Комплексные проблемы сердечно-сосудистых заболеваний最新文献

{"title":"CARDIAC ONCOLOGY: A MODERN VIEW ON THE PROBLEM OF CHOOSING AN OPTIMAL STRATEGY FOR THE TREATMENT OF CORONARY ARTERY DISEASE AND CANCER","authors":"Bagrat G. Alekyan, Narek G. Karapetyan, Aleksandr A. Gritskevich, Lilit G. Gyoletsyan, Arthur V. Galstyan, Amiran Sh. Revishvili","doi":"10.17802/2306-1278-2023-12-3-98-108","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-98-108","url":null,"abstract":"Highlights The article presents an overview of the main studies on the treatment of patients with coronary artery disease and cancer. Abstract Cardiovascular and oncological diseases remain the leading causes of death globally. The combination of coronary artery disease and cancer is becoming more common in clinical practice. Despite the achievements in the treatment of both of these diseases separately, their combination is a considerable issue for specialists. This review article discusses the main issues of managing patients with cancer and coronary artery disease. Moreover, the article presents various treatment strategies, including simultaneous and step-by-step interventions, and shows the current trends of endovascular approach to the treatment of these patients.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREMATURITY AND THE MECHANICS OF THE INFANT HEART","authors":"Elena N. Pavlyukova, Marina V. Kolosova, Vasily V. Poddubny, Galina V. Neklyudova, Rostislav S. Karpov","doi":"10.17802/2306-1278-2023-12-3-66-83","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-66-83","url":null,"abstract":"Highlights The differences in the postnatal ontogenesis of the heart in children from one to five years old born prematurely and with low, very low, and extremely low birth weight were revealed. The coexistence of different models in contractile-rotational processes of the left ventricle was demonstrated. Abstract Aim . To expand the traditional ideas about the left ventricle (LV) mechanics formation processes in children born with low, very low and extremely low body weight in the postnatal period during the process of growth and development. Methods. The study was conducted in 237 children aged from one to five years old: 51 children born healthy and full-term (FT), 68 children born with low body weight (LBW) and 118 children born with very low (VLBW) and extremely low body weight (ELBW). The analysis of clinical, anamnestic data, indicators of standard echocardiography and LV mechanics was performed using discriminant analysis. To demonstrate the assessment of remoteness or proximity between clinical groups, the Mahalanobis distance was used. Visualization of the structure distribution of groups in a multidimensional feature space was carried out in the coordinates of the first two discriminant functions (canonical roots, canonical variables) of discriminant analysis. The evaluation of the discriminant functions significance was verified by Wilks statistics. Statistical analysis was performed on a personal computer using the Statistica program (version 12). Results . The most informative criteria for F (8.462) = 100,84 are “body weight at birth” (p = 0.000000), “character of feeding up to a year” (p = 0.000000) and direction of apex rotation (p = 0.0098). Conclusion . The use of discriminant analysis makes it possible to establish a change in the degree of the selected criteria influence on the level of differences between clinical groups, demonstrating fundamentally new aspects of a child's heart mechanics formation in the history of prematurity.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF THE MORTALITY RATE DYNAMICS DUE TO CIRCULATORY SYSTEM DISEASES IN THE KEMEROVO REGION FOR THE PERIOD 2017-2021.","authors":"Darya P. Tsygankova, Alena S. Agienko, Darya Yu. Sedykh, Sergey A. Makarov, Galina V. Artamonova","doi":"10.17802/2306-1278-2023-12-3-57-65","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-57-65","url":null,"abstract":"Highlights Every year more than 4 million deaths are registered from cardiovascular diseases (CVD), which is 46% of all deaths. Over the past 40 years, a downward trend in mortality from CVD has been revealed. However, the COVID-19 pandemic period has changed the statistics of indicators of both total mortality and mortality from CVD. Aim . To analyze the mortality rate (MR) features from CVD in the Kemerovo Region (KR) from 2017 to 2021, in comparison with the Russian Federation (RF) rate. Materials and Methods . Mortality rates of the adult population of KR and RF for the period 2017–2021 were taken from the official sources. The KR/RF dynamics was approximated by a linear trend using Microsoft Excel 2010. Results. Over the past 5 years (from 2017 to 2021) the increase in mortality from CVD was 58.2% in the KR and in the RF – 9%. In 2017 the mortality