Bioactivities最新文献

Fight for Cancer Diseases using Natural Compounds and Their Semisynthetic Derivatives 利用天然化合物及其半合成衍生物对抗癌症疾病

Bioactivities Pub Date : 2024-07-12 DOI: 10.47352/bioactivities.2963-654x.221

Y. S. Kurniawan, K. Gurning, I. Iksen, Ahmad Bikharudin

{"title":"Fight for Cancer Diseases using Natural Compounds and Their Semisynthetic Derivatives","authors":"Y. S. Kurniawan, K. Gurning, I. Iksen, Ahmad Bikharudin","doi":"10.47352/bioactivities.2963-654x.221","DOIUrl":"https://doi.org/10.47352/bioactivities.2963-654x.221","url":null,"abstract":"Cancer stands as one of the deadliest diseases afflicting contemporary human societies, encompassing over 100 distinct forms, including oral, salivary glands, oropharynx, nasopharynx, hypopharynx, colorectal, liver, pancreas, lung, skin, breast, cervix, ovary, prostate, kidney, brain, thyroid, and leukemia cancers. At the cellular level, the uncontrolled growth of cancerous cells can disrupt the body's normal functions. Chemotherapy, a widely recognized cancer treatment, utilizes anticancer agents to target specific cancer cell lines effectively. Natural compounds are favored for their compatibility with the body, minimal harm to healthy cells, and easy extraction from natural sources. These natural compounds and their derivatives hold promise for cancer therapy, boasting diverse structural and pharmacological characteristics. Additionally, chemical modifications can enhance their anticancer properties. This review explores the anticancer potential of terpenoids, flavonoids, alkaloids, xanthones, and epoxides, as well as elucidates their molecular mechanisms, such as their antiproliferative, apoptotic, antiangiogenic, and antimetastatic actions. Furthermore, the effect of the functional group on the anticancer activity through the structure-activity relationship will be discussed in detail, supported by molecular docking and molecular dynamic simulations. Combining experimental in vitro and in vivo assays with computational in silico assays significantly helps us understand how we shall fight cancer diseases in the modern era.","PeriodicalId":492963,"journal":{"name":"Bioactivities","volume":"42 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Antibacterial Activity and Phytochemical Screening of Galoba (Hornstedtia alliaceae) Seeds Extract 皂荚种子提取物的体外抗菌活性及植物化学筛选

Bioactivities Pub Date : 2023-10-24 DOI: 10.47352/bioactivities.2963-654x.196

Melfan El Shaday Sule, Eka Astuty, Ritha Tahitu

{"title":"In Vitro Antibacterial Activity and Phytochemical Screening of Galoba (Hornstedtia alliaceae) Seeds Extract","authors":"Melfan El Shaday Sule, Eka Astuty, Ritha Tahitu","doi":"10.47352/bioactivities.2963-654x.196","DOIUrl":"https://doi.org/10.47352/bioactivities.2963-654x.196","url":null,"abstract":"Hornstedtia alliacea has been traditionally used by indigenous people for a variety of medicinal purposes. This study aimed to determine the antibacterial activity of ethanol extracts of Galoba seeds (Hornstedtia alliacea) against standard bacterial cultures of Staphylococcus aureus (ATCC-29213) and Escherichia coli (FNCC-6183) using Kirby-Bauer disk diffusion method. The phytochemical tests were carried out to determine the presence of active substances which are antibacterial in the results of the extraction. The color intensity or the precipitate formation was used as analytical response to these tests. The major phytochemical constituents identified in galoba seeds ethanol extracts were tannins, flavonoids, saponins, quinones, and steroids. The antibacterial assay showed that galoba seed extract inhibited the growth of S. aureus and E. coli. The diameter of the inhibition zone increased as the extract concentration increased. The largest inhibition zone for S. aureus was at a concentration of 100% with a diameter of 20.93 mm and the largest inhibition zone for E. coli was at a concentration of 100% with a diameter of 18.05 mm. The results of this study indicated that the plant contains some major bioactive compounds that inhibit the growth of microorganisms, thereby showing great potency as an effective source of drugs. The phytochemical analysis also reveals that the plant contains similar constituents useful for medicinal purposes.","PeriodicalId":492963,"journal":{"name":"Bioactivities","volume":"5 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135267346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial Effect of Juglans regia, Citrus sinensis, Vicia faba, and Urtica urens Extracts under In vitro Conditions 王核桃、柑橘、蚕豆和荨麻提取物的体外抑菌作用

