Sexual Development最新文献_第10页

Noncoding Genes on Sex Chromosomes and Their Function in Sex Determination, Dosage Compensation, Male Traits, and Diseases. 性染色体上的非编码基因及其在性别决定、剂量补偿、雄性性状和疾病中的作用。

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-11-18 DOI: 10.1159/000519622

Michelle C Maier, Molly-Rose A McInerney, Jennifer A Marshall Graves, Fadi J Charchar

引用次数: 3

Sex Differentiation in Amphibians: Effect of Temperature and Its Influence on Sex Reversal. 两栖动物性别分化:温度的影响及其对性别逆转的影响。

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-05-17 DOI: 10.1159/000515220

Adrián Ruiz-García, Álvaro S Roco, Mónica Bullejos

{"title":"Sex Differentiation in Amphibians: Effect of Temperature and Its Influence on Sex Reversal.","authors":"Adrián Ruiz-García, Álvaro S Roco, Mónica Bullejos","doi":"10.1159/000515220","DOIUrl":"https://doi.org/10.1159/000515220","url":null,"abstract":"The role of environmental factors in sexual differentiation in amphibians is not new. The effect of hormones or hormone-like compounds is widely demonstrated. However, the effect of temperature has traditionally been regarded as something anecdotal that occurs in extreme situations and not as a factor to be considered. The data currently available reveal a different situation. Sexual differentiation in some amphibian species can be altered even by small changes in temperature. On the other hand, although not proven, it is possible that temperature is related to the appearance of sex-reversed individuals in natural populations under conditions unrelated to environmental contaminants. According to this, temperature, through sex reversal (phenotypic sex opposed to genetic sex), could play an important role in the turnover of sex-determining genes and in the maintenance of homomorphic sex chromosomes in this group. Accordingly, and given the expected increase in global temperatures, growth and sexual differentiation in amphibians could easily be affected, altering the sex ratio in natural populations and posing major conservation challenges for a group in worldwide decline. It is therefore particularly urgent to understand the mechanism by which temperature affects sexual differentiation in amphibians.","PeriodicalId":49536,"journal":{"name":"Sexual Development","volume":"15 1-3","pages":"157-167"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38910109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Might Gene Duplication and Neofunctionalization Contribute to the Sexual Lability Observed in Fish? 基因复制和新功能化可能导致鱼类的性不稳定性?

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-06-24 DOI: 10.1159/000515425

Jonika Edgecombe, Lara Urban, Erica V Todd, Neil J Gemmell

引用次数: 5

Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals? 男性勃起功能障碍的增加:是否与内分泌干扰物有关?

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-06-16 DOI: 10.1159/000516600

Samuel M Cripps, Deidre M Mattiske, Andrew J Pask

{"title":"Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?","authors":"Samuel M Cripps, Deidre M Mattiske, Andrew J Pask","doi":"10.1159/000516600","DOIUrl":"https://doi.org/10.1159/000516600","url":null,"abstract":"Erectile dysfunction (ED) is one of the most prevalent chronic conditions affecting men. ED can arise from disruptions during development, affecting the patterning of erectile tissues in the penis and/or disruptions in adulthood that impact sexual stimuli, neural pathways, molecular changes, and endocrine signalling that are required to drive erection. Sexual stimulation activates the parasympathetic system which causes nerve terminals in the penis to release nitric oxide (NO). As a result, the penile blood vessels dilate, allowing the penis to engorge with blood. This expansion subsequently compresses the veins surrounding the erectile tissue, restricting venous outflow. As a result, the blood pressure localised in the penis increases dramatically to produce a rigid erection, a process known as tumescence. The sympathetic pathway releases noradrenaline (NA) which causes detumescence: the reversion of the penis to the flaccid state. Androgen signalling is critical for erectile function through its role in penis development and in regulating the physiological processes driving erection in the adult. Interestingly, estrogen signalling is also implicated in penis development and potentially in processes which regulate erectile function during adulthood. Given that endocrine signalling has a prominent role in erectile function, it is likely that exposure to endocrine disrupting chemicals (EDCs) is a risk factor for ED, although this is an under-researched field. Thus, our review provides a detailed description of the underlying biology of erectile function with a focus on the role of endocrine signalling, exploring the potential link between EDCs and ED based on animal and human studies.","PeriodicalId":49536,"journal":{"name":"Sexual Development","volume":"15 1-3","pages":"187-212"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000516600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39236895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Environmental Cues and Mechanisms Underpinning Sex Change in Fish. 鱼类性别变化的环境线索和机制。

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-06-10 DOI: 10.1159/000515274