rates in the RF were higher than in the KR and they levelled off by 2018. However, in the period 2019-2021 there was a sharp increase rate in the KR, in comparison with the RF. According to Kemerovo Statistical Office, the mortality rate from CVD in the region in 2021 was 10.8% higher than in 2020. The structure of mortality from CVD in 2021 in the KR had 52.8% of death cases due to coronary heart disease and 32.6% were caused by the cerebrovascular disease. During the COVID-19 pandemic (2019–2021) the first 3 places among the causes of total mortality in the KR were occupied by CVD (46.3% – 49.4% – 49.3%, respectively), neoplasms (17.1% – 15.2% – 13.2%) and external causes of death (9% – 7.7% – 6.5%). In the structure of total mortality cases the COVID-19 share is 2% in 2020 and 6.4% in 2021, respectively, which raised them to the 4th place in 2021. Conclusion. An increase in mortality rates in the region may indicate both the real causes of death, they can also be associated with the peculiarities the death cases coding and the impact of clinical and organizational technologies as well as the aging of the population. All the data require further in-depth research.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POSSIBILITIES OF APPLYING MACHINE LEARNING TECHNOLOGIES IN THE SPHERE OF PRIMARY PREVENTION OF CARDIOVASCULAR DISEASES","authors":"Vladimir S. Kaveshnikov, Dmitry S. Bragin, Valery Kh. Vaizov, Artyom V. Kaveshnikov, Maria A. Kuzmichkina, Irina A. Trubacheva","doi":"10.17802/2306-1278-2023-12-3-109-125","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-109-125","url":null,"abstract":"Highlights The review analyzes the studies devoted to the possibility of using machine learning methods to predict the occurrence of atrial fibrillation, cardiovascular risk factors, carotid atherosclerosis, and total cardiovascular risk. The combinations of machine learning methods with mobile, cloud and telemedicine technologies have significant prospects. In the near future, such technologies are expected to be used for atrial fibrillation screening and risk stratification using cardiac imaging data. Based on machine learning methods, mobile preventive technologies are being developed, particularly for nutritional behavior management. Abstract The article reviews the main directions of machine learning (ML) application in the primary prevention of cardiovascular diseases (CVD) and highlights examples of scientific and practical problems solved with its help. Currently, the possibility of using ML to predict cardiovascular risk, occurrence of atrial fibrillation (AF), cardiovascular risk factors, carotid atherosclerosis, etc. has been studied. The data of questionnaires, medical examination, laboratory indices, electrocardiography, cardio visualization, medications, genomics and proteomics are used in ML models. The most common classifiers are Random Forest, Support Vector, Neural Networks. As compared to traditional risk calculators many ML algorithms show improvement in prediction accuracy, but no evident leader has been defined yet. Deep ML technologies are at the very early stages of development. Mobile, cloud and telemedicine technologies open new possibilities for collection, storage and the use of medical data and can improve CVD prevention. In the near future, such technologies are expected to be used for atrial fibrillation screening as well as cardiovascular risk stratification using cardiac imaging data. Moreover, the addition of them to traditional risk factors provides the most stable risk estimates. There are examples of mobile ML technologies use to manage risk factors, particularly eating behavior. Attention is paid to such problems, as need to avoid overestimating the role of artificial intelligence in healthcare, algorithms’ bias, cybersecurity, ethical issues of medical data collection and use. Practical applicability of ML models and their impact on endpoints are currently understudied. A significant obstacle to implementation of ML technologies in healthcare is the lack of experience and regulation.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATIONS OF LOW-DENSITY LIPOPROTEIN CHOLESTEROL LEVEL WITH BIOMOLECULES IN METABOLIC DISORDERS IN YOUNG PEOPLE AGED 25–44 YEARS","authors":"Elena V. Kashtanova, Yana V. Polonskaya, Lilia V. Shcherbakova, Ekaterina M. Stakhneva, Victoria S. Shramko, Alexander N. Spiridonov, Yulia I. Ragino","doi":"10.17802/2306-1278-2023-12-3-152-160","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-152-160","url":null,"abstract":"Highlights The study is devoted to the analysis of metabolic hormones and their relationship with the main risk factors for cardiovascular diseases, in particular, elevated levels of low-density lipoprotein cholesterol. The study included people under the age of 45 with active hormones. Abstract Aim . To assess the relationship between the levels of LDL and metabolic hormones reflecting metabolic disorders in young people. Methods . The study included 305 people. The group 1 included 146 people with an LDL level of <2.1 mmol/L, the group 2 included 159 people with an LDL level of ≥4.2 mmol/L. Serum total cholesterol (TC), triglycerides, HDL and glucose concentrations were determined by enzymatic method using Thermo Fisher Scientific kits (Finland) on a 30i KonelabPrime clinical chemistry analyzer. The calculation of concentrations of LDL was carried out according to the Friedwald formula. