Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin最新文献

[Pigmented adrenal cortex adenoma]. [色素肾上腺皮质腺瘤]。

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2020-02-07 DOI: 10.32388/34vgh2

C. Luders

引用次数: 1

Kinetic analyses of vasculogenesis inform mechanistic studies. 血管生成的动力学分析为机理研究提供了信息。

IF 5

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2017-04-01 Epub Date: 2017-01-18 DOI: 10.1152/ajpcell.00367.2016

Kaela M Varberg, Seth Winfree, Chenghao Chu, Wanzhu Tu, Emily K Blue, Cassandra R Gohn, Kenneth W Dunn, Laura S Haneline

{"title":"Kinetic analyses of vasculogenesis inform mechanistic studies.","authors":"Kaela M Varberg, Seth Winfree, Chenghao Chu, Wanzhu Tu, Emily K Blue, Cassandra R Gohn, Kenneth W Dunn, Laura S Haneline","doi":"10.1152/ajpcell.00367.2016","DOIUrl":"10.1152/ajpcell.00367.2016","url":null,"abstract":"Vasculogenesis is a complex process by which endothelial stem and progenitor cells undergo de novo vessel formation. Quantitative assessment of vasculogenesis is a central readout of endothelial progenitor cell functionality. However, current assays lack kinetic measurements. To address this issue, new approaches were developed to quantitatively assess in vitro endothelial colony-forming cell (ECFC) network formation in real time. Eight parameters of network structure were quantified using novel Kinetic Analysis of Vasculogenesis (KAV) software. KAV assessment of structure complexity identified two phases of network formation. This observation guided the development of additional vasculogenic readouts. A tissue cytometry approach was established to quantify the frequency and localization of dividing ECFCs. Additionally, Fiji TrackMate was used to quantify ECFC displacement and speed at the single-cell level during network formation. These novel approaches were then implemented to identify how intrauterine exposure to maternal diabetes mellitus (DM) impairs fetal ECFC vasculogenesis. Fetal ECFCs exposed to maternal DM form fewer initial network structures, which are not stable over time. Correlation analyses demonstrated that ECFC samples with greater division in branches form fewer closed network structures. Additionally, reductions in average ECFC movement over time decrease structural connectivity. Identification of these novel phenotypes utilizing the newly established methodologies provides evidence for the cellular mechanisms contributing to aberrant ECFC vasculogenesis.","PeriodicalId":49378,"journal":{"name":"Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin","volume":"256 1","pages":"C446-C458"},"PeriodicalIF":5.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73065289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cellular stress response of the scleractinian coral Goniopora columna during the progression of the black band disease. 硬骨珊瑚 Goniopora columna 在黑带病发展过程中的细胞应激反应。

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2017-03-01 Epub Date: 2016-12-17 DOI: 10.1007/s12192-016-0756-7

Davide Seveso, Simone Montano, Melissa Amanda Ljubica Reggente, Davide Maggioni, Ivan Orlandi, Paolo Galli, Marina Vai

{"title":"The cellular stress response of the scleractinian coral Goniopora columna during the progression of the black band disease.","authors":"Davide Seveso, Simone Montano, Melissa Amanda Ljubica Reggente, Davide Maggioni, Ivan Orlandi, Paolo Galli, Marina Vai","doi":"10.1007/s12192-016-0756-7","DOIUrl":"10.1007/s12192-016-0756-7","url":null,"abstract":"Black band disease (BBD) is a widespread coral pathology caused by a microbial consortium dominated by cyanobacteria, which is significantly contributing to the loss of coral cover and diversity worldwide. Since the effects of the BBD pathogens on the physiology and cellular stress response of coral polyps appear almost unknown, the expression of some molecular biomarkers, such as Hsp70, Hsp60, HO-1, and MnSOD, was analyzed in the apparently healthy tissues of Goniopora columna located at different distances from the infection and during two disease development stages. All the biomarkers displayed different levels of expression between healthy and diseased colonies. In the healthy corals, low basal levels were found stable over time in different parts of the same colony. On the contrary, in the diseased colonies, a strong up-regulation of all the biomarkers was observed in all the tissues surrounding the infection, which suffered an oxidative stress probably generated by the alternation, at the progression front of the disease, of conditions of oxygen supersaturation and hypoxia/anoxia, and by the production of the cyanotoxin microcystin by the BBD cyanobacteria. Furthermore, in the infected colonies, the expression of all the biomarkers appeared significantly affected by the development stage of the disease. In conclusion, our approach may constitute a useful diagnostic tool, since the cellular stress response of corals is activated before the pathogens colonize the tissues, and expands the current knowledge of the mechanisms controlling the host responses to infection in corals.","PeriodicalId":49378,"journal":{"name":"Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin","volume":"258 1","pages":"225-236"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73387415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactivation of telomerase in cancer. 癌症中端粒酶的重新激活。

