{"title":"Resolvent and Proximal Compositions","authors":"P. L. Combettes","doi":"10.1007/s11228-023-00678-z","DOIUrl":"https://doi.org/10.1007/s11228-023-00678-z","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49404859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On the Weak Second-order Optimality Condition for Nonlinear Semidefinite and Second-order Cone Programming","authors":"E. H. Fukuda, G. Haeser, L. M. Mito","doi":"10.1007/s11228-023-00676-1","DOIUrl":"https://doi.org/10.1007/s11228-023-00676-1","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":"31 1","pages":"1-28"},"PeriodicalIF":1.6,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42816472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Jeyakumar, J. Lee, G. M. Lee, G. Li, D. Woolnough
{"title":"Sums of Squares Polynomial Program Reformulations for Adjustable Robust Linear Optimization Problems with Separable Polynomial Decision Rules","authors":"V. Jeyakumar, J. Lee, G. M. Lee, G. Li, D. Woolnough","doi":"10.1007/s11228-022-00648-x","DOIUrl":"https://doi.org/10.1007/s11228-022-00648-x","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":"30 1","pages":"1363 - 1380"},"PeriodicalIF":1.6,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49073576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Convex Robust Sum Optimization Problems with Conic and Set Constraints: Duality and Optimality Conditions Revisited","authors":"N. Dinh, D. H. Long, M. Volle","doi":"10.1007/s11228-022-00646-z","DOIUrl":"https://doi.org/10.1007/s11228-022-00646-z","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":"30 1","pages":"1381 - 1402"},"PeriodicalIF":1.6,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41697884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stability and Sensitivity of Uncertain Linear Programs","authors":"M. J. Cánovas, J. Parra","doi":"10.1007/s11228-022-00645-0","DOIUrl":"https://doi.org/10.1007/s11228-022-00645-0","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":"30 1","pages":"1403 - 1421"},"PeriodicalIF":1.6,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42856449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Note on the Hausdorff Distance Between Norm Balls and Their Linear Maps","authors":"Shadi Haddad, A. Halder","doi":"10.1007/s11228-023-00692-1","DOIUrl":"https://doi.org/10.1007/s11228-023-00692-1","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49536005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On Subdifferentials Via a Generalized Conjugation Scheme: An Application to DC Problems and Optimality Conditions","authors":"M. D. Fajardo, J. Vidal","doi":"10.1007/s11228-022-00644-1","DOIUrl":"https://doi.org/10.1007/s11228-022-00644-1","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":"30 1","pages":"1313 - 1331"},"PeriodicalIF":1.6,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41838921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Homogenization Cone: Polar Cone and Projection","authors":"Heinz H. Bauschke, Theo Bendit, Han-Chung Wang","doi":"10.1007/s11228-023-00687-y","DOIUrl":"https://doi.org/10.1007/s11228-023-00687-y","url":null,"abstract":"","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45350327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mónica Guberman, Miroslav Kosar, Anahid Omran, Erick M Carreira, Marc Nazaré, Uwe Grether
{"title":"Reverse Design toward Optimized Labeled Chemical Probes - Examples from the Endocannabinoid System.","authors":"Mónica Guberman, Miroslav Kosar, Anahid Omran, Erick M Carreira, Marc Nazaré, Uwe Grether","doi":"10.2533/chimia.2022.425","DOIUrl":"10.2533/chimia.2022.425","url":null,"abstract":"<p><p>Labeled chemical probes are of utmost importance to bring drugs from the laboratory through the clinic and ultimately to market. They support and impact all research and discovery phases: target verification and validation; assay development; lead optimization; and biomarker engagement in the context of preclinical studies and human trials. Probes should display high potency and selectivity as well as fulfill specific criteria in connection with absorption, distribution, metabolism, excretion and toxicology (ADMET) profile. Progress in fields such as imaging and proteomics increased the need for specialized probes to support drug discovery. Labeled probes carrying an additional reporter group are valuable tools to meet specific application requirements, but pose significant challenges in design and construction. In the reverse-design approach, small molecules previously optimized in medicinal chemistry programs form the basis for the generation of such high-quality probes. We discuss the reverse design concept for the generation of labeled probes targeting the endocannabinoid system (ECS), a complex lipid signaling network that plays a key role in many human health and disease conditions. The examples highlighted include diverse reporter units for a range of applications. In several cases the reported probes were the product of mutually rewarding and highly cross-fertilizing collaborations among academic and industry research programs, a strategy that can serve as a blueprint for future probe generation efforts.</p>","PeriodicalId":49537,"journal":{"name":"Set-Valued and Variational Analysis","volume":"23 1","pages":"425-434"},"PeriodicalIF":1.2,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74145836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}