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 (GLP-1), glucagon, interleukin 6, insulin, leptin, monocyte chemoattractant protein-1, pancreatic polypeptide, peptide YY, tumor necrosis factor alpha were determined by multiplex analysis using the Human Metabolic Hormone V3 (MILLIPLEX) panel on a Luminex MAGPIX flow fluorimeter. Results . In the group of patients with LDL ≥4.2 mmol/L, fasting glucose disorders were much more prevalent, the average BMI (p = 0,0001) was higher, and arterial hypertension was twice as frequent (24.8% vs. 11.6%, p = 0.003) compared with the group 1. The levels of triglycerides, TC, and glucose were higher, whereas HDL level was lower in the group 2(p = 0,0001). In patients with LDL ≥4.2 mmol/L, the values of HOMA-IR and the occurrence of IR (83.8%) according to the HOMA-IR were higher compared with the group with LDL <2.1 mmol/L (p = 0,0001). Statistically significant differences in the levels of the studied indicators between the groups 1 and 2 were obtained for C-peptide, GLP-1, insulin and leptin. The relative chance of having LDL≥4.2 mmol/L is associated with an increase in the level of C-peptide (OR = 2.042, 95% CI 1.209–3.449, p = 0.008) and a decrease in the level of GLP-1 (OR = 0.997, 95% CI 0.996–0.999, p = 0.001). Conclusion . An increase in LDL levels in young people is associated with disorders of lipid and carbohydrate metabolism. These data are confirmed by changes in the serum metabolic markers that characterize metabolic disorders in the human body.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TYPE 2 MYOCARDIAL INFARCTION: A MODERN VIEW ON THE PROBLEM","authors":"Anna V. Motova, Victoria N. Karetnikova, Olga L. Barbarash","doi":"10.17802/2306-1278-2023-12-3-192-199","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-192-199","url":null,"abstract":"Highlights The article describes the main differences between the types of myocardial infarction, in particular, differences between type 1 and type 2 myocardial infarction, the complexity of diagnosis and management of patients with myocardial infarction type 2, and summarizes data on the prevalence of patients with myocardial infarction type 2. The arguments supporting the need for further researches to differentiate various phenotypes of myocardial infarction are provided. Abstract Despite the high interest in the study of type 2 MI, many unresolved issues concerning diagnosis, criteria for diagnosis and, especially, therapeutic tactics remain unresolved. The available data regarding type 2 MI remain limited and inconsistent, and are based on sources that include the analysis of type 1 MI. According to various predictions, the prevalence of type 2 MI will increase even more. Type 2 MI management strategy should be patient-specific and in accordance with the etiology and pathogenesis, therefore, timely diagnosis, and MI differentiation according to universally accepted definitions is a relevant scientific topic and a practical necessity. Thus, summarizing all the above, we can say that type 2 myocardial infarction is a topic that encompasses many unresolved issues concerning diagnosis, patient management and further secondary prevention.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"312 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECHOCARDIOGRAPHIC PREDICTORS OF ADVERSE CLINICAL EVENTS IN HEART FAILURE WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION IN COMBINATION WITH OBSTRUCTIVE SLEEP APNEA","authors":"Alexey V. Yakovlev, Ivan A. Efremov, Andrey N. Ryabikov, Natalia F. Yakovleva, Ilya V. Shirokikh, Sergey N. Shilov, Alexander T. Teplyakov, Elena V. Grakova, Kristina V. Kopeva","doi":"10.17802/2306-1278-2023-12-3-161-172","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-161-172","url":null,"abstract":"Highlights Repeated hospitalizations occupy a special place in adverse clinical events in heart failure, currently representing one of the most powerful predictors of adverse outcomes in this group of patients. Echocardiographic parameters such as longitudinal myocardial deformation, displacement in the annulus of the tricuspid valve, and left atrial volume index can serve as predictors of hospitalization for cardiovascular diseases in