IF 8

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2016-04-01 Epub Date: 2016-02-04 DOI: 10.1007/s00018-016-2146-9

Semih Can Akincilar, Bilal Unal, Vinay Tergaonkar

引用次数: 0

Effects of diets differing in protein source and technical treatment on digestibility, performance and visceral and biochemical parameters of fattening pigs. 不同蛋白质来源和技术处理的日粮对育肥猪消化率、生产性能、内脏和生化指标的影响

IF 2

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2016-01-01 DOI: 10.1080/1745039X.2016.1157983

Wendy Liermann, Andreas Berk, Verena Böschen, Sven Dänicke

{"title":"Effects of diets differing in protein source and technical treatment on digestibility, performance and visceral and biochemical parameters of fattening pigs.","authors":"Wendy Liermann, Andreas Berk, Verena Böschen, Sven Dänicke","doi":"10.1080/1745039X.2016.1157983","DOIUrl":"10.1080/1745039X.2016.1157983","url":null,"abstract":"The aim of the experiment on 100 cross-bred barrows was to compare commercial diets for fattening pigs based on either soya bean meal (SBM) imported from non-European countries with diets based on a mixture of locally produced rape seed meal, distillers' dried grains with solubles and soya beans as main protein sources. In addition, these both types of diets were processed by two different technical feed treatments, i.e. coarse grinding without hydrothermal treatment or fine grinding and pelleting. With only few exceptions, nutrients of the diet without SBM were more digestible (p < 0.05) resulting in a higher metabolisable energy (ME) content. Fine grinding and pelleting increased also the ME content and the nutrient digestibility with the exception of crude fibre. Higher feed intake of animals that fed diets without SBM (p < 0.01) resulted in higher average daily gain (p < 0.01). However feeding this diet, the higher digestibility was not reflected in a decreased feed-to-gain ratio (FGR), but fine grinding and pelleting reduced FGR (p < 0.001). A higher pH value and a lower DM content of caecal chymus were detected in animals that received coarsely ground feed (p < 0.05). Animals that fed finely ground and pelleted feed had higher slaughter and relative liver weights and higher blood cholesterol concentrations (p = 0.040). The urea concentrations of blood were lower (p = 0.019) after feeding diets without SBM. In conclusion, SBM imported from non-European countries can be replaced by alternative local protein sources without compromising digestibility or performances of animals. Although fine grinding and thermal treatment particularly seemed to be advantageous for digestibility and performance, the possible risk of development of stomach lesions should be considered. ","PeriodicalId":49378,"journal":{"name":"Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin","volume":"281 1","pages":"190-208"},"PeriodicalIF":2.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/1745039X.2016.1157983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73375977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Generalisierte Retothelsarkomatose 全身性retothe肉瘤病

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2007-01-01 DOI: 10.1007/BF02593352

Dr. Werner Gloggengießer

引用次数: 0

Über Glomerulosklerose 关于Glomerulosklerose

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2007-01-01 DOI: 10.1007/BF02593941

Th. Fahr

引用次数: 0

Beitrag zur pathologischen Anatomie und Histologie des Ophidismus 对解剖学和和学科学的贡献

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2007-01-01 DOI: 10.1007/BF02595092

W. Rotter

引用次数: 0

Ein Beitrag zur Frage der Chondrodystrophie 这是关于重症患者的素材

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2007-01-01 DOI: 10.1007/BF02595091

R. V. Oeynhausen

引用次数: 0

Über Oesophagushypertrophie 关于Oesophagushypertrophie

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin Pub Date : 2007-01-01 DOI: 10.1007/BF02595188

Dozent Dr. Karlheinz Helmke

引用次数: 2