{"title":"[Pre- and Postsynaptic Mechanisms of the Deprivational Potentiation of Population Responses in Rat Hippocampal CA1 Neurons].","authors":"V A Popov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mechanisms of the deprivational potentiation (DeP) of the population responses in rat hippocampal CA1 neurons after 60-min period of the cessation of rare (0.05 Hz) test stimulation of Schaffer collaterals was investigated in vitro. It has been demonstrated that two independent mechanisms are involved in DeP induction: presynaptic component in initial phase of DeP and postsynaptic one responsible for the long-term phase of DeP. The competitive interference between mechanisms of the long-term phase of DeP and the protein phosphorylation phase of long-term potentiation (LTP) was confirmed. It was shown that not NMDA receptors, but purinergic P2 receptors participate in Ca(2+) -dependent mechanism of induction of the postsynaptic component of DeP. The common curve of dependence of synaptic strength on synaptic use/disuse, including the DeP, long-term depression (LTD) and LTP areas, is presented.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 2","pages":"209-19"},"PeriodicalIF":0.3,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34318018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Motor Proteins of Microtubules and Mechanisms of Synaptic Plasticity].","authors":"N A Vasilyeva, A S Pivovarov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Motor proteins of microtubules, kinesin and dynein superfamily proteins play an important role in the intracellular transport. Inside a neuron they are involved in the transport of organelles, proteins and mRNAs along the axons and dendrites to the nerve terminals and back to the cell bodies. Disturbance of axonal transport may affect neurotransmitter release and short-term presynaptic plasticity. Disturbance of dendritic transport, in particular the recycling of synaptic receptors, affects postsynaptic plasticity. The review attempts to trace the connections between the motor proteins of microtubules and mechanisms of synaptic plasticity from the perspective of their involvement in the intracellular transport of proteins and organelles, which play role in the mechanisms of synaptic plasticity.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 2","pages":"148-62"},"PeriodicalIF":0.3,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34318014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Мартынова Ольга Владимировна, Портнова Галина Владимировна, Орлов Иван Юрьевич
{"title":"Исследование методом фМРТ эмоционального восприятия эротических изображений у мужчин 49–74 лет","authors":"Мартынова Ольга Владимировна, Портнова Галина Владимировна, Орлов Иван Юрьевич","doi":"10.7868/S0044467715060064","DOIUrl":"https://doi.org/10.7868/S0044467715060064","url":null,"abstract":"","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"33 1","pages":"24-35"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91284773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Delayed Copying of Unfamiliar Contour Shapes: Does Reaction Time Decrease with Growing Delay Reflect a Change in Internal Representation Of Fothcoming Movement?].","authors":"A A Korneev, D I Lomakin, A V Kurgansky","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Group of 24 adults has performed the delayed reproduction (copying) of unfamiliar contour shapes (trajectory templates). Templates were shown for 250 ms and the participants were asked to reproduce them upon detecting acoustical go signal (short click). Go signal was delayed relatively to the end of a visual template exposure by T = 0, 500, 1000, 2000 or 4000 ms. Block design of the experiment was used when delay T was held constant within a block consisted of 32 trials. We analyzed reaction time (RT), mean movement time (MT) along a single segment of trajectory, and the mean dwell time (DT) in the vertices of the template. It is shown that RT does not depend monotonically on the delay T showing a decrease at T ≤ 1000 ms and increase at T ≤ 2000 ms. The RT of T curve is well described by a simple additive model that includes a linearly growing and an exponentially decaying terms. The linear growth reflects the foreperiod effect, i.e., decreasing capacity to predict an exact moment of go signal with the growing delay T [Niemi, Naatanen, 1981; Meulenbroek, Van Galen, 1988]. We suggested that exponentially decaying term may be caused by the internal representation of a trajectory undergoing some transformation during retention in the working memory.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 1","pages":"51-61"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34451052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R V Kozhemyakina, M Yu Konoshenko, D G Sakharov, D A Smagin, A L Markel
{"title":"[Comparative Analysis of Behavior in The Open-field Test in Wild Grey Rats (Rattus norvegicus) and in Grey Rats Subjected to Prolonged Selection for Tame And Aggressive Behavior].","authors":"R V Kozhemyakina, M Yu Konoshenko, D G Sakharov, D A Smagin, A L Markel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this work is analysis of the open-field behavior in grey rats selected for the tame and aggressive behavior in comparison with the wild grey rats. Significant influences of the rat group factor on the 13 of 19 behavioral features studied in the open-field were found. This effect, in general, depends on existence of great differences between behaviors of the wild rats from the one hand and behaviors of the tame and aggressive rats from the other. The behaviors of the rats from the last two groups are practically identical. Multidimensional analysis confirms the distinct separation in coordinates of the two main components of the wild rat behavior from the behavior of both the tame and selectively bred aggressive rats. The first main component dimension corresponds to the grade of fear, which was significantly enhanced in the wild rats. So, in spite of the equality of behavioral aggressiveness of the wild rats and the rats selected for aggression with the glove test, the behavior of selected aggressive rats in the open-field is analogous to behavior of the rats selected for tameness. Comparison of behavioral features with the hormonal stress responsiveness allowed us to conclude that the aggressive behavior of the wild and se lected for aggression rats based on different motivational and neuroendocrine processes.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 1","pages":"92-102"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34547270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Портнова Галина Владимировна, Атанов Михаил Сергеевич, Гладун Ксения Викторовна, Мартынова Ольга Владимировна