patients with heart failure with preserved ejection fraction and obstructive sleep apnea. Abstract Aim . To study the prognostic role of individual echocardiographic parameters in heart failure with preserved ejection fraction (HFpEF) in patients with arterial hypertension and obstructive sleep apnea (OSA). Methods. The study included 59 men with hypertension and OSA (apnea/hypopnea index &gt;15 per hour). At baseline all patients underwent a sleep study and echocardiography with an additional assessment of the global longitudinal strain (GLS). Upon inclusion in the study and after 12 months of follow-up, a 6-minute walk test was performed. After 12 months, the clinical course of the disease was retrospectively assessed. The criteria for an adverse clinical course were episodes of hospitalization for cardiovascular diseases, the development of paroxysmal atrial fibrillation or high-grade ventricular arrhythmias (III–V class according to Ryan), worsening of heart failure with a transition to a higher functional class according to NYHA. Results. Significant differences were found in several echocardiographic parameters between the groups of patients with and without hospitalizations within 12 months of follow-up: tricuspid annular plane systolic excursion (TAPSE) (p = 0.017), GLS (p = 0.005), left atrial volume index (LAVI) (p = 0.032). According to the regression analysis results, TAPSE, GLS and left ventricular ejection fraction make a statistically significant contribution to the probability of hospitalizations among the evaluated echocardiographic predictors. Conclusion. The results of the study allow us to consider certain echocardiographic parameters, in particular GLS, TAPSE and LAVI, as predictors of hospitalizations in patients with HFpEF and OSA.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEALTH AND DEMOGRAPHIC SITUATION IN MOSCOW AND RUSSIAN FEDERATION DURING THE COVID-19 PANDEMIC","authors":"Aleftina A. Kalininskaya, Vladimir O. Schepin, Andrey V. Lazarev, Mikhail V. Kizeev, Sofia I. Shlyafer","doi":"10.17802/2306-1278-2023-12-3-181-191","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-181-191","url":null,"abstract":"Highlights Higher rates of COVID-19 morbidity and mortality compared to Russia as a whole were noted in Moscow during the COVID-19 pandemic and after it (2020-2021). We have reached the conclusion that it is necessary to develop regional prevention and rehabilitation approaches for COVID patients. Aim. To analyze health and demographic indicators of Moscow, Russia and its constituent entities in the context of the COVID-19 pandemic to develop regional prevention, management and rehabilitation programs for COVID patients. Methods . The study incorporated statistical, analytical, and observational methods. The data of the Federal State Statistics Service, and reports of the Central Research Institute of Healthcare of the Ministry of Health of Russia for 2012–2022 were used for the analysis. Results . General morbidity of the population in Moscow (2021) amounted to 148 906.0 per 100 000 population. The highest rates were noted in the following classes of diseases: diseases of the respiratory system, circulatory system, diseases of the musculoskeletal and connective tissue, genitourinary system, etc. In the Russian Federation, the overall incidence rate in 2021 was 167 713.8‰ 00 , which is 11.6 % higher compared to Moscow. In 2019 (before the COVID-19 pandemic) the frequency of primary morbidity in Moscow was 65 818.1‰ 00 , in 2020 the frequency decreased to 63 204.4‰ 00 , and in 2021 it increased to 71 523.9‰ 00 , which is 8.7% higher than in 2019. Between 2019 and 2021, there was an increase in primary morbidity rates in the following classes of diseases in Moscow: mental and behavioral disorders by 12.1%, diseases of the blood, hematopoietic organs and disorders involving the immune mechanism – by 5.3%, diseases of the nervous system – by 2.1%, etc., which indicates the need for rehabilitation of patients with this pathology. In 2021 the incidence rate of COVID-19 in Moscow increased to 8 976.0‰ 00 , in the Russian Federation the incidence rate was lower – 8 085.7‰ 00 . The difference in indicators between the constituent entities of the Russian Federation is quite high and amounts to 11.8. The pandemic has exacerbated the demographic situation in Russia. Mortality rates (for 2019–2021) increased in the Russian Federation from 12.3‰ to 13.6, and in Moscow the increase was more significant – from 9.5 to 16.7‰. The results of the analysis indicate the need to improve preventive and management programs for COVID patients, even more so in Moscow. In Moscow and Russian Federation as a whole higher rate of general morbidity in children and adolescents compared to total and adult population morbidity over 10 years (2012–2021) points to the importance of prevention and management programs of this population. Conclusion. The results of the study reaffirm the need to develop regional prevention, management and rehabilitation approaches for COVID patients.