Seminars in Pediatric Neurology最新文献_第5页

Diagnosis and Treatment of Disorders of Sleep in Children: Current Concepts 儿童睡眠障碍的诊断与治疗：当前概念

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-12-01 DOI: 10.1016/j.spen.2023.101102

Thomas J. Dye

引用次数: 0

Sleep in pediatric neuromuscular disorders 睡眠对小儿神经肌肉疾病的影响

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-12-01 DOI: 10.1016/j.spen.2023.101092

John E Pascoe , Alexander Zygmunt , Zarmina Ehsan , Neepa Gurbani

引用次数: 0

Sleep and Epilepsy 睡眠与癫痫

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-12-01 DOI: 10.1016/j.spen.2023.101087

Wei K. Liu , Sanjeev Kothare , Sejal Jain

引用次数: 1

Sleep and Circadian Disturbances in Children With Neurodevelopmental Disorders 神经发育障碍儿童的睡眠与昼夜节律紊乱

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-12-01 DOI: 10.1016/j.spen.2023.101090

Sharon Tamir , Thomas J. Dye , Rochelle M. Witt

引用次数: 1

If the Patient Does Not Take the Medication, It Will Not Work 如果病人不服药，它就不会起作用

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-10-01 DOI: 10.1016/j.spen.2023.101079

Iván Sánchez Fernández , Adriana Ulate-Campos

引用次数: 0

Contemporary Understanding of the Central Autonomic Nervous System in Fetal-Neonatal Transition 胎儿-新生儿过渡期中枢自主神经系统的现代理解。

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-10-01 DOI: 10.1016/j.spen.2023.101081

Sarah B. Mulkey

{"title":"Contemporary Understanding of the Central Autonomic Nervous System in Fetal-Neonatal Transition","authors":"Sarah B. Mulkey","doi":"10.1016/j.spen.2023.101081","DOIUrl":"10.1016/j.spen.2023.101081","url":null,"abstract":"<div><h3>The Critical Role of the Central Autonomic Nervous System in Fetal-Neonatal Transition</h3><p>Sarah B. Mulkey, Adre dú Plessis Seminars in Pediatric Neurology Volume 28, December 2018, Pages 29–37</p><p>The objective of this article is to understand the complex role of the central autonomic nervous system in normal and complicated fetal-neonatal transition and how autonomic nervous system dysfunction can lead to brain injury. The central autonomic nervous system supports coordinated fetal transitional cardiovascular, respiratory, and endocrine responses to provide safe transition of the fetus at delivery. Fetal and maternal medical and environmental exposures can disrupt normal maturation of the autonomic nervous system in utero, cause dysfunction, and complicate fetal-neonatal transition. Brain injury may both be caused by autonomic nervous system failure and contribute directly to autonomic nervous system dysfunction in the fetus and newborn. The central autonomic nervous system has multiple roles in supporting transition of the fetus. Future studies should aim to improve real-time monitoring of fetal autonomic nervous system function and in supporting typical autonomic nervous system development even under complicated conditions.</p></div>","PeriodicalId":49284,"journal":{"name":"Seminars in Pediatric Neurology","volume":"47 ","pages":"Article 101081"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epilepsy Impacts Families and Communities: Persistent Gaps and Inequities 癫痫影响家庭和社区：持续的差距和不平等。

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-10-01 DOI: 10.1016/j.spen.2023.101084

Adam P. Ostendorf

{"title":"Epilepsy Impacts Families and Communities: Persistent Gaps and Inequities","authors":"Adam P. Ostendorf","doi":"10.1016/j.spen.2023.101084","DOIUrl":"10.1016/j.spen.2023.101084","url":null,"abstract":"<div><h3>Effect of Epilepsy on Families, Communities, and Society</h3><p>Adam P. Ostendorf , Satyanarayana Gedela Seminars in Pediatric Neurology Volume 24, Issue 4, November 2017, Pages 340–347</p><p>The effect of epilepsy extends beyond those with the diagnosis and impacts families, communities and society. Caregiver and sibling quality of life is often negatively affected by frequent seizures, comorbid behavioral and sleep disorders and stigma surrounding the diagnosis. Furthermore, the negative effects can be magnified by individual coping styles and resources available to families of those with epilepsy. Beyond the family and immediate caregivers, epilepsy affects local communities by drawing additional resources from education systems. The direct costs of caring for an individual with epilepsy and the indirect costs associated with decreased productivity place financial strain on individuals and health care systems throughout the world. This review details factors affecting family and caregiver quality of life and provides several approaches through which health care providers may address these concerns. Furthermore, we examine the financial effect of epilepsy on society and review emerging strategies to lessen health care use for individuals with epilepsy.</p></div>","PeriodicalId":49284,"journal":{"name":"Seminars in Pediatric Neurology","volume":"47 ","pages":"Article 101084"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71428345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update of Our Understanding of Fetal Heart Rate Patterns in Health and Disease 我们对健康和疾病中胎儿心率模式的最新了解

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-10-01 DOI: 10.1016/j.spen.2023.101072