{"title":"Параметры ЭЭГ состояний покоя коррелируют с данными УЗДГ МАГ и когнитивными нарушениями у пациентов с хронической ишемией мозга и инсультом различной латерализации","authors":"Портнова Галина Владимировна, Атанов Михаил Сергеевич, Гладун Ксения Викторовна, Мартынова Ольга Владимировна","doi":"10.7868/S0044467716060095","DOIUrl":"https://doi.org/10.7868/S0044467716060095","url":null,"abstract":"","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"1 1","pages":"698-709"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75611644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Method of Calculating the Distance Between the Classes of the Structural Components of the Forebrain Birds].","authors":"L N Voronov, V Y Konstantinov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The method of calculating the distance between the classes of the structural components of the brain of birds. Compared interclass distances of glia, neurons and neuroglial complexes in the forebrain hooded crow (Corvus cornix) (a bird with a highly rational activity) and common crossbill (Loxia curvirostra) (birds with a medium level of rational activity).</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 1","pages":"113-24"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34547721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M I Zaichenko, D A Bazhenova, G A Grigoryan, G Kh Merzhanova
{"title":"[Does Impulsivity Affect a Long-term and Working Memory in rats?].","authors":"M I Zaichenko, D A Bazhenova, G A Grigoryan, G Kh Merzhanova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present paper usingthe method of delay discounting three groups of animals were discovered: a) those that at choice between immediate weak and delayed strong rewards have chosen an immediate reinforcement (high impulsive rats); b) those that were able to inhibit its own behavior and get the delayed reinforcement (low impulsive rats); and c) the rats with both types of reactions. In the water maze the different groups of rats did find a hidden platform for different time, swum various distance and with different speed. The differences however were significant only at overall comparison (for all days and trials) of the above mentioned parameters of the water maze learning. ANOVAs Group x Days, Group x Trials, and Groups x Days x Trials interactions were insignificant. The data obtained indicate that the difference between groups was appeared evidently due to the difference in general motor activity, rather than difference in their cognitive abilities assessed by reference and working memory tasks.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 1","pages":"82-91"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34612975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Thalamo-Cortical Mechanisms of Initiation, Maintenance and Termination of Spike-wave Discharges at WAG/Rij rats].","authors":"M V Sysoeva, E Sitnikova, I V Sysoev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Generalized spike and wave discharges (SWDs) are generated within the cortico-thalamo-cortical system, being an electroencephalographic sign of absence epilepsy. The current work aims to identify mechanisms of SWD initiation, maintenance and termination. Dynamics and directionality of mutual interactions between neocortex (occipital (OC) and frontal (FC) cortex) and thalamus (reticular (RTN) and ventral postero medial (VPM) thalamic nuclei) were investigated. SWD initiation process is revealed several seconds before seizure onset in interaction between all brain areas, except intrathalamic pair (RTN-VPM). This process begins at different moments relatively to SWD onset. The interaction increase is observed earlier and most obviously when thalamus and OC drive FC. The maintenance process (the first few seconds of SWD) is accompanied with high level interaction inside thalamus and increase of driving from thalamus to occipital cortex. Thus interaction from thalamus and occipital cortex to frontal cortex and influence to VPM occur to be below baseline level. At the SWD offset thalamo-cortical interactions were found to return to baseline level quickly.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 1","pages":"103-12"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34612978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E V Korneeva, A A Tiunova, L I Alexandrov, T B Golubeva
{"title":"[Wulst Activation in Pied Flycatcher Nestlings in Feeding Behavior Induced by Patterned Visual Stimulus].","authors":"E V Korneeva, A A Tiunova, L I Alexandrov, T B Golubeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunohistochemical detection of c-Fos was used to study the transcriptional activation in two higher visual centers (Wulst area and Entopallium) of 12-day-old pied flycatcher (Ficedula hypoleuca) during the realization of feeding behavior guided by patterned visual stimulus, simulating the species-specific one. Activation was compared in 4 groups of nestlings. Control group was not subjected to any experimental influence. In binocular, right-field (deprivation of the left eye) and left-filed (deprivation of the right eye) groups the vision feeding responses were provoked, reinforced and evaluated. It was shown that the visual afferentation from the right eye was more significant for the organization of early feeding behavior guided by a moving patterned visual stimulus as compared with the afferentation from the left eye. Feeding behavior induced activation of c-Fos expression only in neurons of the higher center of thalamofugal system--Wulst area. The comparison of transcriptional activation in different groups revealed the significant increase of c-Fos induction related with feeding behavior only in the left hemisphere and only in binocular and right-field groups.</p>","PeriodicalId":49337,"journal":{"name":"Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I P Pavlova","volume":"66 1","pages":"74-81"},"PeriodicalIF":0.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34612973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}