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RELATIONSHIP BETWEEN BIOMOLECULES ASSOCIATED WITH THE SECRETORY ACTIVITY OF VISCERAL ADIPOCYTES AND ELECTROPHYSIOLOGICAL SIGNS OF METABOLIC CARDIOMYOPATHIES IN PERSONS UNDER 45 YEARS OF AGE","authors":"Natalia A. Kuzminykh, Lilia V. Shcherbakova, Elena V. Kashtanova, Yana V. Polonskaya, Victoria S. Shramko, Evgeniya V. Garbuzova, Yulia I. Ragino","doi":"10.17802/2306-1278-2023-12-3-38-49","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-38-49","url":null,"abstract":"Highlights ECG signs of metabolic cardiomyopathies in men aged 25–44 years, regardless of age and waist circumference, are directly associated with the serum adipsin concentration and inversely associated with the concentration of glucagon-like peptide 1 in the blood. ECG signs of metabolic cardiomyopathies in women aged 25–44 years are directly associated with the serum c-peptide concentration and inversely associated with the concentration of glucose-dependent insulinotropic polypeptide 1 in the blood. Abstract Aim . To study the relationship between electrophysiological signs of metabolic cardiomyopathy (MC) and biomolecules associated with the secretory activity of visceral adipocytes in persons aged 25–44 years residing in Novosibirsk. Methods. The study included 1 198 subjects. A single-stage survey of a random sample of the 25–44-year-old population of Novosibirsk (49,7% men, 50,3% women) was conducted. During the examination, among other things, a resting 12-lead ECGs was recorded, and later the ECGs were classified according to Minnesota Code categories. Five ECG signs of MC were analysed: 1) ST-segment displaced above baseline (ST-segment elevation); 2) ST-segment displaced below baseline (ST-segment depression); 3) T wave changes; 4) TV1&gt;TV6 patterns and 5) ECG signs of left ventricular hypertrophy. Serum concentrations of biomolecules associated with the secretory activity of visceral adipocytes were determined by multiplex analysis. Results . The results of multivariate logistic regression analysis showed that the ECG signs of MC in men aged 25–44 years, regardless of age and waist circumference, are directly associated with the serum adipsin concentration (Exp B 1,039, 95% CI 1,002–1,077, p = 0.039) and inversely associated with the concentration of glucagon-like peptide 1 in the blood (Exp B 0.999, 95% CI 0.998–1,000, p = 0.042). ECG signs of MC in women aged 25–44 years are directly associated with the serum peptide concentration (Exp B 1,439, 95% CI 1,082–1,915, p = 0.012) and inversely associated with the concentration of glucose-dependent insulinotropic polypeptide in the blood (Exp B 0.986, 95% CI 0.978–0.995, p = 0.001). Conclusion . The results obtained reflect the significant influence of these biomolecules associated with the secretory activity of visceral adipocytes on the occurrence of ECG signs of MC in young people aged 25–44 years.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE MODIFIED NORWOOD PROCEDURE FOR HYPOPLASTIC LEFT HEART SYNDROME: FIRST EXPERINCE OF USING THE «KEMANGIOPROTEZ» VASCULAR XENOGRAFT","authors":"Ivan K. Halivopulo, Nikita M. Troshkinev, Ilmir F. Shabaev, Dmitry V. Borisenko, Anton A. Lyapin, Alexey V. Evtushenko, Leonid S. Barbarash","doi":"10.17802/2306-1278-2023-12-3-145-151","DOIUrl":"https://doi.org/10.17802/2306-1278-2023-12-3-145-151","url":null,"abstract":"Highlights The article presents a unique clinical case of correction of hypoplastic left heart syndrome with Norwood procedure using a “KemAngioprosthesis” vascular xenograft as a Sano shunt. Abstract We present the first successful clinical case of using the “KemAngioprosthesis” vascular xenograft in the pulmonary position as the Sano shunt in the Norwood procedure for correction of hypoplastic left heart syndrome. A newborn baby (gestation period of 38 weeks) diagnosed with congenital heart disease, and hypoplastic left heart syndrome was admitted to the Research Institute for Complex Issues of Cardiovascular Diseases. The child survived the first stage of the modified Norwood procedure (Sano shunt) using a biological vascular prosthesis. This clinical case showed that using the “KemAngioprosthesis” vascular xenograft in Norwood procedure to modify pulmonary blood flow by creating an anastomosis between the right ventricle and bifurcation of the pulmonary artery is effective and safe in the short-term period.","PeriodicalId":494775,"journal":{"name":"Комплексные проблемы сердечно-сосудистых заболеваний","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135866741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}