Visual Computer最新文献

Human Plasma Proteomic Profile of Clonal Hematopoiesis. 克隆性造血的人体血浆蛋白质组概况

IF 3 3区计算机科学

Visual Computer Pub Date : 2024-10-31 DOI: 10.1101/2023.07.25.550557

Zhi Yu, Amélie Vromman, Ngoc Quynh H Nguyen, Art Schuermans, Thiago Rentz, Shamsudheen K Vellarikkal, Md Mesbah Uddin, Abhishek Niroula, Gabriel Griffin, Michael C Honigberg, Amy E Lin, Christopher J Gibson, Daniel H Katz, Usman Tahir, Shi Fang, Sara Haidermota, Shriienidhie Ganesh, Tajmara Antoine, Joshua Weinstock, Thomas R Austin, Vasan S Ramachandran, Gina M Peloso, Whitney Hornsby, Peter Ganz, JoAnn E Manson, Bernhard Haring, Charles L Kooperberg, Alexander P Reiner, Joshua C Bis, Bruce M Psaty, Yuan-I Min, Adolfo Correa, Leslie A Lange, Wendy S Post, Jerome I Rotter, Stephen S Rich, James G Wilson, Benjamin L Ebert, Bing Yu, Christie M Ballantyne, Josef Coresh, Vijay G Sankaran, Alexander G Bick, Siddhartha Jaiswal, Robert E Gerszten, Peter Libby, Rajat M Gupta, Pradeep Natarajan

{"title":"Human Plasma Proteomic Profile of Clonal Hematopoiesis.","authors":"Zhi Yu, Amélie Vromman, Ngoc Quynh H Nguyen, Art Schuermans, Thiago Rentz, Shamsudheen K Vellarikkal, Md Mesbah Uddin, Abhishek Niroula, Gabriel Griffin, Michael C Honigberg, Amy E Lin, Christopher J Gibson, Daniel H Katz, Usman Tahir, Shi Fang, Sara Haidermota, Shriienidhie Ganesh, Tajmara Antoine, Joshua Weinstock, Thomas R Austin, Vasan S Ramachandran, Gina M Peloso, Whitney Hornsby, Peter Ganz, JoAnn E Manson, Bernhard Haring, Charles L Kooperberg, Alexander P Reiner, Joshua C Bis, Bruce M Psaty, Yuan-I Min, Adolfo Correa, Leslie A Lange, Wendy S Post, Jerome I Rotter, Stephen S Rich, James G Wilson, Benjamin L Ebert, Bing Yu, Christie M Ballantyne, Josef Coresh, Vijay G Sankaran, Alexander G Bick, Siddhartha Jaiswal, Robert E Gerszten, Peter Libby, Rajat M Gupta, Pradeep Natarajan","doi":"10.1101/2023.07.25.550557","DOIUrl":"10.1101/2023.07.25.550557","url":null,"abstract":"Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 ancestrally diverse participants (3,881 with CHIP) from NHLBI TOPMed and UK Biobank with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2,917 proteins by Olink in UK Biobank), we identified 32 and 345 unique proteins from TOPMed and UK Biobank, respectively, associated with the most prevalent driver genes (DNMT3A, TET2, and ASXL1). These associations showed substantial heterogeneity by driver genes, sex, and race, and were enriched for immune response and inflammation pathways. Mendelian randomization in humans, coupled with ELISA in hematopoietic Tet2-/- vs wild-type mice validation, disentangled causal proteomic perturbations from TET2 CHIP. Lastly, we identified plasma proteins shared between CHIP and CAD.","PeriodicalId":49376,"journal":{"name":"Visual Computer","volume":"31 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73564233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}