Химический журнал Казахстана最新文献

{"title":"SYNTHESIS AND BIOLOGICAL ACTIVITY OF NEW MORPHOLIN-CONTAINING THIOANHYDRIDES","authors":"I.N. Anuarbekova, Ye.S. Sychyeva, D.B. Markina, M.S. Mukanova","doi":"10.51580/2023-3.2710-1185.29","DOIUrl":"https://doi.org/10.51580/2023-3.2710-1185.29","url":null,"abstract":"Morpholine is a promising and versatile six-membered heterocycle, a popular pharmacophore with a wide spectrum of biological and pharmacological activity. The purpose of this work is the synthesis of biologically active compounds, based on 3-morpholinepropylamine, the determination of the structure and biological activity of the synthesized compounds. Results and discussion. Acetic, propionic, benzoic, 4-chlorobenzoic and 2,4-dichlorobenzoic 3-morpholinopropylcarbamothioic thioanhydrides have been synthesized as a result of acylation of sodium 3-morpholylpropylcarbadithioate with the corresponding acid’s chlorides. The synthesis has been carried out in acetone at the room temperature for 2 – 3 h. The structure of the synthesized compounds has been established on the basis of the elemental analysis data, IR spectra, 1Н and 13С NMR spectroscopy. Conclusion. As a result of the laboratory and field tests, it has been found that the use of morpholinopropylcarbamothioic thioanhydrides contribute to an increase in the seed shoot formation of wheat and spruce. Propionic 3-morpholinopropylcarbamothioic thioanhydride activates at a concentration of 0.01% the seedlings length of wheat seeds up to 5.1 cm and increases the germination of shoots up to 88%, and on spruce seeds, the seedlings length is 7.3 cm and the germination of shoots is 87% as compared with the control (4.4 cm, 86% and 4.0 cm, 84%), respectively. Benzoic (3-morpholinopropyl)carbamothioic thioanhydride has shown at a concentration of 0.01% a high shoot-forming ability, the length of shoots by cutting Spiraea Vanhouttei is on average 3.91 cm, as compared with the control (1.63 cm) and with the preparations Kornevin (2.58 cm) and KN-2 (3.59 cm).","PeriodicalId":494584,"journal":{"name":"Химический журнал Казахстана","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135486725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYNTHESIS AND CHEMICAL MODIFICATION OF NEW HYDROXYBEZALDEHYDE DERIVATIVES","authors":"Ye.S. Sychyeva, M.S. Mukanova","doi":"10.51580/2023-3.2710-1185.34","DOIUrl":"https://doi.org/10.51580/2023-3.2710-1185.34","url":null,"abstract":"A high pharmacological ability of aromatic benzaldehydes makes them important intermediates for the synthesis of medicinal preparations, such as anticancer, bactericidal, antifungal, and herbicidal drugs. The purpose of this work is the synthesis of biologically active compounds, based on 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde and the establishment of the structure of the synthesized compounds. Results and discussion. New carbonodithioates, based on O-aromatic systems have been synthesized by the interaction of 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde with carbon disulfide in the presence of sodium hydroxide in ethanol at the room temperature. As a result of the reactions, sodium O-(4-formylphenyl)carbodithioate (86 %) and sodium O-(4-formyl-2-methoxyphenyl)carbodithioate (80%) have been isolated. The interaction of sodium xanthates with acid chlorides (4-methoxy-, 4-nitro-, 2,4-dinitrobenzoic) in chloroform has led to the formation of aromatic thioanhydrides of carbonodithioic acids in 55-80 % yields. The reactivity of hydroxybenzaldehydes and their dithiocarboxylic derivatives has been studied in the propargylation reaction. Propargylation of 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde has been carried out with propargyl bromide in the presence of a 3-fold excess of K2CO3 in acetone at the temperature of 60°C. The propargylation reaction of sodium xanthate has been carried out with propargyl bromide in acetone at the room temperature. Conclusion. As a result of the reactions, carbonodithioates, thioanhydrides, acetylenic and thioacetylenic ethers have been synthesized based, on O-aromatic systems (4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde). The structure of the synthesized compounds has been established on the basis of elemental analysis data, IR spectra, 1Н and 13С NMR spectroscopy.","PeriodicalId":494584,"journal":{"name":"Химический журнал Казахстана","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135486819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GROWTH PROMOTING ACTIVITY OF FLAVONOIDS OF EXTRACTS OF POPULUS POPULUS BALSAMIFERA BUDS","authors":"A.G. Meshchanova, V.V. Polyakov","doi":"10.51580/2023-2.2710-1185.22","DOIUrl":"https://doi.org/10.51580/2023-2.2710-1185.22","url":null,"abstract":"Currently, the urgent task is to accelerate the development of alternative plant protection measures, which is associated with the aggravation of the environmental situation, the desire to reduce pollution of agricultural landscapes and obtain agricultural products with minimal use of agrochemicals. Poplar extract is a plant growth stimulant due to the presence in its composition of saturated and unsaturated fatty acids, lipids, phenolic and polyphenolic compounds, amino acids, essential oils, vitamins, which provide a stable growth-stimulating effect. The advantages of biological preparations, based on balsamic poplar, include their low cost, the absence of a negative effect on plant productivity, high specificity, low toxicity. The main difference between biological preparations and other plant protection products is that they are able to stimulate the natural protective abilities of the plants themselves, thereby affecting harmful organisms. The use of such drugs is one of the ways to solve environmental problems in agriculture and a powerful means of increasing the effectiveness of both plant protection from phytopathogens and crop production in general. The purpose is to evaluate the stimulating activity of the extracts of the buds of poplar balsamic Populusbalsamifera on the seed productivity of flax. The objecvtives: to isolate the sum of flavonoids from balsamic poplar; to establish the growth-stimulating activity of the extract of the buds of balsamic poplar in relation to flax seeds. Methodology. The method of obtaining the proposed balsamic poplar extract includes the use of balsamic poplar buds, air drying, grinding, extraction with 90% ethanol in a Soxlet apparatus, filtration and evaporation until the target product is obtained. The results. The obtained results and conclusions. In the course of the study, flavonoids have been isolated from the buds of balsamic poplar. The presence of flavonoids in the ethanol extract is confirmed by qualitative reactions. The composition of poplar kidney extract has been investigated by thin-layer chromatography. Conclusion. It has been found that the extract from the poplar buds mainly contains substances of a flavonoid nature. The results of studying the growth-stimulating activity of the extracts of balsamic poplar Populusbalsamifera showed high seed productivity of flax of Tomsk selection in the control group; reproduction conditions have positively affected the yield of flax.","PeriodicalId":494584,"journal":{"name":"Химический журнал Казахстана","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134982220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}