Laura Casas, Fran Saborido-Rey

{"title":"Environmental Cues and Mechanisms Underpinning Sex Change in Fish.","authors":"Laura Casas, Fran Saborido-Rey","doi":"10.1159/000515274","DOIUrl":"https://doi.org/10.1159/000515274","url":null,"abstract":"Fishes are the only vertebrates that undergo sex change during their lifetime, but even within this group, a unique reproductive strategy is displayed by only 1.5% of the teleosts. This lability in alternating sexual fate is the result of the simultaneous suppression and activation of opposing male and female networks. Here, we provide a brief review summarizing recent advances in our understanding of the environmental cues that trigger sex change and their perception, integration, and translation into molecular cascades that convert the sex of an individual. We particularly focus on molecular events underpinning the complex behavioral and morphological transformation involved in sex change, dissecting the main molecular players and regulatory networks that shape the transformation of one sex into the opposite. We show that histological changes and molecular pathways governing gonadal reorganization are better described than the neuroendocrine basis of sex change and that, despite important advances, information is lacking for the majority of hermaphrodite species. We highlight significant gaps in our knowledge of how sex change takes place and suggest future research directions.","PeriodicalId":49536,"journal":{"name":"Sexual Development","volume":"15 1-3","pages":"108-121"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515274","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39082180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Is Thermal Responsiveness Affected by Maternal Estrogens in Species with Temperature-Dependent Sex Determination? 在温度依赖性别决定的物种中，雌性雌激素是否影响热反应性?

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-04-26 DOI: 10.1159/000515187

Rachel M Bowden, Ryan T Paitz

{"title":"Is Thermal Responsiveness Affected by Maternal Estrogens in Species with Temperature-Dependent Sex Determination?","authors":"Rachel M Bowden, Ryan T Paitz","doi":"10.1159/000515187","DOIUrl":"https://doi.org/10.1159/000515187","url":null,"abstract":"In species with temperature-dependent sex determination (TSD), incubation temperatures regulate the expression of genes involved in gonadal differentiation and determine whether the gonads develop into ovaries or testes. For most species, natural incubation conditions result in transient exposure to thermal cues for both ovarian and testis development, but how individuals respond to this transient exposure varies and can drive variation in the resulting sex ratios. Here, we argue that variation in the timing to respond to temperature cues, or thermal responsiveness, is a trait needing further study. Recent work in the red-eared slider turtle (Trachemys scripta) has found that when embryos experience transient exposure to warm conditions (i.e., heatwaves), some embryos show high responsiveness, requiring only short exposures to commit to ovarian development, while others show low responsiveness, developing testes even after more extended exposures to warm conditions. We discuss how maternal estrogens might influence thermal responsiveness for organisms that develop under thermal fluctuations. Examining the interplay of molecular responses to more subtle thermal and endocrine environments may reveal significant insights into the process of sex determination in species with TSD.","PeriodicalId":49536,"journal":{"name":"Sexual Development","volume":"15 1-3","pages":"69-79"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000515187","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38843839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Epigenetic Regulation during Primordial Germ Cell Development and Differentiation. 原始生殖细胞发育和分化过程中的表观遗传调控

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-11-30 DOI: 10.1159/000520412

Navin B Ramakrishna, Keir Murison, Eric A Miska, Harry G Leitch

引用次数: 0

Epigenetic Regulation and Environmental Sex Determination in Cichlid Fishes. 慈鲷的表观遗传调控和环境性别决定。

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-08-25 DOI: 10.1159/000517197

Suzy C P Renn, Peter L Hurd

{"title":"Epigenetic Regulation and Environmental Sex Determination in Cichlid Fishes.","authors":"Suzy C P Renn, Peter L Hurd","doi":"10.1159/000517197","DOIUrl":"10.1159/000517197","url":null,"abstract":"Studying environmental sex determination (ESD) in cichlids provides a phylogenetic and comparative approach to understand the evolution of the underlying mechanisms, their impact on the evolution of the overlying systems, and the neuroethology of life history strategies. Natural selection normally favors parents who invest equally in the development of male and female offspring, but evolution may favor deviations from this 50:50 ratio when environmental conditions produce an advantage for doing so. Many species of cichlids demonstrate ESD in response to water chemistry (temperature, pH, and oxygen concentration). The relative strengths of and the exact interactions between these factors vary between congeners, demonstrating genetic variation in sensitivity. The presence of sizable proportions of the less common sex towards the environmental extremes in most species strongly suggests the presence of some genetic sex-determining loci acting in parallel with the ESD factors. Sex determination and differentiation in these species does not seem to result in the organization of a final and irreversible sexual fate, so much as a life-long ongoing battle between competing male- and female-determining genetic and hormonal networks governed by epigenetic factors. We discuss what is and is not known about the epigenetic mechanism behind the differentiation of both gonads and sex differences in the brain. Beyond the well-studied tilapia species, the 2 best-studied dwarf cichlid systems showing ESD are the South American genus Apistogramma and the West African genus Pelvicachromis. Both species demonstrate male morphs with alternative reproductive tactics. We discuss the further neuroethology opportunities such systems provide to the study of epigenetics of alternative life history strategies and other behavioral variation.","PeriodicalId":49536,"journal":{"name":"Sexual Development","volume":"15 1-3","pages":"93-107"},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440468/pdf/nihms-1716129.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39357790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional Regulation of the Y-Linked Mammalian Testis-Determining Gene SRY. y连锁哺乳动物睾丸决定基因SRY的转录调控。

IF 2.3 4区医学

Sexual Development Pub Date : 2021-01-01 Epub Date: 2021-09-28 DOI: 10.1159/000519217

Naoki Okashita, Makoto Tachibana

引用次数: 8

Contents Vol. 13, 2019 目录2019年第13卷

IF 2.3 4区医学

Sexual Development Pub Date : 2020-10-01 DOI: 10.1159/000512412

M. Schartl

引用次数: 0