally. This issue has only been exacerbated as the growing disparity of cancer incidence between high-income countries (HIC) and low and middle-income countries (LMICs) widens, with a pronounced increase in cancer cases in LMICs. Even within HICs, iniquities within local communities may lead to a lack of access to care.</p><p>Due to these trends, it is imperative to find solutions to narrow global disparities. This requires the engagement of a diverse cohort of stakeholders, including working professionals, non-governmental organizations, nonprofits, professional societies, academic and training institutions, and industry.</p><p>This review brings together a diverse group of experts to highlight critical areas that could help reduce the current global disparities in radiation oncology. Advancements in technology and treatment, such as artificial intelligence, brachytherapy, hypofractionation, and digital networks, in combination with implementation science and novel funding mechanisms, offer means for increasing access to care and education globally. Common themes across sections reveal how utilizing these new innovations and strengthening collaborative efforts among stakeholders can help improve access to care globally while setting the framework for the next generation of innovations.</p></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"34 4","pages":"Pages 477-493"},"PeriodicalIF":2.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142168397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Peaks and Valleys of Photon Versus Proton Spatially Fractionated Radiotherapy 光子与质子空间分割放疗的波峰与波谷

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.04.007

Khadija Sheikh , Heng Li , Jean L. Wright , Theodore K. Yanagihara , Aditya Halthore

引用次数: 0

The Story Behind the First Mini-BEAM Photon Radiation Treatment: What is the Mini-Beam and Why is it Such an Advance? 首例迷你 BEAM 光子放射治疗背后的故事：什么是 Mini-Beam 以及它为何如此先进？

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.04.003

Vijayananda Kundapur FRCR , Emina Torlakovic MD, PhD , Roland N. Auer MD, PhD

引用次数: 0

Corrigendum to “The Use of MR-Guided Radiation Therapy for Head and Neck Cancer and Recommended Reporting Guidance” Seminars in Radiation Oncology Volume 34 (2024) 69-83 头颈部癌症磁共振引导放射治疗的使用及建议报告指南》勘误表，《放射肿瘤学研讨会》第 34 卷（2024 年），第 69-83 页

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.04.001

Brigid A. McDonald , Riccardo Dal Bello , Clifton D. Fuller , Panagiotis Balermpas

引用次数: 0

Navigating the Critical Translational Questions for Implementing FLASH in the Clinic 在临床中实施 FLASH 的关键转化问题导航

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.04.008

Billy W. Loo Jr , Ioannis I. Verginadis , Brita Singers Sørensen , Anthony E. Mascia , John P. Perentesis , Albert C. Koong , Emil Schüler , Erinn B. Rankin , Peter G. Maxim , Charles L. Limoli , Marie-Catherine Vozenin

{"title":"Navigating the Critical Translational Questions for Implementing FLASH in the Clinic","authors":"Billy W. Loo Jr , Ioannis I. Verginadis , Brita Singers Sørensen , Anthony E. Mascia , John P. Perentesis , Albert C. Koong , Emil Schüler , Erinn B. Rankin , Peter G. Maxim , Charles L. Limoli , Marie-Catherine Vozenin","doi":"10.1016/j.semradonc.2024.04.008","DOIUrl":"https://doi.org/10.1016/j.semradonc.2024.04.008","url":null,"abstract":"<div><p>The “FLASH effect” is an increased therapeutic index, that is, reduced normal tissue toxicity for a given degree of anti-cancer efficacy, produced by ultra-rapid irradiation delivered on time scales orders of magnitude shorter than currently conventional in the clinic for the same doses. This phenomenon has been observed in numerous preclinical <em>in vivo</em> tumor and normal tissue models. While the underlying biological mechanism(s) remain to be elucidated, a path to clinical implementation of FLASH can be paved by addressing several critical translational questions. Technological questions pertinent to each beam type (<em>eg</em>, electron, proton, photon) also dictate the logical progression of experimentation required to move forward in safe and decisive clinical trials. Here we review the available preclinical data pertaining to these questions and how they may inform strategies for FLASH cancer therapy clinical trials.</p></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"34 3","pages":"Pages 351-364"},"PeriodicalIF":3.5,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovations in Physics, Biology and Clinical Translation of Spatially Fractionated and FLASH Radiotherapy 空间分割和 FLASH 放射治疗在物理学、生物学和临床转化方面的创新

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.05.005

Robert J. Griffin, Chandan Guha

引用次数: 0

Bystander Effects in Spatially Fractionated Radiation Therapy: From Molecule To Organism To Clinical Implications 空间分割放射治疗中的旁观者效应：从分子到生物体再到临床意义

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.05.004

Samir V. Jenkins PhD , Andrew J. Johnsrud MD , Ruud P.M. Dings PhD , Robert J. Griffin PhD