Christopher A. Lear , Austin Ugwumadu , Laura Bennet , Alistair J. Gunn

{"title":"An Update of Our Understanding of Fetal Heart Rate Patterns in Health and Disease","authors":"Christopher A. Lear , Austin Ugwumadu , Laura Bennet , Alistair J. Gunn","doi":"10.1016/j.spen.2023.101072","DOIUrl":"10.1016/j.spen.2023.101072","url":null,"abstract":"<div><h3>Understanding Fetal Heart Rate Patterns That May Predict Antenatal and Intrapartum Neural Injury</h3><p>Christopher A. Lear, Jenny A. Westgate, Austin Ugwumadu, Jan G. Nijhuis, Peter R. Stone, Antoniya Georgieva, Tomoaki Ikeda, Guido Wassink , Laura Bennet , Alistair J. Gunn Seminars in Pediatric Neurology Volume 28, December 2018, Pages 3–16</p><p>Electronic fetal heart rate (FHR) monitoring is widely used to assess fetal well-being throughout pregnancy and labor. Both antenatal and intrapartum FHR monitoring are associated with a high negative predictive value and a very poor positive predictive value. This in part reflects the physiological resilience of the healthy fetus and the remarkable effectiveness of fetal adaptations to even severe challenges. In this way, the majority of “abnormal” FHR patterns in fact reflect a fetus' appropriate adaptive responses to adverse in utero conditions. Understanding the physiology of these adaptations, how they are reflected in the FHR trace and in what conditions they can fail is therefore critical to appreciating both the potential uses and limitations of electronic FHR monitoring.</p></div>","PeriodicalId":49284,"journal":{"name":"Seminars in Pediatric Neurology","volume":"47 ","pages":"Article 101072"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45613992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Management of Tuberculous Meningitis in Children- an Update 儿童结核性脑膜炎的诊断和治疗——最新进展

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-10-01 DOI: 10.1016/j.spen.2023.101071

Ronald van Toorn, Regan Solomons

{"title":"Diagnosis and Management of Tuberculous Meningitis in Children- an Update","authors":"Ronald van Toorn, Regan Solomons","doi":"10.1016/j.spen.2023.101071","DOIUrl":"10.1016/j.spen.2023.101071","url":null,"abstract":"<div><h3>Update on the Diagnosis and Management of Tuberculous Meningitis in Children</h3><p>Ronald van Toorn, Regan Solomons Seminars in Pediatric Neurology Volume 21, Issue 1, March 2014, Pages 12–18</p><p>Tuberculous meningitis (TBM), the most devastating manifestation of tuberculosis, is often missed or overlooked because of nonspecific symptoms and difficulties in diagnosis. It continues to be an important cause of neurologic handicap in resource-poor countries. Owing to the suboptimal performance of diagnostic tests of TBM, diagnosis relies on thorough history, clinical examination, and relevant investigations. The development of affordable, accurate diagnostic tests for TBM in resource-poor settings remains a priority. Short intensified treatment is safe and effective in both human immunodeficiency virus (HIV)-infected and HIV-uninfected children. Treatment of tuberculous hydrocephalus depends on the level of the cerebrospinal fluid obstruction. Corticosteroids reduce risk of neurodisability and death in HIV-uninfected children. Thalidomide should be considered in children compromised by tuberculosis abscesses and tuberculous-related optochiasmic arachnoiditis. In resource-poor countries, home-based TBM treatment after initial in-hospital stabilization is feasible in carefully selected patients. Early diagnosis and treatment of TBM is the single most important factor determining outcome.</p></div>","PeriodicalId":49284,"journal":{"name":"Seminars in Pediatric Neurology","volume":"47 ","pages":"Article 101071"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47237485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment: Amenable Treatable Severe Pediatric Epilepsies 评论：可治疗的重症小儿癫痫

IF 2.7 4区医学

Seminars in Pediatric Neurology Pub Date : 2023-10-01 DOI: 10.1016/j.spen.2023.101073

Phillip L. Pearl

{"title":"Comment: Amenable Treatable Severe Pediatric Epilepsies","authors":"Phillip L. Pearl","doi":"10.1016/j.spen.2023.101073","DOIUrl":"10.1016/j.spen.2023.101073","url":null,"abstract":"<div><h3>Amenable Treatable Severe Pediatric Epilepsies</h3><p>Phillip L. Pearl Seminars in Pediatric Neurology Volume 23, Issue 2, May 2016, Pages 158–166</p><p>Vitamin-dependent epilepsies and multiple metabolic epilepsies are amenable to treatment that markedly improves the disease course. Knowledge of these amenably treatable severe pediatric epilepsies allows for early identification, testing, and treatment. These disorders present with various phenotypes, including early onset epileptic encephalopathy (refractory neonatal seizures, early myoclonic encephalopathy, and early infantile epileptic encephalop athy), infantile spasms, or mixed generalized seizure types in infancy, childhood, or even adolescence and adulthood. The disorders are presented as vitamin responsive epilepsies such as pyridoxine, pyridoxal-5-phosphate, folinic acid, and biotin; transportopathies like GLUT-1, cerebral folate deficiency, and biotin thiamine responsive disorder; amino and organic acidopathies including serine synthesis defects, creatine synthesis disorders, molybdenum cofactor deficiency, and cobalamin deficiencies; mitochondrial disorders; urea cycle disorders; neurotransmitter defects; and disorders of glucose homeostasis. In each case, targeted intervention directed toward the underlying metabolic pathophysiology affords for the opportunity to significantly effect the outcome and prognosis of an otherwise severe pediatric epilepsy.</p></div>","PeriodicalId":49284,"journal":{"name":"Seminars in Pediatric Neurology","volume":"47 ","pages":"Article 101073"},"PeriodicalIF":2.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48644992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0