Bioactivities Pub Date : 2023-10-20 DOI: 10.47352/bioactivities.2963-654x.195

Ali Khakpour, Negar Ahmadi Shadmehri, Hanif Amrulloh, Hamed Kioumarsi

{"title":"Antibacterial Effect of Juglans regia, Citrus sinensis, Vicia faba, and Urtica urens Extracts under In vitro Conditions","authors":"Ali Khakpour, Negar Ahmadi Shadmehri, Hanif Amrulloh, Hamed Kioumarsi","doi":"10.47352/bioactivities.2963-654x.195","DOIUrl":"https://doi.org/10.47352/bioactivities.2963-654x.195","url":null,"abstract":"Various agricultural products are known to have anti-microbial, anti-cancer, and anti-inflammatory effects. As we can mention, Walnut (Juglans regia) husk, orange (Citrus sinensis) peel, Broad bean (Vicia faba) peel, and Nettle (Urtica urens) are proven to have antimicrobial and anticancer actions. Also, plant diseases such a Pectobacterium carotovorum, Ralstonia solanacearum, Dickeya chrysanthemi, and Pseudomonoas syringae are known to cause annual damage to plant products. Therefore, in the current study, the researchers evaluated their antibacterial activity on the mentioned bacteria under in vitro conditions. Extracts of J. regia husk, C. sinensis peel, V. faba outer peel and U. urens were prepared by maceration method and their anti-bacterial activity on P. carotovorum, D. chrysanthemi, P. syringae, R. solancearum was evaluated using blank disk and well diffusion to obtain minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. J. regia (husk) and V. faba (outer peel) extracts revealed an anti-bacterial effect on all 4 studied bacteria, while C. sinensis (peel) only inhibited the growth of P. syringae and U. urens only had this effect on P. syringae and R. Solancearum. The inhibition zones varied from 8 to 14 mm, while almost all MIC and MBC rates were 6.25 and 12.5 mg/mL, respectively. Based on the antimicrobial results, the extracts that showed suitable antibacterial effects on certain bacteria can be further studied to be used as natural pesticides.","PeriodicalId":492963,"journal":{"name":"Bioactivities","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico Exploration on The Potency of Basil (Ocimum basilicum) as an Anti-Aging Skin Agent 罗勒(ocum basilicum)抗衰老皮肤剂效能的硅片探索

Bioactivities Pub Date : 2023-10-06 DOI: 10.47352/bioactivities.2963-654x.193

Wega Nasyita Amala, Raden Ahmad Zainul Aziz, Nur Rohmah, Hanun Najah Imtiyaz, Muhamad Dandi Iqbal Iskandar, Erlix Rakhmad Purnama

{"title":"In silico Exploration on The Potency of Basil (Ocimum basilicum) as an Anti-Aging Skin Agent","authors":"Wega Nasyita Amala, Raden Ahmad Zainul Aziz, Nur Rohmah, Hanun Najah Imtiyaz, Muhamad Dandi Iqbal Iskandar, Erlix Rakhmad Purnama","doi":"10.47352/bioactivities.2963-654x.193","DOIUrl":"https://doi.org/10.47352/bioactivities.2963-654x.193","url":null,"abstract":"New and improved skin care products and procedures have been established by technological advances and scientific investigation. By increasing the skin's moisture, firmness, and elasticity, anti-aging skin care can enhance the skin's overall condition. The objective of this study was to examine the potential of basil's chemical compounds as an in silicoanti-aging agent. Exploration of online databases, scholarly articles from national and international journals, and analysis using docking software are selected as examples of data collection methods. Matrix metalloproteinase 1 (MMP1), with PDB code 966C, is one of the targeted proteins related to skin anti-aging. Ladanein, acacetin, luteolin, 5-hydroxy-7,4'-dimethoxyflavone and genkwanin are five basil compounds that are predicted to exhibit anti-aging agents based on the presence of the binding affinity score indicator and the similarity of the appropriate attachment sites compared to the native ligand used. The scores for the binding affinity of luteolin, ladanein, acacetin, 5-hydroxy-7,4'-dimethoxyflavone, and genkwanin are -10, -9.9, -9.9, -9.8, and -9.6 kcal/mol, respectively. At the attachment positions of five basil compounds, the interactions with ASN 180, LEU 181 and ALA 182 key amino acids, which are the attachment sites for the native ligands, were also formed.","PeriodicalId":492963,"journal":{"name":"Bioactivities","volume":"214 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135351502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Journey of Natural Products: From Isolation Stage to Drug’s Approval in Clinical Trials 天然产物之旅:从分离阶段到药物临床试验批准

Bioactivities Pub Date : 2023-09-12 DOI: 10.47352/bioactivities.2963-654x.190

Yehezkiel Steven Kurniawan, Tantiana Indriani, Hanif Amrulloh, Langit Cahya Adi, Arif Cahyo Imawan, Krisfian Tata Aneka Priyangga, Ervan Yudha

{"title":"Journey of Natural Products: From Isolation Stage to Drug’s Approval in Clinical Trials","authors":"Yehezkiel Steven Kurniawan, Tantiana Indriani, Hanif Amrulloh, Langit Cahya Adi, Arif Cahyo Imawan, Krisfian Tata Aneka Priyangga, Ervan Yudha","doi":"10.47352/bioactivities.2963-654x.190","DOIUrl":"https://doi.org/10.47352/bioactivities.2963-654x.190","url":null,"abstract":"Nature serves as an excellent inspiration for researchers in the fields of chemistry and medicine. Terrestrial or marine organisms produce billions of natural products with unique chemical and physical properties. Some of them have been used in traditional therapy for specific diseases since ancient times. Although their exact chemical structures have yet to be elucidated clearly in that time, investigations in medicinal chemistry have been well documented. Furthermore, utilizing natural products in drug design and development offers advantages such as high biocompatibility, low toxicity, fewer side effects, wide bioactivities, and large structure diversity. Nowadays, rational drug research using computer-aided drug design is well established to cut the long way of drug discovery and overcome the resistance cases and the increment in the number of active patients. This review will highlight some natural products to comprehensively understand their journey from unknown natural products, isolation, purification, characterization, in silico evaluation, bioactivity screening assay, drug modifications, in vitro investigation, in vivo examination, and clinical trial.","PeriodicalId":492963,"journal":{"name":"Bioactivities","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135825571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1