{"title":"Efficacy of CycloMesh™ + Ropivacaine in the treatment of uncomplicated inguinal hernia after the Lichtenstein procedure: Results of a prospective multicentric double-blind study","authors":"Frank-Olivier Breleur , Haitham Khalil , André Dabrowski , Francois Mauvais , Irakli Pipia , Mathieu Messager , Mégane Homa , Jean-Marc Regimbeau","doi":"10.1016/j.jviscsurg.2024.11.006","DOIUrl":"10.1016/j.jviscsurg.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Twenty to 30% of patients undergoing inguinal hernia surgery (20 million patients per year worldwide) present early postoperative pain. The aim of this study was to assess the interest of a mesh (CycloMesh™, Cousin Biotech) soaked with ropivacaine for managing early postoperative pain.</div></div><div><h3>Materials and methods</h3><div>This was a randomized, phase III, comparative superiority, double-blind, international multicenter study. From October 2019 to February 2022, 290 patients underwent surgery for uncomplicated inguinal hernia, under general anesthesia, using the Liechtenstein technique. Each patient was randomly assigned to either the experimental group (mesh soaked in ropivacaine hydrochloride 10<!--> <!-->mg/mL) or the control group (mesh soaked in physiological saline solution). The primary endpoint was the pain at cough assessment with the visual analogue scale (VAS) at H6 after the surgery. The secondary endpoints were the global pain assessment at H2, H4, H6, day 1, day 2, day 3, day 7, 1<!--> <!-->month, 1<!--> <!-->year, and 2<!--> <!-->years after the surgery, assessment of antalgic consumption, description of the surgical procedure and postoperative complications rate, hospitalization and post-hospital discharge data (number of conversions from outpatient to inpatient care), and recurrence.</div></div><div><h3>Results</h3><div>Of the 290 patients included in the study, 150 and 140 patients were in the experimental or control group respectively. The per-protocol (PP) population (240 patients) comprised 125 patients in the ropivacaine group and 115 in the control group. The mesh soaking solution had no significant effect on the pain at cough at H6, either in the intention-to-treat population (3.3 vs 3.2, <em>P</em> <!-->=<!--> <!-->0.12) or in the PP population (3.3 vs 3.7, <em>P</em> <!-->=<!--> <!-->0.15). The ropivacaine-soaked prosthesis resulted in a reduction in overall pain at H2 (2.3 vs 3.2, <em>P</em> <!--><<!--> <!-->0.0001), H4 (2.3 vs 3.1, <em>P</em> <!--><<!--> <!-->0.0001) and H6 (2.3 vs 2.7, <em>P</em> <!-->=<!--> <!-->0.0039). There was no difference between the two groups in terms of antalgic consumption, postoperative complications, or the number of ambulatory conversions.</div></div><div><h3>Conclusion</h3><div>The placement of CycloMesh™ soaked with ropivacaine did not reduce the pain at cough at H6 but did reduce overall pain in the first 6<!--> <!-->hours after surgery and could simplify patient management.</div></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":"162 1","pages":"Pages 19-30"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clément Louis-Gaubert, Bastien Le Floc’h, Heithem Jeddou
{"title":"Laparoscopic left hepatectomy (with video)","authors":"Clément Louis-Gaubert, Bastien Le Floc’h, Heithem Jeddou","doi":"10.1016/j.jviscsurg.2024.09.004","DOIUrl":"10.1016/j.jviscsurg.2024.09.004","url":null,"abstract":"","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":"162 1","pages":"Pages 65-68"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Quentin Chenevas-Paule, Pierre-Yves Sage, Mircea Chirica
{"title":"Management of Boerhaave syndrome by right thoracoscopy in prone position (with video)","authors":"Quentin Chenevas-Paule, Pierre-Yves Sage, Mircea Chirica","doi":"10.1016/j.jviscsurg.2024.09.002","DOIUrl":"10.1016/j.jviscsurg.2024.09.002","url":null,"abstract":"","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":"162 1","pages":"Pages 61-64"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RE: RE “Asymptomatic gastric band migration”","authors":"Ymer Durmishi","doi":"10.1016/j.jviscsurg.2024.11.010","DOIUrl":"10.1016/j.jviscsurg.2024.11.010","url":null,"abstract":"","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":"162 1","pages":"Page 70"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Pessaux, Zineb Cherkaoui, Collectif d’écoresponsabilité en santé (CERES)
{"title":"A new healthcare paradigm: Integration of the environment in value-based health care. EROMs: Environment-related outcome measures","authors":"Patrick Pessaux, Zineb Cherkaoui, Collectif d’écoresponsabilité en santé (CERES)","doi":"10.1016/j.jviscsurg.2024.11.001","DOIUrl":"10.1016/j.jviscsurg.2024.11.001","url":null,"abstract":"","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":"162 1","pages":"Pages 2-3"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Floryn Cherbanyk , Marie Burgard , Lucien Widmer , François Pugin , Bernhard Egger
{"title":"Risk factors for local recurrence of rectal cancer after curative surgery: A single-center retrospective study","authors":"Floryn Cherbanyk , Marie Burgard , Lucien Widmer , François Pugin , Bernhard Egger","doi":"10.1016/j.jviscsurg.2024.10.001","DOIUrl":"10.1016/j.jviscsurg.2024.10.001","url":null,"abstract":"<div><h3>Purpose</h3><div>Approximately 7% of patients with rectal cancer experience local recurrence within 5 years of curative surgery. A positive circumferential resection margin (CRM) is among the most significant risk factors. Other reported risk factors include histopathologic type, anastomotic leakage, positive distal margins, and more recently, the anterior localization of the tumor. In this retrospective cohort study, we aimed to assess risk factors for local recurrence in our institution, with a focus on tumor localization as an independent negative predictive factor.</div></div><div><h3>Patients and methods</h3><div>From 2007 to 2018, all patients with stage II or III rectal cancer were included in this study. Patients underwent neoadjuvant chemoradiotherapy followed by surgical resection with total mesorectal excision. The tumor's anterior or posterior localization was assessed by preoperative endosonography or magnetic resonance imaging. Risk factors for local recurrence were assessed using univariate and multivariate regression analyses.</div></div><div><h3>Results</h3><div>A total of 128 patients were included. The 3-year and 5-year local recurrence rates were 4.7% and 7%, respectively. In univariate and multivariate analyses, the histologic type of a poorly differentiated tumor (<em>P</em> <!-->=<!--> <!-->0.001) and a positive CRM (<em>P</em> <!-->=<!--> <!-->0.001) were correlated with local recurrence. Tumor localization (anterior or posterior) was not identified as a statistically significant factor associated with local recurrence.</div></div><div><h3>Conclusion</h3><div>Positive CRM and a poorly differentiated tumor histological subtype were found to be independent risk factors for local recurrence. In contrast to previous findings, anterior localization was not identified as an independent risk factor for local recurrence in our patient cohort.</div></div>","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":"162 1","pages":"Pages 4-12"},"PeriodicalIF":2.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Baron, Charles De Ponthaud, Sébastien Gaujoux
{"title":"Intraoperative pancreatoscopy during left pancreatectomy for intraductal papillary mucinous neoplasia (with video).","authors":"Thomas Baron, Charles De Ponthaud, Sébastien Gaujoux","doi":"10.1016/j.jviscsurg.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.jviscsurg.2025.01.004","url":null,"abstract":"","PeriodicalId":49271,"journal":{"name":"Journal of Visceral Surgery","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}