{"title":"Bystander Effects in Spatially Fractionated Radiation Therapy: From Molecule To Organism To Clinical Implications","authors":"Samir V. Jenkins PhD , Andrew J. Johnsrud MD , Ruud P.M. Dings PhD , Robert J. Griffin PhD","doi":"10.1016/j.semradonc.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.semradonc.2024.05.004","url":null,"abstract":"<div><p>The standard of care for radiation therapy is numerous, low-dose fractions that are distributed homogeneously throughout the tumor. An alternative strategy under scrutiny is to apply spatially fractionated radiotherapy (high and low doses throughout the tumor) in one or several fractions, either alone or followed by conventional radiation fractionation . Spatial fractionation allows for significant sparing of normal tissue, and the regions of tumor or normal tissue that received sublethal doses can give rise to beneficial bystander effects in both cases. Bystander effects are broadly defined as biological responses that are significantly greater than would be anticipated based on the radiation dose received. Typically these effects are initiated by diffusion of reactive oxygen species and secretion of various cytokines. As demonstrated in the literature, spatial fractionation related bystander effects can occur locally from cell to cell and in what are known as “cohort effects,” which tend to take the form of restructuring of the vasculature, enhanced immune infiltration, and development of immunological memory. Other bystander effects can take place at distant sites in what are known as “abscopal effects.” While these events are rare, they are mediated by the immune system and can result in the eradication of secondary and metastatic disease. Currently, due to the complexity and variability of these bystander effects, they are not thoroughly understood, but as knowledge improves they may present significant opportunities for improved clinical outcomes.</p></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"34 3","pages":"Pages 284-291"},"PeriodicalIF":3.5,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Radiation Dose Heterogeneity on the Tumor Microenvironment and Anti-Tumor Immunity 辐射剂量异质性对肿瘤微环境和抗肿瘤免疫的影响

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.04.004

Maya E. Takashima, Tracy J. Berg, Zachary S. Morris

{"title":"The Effects of Radiation Dose Heterogeneity on the Tumor Microenvironment and Anti-Tumor Immunity","authors":"Maya E. Takashima, Tracy J. Berg, Zachary S. Morris","doi":"10.1016/j.semradonc.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.semradonc.2024.04.004","url":null,"abstract":"<div><p>Radiotherapy elicits dose- and lineage-dependent effects on immune cell survival, migration, activation, and proliferation in targeted tumor microenvironments. Radiation also stimulates phenotypic changes that modulate the immune susceptibility of tumor cells. This has raised interest in using radiotherapy to promote greater response to immunotherapies. To clarify the potential of such combinations, it is critical to understand how best to administer radiation therapy to achieve activation of desired immunologic mechanisms. In considering the multifaceted process of priming and propagating anti-tumor immune response, radiation dose heterogeneity emerges as a potential means for simultaneously engaging diverse dose-dependent effects in a single tumor environment. Recent work in spatially fractionated external beam radiation therapy demonstrates the expansive immune responses achievable when a range of high to low dose radiation is delivered in a tumor. Brachytherapy and radiopharmaceutical therapies deliver inherently heterogeneous distributions of radiation that may contribute to immunogenicity. This review evaluates the interplay of radiation dose and anti-tumor immune response and explores emerging methodological approaches for investigating the effects of heterogeneous dose distribution on immune responses.</p></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"34 3","pages":"Pages 262-271"},"PeriodicalIF":3.5,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Democratizing FLASH Radiotherapy FLASH 放射治疗的民主化

IF 3.5 3区医学

Seminars in Radiation Oncology Pub Date : 2024-06-14 DOI: 10.1016/j.semradonc.2024.05.001

Michele Moreau PhD , Serena Mao MD, PhD , Uriel Ngwa , Sayeda Yasmin-Karim MD, PhD , Debarghya China PhD , Hamed Hooshangnejad PhD , Daniel Sforza PhD , Kai Ding PhD , Heng Li PhD , Mohammad Rezaee PhD , Amol K. Narang MD , Wilfred Ngwa PhD

{"title":"Democratizing FLASH Radiotherapy","authors":"Michele Moreau PhD , Serena Mao MD, PhD , Uriel Ngwa , Sayeda Yasmin-Karim MD, PhD , Debarghya China PhD , Hamed Hooshangnejad PhD , Daniel Sforza PhD , Kai Ding PhD , Heng Li PhD , Mohammad Rezaee PhD , Amol K. Narang MD , Wilfred Ngwa PhD","doi":"10.1016/j.semradonc.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.semradonc.2024.05.001","url":null,"abstract":"<div><p>FLASH radiotherapy (RT) is emerging as a potentially revolutionary advancement in cancer treatment, offering the potential to deliver RT at ultra-high dose rates (>40 Gy/s) while significantly reducing damage to healthy tissues. Democratizing FLASH RT by making this cutting-edge approach more accessible and affordable for healthcare systems worldwide would have a substantial impact in global health. Here, we review recent developments in FLASH RT and present perspective on further developments that could facilitate the democratizing of FLASH RT. These include upgrading and validating current technologies that can deliver and measure the FLASH radiation dose with high accuracy and precision, establishing a deeper mechanistic understanding of the FLASH effect, and optimizing dose delivery conditions and parameters for different types of tumors and normal tissues, such as the dose rate, dose fractionation, and beam quality for high efficacy. Furthermore, we examine the potential for democratizing FLASH radioimmunotherapy leveraging evidence that FLASH RT can make the tumor microenvironment more immunogenic, and parallel developments in nanomedicine or use of smart radiotherapy biomaterials for combining RT and immunotherapy. We conclude that the democratization of FLASH radiotherapy represents a major opportunity for concerted cross-disciplinary research collaborations with potential for tremendous impact in reducing radiotherapy disparities and extending the cancer moonshot globally.</p></div>","PeriodicalId":49542,"journal":{"name":"Seminars in Radiation Oncology","volume":"34 3","pages":"Pages 344-350"},"PeriodicalIF":3.5,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1053429624000298/pdfft?md5=4feb9855e5534284cf1b9e60ed7135d0&pid=1-s2.0-S1053429624000298-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141325750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0