{"title":"Determination of hallucinogenic active substances of Ephedra distachya L., a cosmopolitan plant species, by GC-MS Method","authors":"Handan Uysal, Mehmet İnce","doi":"10.46239/ejbcs.1480648","DOIUrl":"https://doi.org/10.46239/ejbcs.1480648","url":null,"abstract":"Hallucinogens are defined as substances that, when used, distract the person from the real world and direct them to utopian thoughts. In people who use these substances, time and space become unimportant, and thought, perception and sensory disorders are observed. Prime examples of hallucinogens are marijuana, phencyclidine, lysergic acid diethylamide, and psilocybin. All these addictive substances affect vital organs such as the central nervous system, liver and kidneys, and also cause many fatal diseases such as tuberculosis, cancer and gangrene. This study was carried out to draw attention to the Ephedraceae family, which is used constantly throughout the day because it makes people feel good, is cosmopolitan and grows easily and everywhere, and its use is not prohibited. Especially the above-ground parts of Ephedra distachya L. such as stem, seeds and flowers are used among the public. For this reason, methanol and water extracts of these dried and powdered parts were prepared and evaluated for all chemical components by GC-MS method. According to the GC-MS data obtained, hallucinogenic active ingredients were found only in both extracts of the body part. In addition, determining the potential active substances of herbal extracts is very important for both public health and criminal perspective.","PeriodicalId":492162,"journal":{"name":"Eurasian journal of biological and chemical sciences","volume":" 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141368384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sideritis species in challenging against cancer: Cytotoxic, antiproliferative and apoptotic roles on different cancer cells","authors":"Önder Yumrutaş, Mustafa Pehli̇van, Pınar Yumrutaş","doi":"10.46239/ejbcs.1379553","DOIUrl":"https://doi.org/10.46239/ejbcs.1379553","url":null,"abstract":"Sideritis species belonging to the Lamiaceae family are represented by many species around the world. They exhibit many bioactivities due to their important phytochemicals. They have remarkable bioactivities such as antioxidant, anticancer, antimicrobial, anti-inflammatory, etc. for important sectors such as pharmaceuticals and food. They are thought to be important resources in the fight against cancer, especially due to their cytotoxic effects on cancer cells. Many studies on various cancer cells have reported cytotoxic, antiproliferative and apoptotic properties of sideritis species. In this study, the phytochemical contents of sideritis species growing in different geographies and their cytotoxic, antiproliferative and apoptotic effects in the fight against cancer were discussed in detail molecularly.","PeriodicalId":492162,"journal":{"name":"Eurasian journal of biological and chemical sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitogen-activated protein kinase and phosphatidylinositol 3-kinase/akt signaling pathways in the pathogenesis of obesity","authors":"Adem Keskin","doi":"10.46239/ejbcs.1365464","DOIUrl":"https://doi.org/10.46239/ejbcs.1365464","url":null,"abstract":"Dünya çapında önemli bir sağlık sorunu olan ve vücutta aşırı yağ birikmesiyle karakterize edilen obezite, tip 2 diyabet, kalp-damar hastalıkları ve alkole bağlı olmayan yağlı karaciğer hastalığı gibi bir dizi kronik hastalık riskini keskin bir şekilde artırır. Diyet ve egzersiz gibi yaşam tarzı müdahalelerinin obeziteyle mücadelede önemli etkileri olmasına rağmen, kilo vermede uzun vadeli başarıyı yakalamak son derece zordur ve obezite prevalansı dünya çapında artmaya devam etmektedir. Geçtiğimiz birkaç on yılda, obezitenin patofizyolojisi kapsamlı bir şekilde araştırılmış ve artan sayıda sinyal yolu obezite ile ilişkilendirilmiş, obeziteyle daha etkili ve kesin bir şekilde mücadele etmek için sinyal yollarına odaklanılmıştır. Mitojenle aktifleşen protein kinaz (MAPK) sinyal yolu iştah kontrolüne, glukoz seviyelerinin düzenlenmesine ve yağ hücresi oluşumuna katkıda bulunurken aynı zamanda insülin direncinin gelişmesine de yol açabilir. MAPK'nın rolü özellikle hipotalamus ve yağ dokusunda vurgulanmıştır. Fosfatidilinositol 3-kinaz/AKT sinyal yolu, hücre büyümesinin ve çoğalmasının düzenlenmesinde kritik bir rol oynar. Bu yolun anormal aktivasyonu obezitenin gelişimini teşvik edebilir ve insülin direncine katkıda bulunabilir. Araştırmalar, iştahın düzenlenmesinde sinyal yolları, yağ dokusu metabolizması ve enerji dengesi arasındaki ilişkilerin daha iyi anlaşılması gerektiğini göstermektedir. Sonuç olarak obezite yönetimine yönelik yenilikçi ve güvenli önlemlerin araştırılması gerekmektedir. Sinyal yolakları obezitenin patogenezinde önemli bir rol oynamaktadır ve gelecekteki çalışmaların bu konuya daha fazla odaklanması gerekmektedir.","PeriodicalId":492162,"journal":{"name":"Eurasian journal of biological and chemical sciences","volume":"136 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}